Clinical trials: Ossification of Posterior Longitudinal Ligament
Ossification of the Posterior Longitudinal Ligament
A Prospective Study Comparing the Efficacy of Laminoplasty and Laminectomy With Fusion for Ossification of the Posterior Longitudinal Ligament With High Occupation Rate in Cervical Spine
The efficacy of laminoplasty and laminectomy with fusion for ossification of the posterior longitudinal ligament with high occupation rate in the cervical spine is not clear in the literature report so far.
- Trial name
- NCT05019001
- Testing
- Laminoplasty, Laminectomy With Fusion
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Cervical Myelopathy, Ossification of Posterior Longitudinal Ligament in Cervical Region
The Establishment of the Integration of Surgery and Postoperative Intensive Recovery of Patients With CSM
This study aims to establish the specialist consensus of the integration of posterior approach surgical treatment and postoperative intensive recovery management for CSM or OPLL patients, and verify its safety, practicability and…
- Trial name
- NCT04947891
- Testing
- Intensive recovery management
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Peking University Third Hospital
Cervical Spondylotic Myelopathy, Ossification of Posterior Longitudinal Ligament in Cervical Region
The Application of Enhanced Recovery After Surgery Clinical Pathway in Posterior Cervical Spine Surgery
This study intends to establish a multidisciplinary collaborative ERAS clinical pathway of cervical posterior surgery,and to verify its effectiveness, safety and value in health economics.
- Trial name
- NCT05149404
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
OPLL, Medicine, Korean Traditional
Long Term Follow-Up of Post Neck Pain Patients Accompanying Ossification of Posterior Longitudinal Ligament Treated With Integrated Complementary and Alternative Medicine: Observational Study
The purpose of this study is to reveal the effectiveness and safety of integrative Korean medicine for Ossification of Posterior Longitudinal Ligament(OPLL) by observation inpatients treated with integrative Korean medicine.
- Trial name
- NCT04446221
- Testing
- phone survey
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Jaseng Medical Foundation
Indications and Effectiveness for Extended Posterior Circumferential Decompression
Safety and Effectiveness of Extended Circumferential Decompression for Thoracic Ossification of Posterior Longitudinal Ligament
The study was to evaluate the indications, efficiency and safety of the extended posterior circumferential decompression technique for the treatment of thoracic ossification of posterior longitudinal ligament (TOPLL) with dura…
- Trial name
- NCT04910737
- Testing
- extended posterior circumferential decompressive surgery
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ossification Posterior Longitudinal Ligament, Cervical Spondylotic Myelopathy
Comparison of IONM Between Remimazolam and Propofol
Inhalation anesthetics significantly can delay latency and reduce amplitude of cortical MEPs and SSEPs signals compared to intravenous anesthetics by acting on not only GABA (γ-aminobutyric acid) receptors but also NMDA…
- Trial name
- NCT04968054
- Testing
- Arm I (Propofol), Arm II (Remimazolam)
- Where
- South Korea
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Ossification of Posterior Longitudinal Ligament, Cervical Spondylosis With Myelopathy
Multi-centre Study to Evaluate ACAF Versus Laminoplasty in Treating Cervical Ossification of the Posterior Longitudinal Ligament
The purpose of this study is to compare the efficacy, safety and imaging outcomes between Anterior Controllable Antedisplacement and Fusion (ACAF) and Laminoplasty in the treatment of severe ossification of cervical posterior…
- Trial name
- NCT04968028
- Testing
- ACAF, Laminoplasty
- Where
- 12 sites in China
- Volunteers
- 167 people
- Sponsor
- Shanghai Changzheng Hospital
Spinal Cord Injury
Optimal Treatment for Spinal Cord Injury Associated With Cervical Canal Stenosis (OSCIS) Study
Controversy exists regarding the optimal management of acute traumatic cervical spinal cord injury (SCI), especially those without bone injury.
- Trial name
- OSCIS (NCT01485458)
- Testing
- Early surgery, Delayed surgery
- Where
- Japan
- Volunteers
- 72 people
- Sponsor
- Tokyo University
Spinal Cord Compression, Spondylosis
UNiD 3D VBR Register
Multicenter study allowing to include the first sixty patients implanted with a custom-made corpectomy implant (UNiD 3D VBR): 30 patient implanted in cervical region and 30 patients implanted in thoracolumbar region.
- Conditions
- Spinal Cord Compression, Spondylosis, Ossification of Posterior Longitudinal Ligament, Spinal Neoplasms
- Trial name
- NCT02926391
- Testing
- UNiD 3D VBR
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Medicrea International
OPLL, PBMCs
RNA-seq Analysis of PBMC in Patients With OPLL
In this study, we planned to identify transcriptome expression profiles (circRNAs, lncRNAs, and mRNAs) from peripheral blood mononuclear cells (PBMCs) of 30 patients with OPLL and 30 other non-OPLL patients by high-throughput…
- Conditions
- OPLL, PBMCs, Transcriptome, Bioinformatics
- Trial name
- NCT04963101
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Ossification of Posterior Longitudinal Ligament
Comparison of ACAF and ACCF in the Treatment of Cervical OPLL
Background: Dr. Shi recently proposed a new technique as Ossification of anterior decompression surgery, which is also called anterior controllable antedisplacement and fusion (ACAF) , for ossification of the posterior…
- Trial name
- ACAF (NCT03312985)
- Testing
- ACAF surgery, ACCF surgery
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Changzheng Hospital
Intervertebral Disk Degeneration, Intervertebral Disk Displacement
Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™
Anterior cervical discectomy and fusion (ACDF) has shown good treatment results for a variety of cervical spine diseases such as herniated intervertebral disc (HIVD), cervical spondylotic radiculopathy (CSR) and cervical…
- Conditions
- Intervertebral Disk Degeneration, Intervertebral Disk Displacement, Ossification of Posterior Longitudinal Ligament
- Trial name
- NCT01615328
- Testing
- Cervios ChronOs, Bonion
- Where
- South Korea
- Volunteers
- 85 people
- Sponsor
- Seoul National University Hospital
Myelopathy Cervical, Kyphosis Post Surgical
Comparison Between C3-6 Laminoplasty and C3 Laminectomy With Cervical Laminoplasty
Investigators performed a prospective randomized controlled trial for comparing postoperative clinical and radiological outcomes between C3 laminectomy with laminoplasty and C3-6 laminoplasty.
- Conditions
- Myelopathy Cervical, Kyphosis Post Surgical, Neck Pain, Ossification of Posterior Longitudinal Ligament
- Trial name
- NCT05006495
- Testing
- C3 laminectomy, C3 laminoplasty
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Seoul National University Hospital
Cervical Disc Herniation, Cervical Spinal Stenosis
Edge Computing Platform for Spine Health Risk Management Based on IoT Technology
This project proposes to monitor the spinal posture of a person at rest and in motion in real time through a sensor device that contains spinal health monitoring as its core.
- Conditions
- Cervical Disc Herniation, Cervical Spinal Stenosis, Ossification of Posterior Longitudinal Ligament, Neckbrace Device
- Trial name
- NCT06092138
- Testing
- Wearable Device
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xuanwu Hospital, Beijing
Ossification of Posterior Longitudinal Ligament
A Multi-center Study：Comparison of ACAF and ACCF in the Treatment of Cervical OPLL
Background:The ACAF technology has been in clinical trials for some time. More and more doctors are starting to pay attention to this technology. There are many hospitals in China that have developed this technology.
- Trial name
- NCT03591692
- Testing
- ACAF surgery, ACCF surgery
- Where
- China
- Volunteers
- 840 people
- Sponsor
- Shanghai Changzheng Hospital