Clinical trials: Osseointegration, open to volunteers
Dental Implants, Immediate Dental Implant Loading
Blue®M Gel Versus Hyaluronic Acid for Stability of Immediately Loaded Dental Implants
This randomized controlled clinical trial aims to compare the effect of topical oxygen therapy (Blue®M Gel) and hyaluronic acid on the stability of immediately loaded dental implants placed in the posterior maxilla.
- Conditions
- Dental Implants, Immediate Dental Implant Loading, Implant Stability
- Trial name
- NCT07844928
- Testing
- Blue®M Gel, Hyaluronic Acid
- Volunteers
- 24 people
- Sponsor
- Mansoura University
Transhumeral Amputation
Optimizing Transhumeral Osseointegration Prosthesis Control
Upper limb amputation above the elbow results in a significant loss of function. There have been many advancements in surgery and prosthetic devices to restore arm function, but many people still reject upper limb prostheses.
- Trial name
- NCT06853938
- Testing
- Myoelectric prosthesis
- Where
- 2 sites in Canada
- Volunteers
- 5 people
- Sponsor
- University of Alberta
Implant Site Reaction
Perioperative Oral Vitamin D3 Supplementation on Implant Osseointegration
The number of patients treated in Implantology at Nantes University Hospital is 400 per year. This pilot study aims to demonstrate the efficacy of a 6-month oral cholecalciferol supplementation on osseointegration in patients…
- Trial name
- OSIVID (NCT06776640)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital
Amputation; Traumatic, Leg, Lower
Transtibial Osseointegration
Purpose: Aim 1: Quantify soft tissue complications and infections of service members with transtibial amputations treated with OPRA OI and compare them to transfemoral OI service members.
- Trial name
- TOSS (NCT06636136)
- Testing
- OPRA
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Walter Reed National Military Medical Center
Dental Implant, Immediate Dental Implant Placement
Melatonin Effect on Immediate Dental Implants in the Posterior Mandible
This pilot randomized controlled clinical trial aims to evaluate the feasibility, clinical safety, and preliminary radiographic osteogenic effects of applying topical 1% w/w melatonin gel during immediate implant placement in the…
- Conditions
- Dental Implant, Immediate Dental Implant Placement, Alveolar Bone Loss, Bone Density
- Trial name
- NCT07869030
- Testing
- 1% w/w Melatonin Gel, Standard Immediate Dental Implant Placement
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Future University in Egypt
Atrophic Maxilla, Partial Edentulism
Prospective Study of Bone Augmentation With Lateral Sinus Lift and Osseointegration of Dental Implants
By using a split-mouth model in the maxilla, lateral sinus lift procedures will be performed using xenograft on one side vs autologous bone augmentation and PRF membranes on the other side.
- Trial name
- NCT07014085
- Testing
- "Histomorphometric Evaluation of Bone Augmentation Using Xenografts Versus Autologous Bone Grafts in Dental Implant Patients: A Comparative Clinical Study
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maria H. Pham
Amputation
Evaluation of a Powered Ankle Prosthesis Capable of Bidirectional Control Via Neural Recording and Cutaneous Stimulation in Free-Space and Walking Tasks
The purpose of this study is to evaluate the performance of a powered ankle prosthesis capable of bidirectional control via neural recording and cutaneous stimulation, during free-space and walking tasks.
- Trial name
- NCT07645729
- Testing
- Powered Prosthesis, Prescribed Prosthesis
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Massachusetts Institute of Technology
Tooth Loss, Edentulism
PMCF Study on the Effectiveness and Safety of BIODENTOSS® and DWC® Dental Implants and Superstructures
This prospective, single-center, interventional post-market clinical follow-up (PMCF) study aims to evaluate the early-term (24 months post-implantation) safety and efficacy of CE-marked BIODENTOSS® and DWC ® Dental Implants and…
- Trial name
- NCT07633665
- Testing
- BIODENTOSS Bone-Level Dental Implant and Superstructures, DWC Bone-Level Dental Implant and Superstructures
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Değirmenci Otomotiv ve Metal Endüstri A.Ş.
Alveolar Bone Loss, Dental Implant
Magnetic Mallet Vs Conventional Drilling in D4 Posterior Maxilla
The goal of this clinical trial is to evaluate whether the magnetic mallet technique improves primary implant stability and clinical outcomes compared with conventional drilling during dental implant placement in the posterior…
- Conditions
- Alveolar Bone Loss, Dental Implant, Osseodensification Drilling Technique
- Trial name
- NCT07424820
- Testing
- Conventional drilling osteotomy, Magnetic mallet osteotomy
- Where
- Iraq
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Mosul
Prosthesis, Lower Limb Amputation Knee
Clinical and Functional Assessment of Patients With Transfemoral Amputation Treated With Osteointegrated Implant
Limb amputation is a traumatic event that significantly reduces the ability to perform daily activities, impairs mobility, and lowers quality of life.
- Conditions
- Prosthesis, Lower Limb Amputation Knee, Amputation; Traumatic, Leg, Lower
- Trial name
- OSTEO-OUTCOME (NCT06737770)
- Testing
- osseointegrated surgery for transfemoral amputation
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Ortopedico Rizzoli
Glenohumeral Osteoarthritis
Poly vs Hybrid Glenoid in Stemless aTSA
Participants are randomized 1:1 to receive either a cemented all-polyethylene pegged glenoid or a hybrid trabecular titanium-pegged glenoid during anatomic total shoulder arthroplasty.
- Trial name
- Poly vs hybrid (NCT07520721)
- Testing
- Anatomic total shoulder arthroplasty with cemented all-polyethylene pegged glenoid, Anatomic total shoulder arthroplasty with hybrid trabecular titanium central-peg glenoid
- Where
- Netherlands
- Volunteers
- 94 people
- Sponsor
- Spaarne Gasthuis
Dental Implant, Bone Grafting
Influence of Alveolar Bone Drilling and Anatomical Position on Integration
The goal of this clinical trial is to learn if alveolar bone drilling and anatomical position of an immediately placed dental implant has influence on the primary stability, osseointegration and function.
- Conditions
- Dental Implant, Bone Grafting, Immediate Dental Implant Placement
- Trial name
- NCT07589140
- Testing
- dental implant placement, Dental implant
- Where
- Lithuania
- Volunteers
- 124 people
- Sponsor
- Lithuanian University of Health Sciences
Amputation, Osseointegration
Advancing Antimicrobial Photodynamic Therapy to Prevent Infection in Osseointegrated Prosthesis Patients
This will be a prospective observational trial enrolling 20 patients with osseointegrated prostheses. Participants will be recruited from the orthopaedic outpatient clinic at Walter Reed National Military Medical Center in…
- Trial name
- NCT06777511
- Testing
- 5-aminolevulinic acid (5-ALA), Photodynamic therapy (PDT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Tooth Loss
Evaluation of Enamel Matrix Derivative in Immediate Dental Implants in the Mandibular Molar Region
This randomized clinical trial will evaluate the effect of using an enamel matrix derivative during immediate dental implant placement in the mandibular molar region.
- Trial name
- NCT07727655
- Testing
- Enamel Matrix Derivative (Emdogain), Immediate Dental Implant Placement
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Mansoura University
Amputation With Osseointegration
Microbiome Population Adaptation Study
The investigators will accomplish our research aims by collecting cutaneous microbiome samples from 50 persons that have undergone the Osseointegration (OI) surgery at eight timepoints, prospectively.
- Trial name
- OLIMPAS (NCT06310239)
- Testing
- Collection of biologic samples and data
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Walter Reed National Military Medical Center
Amputation
Powered Prosthesis for Use With TF Osseointegration Recipients
The purpose of this study is to evaluate functional mobility, control, and user satisfaction from persons who have an amputation above the knee and have received osseo-integration (OI) and targeted muscle reinnervation (TMR)…
- Trial name
- NCT06160882
- Testing
- Powered Prosthesis Training and EMG data collection, Perform Osseointegration (OI) surgery and Targeted Muscle Reinnervation (TMR)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Shirley Ryan AbilityLab
Osseointegration Infection
Intraosseous Antibiotics for Osseointegration
The purpose of this research study is to learn about the characteristics of infection in osseointegration patients. This research study will also study how safe and effective it is to use antibiotics inside the bone.
- Trial name
- IOAOI (NCT07621094)
- Testing
- intraosseous antibiotic delivery
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Severe Maxillary Atrophy
Assessment of Bone Density Following Application of BMAC Around Zygomatic Implant
This prospective case series is designed to evaluate the effect of autologous bone marrow aspirate concentrate applied around zygomatic implants placed via the intrasinus approach.
- Trial name
- BMAC (NCT07657026)
- Testing
- zygomatic implants placement
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Cairo University
Dental Implant Macrodesign, Dental Implant Surface Treatment
Effect of Implant Macro-Design and Surface Treatment on Insertion Torque and Early Implant Stability Quotient (ISQ)
This prospective, randomized pilot clinical trial will evaluate the effect of dental implant macro-design and surface treatment on insertion torque values (ITV) and early implant stability quotient (ISQ) trajectories in healed…
- Conditions
- Dental Implant Macrodesign, Dental Implant Surface Treatment, Dental Implant Primary Stability, Dental Implant Secondary Stability
- Trial name
- NCT07744776
- Testing
- Chairside implant surface treatment with Plasma X Motion device, SLA implant surface, Straumann BLT implant macro design
- Where
- Lithuania
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Dantu implantologijos centras
Jaw, Edentulous, Partially, Bone Resorption
Clinical and Radiographic Evaluation of UV-Treated Dental Implants With or Without Melatonin in the Upper Posterior Jaw
The purpose of this study is to evaluate and compare the clinical and radiographic outcomes of using photofunctionalized (UV-treated) dental implants with or without the application of melatonin hormone in the posterior maxilla…
- Conditions
- Jaw, Edentulous, Partially, Bone Resorption, Dental Implant Failure
- Trial name
- UV-MEL-IMPLANT (NCT07853976)
- Testing
- UV-Photofunctionalized Dental Implant, Conventional Dental Implant
- Where
- Egypt
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Mansoura University