Clinical trials: Osteoarthritis Pain
Gonarthrosis
The Effect of Tail Fat Application on Joint Pain, Joint Stiffness, and Daily Living Activities in Patients With Gonarthrosis
In recent years, experimental and clinical studies conducted on sheep tail fat, a natural and easily accessible resource, have shown that bioactive components found in sheep tail fat, such as palmitic acid, stearic acid, oleic…
- Trial name
- NCT07867405
- Testing
- Sheep Tail Fat, Standard medical treatment
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Inonu University
Osteoarthritis, Knee, Knee Pain Chronic
Impact of Dexamethasone Route on Pain and Inflammation in iPACK With ACB for Knee Arthroplasty
"The Effect of Dexamethasone Administration Route on Pain and Inflammatory Response in iPACK With ACB for Total Knee Arthroplasty" - written in plain language according to ClinicalTrials.gov standards: The goal of this clinical…
- Conditions
- Osteoarthritis, Knee, Knee Pain Chronic, Arthropathy of Knee
- Trial name
- NCT07180953
- Testing
- NaCl 0.9%, Dexamethasone 4mg
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Poznan University of Medical Sciences
Osteoarthritis, Knee
Autologous BMA vs Saline and LAM + LP-PRP vs Saline Evaluations in Knee OA
ABLE OA is a Health Canada authorized (phase II/III) trial [Parent Control #: 263591]. A multi-center, prospective, double-blinded, randomized, placebo-controlled adaptive trial to evaluate the efficacy of two minimally…
- Trial name
- ABLE-OA (NCT05517434)
- Testing
- Bone Marrow Aspirate (BMA): Minimally manipulated autologous cellular preparation, Lipoaspirate Micronized + Leukocyte-Poor Platelet-Rich Plasma (LAM + LP-PRP): Minimally manipulated autologous cellular preparations
- Where
- 2 sites in Canada
- Volunteers
- 148 people
- Sponsor
- University Health Network, Toronto
Osteoarthritis, Knee
Study of StimRouter for Chronic Knee OA Pain
The goal of this study is to evaluate the use of StimRouter Neuromodulation System (StimRouter) in adult subjects with an established diagnosis of primary femorotibial osteoarthritis in the target knee (Kellgren-Lawrence ≥1) who…
- Trial name
- GLEAM (NCT05644639)
- Testing
- StimRouter Neuromodulation System
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Bioventus LLC
Osteoarthritis, Knee
Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for Knee Osteoarthritis
This is a Pilot Study which is randomized, prospective, open label, dose escalation, non-controlled evaluating safety and feasibility of intra-articular Wharton's Jelly (WJ) allograft will be evaluated in patients suffering with…
- Trial name
- NCT06608134
- Testing
- Umbilical Cord Wharton's Jelly Allograft Intra-articular Knee Injection
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- R3 Medical Research
Insomnia Related to Osteoarthritis Pain
OsteoArthritis and Therapy for Sleep
Osteoarthritis (OA) pain affects 50 percent of older adults, more than half of whom also experience significant sleep disturbance.
- Trial name
- OATS (NCT02946957)
- Testing
- Cognitive Behavior Therapy for Insomnia, Education Only Control
- Where
- United States
- Volunteers
- 327 people
- Sponsor
- University of Washington
Hip Osteoarthritis, Pain, Acute
Lumbar Plexus and Suprainguinal Fascia Iliaca Blocks For Total Hip Replacement
The nerves from lumbar plexus (LP) are the current target to achieve analgesia after a total hip arthroplasty (THA). Lumbar plexus block (LPB) is an alternative that provides optimal postoperative analgesia.
- Conditions
- Hip Osteoarthritis, Pain, Acute, Pain, Postoperative, Opioid Use
- Trial name
- NCT03744065
- Testing
- lumbar plexus block, suprainguinal fascia iliaca block
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- University of Chile
Knee Osteoarthritis (OA), Genicular Nerves Block
The Effect of Pulsed Radiofrequency Ablation of the Genicular Nerve on Pain, Balance, and Proprioception in Patients With Chronic Knee Osteoarthritis
Determination of the effect of ultrasound-guided pulsed radiofrequency applied to the genicular nerve on pain, balance, and proprioception in patients with chronic knee osteoarthritis
- Conditions
- Knee Osteoarthritis (OA), Genicular Nerves Block, Radiofrequency Ablation
- Trial name
- NCT07869771
- Testing
- Genicular nerve block via radiofrequency ablation
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Ankara City Hospital Bilkent
Knee Osteoarthritis
Ultrasound Guided Intra Articular Injection of Platelet Rich Fibrin Versus Hyaluronic Acid As Means of Pain Relief in Patients with Moderate Degree Knee Osteoarthritis
Randomised controlled trial
- Trial name
- NCT06797960
- Testing
- Ultra sound guided Injection of PRF intra articularly, Intra articular injection of HA
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Pain Syndrome
Pulsed Radiofrequency to Relieve Knee Pain
Knee osteoarthritis is a leading cause of chronic pain, disability, and decreased quality of life. Lesioning of genicular nerves by continuous radiofrequency treatment proved to be effective in relieving pain and disability…
- Trial name
- NCT03628482
- Testing
- CRF, PRF
- Where
- Belgium
- Volunteers
- 188 people
- Sponsor
- Gasthuis Zusters Antwerpen
Knee Osteoarthritis
HILT Dose Optimization for Knee Osteoarthritis Pain
This study aims to find the best settings (dose) for High-Intensity Laser Therapy (HILT) to reduce pain and improve function in people with moderate knee osteoarthritis.
- Trial name
- NCT06916676
- Testing
- Low-Dose High-Intensity Laser Therapy (10 J/cm²), Medium-Dose High-Intensity Laser Therapy (15 J/cm²), High-Dose High-Intensity Laser Therapy (20 J/cm²)
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Al Hayah University In Cairo
Knee Osteoarthritis, Pain
Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)
Knee osteoarthritis (KOA) is one of the most common causes of chronic pain, mobility problems, and disability among United States Veterans.
- Conditions
- Knee Osteoarthritis, Pain, Depression
- Trial name
- DRIVE (NCT07649291)
- Testing
- Exercise, Duloxetine, PT referral
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Knee Osteoarthritis
Effect of Genicular Arteries Embolization in Symptomatic Knee Osteoarthritis LipioJoint-2
Knee OsteoArthritis (KOA) is a common disease associated with pain and impaired function. Many patients are not relieved of their symptoms with enough efficacy by conservative treatments.
- Trial name
- LIPIOJOINT-2 (NCT06497140)
- Testing
- Ethiodized Oil-based emulsion
- Where
- 3 sites in France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoarthritis, Knee, Osteoarthritis, Hip
An Effectiveness, Safety and Quality of Life Measures With Hydromorphone HCL, Dilaudid CR (Controlled Release)
The purpose of this study was to characterize the effectiveness and safety of OROS hydromorphone HCL and OxyContin in patients with chronic osteoarthritis (OA) of the knee or hip who are receiving chronic nonsteroidal…
- Trial name
- NCT00399048
- Testing
- OROS hydromorphone HCL ; OxyContin
- Volunteers
- 140 people
- Sponsor
- Alza Corporation, DE, USA
Osteoarthritis, Rheumatoid Arthritis
Reciprocating Medical Devices - a Study of a New Safety Device
The study design is a randomized study to directly compare the performance and the outcome of syringe and needle procedures with a standard syringe or the new reciprocating procedure device (RDP), which is a type of safety…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Trauma, Thyroid Nodule
- Trial name
- RPD (NCT00651625)
- Testing
- Reciprocating Procedure Device (RPD) - AVANCA Re No. 1091001, conventional syringe - BD Ref 309604
- Where
- United States
- Volunteers
- 437 people
- Sponsor
- University of New Mexico
Knee Osteoarthritis, Pain, Joint
Efficacy of Hyaluronic Acid Injection in Knee Osteoarthritis
The aim of this clinical trial study is to compare the efficacy of Hyaluronic injection in patients with symptomatic knee osteoarthritis.
- Conditions
- Knee Osteoarthritis, Pain, Joint, Stiffness of Knee, Not Elsewhere Classified, Quality of Life
- Trial name
- NCT06279507
- Testing
- Sodium Hyaluronate, Normal Saline, Triamcinolone Acetonide 10mg/mL
- Where
- Thailand
- Volunteers
- 176 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Pain, Low Back Pain
Longterm Safety Study of BEMA Buprenorphine in Subjects With Chronic Pain
The purpose of this study is to determine whether BEMA Buprenorphine is safe in the treatment of chronic pain.
- Conditions
- Pain, Low Back Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT01298765
- Testing
- BEMA Buprenorphine
- Where
- 26 sites in United States
- Volunteers
- 302 people
- Sponsor
- BioDelivery Sciences International
Unilateral Primary Osteoarthritis of Hip
Comparing the Clinical Effects of Posterior Approach Versus Lateral Approach in Osteoarthritis Patients With a THA
The aim of this study is to investigate the clinical outcome of the two different, but widely used, surgical approaches (Posterior approach and Lateral approach) of primary total hip arthroplasty in patients diagnosed with…
- Trial name
- COMPALA (NCT01616667)
- Testing
- Total hip arthroplasty
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Postoperative Pain, Knee Osteoarthritis
Preop Cooled Radiofrequency Ablation for Total Knee Replacement
Total knee replacement surgery is commonly performed for patients suffering from severe knee osteoarthritis. However, 20% of patients continue to experience pain after surgery.
- Trial name
- NCT03893292
- Testing
- Total knee replacement, COOLIEF
- Where
- United States
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis, Knee
Effect of J-Shaped Incision After Total Knee Arthroplasty (J-TKA)
This prospective randomized controlled trial evaluates whether a modified J-shaped skin incision can reduce peri-incisional numbness after primary total knee arthroplasty (TKA) compared with the conventional midline skin…
- Trial name
- NCT07514598
- Testing
- Conventional Midline Incision, J-shaped Incision
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
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