Clinical trials: Out-of Hospital Cardiac Arrest
Out-Of-Hospital Cardiac Arrest
First Responder Airway & Compression Rate Trial
The First responder Airway \& Compression rate Trial (FACT) Study will address basic life support (BLS) treatments administered by Emergency Medical Services (EMS) first responders to patients who suffer a sudden circulatory…
- Trial name
- FACT (NCT05969028)
- Testing
- igel, Compression Rate
- Where
- United States
- Volunteers
- 4,200 people
- Sponsor
- University of Washington
Cardiac Arrest
Cardiac Arrest and Intra Osseous Infusion
the international recommendations don't explain the place of the intraosseous infusion in the reanimation of adult cardiac arrest; the goal of this preliminary study is to inform the delay for obtaining a vascular access by…
- Trial name
- ACCIO (NCT01803971)
- Testing
- Obtention of vascular access in out-of-hospital cardiac arrest patients according to the current strategy
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Bordeaux
Cardiac Arrest (CA), Anoxic Brain Injury
Early WAKE-up Predictors After Out-of-Hospital Cardiac Arrest
WAKE-OHCA is a prospective observational substudy of the Danish Out-of-Hospital Cardiac Arrest (DANOHCA) trial, identifier NCT05895838.
- Conditions
- Cardiac Arrest (CA), Anoxic Brain Injury, Comatose Survivors of Cardiac Arrest, EEG
- Trial name
- WAKE-OHCA (NCT06979700)
- Testing
- Automated Pupillometry, Transcranial Doppler Ultrasound, Optic Nerve Sheath Diameter
- Where
- 2 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- University of Aarhus
Out of Hospital Cardiac Arrest, Brain Injury
Therapeutic Hypothermia and eArly Waking
Unconscious survivors of cardiac arrest who are treated with intravenous therapeutic hypothermia for 24 hours will be assessed after 12 hours for appropriateness to be woken early and extubated whilst continuing to receive…
- Trial name
- THAW (NCT03065946)
- Testing
- Early wakening
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Cardiac Arrest, Out-Of-Hospital
International Device Assisted Controlled Sequential Elevation CPR Registry
The purpose of this prospective observational cardiopulmonary resuscitation (CPR) registry is to track the use and clinical outcomes from emergency medical systems across the US and Europe that have implemented a system of care…
- Trial name
- NCT05588024
- Testing
- Head Up CPR based bundle of care
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Hennepin Healthcare Research Institute
Cardiac Arrest, Out-Of-Hospital, Sudden Cardiac Arrest
Epinephrine Dose: Optimal Versus Standard Evaluation Trial
The objective of this randomized controlled trial is to evaluate whether a low cumulative dose of epinephrine ("low dose") is non-inferior to a standard cumulative dose of epinephrine ("standard dose") with respect to survival to…
- Conditions
- Cardiac Arrest, Out-Of-Hospital, Sudden Cardiac Arrest, Ventricular Fibrillation, Ventricular Tachycardia-Pulseless
- Trial name
- EpiDOSE (NCT03826524)
- Testing
- Epinephrine
- Where
- 9 sites in Canada
- Volunteers
- 1,250 people
- Sponsor
- Unity Health Toronto
Out of Hospital Cardiac Arrest, Inhospital Cardiac Arrest
Skeletal Muscle Mass on Prognosis and Recovery in Clinical Trial
The objective of this research project is to develop an automated muscle mass measurement system based on computed tomography (CT) images using deep learning and artificial intelligence, and to construct a prognostic prediction…
- Trial name
- NCT07034170
- Testing
- Enhanced Rehabilitation Program
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Taiwan University Hospital
Out-Of-Hospital Cardiac Arrest, Heart Arrest
The PulsePoint Study
This randomized controlled trial will evaluate whether use of the PulsePoint system increases bystander CPR or defibrillator use compared to standard dispatch procedures in patients who suffer non-traumatic, out-of-hospital…
- Conditions
- Out-Of-Hospital Cardiac Arrest, Heart Arrest, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT04806958
- Testing
- PulsePoint notification
- Where
- 2 sites in United States, Canada
- Volunteers
- 340 people
- Sponsor
- Dr. Steven Brooks
Cardiac Arrest (CA), Proteomics
Proteomic Analysis of Serum Samples After Cardiac Arrest: a TTM-trial Substudy
Cardiac arrest remains a large contributor to morbidity and mortality. Animal studies suggest an improvement in mortality and neurological function with hypothermia after cardiac arrest, a finding that could not be verified in…
- Trial name
- NCT07017374
- Testing
- Proteomic analysis, targeted temperature management
- Where
- Sweden
- Volunteers
- 682 people
- Sponsor
- Region Skane
Out-Of-Hospital Cardiac Arrest
Dynamics of the Capillary Lactate Levels in OHCA
Serial capillary lactate measurements during cardiopulmonary resuscitation (CPR) in patients with out-of-hospital cardiac arrest (OHCA).
- Trial name
- NCT04571281
- Testing
- capillary lactate measurements
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Maribor
Cardiac Arrest, Out-Of-Hospital, Ventricular Fibrillation
Utility and Procedural Feasibility of REBOA Operationalized for Non-Trauma Application (UP-FRONT)
Single center randomized-controlled trial in out-of-hospital cardiac arrest (OHCA) patients. This study will investigate the feasibility and utility of the Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA)…
- Conditions
- Cardiac Arrest, Out-Of-Hospital, Ventricular Fibrillation, Ventricular Tachycardia
- Trial name
- UP-FRONT (NCT05236920)
- Testing
- Resuscitative Endovascular balloon occlusion of the aorta using a REBOA catheter device
- Sponsor
- University of Alabama at Birmingham
Shockable Out of Hospital Cardiac Arrest
CYclosporine A in Shockable Out-of-hospital Cardiac Arrest ResUScitation
Cardiac arrest (CA) is a public health problem in industrialized countries. The prognosis of these patients remains poor with significant mortality and severe neurological sequelae in survivors.
- Trial name
- CYRUS II (NCT02887807)
- Testing
- Single intravenous bolus of cyclosporine A (2.5 mg/kg) at the onset of resuscitation
- Where
- France
- Sponsor
- Hospices Civils de Lyon
Cardiac Arrest, Cardiopulmonary Resuscitation
Circulation Improving Resuscitation Care (CIRC)
During resuscitation of out of hospital cardiac arrest patients the use of a mechanical chest compression device Autopulse will improve survival compared to manual compressions.
- Trial name
- CIRC (NCT00597207)
- Testing
- AutoPulse, Manual
- Where
- 5 sites in United States, Austria and 1 more
- Volunteers
- 4,231 people
- Sponsor
- Zoll Medical Corporation
Out-Of-Hospital Cardiac Arrest
Epinephrine Versus Isoprenaline During Out-of-Hospital Cardiac Arrest With Asystole
Background: During out-of-hospital cardiac arrest (OHCA), the patient presents with either a shockable or a non-shockable rhythm.
- Trial name
- EPISO (NCT06473116)
- Testing
- Isoprenaline Only Product
- Where
- Denmark
- Volunteers
- 1,178 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Resuscitation, Outcome, Fatal
Outcome After Out of Hospital Cardiac Arrest in Bern, Switzerland
Sudden cardiac arrests is one of the most frequent causes of death. In Switzerland every year 8000-10.000 people suffer from a cardiac arrest.
- Conditions
- Resuscitation, Outcome, Fatal, Out-Of-Hospital Cardiac Arrest
- Trial name
- NCT03759210
- Where
- Switzerland
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cardiac Arrest
Anti-inflammatory Effect of Therapeutic Hypothermia in Out-hospital Cardiac Arrest Patients With Cardiogenic Shock
Acute myocardial infarction complicated with cardiogenic shock trigger IL-6, the strong inflammatory response, result in multiple organ failure, even death.
- Trial name
- NCT02633358
- Testing
- Therapeutic hypothermia group
- Where
- Taiwan
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Cardiopulmonary Arrest
REBOA in Nontraumatic OHCA
The investigators propose a multicenter randomized controlled trial in South Korea and Taiwan to observe the clinical effects of REBOA on nontraumatic out-of-hospital-cardiac-arrest (OHCA) patients.
- Trial name
- REBOA (NCT06031623)
- Testing
- REBOA
- Where
- South Korea
- Volunteers
- 234 people
- Sponsor
- Seoul National University Hospital
Cardiac Arrest, Out-Of-Hospital Cardiac Arrest
Initial Double Sequential External Defibrillation in Out of Hospital Cardiac Arrest
Double Sequential External Defibrillation (DSED) represents an alternative treatment of refractory ventricular fibrillation (rVF) in out-of-hospital cardiac arrest (OHCA).
- Conditions
- Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation
- Trial name
- DUALDEFIB (NCT06672159)
- Testing
- Two defibrillators, One defibrillator
- Where
- Norway
- Volunteers
- 356 people
- Sponsor
- St. Olavs Hospital
Out of Hospital Cardiac Arrest
Functional Outcome After Cardiac Arrest
Descriptive and prognosis study of the functional outcome after cardiac arrest for the patients awake within the first 15 days.
- Trial name
- HANOX (NCT02292147)
- Where
- France
- Volunteers
- 140 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Out-Of-Hospital Cardiac Arrest
EXecution of Trans-Esophagus Echo Cardiogram in CardioPulmonary Resuscitation for Patients With Out-of-hospital Cardiac Arrest
The purpose of this single center, randomized clinical control trial is to determine that changing chest compression site during cardiopulmonary resuscitation according to the examination of the TEE could increase the level of…
- Trial name
- EXECT_CPR (NCT05907460)
- Testing
- transesophageal echocardiography examination during cardiopulmonary resuscitation
- Where
- Taiwan
- Volunteers
- 132 people
- Sponsor
- Far Eastern Memorial Hospital