Clinical trials: Osteoarthritis
Osteoarthritis, Rheumatoid Arthritis
Total Knee Replacement Using Simplex® or Cobalt™ Bone Cement
The purpose of this study is to collect radiographic and clinical outcomes of total knee replacement using Simplex® or Cobalt™ Bone Cement.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Knee Arthritis
- Trial name
- NCT00589485
- Testing
- Simplex® Bone Cement, Cobalt™ Bone Cement
- Where
- United States
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Patient-Reported and Radiographic Outcomes in Evaluating Lorecivivint (SM04690) for the Treatment of Knee Osteoarthritis
This phase 3 study is a multicenter, randomized, double-blind, placebo-controlled study of lorecivivint injected intra-articularly (IA) into the target knee (most painful) joint of moderately to severely symptomatic…
- Trial name
- STRIDES-Xray (NCT03928184)
- Testing
- Lorecivivint
- Where
- 99 sites in United States
- Volunteers
- 501 people
- Sponsor
- Biosplice Therapeutics, Inc.
Osteoarthritis
Analgesic Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the Knee
To study the efficacy and safety of naproxcinod vs. placebo and naproxen in the treatment of signs and symptoms of Osteoarthritis.
- Trial name
- NCT00542555
- Testing
- Naproxcinod 375 mg, Naproxen, Naproxcinod 750 mg
- Volunteers
- 918 people
- Sponsor
- NicOx
Osteoarthritis, Knee
Investigational Testing of Bodycad Unicompartmental Knee Prosthesis (UKS)
This study is designed to observe clinical outcomes of patient-specific knee arthroplasty in patients with osteoarthritis of the medial condyle.
- Trial name
- NCT03432481
- Testing
- Unicompartmental Knee Arthroplasty Surgery, Bodycad Unicompartmental Knee System (BUKS)
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Laboratoires Bodycad Inc.
Osteoarthritis, Knee
nCap Pain Relief Patch vs. Placebo
The purpose of this study is to determine whether use of the nCap Medical Nano-Capacitive pain relief patch reduces subject pain as measured by subject pain scores, WOMAC scores (pain, stiffness and physical function), global…
- Trial name
- NCT04753567
- Testing
- nCap pain relief patch
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- nCap Medical
Rheumatoid Arthritis, Systemic Lupus Erythematosus
Ascension® Post- Approval Study; PyroCarbon Metacarpophalangeal Total Joint Prosthesis
This study is a non-randomized, consecutive enrollment, one-year post-approval study of patients who are treated with the Ascension® MCP.
- Conditions
- Rheumatoid Arthritis, Systemic Lupus Erythematosus, Osteoarthritis, Post-traumatic Arthritis
- Trial name
- MCP (NCT02408471)
- Testing
- Ascension® MCP Finger Implant
- Where
- 9 sites in United States
- Volunteers
- 97 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis, Post-traumatic Arthritis
ATTUNE Single-Use Instrumentation vs. ATTUNE Reusable Instrumentation in Primary Total Knee Arthroplasty
This post-marketing investigation will evaluate the mechanical axis alignment achieved with the ATTUNE Single-Use Instrumentation (SUI) as compared to the mechanical axis alignment achieved with the ATTUNE Reusable…
- Trial name
- SOLO (NCT02574312)
- Testing
- ATTUNE TKA with ATTUNE RUI, ATTUNE TKA with ATTUNE SUI
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 88 people
- Sponsor
- DePuy Orthopaedics
Osteo Arthritis Knee
A Retrospective Study to Evaluate the ConforMIS iTotal® Posterior Stabilized (PS) Knee Replacement System
This study is a retrospective, multi-center study, with one single remote follow up contact. This study will include a minimum of 80 patients and a maximum 100 patients who have been treated with the ConforMIS iTotal PS knee…
- Trial name
- NCT03289000
- Testing
- iTotal Posterior Stabilized (PS) Knee Replacement System
- Where
- 2 sites in United States
- Volunteers
- 93 people
- Sponsor
- Restor3D
Pain
A 12-Week Efficacy Study of Paracetamol 1000mg Sustained-release Tablets in Patients With Osteoarthritis
The purpose of the study is to determine whether paracetamol 1000 mg sustained-release (SR) tablets administered orally, twice daily are effective and safe in the treatment of patients with osteoarthritis of the knee or hip.
- Trial name
- NCT02311881
- Testing
- Paracetamol 1000 mg SR tablets, Paracetamol 665 mg SR tablets
- Where
- 56 sites in United States
- Volunteers
- 960 people
- Sponsor
- GlaxoSmithKline
Osteoarthritis, Osteoarthritis, Knee
Effect of Diacerein vs Celecoxib on Symptoms and Structural Changes in Symptomatic Knee Osteoarthritis
Osteoarthritis (OA) of the knee is the most frequent cause of knee pain after the age of 50 years. OA is a joint disease characterised by articular cartilage loss associated with structural changes in the cartilage and adjacent…
- Trial name
- DISSCO (NCT02688400)
- Testing
- Diacerein, Celecoxib
- Where
- 22 sites in Austria, Belgium and 3 more
- Volunteers
- 380 people
- Sponsor
- TRB Chemedica International SA
Knee Pain
The Effects of Transcutaneous Electrical Nerve Stimulation on People With Knee Osteoarthritis (OA) and or Chronic Pain
The purpose of this study is to evaluate the effect of TENS at the knee pain.
- Trial name
- NCT04084236
- Testing
- electrical stimulation
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Omron Healthcare Co., Ltd.
Osteoarthritis, Knee
A Controlled Surveillance of the Osteoarthritic Knee Microenvironment With Regenexx® SD Treatment
The primary objective of this study is to determine the levels of proteins and/or cellular components of the synovial fluid that are indicative of microenvironment phenotypes of the osteoarthritic knee compared to unilateral…
- Trial name
- NCT02370823
- Testing
- Regenexx SD
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Regenexx, LLC
Pain
Patient-Reported Effectiveness and Safety of Etoricoxib in Osteoarthritis (OA)(0663-113)
The purpose of this study is to collect disease burden of OA and the effectiveness and patient satisfaction of treatment by Etoricoxib in the normal practice setting.
- Trial name
- NCT00757627
- Testing
- etoricoxib
- Volunteers
- 500 people
- Sponsor
- Organon and Co
Muscle Atrophy
Safety and Tolerability of IMM01-STEM in Patients With Muscle Atrophy Related to Knee Osteoarthritis.
An open-label dose escalation study to assess the safety and tolerability of IMM01-STEM in participants with muscle atrophy related to knee osteoarthritis
- Trial name
- STEM-MYO (NCT05211986)
- Testing
- IMM01-STEM
- Where
- 2 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Immunis, Inc.
Osteoarthritis, Knee
Validation of a Surgical Navigation Algorithm During Knee Replacements in Patients With Knee Osteoarthritis
Ganymed Robotics develops a novel solution of surgical navigation to assist surgeons during knee remplacement surgeries. The aim of this study is to train and validate this novel algorithm.
- Trial name
- VALALGON (NCT04912908)
- Testing
- Images taken during knee replacement surgery
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Ganymed Robotics
Degenerative Joint Disease
R3 Delta Ceramic Acetabular System PAS U.S.
R3 Delta Post-Approval Study U.S.
- Trial name
- R3-PAS (NCT03056534)
- Testing
- R3 Biolox Delta Ceramic Acetabular System
- Where
- 8 sites in United States
- Volunteers
- 189 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis (OA) of the Knee, Osteoarthritis Knee Pain
First in Human Study of SakuraBead for Genicular Artery Embolization to Treat Pain Secondary to Knee Osteoarthritis
A prospective, single-centre, single-arm, unmasked, First in Human study that aims to evaluate the safety and efficacy of SakuraBead resorbable microspheres in adult patients suffering from pain secondary to knee osteoarthritis.
- Conditions
- Osteoarthritis (OA) of the Knee, Osteoarthritis Knee Pain, Joint Diseases, Musculoskeletal Diseases
- Trial name
- NCT06718478
- Testing
- SakuraBead Resorbable Microspheres
- Where
- Uzbekistan
- Volunteers
- 15 people
- Sponsor
- CrannMed
Non-inflammatory Degenerative Joint Disease, Osteoarthritis
28mm Ceramic-on-Ceramic Total Hip Replacement Study
This study is intended to gather medium (0-5 years) and long-term (6-10 years) information regarding the performance and safety of the commercially available Ceramax™ Ceramic on Ceramic Total Hip System.
- Conditions
- Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Post-traumatic Arthritis
- Trial name
- COC28 (NCT01657435)
- Testing
- Ceramax Acetabular System
- Where
- 13 sites in United States, Canada
- Volunteers
- 185 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis of the Knee
Safety and Efficacy of Etoricoxib 30 mg Versus Celecoxib 200 mg in Korean Participants With Osteoarthritis
The main purpose of this study is to establish that etoricoxib 30 mg is safe and not inferior to celecoxib 200 mg in the treatment of the signs and symptoms of osteoarthritis in Korean patients.
- Trial name
- NCT01554163
- Testing
- Etoricoxib 30 mg, Celecoxib 200 mg
- Volunteers
- 239 people
- Sponsor
- Organon and Co
Joint Disease
Evaluation of Bone Mineral Density Changes After Total Hip Replacement: A Two-Year Clinical and DXA Analysis
Sponsor is conducting this post-market study to evaluate the clinical outcome and femoral bone mineral density (BMD) changes associated with the PROFEMUR® PRESERVE hip stem when used as indicated for primary total hip…
- Trial name
- NCT02865447
- Testing
- total hip arthroplasty implant
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- MicroPort Orthopedics Inc.
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