Clinical trials: Osteoarthritis (OA)
Knee Osteoarthritis
Allogeneic Bone Marrow MSC Therapy for Knee Osteoarthritis
The Clinical trial is a phase I/IIa clinical study for treatment of knee osteoarthritis by intra-articular injection of bone marrow derived allogeneic mesenchymal stem cells.
- Trial name
- NCT03589287
- Testing
- Chondrochymal®
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Osteoarthritis
Efficacy and Safety of Oral Salmon Calcitonin in Patients With Knee Osteoarthritis (OA 2 Study)
The purpose of this phase III study is to Evaluate the Efficacy and Safety of Oral Salmon Calcitonin in the Treatment of Patients with Osteoarthritis of the Knee
- Trial name
- NCT00704847
- Testing
- Oral Salmon Calcitonin
- Where
- 18 sites in United States, Belgium and 8 more
- Volunteers
- 1,030 people
- Sponsor
- Nordic Bioscience A/S
Osteoarthritis, Knee
Double-Blind, Double Dummy, Randomized Comparison Study to Evaluate the Efficacy and Safety of Valdecoxib 10 mg Once Daily and Naproxen 500 mg Twice Daily in Treating the Signs and Symptoms of Osteoarthritis of the Knee
This study was performed to demonstrate that treatment with valdecoxib 10 mg daily (QD) was at least as effective as with naproxen 500 mg twice daily (BID), a standard non-steroidal anti-inflammatory drug (NSAID), when taken for…
- Trial name
- NCT00652808
- Testing
- valdecoxib, naproxen
- Where
- 8 sites in South Korea
- Volunteers
- 265 people
- Sponsor
- Pfizer
Knee Osteoarthritis
The Effect of Mobilization on Inflammatory Biomarkers in Patients With Knee Osteoarthritis.
This study is designed to investigate whether a hands-on therapy called Mobilization with Movement (MWM) can reduce pain and inflammation in individuals with knee osteoarthritis (OA).
- Trial name
- NCT07166068
- Testing
- Manual Therapy (Mobilization with Movement), Exercise
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- University of Jazan
Knee Osteoarthritis
Effects of Bracing on Knee Osteoarthritis (OA)
Knee osteoarthritis (OA) is characterized by complaints of knee pain, aching and stiffness that commonly alter the way one will climb stairs and walk reducing an individual's function and the activities they may perform on a…
- Trial name
- NCT01886144
- Testing
- Knee OA Brace
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Knee Osteoarthritis
The Efficacy of Exercise and Alternative Applications of NMES on Pain and Function in Patients With Knee OA
The aim of the study was to investigate the efficacy of exercise and different size electrodes of neuromuscular electrical stimulation (NMES) applications on pain, range of motion (ROM), muscle strength, function status and…
- Trial name
- NCT03571698
- Testing
- Neuromuscular Electrical Stimulator
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Osteo Arthritis Knee, Joint Diseases
SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization
An open label, prospective, two-arm, multicenter, randomized controlled trial comparing SakuraBead genicular artery embolization (GAE) with a control (corticosteroid injection).
- Conditions
- Osteo Arthritis Knee, Joint Diseases, Musculoskeletal Diseases, Rheumatic Diseases
- Trial name
- SURE (NCT06550024)
- Testing
- SakuraBead Resorbable Microspheres, Corticosteroid Injection
- Where
- 8 sites in United States, Georgia and 2 more
- Volunteers
- 89 people
- Sponsor
- CrannMed
Knee Osteoarthritis (Knee OA)
Effects of Core Stabilization Exercises in Female Patients With Gonarthrosis
Osteoarthritis (OA) is a non-inflammatory degenerative disease characterized by progressive deterioration of cartilage tissue, synovial membrane, and joint capsule, primarily affecting weight-bearing joints.
- Trial name
- NCT07482332
- Testing
- 10 days of conventional physiotherapy (Hot Pack, TENS, Ultrasound) and 6 weeks of routine knee exercises, Six weeks of core stabilization exercises.
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Cumhuriyet University
Bilateral Knee Osteoarthritis
Study to Compare Exposure of TA Following Administration of Either FX006 or TAcs in Patients With Bilateral Knee OA
This is a randomized, open-label, parallel group study to compare systemic exposure of triamcinolone acetonide following administration into both knees of either FX006 or TAcs.
- Trial name
- NCT03378076
- Testing
- FX006 32 mg, TAcs 40 mg
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis, Knee
Prospective Post-Market Data Collection on Patients With Knee OA and Treated With nSTRIDE APS
This study will document treatment effects, changes in quality of life, procedure complications, adverse events, healthcare resource utilization, and further needed intervention(s) following treatment with nSTRIDE autologous…
- Trial name
- PROGRESS III (NCT02580643)
- Testing
- APS
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- Zimmer Biomet
Osteoarthritis (OA) of the Knee
Kinesio Taping After Platelet-Rich Plasma Treatment in Individuals With Knee Osteoarthritis
This randomized controlled study evaluated whether kinesio taping provided additional benefits compared with sham taping in women with knee osteoarthritis who had received platelet-rich plasma (PRP) treatment as part of routine…
- Trial name
- NCT07773324
- Testing
- Kinesio Taping
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Agri Ibrahim Cecen University
Osteoarthritis, Knee
Multiple Ascending Doses (MAD) of Anti-A Disintegrin and Metalloproteinase With Thrombospondin Motifs-5 (Anti-ADAMTS-5) Nanobody in Participants With Knee Osteoarthritis (OA)
The study will be conducted in participants with symptomatic knee OA to explore the safety, tolerability, immunogenicity, pharmacokinetics (PK), and pharmacodynamics (PD) of MAD of M6495.
- Trial name
- NCT03583346
- Testing
- M6495
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Hip Osteoarthritis
Platelet Rich Plasma Versus Corticosteroids in Hip Osteoarthritis Pain
Prospective, single-center that may go on to being multicenter, randomized trial comparing platelet rich plasma (PRP) versus corticosteroid injection for the treatment of symptoms of Hip osteoarthritis.
- Trial name
- NCT06793982
- Testing
- Platelet Rich Plasma Joint Injection, Corticosteroid Injection
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- LifeBridge Health
Osteoarthritis, Joint Diseases
Knee Stability Training for Knee Osteoarthritis (OA)
People with knee osteoarthritis (OA) frequently complain of knee instability. This study will test whether certain exercises can improve knee stability, reduce pain, and improve physical function in people with knee OA.
- Trial name
- NCT00078624
- Testing
- Traditional exercise therapy for knee osteoarthritis, Knee stability training
- Where
- United States
- Volunteers
- 231 people
- Sponsor
- University of Pittsburgh
Osteoarthritis
Effects of Osteoarthritis Pain, Morphine, and Placebo on Neuroendocrine Function in Men
This study will examine the effects of morphine on leuteinizing hormone, testosterone, adrenocorticotropic hormone and cortisol in men.
- Trial name
- NCT00088296
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Knee Osteoarthritis (Knee OA)
Exercise-induced Irisin in Individuals With Knee Osteoarthritis.
The goal of this prospective randomised controled study is to investigate the effect of 8-weeks brisk walking exercise on irisin levels, physical and psychosocial parameters in individuals with knee osteoarthritis, and the…
- Trial name
- Osteoarthritis (NCT06758388)
- Testing
- home exercise program, home exercise program + brisk walking exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Ümmahani Kuş
Knee Osteoarthritis
Impact of Sensor Technology in Knee OA
OBJECTIVES: Physical activity has been established as an important component of rehabilitation for knee osteoarthritis (OA), and is often guided by a physical therapist.(1) Physical therapy for knee OA typically involves 1-3…
- Trial name
- NCT05222503
- Testing
- Knee Brace + OPUM Digital Knee, Knee Brace
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- OPUM Technologies US LTD
Osteoarthritis
Effectiveness of Manual Therapy and Exercise in Shoulder OA
Approximately 60 subjects from a sample of convenience diagnosed with shoulder arthritis will be randomized into a two groups. The control group will receive usual medical advice and the experimental group will be referred to…
- Trial name
- NCT02587559
- Testing
- physical therapy
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Rehabilitation, Excercise
The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults.
The study is a Random control trail study conducted at King Khalid University Hospital in Riyadh, Saudi Arabia, focusing on Application of 5 framework in rehabilitation program of knee arthritis.
- Conditions
- Rehabilitation, Excercise, Geriatric, Physical Therapy
- Trial name
- 5Ms/PT/KOA/OA (NCT07640529)
- Testing
- Geriatric 5Ms framework, Exercises PT
- Where
- Saudi Arabia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King Saud University
Knee Osteoarthritis, Mind-body Exercise
Tai Chi for Knee OA Pain Management: a Mechanistic Study
This study is to determine how 8-week Tai Chi intervention alters plasma endocannabinoid and its receptors in monocytes/marcrophages, plasma oxylipinds, plasma brain-derived neurotrophic factor, brain white matter…
- Trial name
- NCT04046003
- Testing
- Tai chi exercise
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Texas Tech University Health Sciences Center