Clinical trials: Osteoarthropathy
Charcot's Joint, Complications of Diabetes Mellitus
Characterization of the Charcot Foot
The project concerns a type of very debilitating diabetic foot complications called Charcots osteoarthropathy (COA). This disease is characterized by a rapidly progressing destruction of the load bearing joints, primarily in the…
- Trial name
- NCT02335931
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Bispebjerg Hospital
Diabetic Foot Neuroarthropathy Charcot
Management of Diabetic Patients With Neuropathic Osteoarthropathy (Charcot Foot) : Descriptive Study in Diabetic-foot Centers
Despite the prominence of diabetes prevalence (more than 8% of the world population in 2012) and its expected increase in the next 15 years, Charcot foot remains a widely unknown diabetes complication.
- Trial name
- EPiChar (NCT03744039)
- Where
- 2 sites in France
- Volunteers
- 1,160 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Skeletal Disorder
Bone and Muscle Health in Kids
Vitamin D deficiency in childhood leads to poor bone growth and muscle weakness, yet it is unknown if the amount of vitamin D a woman consumes during her pregnancy affects her child's bone and muscle development.
- Trial name
- BONUSKids (NCT03537443)
- Testing
- Cholecalciferol (vitamin D3)
- Where
- Bangladesh
- Volunteers
- 642 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Musculoskeletal Disorders, Skeletal Disorder
Observational Prospective PMCF Study to Confirm Performance and Safety of Intelect® Devices in Real World
DJO UK Ltd (ENOVIS) is conducting this study to confirm the performance and safety of the Chattanooga Intelect® devices in real world use.
- Conditions
- Musculoskeletal Disorders, Skeletal Disorder, Muscle Disorder
- Trial name
- INTELECT (NCT06809283)
- Where
- 4 sites in France, Italy and 1 more
- Volunteers
- 144 people
- Sponsor
- DJO UK Ltd
Intervertebral Disc Degeneration, Intervertebral Disc Displacement
Protection of Autonomic Nervous System During Lower Spine Surgical Procedures: A Safety and Feasibility Study
A safety and feasibility study of free-run and stimulated corporal electromyography (EMG) to assess autonomic neural function during spinal and/or pelvic surgery in women and men.
- Conditions
- Intervertebral Disc Degeneration, Intervertebral Disc Displacement, Spinal Curvatures, Spinal Stenosis
- Trial name
- NCT02873182
- Testing
- Autonomic nervous system monitoring
- Volunteers
- 20 people
- Sponsor
- Stanley Skinner
Primary Hypertrophic Osteoarthropathy
Effect Observation Study of COX-2 Inhibitor to Treat Primary Hypertrophic Osteoarthropathy
The purpose of this study is to determine whether COX-2 inhibitor is effective in the treatment of primary hypertrophic osteoarthropathy
- Trial name
- EOSCITPHO (NCT02438709)
- Testing
- COX-2 inhibitor
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Occupational Diseases, Work Related Upper Limb Disorder
ARPE Training for Manual Handling Workers: A Quasi-Experimental Study on Ergonomic Knowledge and Practice
The goal of this study is to evaluate whether an Augmented Reality-based ergonomic training module (ARPE) can improve ergonomic knowledge, self-prevention, and self-evaluation practices among adult manual material handling (MMH)…
- Trial name
- ARPE;MMH (NCT06993298)
- Testing
- Augmented Reality Ergonomics Training (ARPE), Conventional Ergonomics Training
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Universiti Teknologi Mara
Diabetes Mellitus, Polyneuropathies
Neurogenic Inflammation in Diabetes
Polyneuropathy is a complication of diabetes mellitus which leads to decreased sensation in arms and legs. This in turn can lead to the development of (infected) foot ulcers.
- Conditions
- Diabetes Mellitus, Polyneuropathies, Arthropathy, Neurogenic
- Trial name
- NCT01370837
- Testing
- Intracutaneous injection of Candida albicans antigen., Temperature measurement.
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Charcot Joint, Diabetic Foot
Characterizing and Diagnosis's of the Charcot Foot (Charcot Osteoarthropathy) in Diabetic Patients
The condition Charcot foot has been known in more than 130 years, and yet there still remains a large effort to find the cause, diagnostic and medical treatment of the condition.
- Trial name
- NCT00157222
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Bispebjerg Hospital
Arthropathy, Neurogenic, Diabetes Complications
Characterization of Local and Systemic Bone Markers in Diabetes Patients With Charcot Osteoarthropathy
The study is designed to investigate biomarkers related to bone turnover in diabetics with charcot foot. This is done by measuring local blood samples in the feet, and systemically in a vene and an artery.
- Conditions
- Arthropathy, Neurogenic, Diabetes Complications, Diabetes Mellitus
- Trial name
- NCT02386579
- Testing
- Blood sample measurements
- Volunteers
- 5 people
- Sponsor
- Bispebjerg Hospital
Charcot Joint of Foot
RANKL Antibody for Acute Charcot Neuro-osteoarthropathy
This study's goal was to determine how denosumab 60 mg, combined with total contact casting and restricted weightbearing status, would affect the treatment of acute CN with CKD.
- Trial name
- DANCN-CKD (NCT05797259)
- Testing
- Danosumab, Normal Saline
- Where
- India
- Volunteers
- 78 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Stomach Neoplasms, Colonic Neoplasms
Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients
Postoperative delirium（POD）is a common complication that can directly affect important clinical outcomes, and exert an enormous burden on patients, their families, hospitals, and public resources.
- Conditions
- Stomach Neoplasms, Colonic Neoplasms, Rectal Neoplasms, Sigmoid Neoplasms
- Trial name
- NCT05068180
- Testing
- low-dose neuroleptanalgesia
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Genetic Skeletal Diseases, Skeletal Dysplasia
Decoding the Genetic Landscape of Skeletal Diseases
This 5-year project aims to (1) search for genetic causes for yet unsolved congenital skeletal disorders (GSDs); (2) study consequences of the newly identified pathogenic variants in cells and in transgenic mice, (3) summarize…
- Conditions
- Genetic Skeletal Diseases, Skeletal Dysplasia, Molecular Causes, Skeletal Disorder
- Trial name
- SKDLAND (NCT05876416)
- Where
- Sweden
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Muscle Skeletal Disorders
Epidemiological Study of Quality of Life in Osteopathy
Aim of this study is to evaluate the effectiveness of osteopathy in changing quality of life in a large sample of naive patients undergoing osteopathic manipulative treatment.
- Trial name
- ESoQoLiO (NCT01965678)
- Testing
- Osteopathic Manipulative Treatment
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- European Institute for Evidence Based Osteopathic Medicine
Kashin-Beck Disease
Antioxidant Supplementation in Patients With Kashin-Beck Disease
The purpose of this study is to determine whether antioxidant supplementation can have a positive health effect on patients suffering from Kashin-Beck disease.
- Trial name
- NCT00376025
- Testing
- Biological Antioxidant Supplementation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Innovative Humanitarian Solutions
Osteoarthritis
Toward Better Outcomes in Osteoarthritis
This study will determine if there is a difference between commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (a pain-reliever that does not prevent inflammation) for treating knee pain in…
- Trial name
- NCT00000425
- Testing
- Nonsteroidal anti-inflammatory drugs (NSAIDs), Acetaminophen
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Stanford University
Pressure Ulcer, Diabetes Mellitus Type 2
The Effect of Shear- Force at the Skin in Patients With Diabetes Mellitus
1. The objective of this study is to acquire knowledge about the development of reactive hyperaemia and inflammatory responses of the skin after shear- force and pressure loading.
- Conditions
- Pressure Ulcer, Diabetes Mellitus Type 2, Charcot- Osteoarthropathy
- Trial name
- NCT02348294
- Testing
- Shear- force 19 newton and 3,9 kpa pressure for half an hour
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Rheumatoid Arthritis, Adjuvant Arthritis
Antifolate Effectiveness in Arthritis
This study looks at how the arthritis drug methotrexate works in low doses to treat rheumatoid arthritis. (High doses of methotrexate are used to treat some types of cancer.) Methotrexate blocks the action of the B-vitamin known…
- Trial name
- NCT00000395
- Testing
- Methotrexate, Folinic acid, Folic acid
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Charcot Joint of Foot, Osteoarthropathy
Factors Associated With an Evolution in the Quality of Life of Diabetic Patients With Chronic, Wound-free Charcot Foot
Charcot foot, characterized by progressive destructive damage to bone, soft tissue and tendons, involving joint dislocation in the ankle and foot, is a complication of diabetes that is still poorly understood by patients and…
- Trial name
- CHARQUAM (NCT05491577)
- Testing
- Filling in the SF-36, FAAM-F, PHQ-9, PHQ-2 and the simplified version of the EPICES score questionnaire
- Where
- 17 sites in France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Osteoarthritis
Doxycycline and OA Progression
This study will determine whether doxycycline decreases the severity or rate of progression of osteoarthritis (OA) in the knee. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most popular agents used to treat OA, but…
- Trial name
- NCT00000403
- Testing
- Doxycycline
- Where
- 6 sites in United States
- Volunteers
- 432 people
- Sponsor
- Indiana University