Clinical trials: Osteo Arthritis
Osteo Arthritis Knee
Incorporating Patient-Reported Outcomes Into Shared Decision Making With Patients With Osteoarthritis of the Hip or Knee
Osteoarthritis (OA) of the knee constitutes a major public health problem. Treatment options for knee OA range from lifestyle changes to pharmacological management to total knee replacement surgery.
- Trial name
- NCT04805554
- Testing
- Joint Insights decision aid
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Osteo Arthritis Knee, Pain, Postoperative
Single Dose Adductor Canal Block vs SPANK Block for TKA
This is a prospective, randomized control trial to compare SPANK block combined with adductor canal block to adductor canal block alone in treatment of post-operative pain after total knee arthroplasty.
- Conditions
- Osteo Arthritis Knee, Pain, Postoperative, Pain, Acute
- Trial name
- NCT03502889
- Testing
- SPANK Block (Sensory Posterior Articular Nerves of the Knee), Adductor Canal Block, Ropivacaine Hcl 0.5% Inj Vil 30Ml
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- San Antonio Uniformed Services Health Education Consortium
Osteo Arthritis Knee
Traditional Versus Alternative Alignment in TKR
As many as 20% of patients are unhappy with the results of total knee replacement (TKR). Various changes to surgical technique have tried to address this but have not led to a significant improvement in the numbers of patients…
- Trial name
- NCT03196011
- Testing
- TKR with mechanical alignment method, TKR with alternative alignment method
- Where
- United Kingdom
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Healthy, Osteo Arthritis Knee
[Tc-99m]-RPI-087 as an Imaging Marker in Osteoarthritis of the Knee Compared to Healthy Volunteers
The main purpose of this study is to test the safety and tolerability of T-087. The study will enroll 6 healthy volunteers (HVs) and 6-18 subjects with KOA.
- Trial name
- NCT03503825
- Testing
- [Tc-99m]-RPI-T-087 Injection
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Reiley Pharmaceuticals Inc.
Chronic Pain, Osteo Arthritis Knee
Persistent Pain in Pharmacologically or Surgical Treated Osteoarthritis: Role of Mu-Limpho Marker
The goal of this prospective observational study is to analyze the percentage of expression of B and NK cells expressing Mu opioid receptor on their surface, named Mu-Lympho-Marker (MLM), to measure pain progression in…
- Trial name
- MLM (NCT06637709)
- Where
- Italy
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Total Shoulder Arthroplasty, Osteo Arthritis Shoulders
Posterior Approach to Total Shoulder Arthroplasty
The purpose of this study is to evaluate preoperative objective measurements and operative objective measurements to determine if there is any effect to postoperative outcomes.
- Trial name
- pTSA (NCT03623269)
- Testing
- posterior approach to total shoulder arthroplasty
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- The Orthopaedic Research & Innovation Foundation
Osteo Arthritis of the Knee, Pain
The Effectiveness of BETY in Knee Osteoarthritis With Intra-Articular Injections
Osteoarthritis (OA) is the most common condition in middle-aged and elderly populations; it causes pain and physical disability and is characterized by cartilage degeneration, changes in bone tissue, inflammation of the synovial…
- Conditions
- Osteo Arthritis of the Knee, Pain, Pain Management, Exercise
- Trial name
- NCT07496203
- Testing
- BETY
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Osteo Arthritis Knee
Measurement of Osteoarthritic Patient Pain Through Electrodermal Activity Signals
This pilot study aims to investigate the viability of using a smartwatch-based electrodermal activity (EDA) sensor to capture enough EDA signal to quantitatively assess pain in osteoarthritis subjects and test the feasibility of…
- Trial name
- NCT06701461
- Testing
- Electrodermal Activity signal
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Osteo Arthritis Knee
Comparision of IPACK and Periarticular Block With Adductor Block Alone After Total Knee Artroplasty
105 patients ASA I-III, undergoing total knee arthroplasty under spinal anesthesia, will be randomly assigned into one of three groups, namely group A (n=35), where an adductor canal block, group B (N:35) where an adductor canal…
- Trial name
- NCT04931966
- Testing
- block, adductor canal block, Adductor Canal Block plus IPACK Block
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Karaman Training and Research Hospital
Osteo Arthritis of the Knee, Rhematoid Arthritis
Rehabilitation Approaches Used in Total Knee Replacement
In this study, we will investigate the rehabilitation approaches commonly used by physiotherapists in Pakistan following total knee replacement.
- Trial name
- NCT07375082
- Testing
- Questionnaire
- Where
- Pakistan
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Bahria University
Unicompartmental Knee Replacement, Osteo Arthritis Knee
RCT: Mako Medial Unicondylar Knee Arthroplasty vs Oxford Unicondylar Knee Arthroplasty
The overall aim of this prospective, randomised, single-blinded, controlled trial is to compare clinical outcomes and accuracy of implant positioning in Mako robotic UKA versus jig-based Oxford UKA with navigation control.
- Conditions
- Unicompartmental Knee Replacement, Osteo Arthritis Knee, Surgery
- Trial name
- NCT04095637
- Testing
- Medial knee arthroplasty
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University College, London
Osteo Arthritis Knee
Efficacy of Duloxetine Compared to NSIADs in Osteoarthritis of Knee
Osteoarthritis (OA) is the most common degenerative joint disease, affecting more than 25% of the population . Knee OA is an insidious disease related to structural changes in the joint over many years.
- Trial name
- Duloxetine (NCT05486026)
- Testing
- Duloxetine 30 MG, Nonsteroidal Antiinflammatory Drug
- Where
- Iraq
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
Osteo Arthritis Knee, Total Knee Arthroplasty
Comparing Surgical and Economical Parameters of Total Knee Replacement.
Randomized study comparing surgical and economic parameter of Total Knee Arthroplasty performed using two different specific surgical techniques.
- Trial name
- NCT03427047
- Testing
- MyKnee with single use Efficiency Instrument, Stryker Navigational with conventional metal instruments
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Medacta USA