Clinical trials: Osteonecrosis
Osteoradionecrosis of the Jaw, Medicine Related Osteonecrosis of the Jaw
L-PRF in Prevention of ORN and MRONJ Following Tooth Extractions;v3.0
Osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) are debilitating complications following dental extractions in patients who have received head and neck radiotherapy or antiresorptive therapy.
- Trial name
- NCT07585123
- Testing
- L-PRF, Standard Extraction
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Swansea Bay University Health Board
Osteonecrosis of the Femoral Head
RAB001（LLP2A-Ale） in Healthy Subjects
This trial is a single center, randomized, double-blind, placebo-controlled dose escalation study aimed at examining the safety, tolerability, and pharmacokinetics/pharmacodynamics of single and multiple injections of RAB001 in…
- Trial name
- LLP2A-Ale (NCT07545018)
- Testing
- RAB001 400 μg/kg group, RAB001 750 μg/kg group, Normal saline
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd.
Avascular Necrosis, Osteonecrosis
The Use of Genex in the Management of Early-Stage Osteonecrosis of the Femoral Head
The purpose of this study is to assess the clinical and x-ray results of patients who are treated with core decompression of the hip and the injection of a bone marrow concentrate and the use of the Bone Graft Substitute Genex®.
- Trial name
- Genex (NCT05706909)
- Testing
- Genex with ABMC
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Osteoarthritis Shoulder, Avascular Necrosis of the Head of Humerus
Catalyst CSR Shoulder System for Semi or Total Shoulder Arthroplasty
Evaluation of the performance and safety of the Catalyst CSR Shoulder System with clinical and radiographic results at multiple time points through 24 months postoperatively This study will be a prospective multi-center study…
- Conditions
- Osteoarthritis Shoulder, Avascular Necrosis of the Head of Humerus, Rheumatoid Arthritis Shoulder
- Trial name
- NCT04968405
- Testing
- Catalyst CSR Total Shoulder System
- Where
- 3 sites in United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Catalyst OrthoScience
MEDICATION RELATED OSTEONECROSIS OF THE JAW
OZONE_EXO: Comparative Analysis of Protocols for Dental Exactions in Patients at Risk of MRONJ: Case-control Study
Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction of antiresorptive and antiangiogenic agents; it is also a potentially painful and debilitating condition.
- Trial name
- OZONE_EXO (NCT06072404)
- Testing
- OxigenOzone_Insufflation
- Where
- Italy
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Medication-Related Osteonecrosis of Jaw
Therapeutic Exposures and Risk Factors in MRONJ
This study focuses on patients who have developed a condition called medication-related osteonecrosis of the jaw (MRONJ), which can occur after using certain medications.
- Trial name
- NCT06430762
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Marmara University
Medication-Related Osteonecrosis of Jaw
Immunological Parameters Between MRONJ Stages
This study aims to conduct a detailed analysis of the immunological response profiles that emerge at different clinical stages of medication-related osteonecrosis of the jaw (MRONJ).
- Trial name
- NCT06420284
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Marmara University
Medically Related Osteonecrosis of the Jaws
Impact of Topical Pentoxifylline and Tocopherol in Treatment and Prevention of Medically-related Osteonecrosis of the Jaws
While there is no doubt about the benefits of antiresorptives, it is known that patients using these drugs are at increased risk of developing osteonecrosis of the jaws (MRNOJ), especially after oral procedures such as tooth…
- Trial name
- NCT06409546
- Testing
- Tocopherol and pentoxifilline topical gel
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Catania
Osteonecrosis of the Jaw
Local and Systemic Changes in Osteonecrosis of the Jawbone
Osteonecrosis of the Jawbone (ONJ) is a serious complication of antiresorptive therapies (ARTs), for example with bisphosphonates or Denosumab.
- Trial name
- SULVO (NCT05329558)
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Avascular Necrosis of Lunate
A Comparative Study Between Radius and Capitate Shortening in Ulna Minus Variance Kienbock's Disease
1. Kienböck's disease refers to avascular necrosis of the lunate carpal bone, known as lunatomalacia. It was first recognized and described by Austrian radiologist Robert Kienböck's in 1910 2.
- Trial name
- NCT05727696
- Testing
- Henry approach; volar approach, dorsal approach
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sohag University
Osteoarthritis, Traumatic Arthritis
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee
The purpose of the study is to assess the long-term performance of the NexGen LPS-Flex Mobile Bearing Knee in the treatment of patients with severe knee pain or degenerative knee disease.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus
- Trial name
- NCT00854295
- Testing
- NexGen LPS-Flex Mobile Bearing Knee
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Osteoarthritis, Avascular Necrosis
Aequalis Pyrocarbon IDE; Replacing the Humeral Head in Hemi-Arthroplasty
The purpose of this study is to demonstrate safety and effectiveness of the Aequalis Pyrocarbon Humeral Head in hemiarthroplasty at 24 months.
- Conditions
- Osteoarthritis, Avascular Necrosis, Traumatic Arthritis
- Trial name
- PYC (NCT02525783)
- Testing
- Aequalis Pyrocarbon Humeral Head
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Stryker Trauma and Extremities
Osteoporosis, With or Without Treatment, Bisphosphonate Treatment
Biomarker Identification in Orthopaedic & Oral Maxillofacial Surgery Subjects to Identify Risks of Bisphosphonate Use
Bisphosphonates are drugs that prevent bone loss by blocking the activity of cells that normally resorb bone. The most common examples of these drugs are Boniva and Fosamax.
- Conditions
- Osteoporosis, With or Without Treatment, Bisphosphonate Treatment, Atypical Femur Fracture, Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ)
- Trial name
- NCT01875458
- Where
- United States
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Arthropathy of Knee, Osteo Arthritis Knee
Meditation and Opioid Consumption in Total Joint Replacement Patients Undergo Primary Total Hip and Knee Replacement
The main purpose of this study is to look at whether meditation techniques can help reduce pain and opioid use after surgery.
- Conditions
- Arthropathy of Knee, Osteo Arthritis Knee, Osteonecrosis, Meditation
- Trial name
- NCT05669066
- Testing
- Mindful meditation
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Noninflammatory Degenerative Joint Disease, Avascular Necrosis
Signature Acetabular Posterior/Lateral Data Collection
The primary purpose of this pilot study is to evaluate the accuracy of cup placement between two instrumentation technologies: Cutting Guide and Conventional Instrumentation.
- Conditions
- Noninflammatory Degenerative Joint Disease, Avascular Necrosis, Rheumatoid Arthritis
- Trial name
- NCT02220478
- Testing
- Posterior Lateral Approach Total Hip Arthroplasty
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
MEDICATION RELATED OSTEONECROSIS OF THE JAW
Infiltration of Medical Ozone for the Treatment of Medication-Related Osteonecrosis of the Jaws (MRONJ)
Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction of antiresorptive and antiangiogenic agents; it is also a potentially painful and debilitating condition.
- Trial name
- OZOPROMAF (NCT05036837)
- Testing
- OZOPROMAF_SEQ1
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Oral Squamous Cell Carcinoma, Medication Related Osteonecrosis of the Jaw
The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the Jaw
Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the head and neck, and its incidence has increased in recent years.
- Conditions
- Oral Squamous Cell Carcinoma, Medication Related Osteonecrosis of the Jaw, Oral Epithelial Dysplasia
- Trial name
- NCT03418454
- Testing
- Buccal mucosa samples for Extraction of BACTERIAL DNA
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Barzilai Medical Center
Osteoarthritis, Avascular Necrosis
AL-2 MP-1 (Polyimide) Acetabular Liner
M.M.A.TECH Ltd. product is an Acetabular Liner Family produced of an advanced polyimide - MP-1™. M.M.A.TECH Ltd. produces the Liners according to EN ISO 13485:2012 approved manufacturing process and supplies them to the customer.
- Conditions
- Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Congenital Dysplasia of the Hip
- Trial name
- NCT02503891
- Testing
- MP-1 Polymer on Ceramic Articulation system
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- M.M.A Tech Ltd.
Kienbock Disease
Kienbock Disease Radiographic Guided Treatment Versus Arthroscopic Guided Treatment
To Compare Between Radiological Guided Treatment And Arthroscopic Guided Treatment Of KIENBOCK Disease
- Trial name
- NCT03291015
- Testing
- radiographic, arthroscopy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Healthy
Pharmacokinetic Interactions With Prednisolone in Healthy Volunteers and HIV-infected Patients Receiving Single-Dose Prednisone
This study will evaluate the impact of the HIV protease inhibitor ritonavir on the pharmacokinetics-that is, the interaction of the medication and the body-of prednisolone after prednisone is given to healthy volunteers.
- Trial name
- NCT00072644
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)