Clinical trials: Osteoarthritis Arthritis
Osteoarthritis, Knee
A Phase 2 Study to Evaluate the Efficacy and Safety of JointStem in Treatment of Osteoarthritis
This study is a double-blind, randomized, controlled study with two arms to evaluate JointStem as a treatment for subjects with osteoarthritis.
- Trial name
- NCT02674399
- Testing
- JointStem, Synvisc-One
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Nature Cell Co. Ltd.
Acupuncture Therapy
Using Omics Technology to Explore the Mechanism of Acupuncture Treatment of Different Acupoints of Knee Osteoarthritis
In recent years, commonly used Omics techniques, including genomics, proteomics, metabolomics, have been applied in the studies on the mechanism of acupuncture effect.
- Trial name
- NCT04733352
- Testing
- acupuncture
- Where
- 2 sites in Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Knee Osteoarthritis
A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients (MOTION-P)
This is a multicenter, prospective, randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of intra-articular administration of PTP-001 (MOTYS) for the treatment of knee osteoarthritis.
- Trial name
- MOTION-P (NCT07219771)
- Testing
- PTP-01
- Where
- 18 sites in United States, Australia
- Volunteers
- 300 people
- Sponsor
- Doron Therapeutics Inc.
Diabetes, High Blood Pressure
Study Title: Food Rx
Researchers are trying to determine if subjects with lack of access to healthy food and a long term health problem, are helped by a weekly box of healthy groceries and nutrition education.
- Conditions
- Diabetes, High Blood Pressure, Obesity, Hypertension
- Trial name
- NCT03937934
- Testing
- Nutrition Education
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
Osteoarthritis of the Hip
Total Hip Arthroplasty (THA) Surgical Techniques Comparing the Direct Anterior Approach to the Posterior Approach
The purpose of this study is to compare the short term effectiveness and return to function of subjects undergoing primary Total Hip Arthroplasty using an Anterior Approach (incision on the front part of the hip joint) versus…
- Trial name
- NCT01807104
- Testing
- Anterior Approach / Posterior Approach, Anterior versus Posterior Approach for total hip replacement
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Barrett, William, M.D.
Knee Osteoarthritis
Efficacy of Bone-marrow-derived and Placenta-derived Multipotent Mesenchymal Stem / Stromal Cells for Osteoarthritis
To define the clinical effects of intra-articular transplantation of bone-marrow-derived (BM-MMSCs) and placenta-derived multipotent mesenchymal stem / stromal cells (P-MMSCs) for knee osteoarthritis.
- Trial name
- NCT04453111
- Testing
- Placenta-derived MMSCs, Bone marrow-derived MMSCs, Hyalgan 20 mg in 2 ML Prefilled Syringe
- Where
- Ukraine
- Volunteers
- 45 people
- Sponsor
- Institute of Cell Therapy
Knee Osteoarthritis, Total Knee Arthroplasty
Effect of AI-Assisted Anatomical Visualization on Anxiety and Kinesiophobia in Knee Arthroplasty Patients
Total knee arthroplasty (TDA) is an effective surgical method applied to reduce pain, improve joint function, and enhance quality of life in patients with advanced osteoarthritis or joint degeneration.
- Trial name
- AI-KNEE (NCT07545447)
- Testing
- Standard Clinical Education, Video-Supported Education, AI-Assisted Anatomical Visualization Training
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Munzur University
Knee Osteoarthritis
Acupuncture as an Adjunctive Therapy to the Pharmacological Treatment in Patients With Chronic Pain in Osteoarthritis of the Knee: a Three Armed Randomized Placebo Controlled Trial
The objective of this study is to assess the efficacy of acupuncture as an adjunctive therapy to pharmacological treatment of chronic pain due to knee osteoarthritis, as well as for, the improvement of physical functioning…
- Trial name
- NCT01398930
- Testing
- acupuncture
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- National and Kapodistrian University of Athens
Degenerative Osteoarthritis, Rheumatoid Arthritis
Orthopilot Elite Post-Market Clinical Follow-Up
Prospective, multicenter, observational, comparative clinical trial on the equivalence of two different OrthoPilot® navigation system generations applied for computer-assisted total knee arthroplasty
- Conditions
- Degenerative Osteoarthritis, Rheumatoid Arthritis, Posttraumatic Arthropathy, Instability, Joint
- Trial name
- NCT03817632
- Testing
- Computer assisted primary total knee replacement with OrthoPilot FS101 navigation system and Software 5.1, Computer assisted primary total knee replacement with OrthoPilot Elite navigation system and Software 6.0
- Where
- 3 sites in Germany
- Volunteers
- 217 people
- Sponsor
- Aesculap AG
Osteoarthritis
Efficacy of Homoeopathy and Physiotherapy in Chronic Low Back Pain Due to Osteoarthritis
Osteoarthritis (OA) is a chronic arthropathy characterised by disruption and possible loss of joint cartilage along with other joint changes.
- Trial name
- NCT02207998
- Testing
- Homeopathic complex and physiotherapy
- Where
- South Africa
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Johannesburg
Hip Osteoarthritis
The Influence of Perioperative Optimisation to the Hip Arthroplasty Outcomes
Success of the hip arthroplasty depends on the measures that optimize perioperative conditions.It is planned to evaluate semi-closed loop system in the hip arthroplasty surgery.
- Trial name
- NCT03260309
- Testing
- Semi-closed loop infusion system tactic., Routine infusion therapy tactic
- Volunteers
- 100 people
- Sponsor
- Vilnius University
Osteoarthritis, Knee
Safety and Efficacy of Celecoxib Versus Naproxen in the 6-month Treatment of Knee Osteoarthritis
To compare the safety and efficacy of celecoxib versus naproxen for the treatment of knee osteoarthritis
- Trial name
- CLOAK (NCT00643799)
- Testing
- Celecoxib, Naproxen
- Where
- 51 sites in United States
- Volunteers
- 586 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Inflammation, Osteo Arthritis Knee
Inflammation Impact on Pain in Knee Osteoarthritis
The aim of this study is to use gold particles as a model compound to modulate specifically and selectively the function of macrophages and mast cells and investigate how this modulates pain and pain sensitization in the…
- Trial name
- NCT03389906
- Testing
- Gold
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Sten Rasmussen, MD, PhD
Malalignment, Bone, Osteoarthritis, Knee
Knee Osteotomy Associated With Allograft Meniscus Transplantation
This is a prospective randomized double-blind controlled clinical trial with parallel arms and 1:1 allocation. The main objective of the BIOMAT project is to demonstrate, through an RCT, whether the combined approach by knee…
- Trial name
- NCT05840887
- Testing
- Knee osteotomy associated with meniscal allograft transplantation, Knee osteotomy
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteo Arthritis Shoulders
BMA vs Cortisone for Glenohumeral Osteoarthritis
This randomized trial seeks to investigate the difference if any between cortisone injection versus bone marrow aspirate injection in the glenohumeral joint of patients with confirmed osteoarthritis.
- Trial name
- BMAC (NCT03580148)
- Testing
- Cortisone, Bone Marrow Aspirate
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- Women's College Hospital
Osteoarthritis
Comparison of Stability and Outcomes in Single-radius Femoral Component for Total Knee Arthroplasty
This is a comparison of the functional results and Varus-Valgus Stability in Single-radius versus Multi-radius Femoral Component for Total Knee Arthroplasty.
- Trial name
- NCT01379755
- Where
- South Korea
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Chonnam National University Hospital
Osteoarthritis, Knee
Ultrasound and Exercises in Knee Osteoarthritis
The aim of this investigation is to compare the effects of continuous (CUS) and pulsed (PUS) ultrasound associated with a program of exercises on pain, range of motion, muscle strength, functionality, mobility and activity in…
- Trial name
- NCT03676790
- Testing
- Group I, Group II, Group III
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo General Hospital
Degenerative Arthritis of Left Glenohumeral Joint, Degenerative Arthritis of Right Glenohumeral Joint
Costs and Consequences of Three Common Orthopedic Procedures on the Upper Extremity
This study compares costs and effectiveness / utility of three common orthopedic surgeries in shoulder and hand from the perspective of the Swiss health system and the clinic.
- Conditions
- Degenerative Arthritis of Left Glenohumeral Joint, Degenerative Arthritis of Right Glenohumeral Joint, Rotator Cuff Tear Arthropathy, Rotator Cuff Tear
- Trial name
- NCT01954433
- Testing
- Operated TSA Patients, Operated RCR Patients, Resection interposition suspension arthroplasty (RISA)
- Where
- Switzerland
- Volunteers
- 450 people
- Sponsor
- Schulthess Klinik
Osteoarthritis of the Knee
Safety and Efficacy of Two Dosages of Diractin® in Osteoarthritis (OA)
The purpose of this study is to provide replicated evidence of safety and efficacy of 50 mg and 100 mg ketoprofen in Diractin®.
- Trial name
- NCT00716547
- Testing
- ketoprofen in Diractin®, celecoxib
- Where
- 4 sites in Czechia, Germany and 2 more
- Volunteers
- 1,399 people
- Sponsor
- IDEA AG
Hip Osteoarthritis, Hip Arthroplasty
Collared Versus Collarless Femoral Implants for Total Hip Arthroplasty
This is a randomized control trial that will investigate whether a collared hip replacement implant provides greater stability compared to a collarless option.
- Trial name
- NCT03558217
- Testing
- Collared Femoral Implant, Collarless Femoral Implant
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's