Clinical trials: Osteonecrosis Due to Drug
Osteonecrosis Due to Drugs, Jaw
Human Amniotic Membrane (hAM) for Stage II Maxillomandibular Osteonecrosis Management
This study aims to demonstrate, during the first standard surgical management of patients with stage II MRONJ, the effect of the implantation of a cryopreserved hAM on the maxillomandibular bone, on the healing of the oral mucosa.
- Trial name
- amniOST (NCT05664815)
- Testing
- Human Amniotic Membrane, Conventional/Standard treatment
- Where
- 5 sites in France
- Volunteers
- 66 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Osteonecrosis Due to Drugs, Jaw, Osteonecrosis of the Jaw, Bisphosphonate Related
Medical and Surgical Treatment of MRONJ (Medication-related Osteonecrosis of the Jaw Bones)
MRONJ is an acronym used to describe medication-related osteonecrosis of the jaw bones. It has been reported by the AAOMS that bisphosphonates or denosumab can cause this condition.
- Conditions
- Osteonecrosis Due to Drugs, Jaw, Osteonecrosis of the Jaw, Bisphosphonate Related, Osteonecrosis of the Jaw, Bisphosphonate Induced
- Trial name
- NCT06917846
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Akdeniz University
Osteonecrosis Due to Drugs, Jaw
Predictive Score For Maxillary Osteonecrosis After Invasive Oral Surgery
Non-interventional prospective multicentre cohort study to determine a predictive score for the occurrence of osteochimionecrosis of the jaws after invasive oral surgery in patients who have received biphosphonates or…
- Trial name
- PREV-ONM (NCT04257721)
- Where
- 5 sites in France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Sud Francilien
Osteonecrosis Due to Drugs, Jaw
Antiresorptive Drug Continuation Compared With Drug Holiday in Cancer Patients Needing Tooth Extraction
The aim of this trial is to evaluate high-dose antiresorptive drug holiday related to tooth extraction with primary mucosal closure (surgical extraction) including how a drug holiday affects the health related quality of life.
- Trial name
- DrugHoliday (NCT04540601)
- Testing
- Continuation of antiresorptives in relation to tooth extraction (surgical tooth removal)
- Where
- 2 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- University of Copenhagen
Oral Mucositis, Osteoradionecrosis
Photobiomodulation in Oral Lesions Resulting From Anti-neoplastic Prevention
Introduction: There are several manifestations in the oral mucosa resulting from antineoplastic treatments by chemo (QT) or radiotherapy (RT).
- Conditions
- Oral Mucositis, Osteoradionecrosis, Osteonecroses, Bisphosphonate, Osteonecrosis Due to Drugs, Jaw
- Trial name
- NCT04717765
- Testing
- Preventive, LLL Phototherapy and topical Vit E, Curative, LLL Phototherapy and topical Vit E, Preventive, LLL Phototherapy and LPRF
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Santiago de Compostela
Hypertension, Osteonecrosis
Hypertension Intervention to Reduce Osteonecrosis in Children With Acute Lymphoblastic Leukemia/Lymphoma
This is a randomized unblinded Phase II clinical trial evaluating the impact of intensive antihypertensive control (targeted to the 50-75th percentile for age, sex, and height) compared to conventional antihypertensive control…
- Conditions
- Hypertension, Osteonecrosis, Osteonecrosis Due to Drug
- Trial name
- NCT04401267
- Testing
- Intensive Antihypertensive Therapy, Conventional Antihypertensive Therapy, Symptom Survey
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- St. Jude Children's Research Hospital
Osteonecrosis of the Jaw, Osteonecrosis Due to Drugs, Jaw
Medication Related Osteonecrosis of the Jaws (MRONJ) in a Cohort of Patients Treated by Antiresorptive Drugs
The objective of this prospective observational study is to investigate the incidence of Medication Related Osteonecrosis of the Jaws (MRONJ) in patients receiving antiresorptive drugs for oncohematologic reasons during a 5-year…
- Conditions
- Osteonecrosis of the Jaw, Osteonecrosis Due to Drugs, Jaw, Osteonecrosis Due to Drug, Bisphosphonate-Associated Osteonecrosis
- Trial name
- NCT06457776
- Testing
- Dental management
- Where
- Italy
- Volunteers
- 126 people
- Sponsor
- Catholic University of the Sacred Heart
Bisphosphonate-Associated Osteonecrosis of the Jaw, Osteonecrosis of the Jaw
Piezoeletric Surgery vs Conventional Surgery for Treatment of MRONJ
To date, surgical therapy of MRONJ remains the therapy of choice while still in association with a medical approach. Surgical intervention aims to stop the progression of the pathology through the removal of the tissue…
- Conditions
- Bisphosphonate-Associated Osteonecrosis of the Jaw, Osteonecrosis of the Jaw, Osteonecrosis Due to Drug
- Trial name
- PIEZOPZ-1 (NCT06622421)
- Testing
- Piezoelectric surgery, Conventional surgery
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Osteonecrosis Due to Drugs, Jaw
Use of Topical Phenytoin in Bisphosphonate-related Osteonecrosis of the Mandible
Patients who had bisphosphonate-related osteonecrosis of the jaw in stage II were allocated in two groups randomly : In group1, 10 patients underwent debridement and primary closer of the area,in group 2 , patients received…
- Trial name
- NCT03269214
- Testing
- Topical Phenytoin 5%
- Volunteers
- 20 people
- Sponsor
- Shiraz University of Medical Sciences
Osteonecrosis Due to Drugs, Jaw
Plasma Rich in Growth Factors for Treatment of Medication Related Osteonecrosis of the Jaw
Medication related Osteonecrosis of the Jaw (MRONJ) consists of progressive destruction of bone in the maxillofacial area. It is an established complication which occurs in patients who take two main classes of antiresorptive…
- Trial name
- NCT03390777
- Testing
- surgery, PRGF after surgery
- Volunteers
- 150 people
- Sponsor
- University of Roma La Sapienza