Clinical trials: Osteoarthritis Pain
Healthy Volunteers, Osteoarthritis
Safety, Tolerability & Pharmacokinetics of LEVI-04 in Healthy Volunteers and Patients With Osteoarthritis Knee Pain
This is a first-in-human, phase 1, single centre, placebo-controlled, double-blind, single ascending dose study of LEVI-04 in heathy volunteers and osteoarthritis patients (with pain attributed to osteoarthritis of the knee)
- Trial name
- NCT03227796
- Testing
- LEVI-04
- Where
- 2 sites in United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Levicept
Osteoarthritis, Knee, Pain
A Study to Evaluate ONO-4474 in Patients With Pain Due to Osteoarthritis of the Knee
The purpose of this phase 2, randomised, double-blind, placebo controlled, parallel group, multicentre study is to investigate the efficacy, safety, tolerability and pharmacokinetics of a compound ONO-4474 in patients with…
- Trial name
- MOTION (NCT02997696)
- Testing
- ONO-4474
- Where
- 47 sites in Denmark, Hungary and 3 more
- Volunteers
- 70 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Knee Osteoarthritis
Effects of Two Bar Knee Off-Load Brace With Non Weight Bearing Strength Training Among Knee Osteoarthritis Patients
The current study is a single-blind, parallel-group randomized controlled trial involving 18 participants with knee osteoarthritis.
- Trial name
- NCT07562646
- Testing
- Two-Bar Knee Off-Load Brace with Non-Weight Bearing Strength Training Intervention, Standard Knee Off-Loader Brace with Non-Weight Bearing Strength Training Intervention
- Volunteers
- 18 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Knee Osteoarthristis, Radiofrequency Ablation
Knee Osteoartritis Genicular Nerve RF Ablation vs Alcohol Neurolysis
The GEN-AL-RF study is a randomized controlled trial designed to compare the clinical efficacy of two interventional techniques for managing chronic knee pain due to osteoarthritis.
- Conditions
- Knee Osteoarthristis, Radiofrequency Ablation, NEUROLYSIS
- Trial name
- GEN-AL-RF (NCT07537335)
- Testing
- genicular nerve block
- Volunteers
- 50 people
- Sponsor
- Sakarya University
Osteoarthritis, Knee
Intra-articular Tenoxicam Versus Triamcinolone Acetonide in Knee Osteoarthritis Management
Knee osteoarthritis is a very common joint condition that leads to pain, stiffness, and difficulty with daily activities, particularly in middle-aged and older adults.
- Trial name
- NCT07194135
- Testing
- Tenoxicam, Triamcinolone Acetonide
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Hip Osteoarthritis, Chronic Pain
Comparative Study Between Steroid Plus Anesthetic Block and CRF in Participants With Hip Osteoarthritis
This will be a prospective, multi-center, double-blinded, randomized study designed to compare the efficacy of Conventional Radiofrequency (CRF) and the anesthetic block of the anterior sensory branches to the hip to control pain…
- Trial name
- NCT04876859
- Testing
- CRF of anterior sensitive branches to the hip, Anesthetic block with steroid injection of anterior sensitive branches to the hip
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Brasilia
Thumb Osteoarthritis, Thumb Injury
Validity And Reliability of the Turkish Version of the Thumb Disability Examination
Purpose of the study is the validity and reliability of the Turkish version of The Thumb Disability Examination (TDX) so that it would be used as an assessment tool for Turkish thumb patients.
- Conditions
- Thumb Osteoarthritis, Thumb Injury, Thumb Fracture, Thumb Laceration
- Trial name
- NCT04627259
- Testing
- Thumb Disability Examination
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Hacettepe University
Osteoarthritis, Knee, Osteo Arthritis Knee
Study to Evaluate Resiniferatoxin in Patients With Knee Osteoarthritis Whose Total Knee Replacement Surgery is Delayed
Efficacy and safety study of resiniferatoxin versus placebo to manage pain in patients with knee osteoarthritis whose TKR surgery is delayed
- Conditions
- Osteoarthritis, Knee, Osteo Arthritis Knee, Knee Pain Chronic
- Trial name
- NCT04386980
- Testing
- Resiniferatoxin
- Sponsor
- Sorrento Therapeutics, Inc.
Osteoarthritis, Knee
Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty
This study will evaluate the use of a local injection around the knee (periarticular) during total knee replacement (TKR) surgery to see if it reduces postoperative pain levels.
- Trial name
- NCT02570503
- Testing
- Ropivacaine, Ketorolac, Clonidine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Knee Osteoarthritis, Cartilage Damage
Clinical Study of Pain Reduction by Peri-arthroscopic PRP Application in Knee Degeneration
The purpose of this study is to investigate reduction of pain, gain of function and improvement of life quality by intraoperative applied platelet- rich- plasma ( PRP ) during knee arthroscopy for degeneration and osteoarthritis…
- Conditions
- Knee Osteoarthritis, Cartilage Damage, Meniscal Tear
- Trial name
- PRP-Bochum (NCT02189408)
- Testing
- Platelet rich plasma
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- Ruhr University of Bochum
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Effect of Inspiratory Muscle Training on Knee Osteoarthritis Pain
Knee osteoarthritis (KOA) is a common joint disease that causes chronic pain and limits daily activities. Current treatments, such as painkillers or surgery, have limitations like side effects or high costs.
- Trial name
- NCT07698418
- Testing
- Inspiratory muscle training
- Volunteers
- 80 people
- Sponsor
- The Hong Kong Polytechnic University
Osteoarthitis, Osteoarthritic Knee Pain
Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee.
- Conditions
- Osteoarthitis, Osteoarthritic Knee Pain, Osteoarthritis (OA), Osteoarthritis (OA) of the Knee
- Trial name
- Medial OA CSI (NCT07804446)
- Testing
- Anteromedial Injection, Anterolateral Injection
- Where
- 5 sites in United States
- Volunteers
- 140 people
- Sponsor
- University of Chicago
Osteoarthritis of Shoulder
HUPS: Hyalgan Use in Painful Shoulder
Three-arm, parallel, double-blind, masked observer, randomized, PB-Saline controlled clinical trial. In order to avoid problems in the interpretation of the final results due to disparate enrollment from various centers, the…
- Trial name
- NCT00377624
- Testing
- sodium hyaluronate
- Where
- United States
- Volunteers
- 602 people
- Sponsor
- Sanofi
Knee Osteoarthritis
Genicular Artery Embolization to Reduce Pain Associated With Unilateral Mild to Moderate Osteoarthritis
The goal of this study is to perform a feasibility study to show the effectiveness of the genicular artery embolization procedure in reducing bilateral or unilateral osteoarthritic knee pain at 12 months as measured by WOMAC…
- Trial name
- GAE (NCT04592562)
- Testing
- the Terumo Hydropearl® microspheres device
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Chicago
Chronic Pain, Osteoarthritis
A Mobile Intervention to Reduce Pain and Improve Health-III
The experience of chronic pain powerfully and negatively affects quality of life and functional independence in aging. Unfortunately, while as many as three in four older adults experience chronic pain, few have access to…
- Conditions
- Chronic Pain, Osteoarthritis, Obesity and Overweight, Inactivity
- Trial name
- MORPH-III (NCT06623669)
- Testing
- MORPH, Measurement Only
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Wake Forest University
Osteoarthritis, Knee, Dementia
Effect of Tai Chi on Osteoarthritic Knee Pain in Elders With Mild Dementia
This is the first study to test the effect of Tai Chi on pain from knee osteoarthritis in community-dwelling elders with mild cognitive impairment.
- Trial name
- NCT01528566
- Testing
- Tai Chi, Attention control
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Arkansas
Osteoarthritis, Knee
Safety and Tolerability of PG110 in Patients With Knee Osteoarthritis Pain
The purpose of this study is to evaluate the safety and tolerability of a single intravenous dose of PG110, a monoclonal antibody that inhibits the effects of the naturally occurring substance, nerve growth factor (NGF).
- Trial name
- NCT00941746
- Testing
- PG110
- Where
- Netherlands
- Volunteers
- 56 people
- Sponsor
- Abbott
Knee Osteoarthritis
Comparative Effects of Strain Counter Strain and Myofascial Release in Patients With Knee Osteoarthritris
Osteoarthritis is a degenerative disease, the cartilage present in the joint gets damaged and the bones become hypertrophied. In US, the most commonly occuring arthritis is osteoarthritis. Myofascial release focuses on fascia.
- Trial name
- NCT07403383
- Testing
- Strain Counter Strain, Myofascial Release
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Osteoarthritis, Knee
Single-Dose Hybrid Hyaluronic Acid and Sodium Chondroitin with Rehabilitation for Sports Adults with Knee Osteoarthritis
: This observational case-control study aims to evaluate the efficacy of a single-dose intra-articular injection of a hybrid purified hyaluronic acid with high molecular weight and sodium chondroitin of biotechnological origin…
- Trial name
- NCT06890247
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Palermo
Osteoarthritis, Pain
Study of Efficacy, Safety of Fulranumab Adjunctive Use in OA of Hip or Knee, PAI3001
The purpose of this study is to demonstrate the efficacy, safety, and tolerability of fulranumab as adjunctive therapy compared with placebo in participants with chronic moderate to severe pain and functional impairment from knee…
- Trial name
- NCT02336685
- Testing
- Fulranumab 1 mg, Fulranumab 3 mg, Opioid
- Where
- 53 sites in United States, Canada and 4 more
- Volunteers
- 79 people
- Sponsor
- Janssen Research & Development, LLC
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