Clinical trials: Osteoporotic Fractures
Osteoporosis, Lower Limb Fracture
OsteoPorotic fracTure preventION System (OPTIONS) Research Study
Osteoporosis is a disease that weakens bones so the bones may break easily. The risk for osteoporosis increases with age in both women and men. Osteoporosis affects 10 million older adults in the US.
- Trial name
- OPTIONS (NCT06731608)
- Testing
- OPTIONS, Enhanced usual care
- Where
- 2 sites in United States
- Volunteers
- 1,344 people
- Sponsor
- Brigham and Women's Hospital
Hip Fractures
Geriatric Fracture Centers - Evaluation of a Geriatric Co-management Program
The study will assess patients with at least one major AE related to treatment / hospitalization / immobilization in the Geriatric Fracture Center (GFC) group compared to the usual care group.
- Trial name
- NCT02297581
- Where
- 12 sites in United States, Austria and 4 more
- Volunteers
- 282 people
- Sponsor
- AO Innovation Translation Center
Vertebral Compression Fracture, Spinal Trauma
VertebrOpLasty Versus Conservative Treatment in Acute Non Osteoporotic Vertebral Fractures
The purpose of this protocol is to prove the efficacy of vertebroplasty in patients suffering from acute non osteoporotic vertebral compression fracture.
- Trial name
- VOLCANO (NCT01643395)
- Testing
- vertebroplasty, conservative therapy
- Where
- France
- Volunteers
- 99 people
- Sponsor
- University Hospital, Clermont-Ferrand
Clinical Decision Support System
Development and Application of a Clinical Decision Support System for Exercise Rehabilitation in Patients With Osteoporotic Vertebral Compression Fractures
This study aims to develop a clinical decision support system for exercise rehabilitation in patients with osteoporotic vertebral compression fractures, based on evidence-based recommendations for postoperative exercise…
- Trial name
- NCT07623304
- Testing
- Decision Support System: A clinical decision support system for exercise rehabilitation in patients with osteoporotic vertebral compression fractures, Basic Postoperative Care, Conventional Postoperative Care
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jiawei Jiang
Sepsis, Osteoporotic Hip Fracture
Prediction of Mortality and Morbidity After Hip Fracture Using Monocyte Distribution Width (MDW)
Hip fracture is a common injury in older adults and is often associated with serious complications, longer hospital stays, and increased risk of death.
- Conditions
- Sepsis, Osteoporotic Hip Fracture, Hip Fracture
- Trial name
- MDW (NCT07350785)
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Osteoporosis
Study Evaluating Bazedoxifene Acetate In Osteoporosis In Postmenopausal Women
The purpose of this study is to determine whether bazedoxifene acetate is safe and effective in the treatment of osteoporosis in postmenopausal women.
- Trial name
- NCT00205777
- Testing
- Bazedoxifene Acetate
- Where
- 375 sites in United States, Argentina and 28 more
- Volunteers
- 7,609 people
- Sponsor
- Pfizer
Osteoporosis
CONFIRM EXTENSION - Long-term Follow-up Study of Patients Treated with AGN1 LOEP
The study is designed as a multi-center study within Europe in up to 60 patients treated with the AGN1 LOEP Kit in CONFIRM. This will be a non-randomized and non-blinded study.
- Trial name
- NCT04511364
- Testing
- Clinical imaging is performed during the 24 and 60 month follow-up visits
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- AgNovos Healthcare, LLC
Osteoporotic Fractures, Vertebral Fracture
Percutaneous Vertebroplasty Vs. Sham for Osteoporotic Vertebral Compression Fractures Focusing on Pain and Economy.
The purpose of this randomized double-blind clinical trial is to determine the efficacy of percutaneous vertebroplasty (PVP) in relieving severe pain in patients with MRI-verified acute or sub-acute osteoporotic vertebral…
- Trial name
- VOPE2 (NCT06141187)
- Testing
- Vertebroplasty
- Where
- Denmark
- Volunteers
- 240 people
- Sponsor
- Spine Centre of Southern Denmark
Osteoporotic Fractures
Osteoporosis Associated Vertebral Fractures - Medical and Socio-economic Aspects in Austria
The purposes of this study were to analyse demographic, medical, gender and socio-economic aspects of osteoporosis associated vertebral fractures.
- Trial name
- NCT02403726
- Testing
- Operation, Non-operative treatment
- Volunteers
- 694 people
- Sponsor
- Medical University of Vienna
Distal Radius Fracture, Fall Patients
Vibration Therapy as a Rehabilitation Intervention for Postural Training and Fall Prevention
The occurrence of distal radius fractures is well known to be a sentinel event as these fractures are associated with 2 to 4 times increased risk of subsequent hip fractures in elderly patients.
- Trial name
- NCT03380884
- Testing
- Low-magnitude high-frequency vibration (LMHFV)
- Where
- Hong Kong
- Volunteers
- 232 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Osteoporosis, Osteoporosis Risk
Risk of Osteoporotic Fracture in Home Care Patients in Turkey
This study will assess the incidence of osteoporosis and osteoporotic fracture risk of registered home health patients in the Anatolian side of Istanbul.
- Conditions
- Osteoporosis, Osteoporosis Risk, Osteoporotic Fractures
- Trial name
- NCT05738785
- Testing
- Document review and scanning
- Where
- Turkey (Türkiye)
- Volunteers
- 370 people
- Sponsor
- Uskudar State Hospital
Fractures Related to Skeleton Fragility
Fracture Prediction by Opportunistic Screening for Osteoporosis
Fractures related to skeleton fragility (i.e. osteoporotic fractures) represent a growing health problem, as the life expectancy and thus the number of frail elderly subjects is increasing.
- Trial name
- OPPORTOS (NCT03570177)
- Where
- France
- Volunteers
- 173,720 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoporosis, Postmenopausal, Osteoporosis
Preventing Osteoporosis Using Denosumab
The purpose of this research study is to find out if denosumab (Prolia®), an injection given in the arm under the skin every 6 months, works to treat bone loss and prevent it from worsening in older men and women (ages 65 and…
- Conditions
- Osteoporosis, Postmenopausal, Osteoporosis, Osteoporotic Fractures
- Trial name
- PROUD (NCT02753283)
- Testing
- denosumab, Calcium and Vitamin D
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Susan L. Greenspan
Osteoporosis
Effectiveness of Automated Inpatient Endocrinology Consultation for Osteoporotic Hip Fracture
Osteoporosis has been called a "silent epidemic" whose prevalence is increasing. It often presents as a fragility fracture, with hospitalizations resulting from minimally traumatic hip fractures.
- Trial name
- NCT00643175
- Testing
- Automated follow up
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- State University of New York - Upstate Medical University
Osteoporosis, Osteoporotic Fractures
Three Year Evaluation of a Cohort of Patients Presenting Osteoporotic Fractures
A specialized osteoporosis clinic has existed in our hospital since 2010. The descriptive retrospective analysis of patients included in this pathway was the subject of a first study on patients included between January 2010 and…
- Trial name
- NCT03994094
- Testing
- Telephone interview
- Where
- France
- Volunteers
- 147 people
- Sponsor
- Centre Hospitalier le Mans
Osteoporosis, Hip Fracture
Evaluating the Ability of Zoledronic Acid to Reduce the Rate of Subsequent Osteoporotic Fractures After a Hip Fracture
The purpose of this study is to evaluate whether zoledronic acid given once yearly for two years to men and women after surgical repair of a recent hip fracture will significantly reduce the rate of all re-occurring (new)…
- Trial name
- NCT00046254
- Testing
- Zoledronic Acid
- Where
- 28 sites in United States, Germany
- Volunteers
- 2,127 people
- Sponsor
- Novartis Pharmaceuticals
Osteoporosis, Secondary Hyperparathyroidism
Calcium and Vitamin D Malnutrition in Elderly Women
This study is designed to test whether calcium supplementation alone or calcium plus vitamin D reduces the incidence of fractures, reduces high parathyroid secretory activity, and halts bone loss in a population-based sample of…
- Trial name
- NCT00352170
- Testing
- calcium supplementation, calcium and vitamin D3 supplementation
- Volunteers
- 1,180 people, healthy volunteers welcome
- Sponsor
- Creighton University
Osteoporotic Vertebral Compression Fractures
CT-Based Deep Learning for Differentiating Acute and Chronic Osteoporotic Vertebral Compression Fractures
Osteoporotic vertebral compression fractures are common in older adults and may present as either acute or chronic fractures. Correctly distinguishing acute from chronic fractures is clinically important because treatment…
- Trial name
- CT-DL-OVCF (NCT07306858)
- Testing
- No Intervention (Observational Study)
- Where
- China
- Volunteers
- 276 people
- Sponsor
- Xin Fan
Healthy, Osteopenia
Clinical Study to Estimate Bone Mineral Density With the POROUS Ultrasound Device
Osteoporosis is a widespread medical condition among older people. It causes the bones to weaken and become more likely to break.
- Conditions
- Healthy, Osteopenia, Osteoporosis
- Trial name
- POROUS-BMD (NCT07187518)
- Testing
- Measurements with the POROUS R4C ultrasound device at the midshaft tibia, DXA measurement of the hip and lumbar spine
- Where
- 2 sites in Germany
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- POROUS GmbH
Acute Osteoporotic Spinal Fractures
Safety and Efficacy Study of Percutaneous Vertebroplasty for Painful Acute Osteoporotic Spine Fractures
Percutaneous vertebroplasty (PVP) is now a therapeutic option for individuals for whom medical management has not been successful or for those who are at risk for developing complications due to long-term immobilization.
- Trial name
- NCT01677806
- Testing
- Percutaneous vertebroplasty, Conservative therapy
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Jinan Military General Hospital