Clinical trials: Out-of Hospital Cardiac Arrest
Cardiac Arrest
Identification of Neurological Prognostic Markers of Cardiac Arrest Patients Alive on 3rd Day
The aim of the study is to identify prognostication predictors of 6-months neurological outcome in survivors at day 3 after cardiac arrest (CA) treated with therapeutic hypothermia (TH).
- Trial name
- NCT02888184
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Out-Of-Hospital Cardiac Arrest
Tissue Oxygenation During Cardiopulmonary Resuscitation as a Predictor of Return of Spontaneous Circulation
The main objective of the trial is to find out if there is correlation between cerebral and skeletal muscle oxygenation values during cardiopulmonary resuscitation and if these values can predict return of spontaneous…
- Trial name
- NCT04058925
- Testing
- NIRS device
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- Miha Košir
Cardio Respiratory Arrest, Cardiac Death
Ventilation in Cardiac Arrest
Over the last decades, research in cardiopulmonary resuscitation was primarily focused on uninterrupted chest compressions to restore sufficient circulation.
- Conditions
- Cardio Respiratory Arrest, Cardiac Death, Ventilation Therapy; Complications, Apnea
- Trial name
- VICA (NCT04657393)
- Testing
- mechanical ventilation
- Where
- Austria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Out-Of-Hospital Cardiac Arrest After Initial Successful Resuscitation
Transcriptome Assessment After Cardiac Arrest
The purpose of this study is to determine whether the blood transcriptome of patients resuscitated after out-of-hospital could be an early predictor of the neurological outcome.
- Trial name
- OMECARD (NCT03895736)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Arrest (CA)
Evaluation of Genetic-molecular Causes of Out-of-Hospital Cardiac Arrest: From Patients to Families
The aims are to define the exact prevalence of hereditary heart diseases in out-of-hospital cardiac arrest (OHCA) patients taking also into account gender, patient and OHCA characteristics, provincial settings and environmental…
- Trial name
- GenetiCA (NCT06844851)
- Where
- Italy
- Volunteers
- 1,725 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Cardiac Arrest, Out-Of-Hospital, Cardiac Arrest Due to Underlying Cardiac Condition
AID-OMIE - Artificial Intelligence in Detection of Occlusive Myocardial Infarction in Emergency Medicine
Study Objective and Hypothesis The study hypothesizes that artificial intelligence (AI)-assisted interpretation of the 12-lead electrocardiogram (ECG) can improve the care of patients resuscitated after out-of-hospital cardiac…
- Trial name
- AID-OMIE (NCT06767709)
- Volunteers
- 200 people
- Sponsor
- Institute of Mountain Emergency Medicine
Healthy Participants, Knowledge Acquisition
Learning Cardiopulmonary Resuscitation in the School Setting: RCP-KNOW Project.
Title: Out-of-hospital cardiorespiratory arrest and learning cardiopulmonary resuscitation in the school setting: evidence synthesis. CPR-KNOW PROYECT.
- Conditions
- Healthy Participants, Knowledge Acquisition, Cardiopulmonary Resuscitation (CPR), Children
- Trial name
- RCP-KNOW (NCT07292532)
- Testing
- Cardiopulmonary Resuscitation Teaching Intervention in Children
- Where
- 2 sites in Spain
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Out of Hospital Cardiac Arrest
Effects of a New Dispatcher-Assisted Basic Life Support Training Program
Despite aggressive cardiopulmonary resuscitation (CPR) training, the outcome of cardiac arrest is not good. The problem is method of education.
- Trial name
- HEROS (NCT02142387)
- Testing
- BLS CPR program with dispatcher assisted CPR simulation
- Where
- South Korea
- Volunteers
- 18,822 people
- Sponsor
- Seoul National University Hospital
Heart Arrest, Cardiac Arrest
Pre-arrival Instructions Effect on Bystander Cardiopulmonary Resuscitation (CPR).
The investigators hypothesized that pre-arrival instructions would increase the likelihood of bystanders performing Cardiopulmonary Resuscitation (CPR).
- Conditions
- Heart Arrest, Cardiac Arrest, Cardiopulmonary Arrest, Out of Hospital Cardiac Arrest
- Trial name
- NCT02007499
- Testing
- Pre-Arrival Instructions
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Medical College of Wisconsin
Heart Arrest, Out-Of-Hospital, Biomarkers
Impact of Vitamin C on Biomarkers of Neurologic Injury in Survivors of Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) is one of the leading cause of death in the world. In Slovenia approximately 25% of resuscitated patients survives to discharge from hospitals, usually with poorer functional status.
- Conditions
- Heart Arrest, Out-Of-Hospital, Biomarkers, Oxidative Stress, Neurological Injury
- Trial name
- NCT04563000
- Testing
- Vitamin C
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Maribor
Out-Of-Hospital Cardiac Arrest, Pediatric Disorder
Etiology, Incidence and Survival of Pediatric Out-of-hospital Cardiac Arrests: a Four-year Danish Analysis
Background: OHCA is a rare condition for children and young adults. Overall incidence rates are reported as 3.3-5.97 per 100.000 inhabitants.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Pediatric Disorder, Cardiopulmonary Arrest
- Trial name
- Child-OHCA (NCT04275856)
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Resuscitation
Incidence of the Out- and in Hospital Cardiac Arrest at a Tertiary Hospital in Germany
Incidence of the background information, incidence and special characteristics of out- and in-hospital cardiac arrest at a tertiary hospital in Germany.
- Trial name
- ProseCPR (NCT05709665)
- Testing
- Time to Decision for eCPR
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Johannes Gutenberg University Mainz
Prehospital Resuscitation, End-Tidal Carbon Dioxide
End-Tidal CO2 (ETCO2) Trends in Out-of-Hospital Cardiac Arrest
The investigators aim to assess the relationship between patient characteristics, prehospital treatments, and vital signs to determine if a threshold EtCO2 value, a change in EtCO2 value (final - initial), or a trend in EtCO2…
- Conditions
- Prehospital Resuscitation, End-Tidal Carbon Dioxide, Cardiac Arrest, Out-Of-Hospital, Prehospital Emergency Medical Services
- Trial name
- NCT07632430
- Where
- United States
- Volunteers
- 3,500 people
- Sponsor
- Office of the Medical Director for EMS in Oklahoma City and Tulsa
Out-Of-Hospital Cardiac Arrest (OHCA)
NEUROprotection Via optimizINg Cerebral Blood Flow afTer cArdiaC arresT (NEURO-INTACT) Study
This single-center proof of concept study aims to assess the efficacy of a blood pressure strategy targeting person- and time-specific cerebral blood flow compared with standard-of-care using neuron-specific enolase as a…
- Trial name
- NCT05679739
- Testing
- Individualized blood pressure strategy
- Where
- Singapore
- Volunteers
- 49 people
- Sponsor
- National University Hospital, Singapore
Cardiac Arrest (CA)
Does Increasing the Compression Pause From 3 to 5 Seconds in Mechanical Compression Devices Increase Ventilation Success Rate and Return of Spontaneous Circulation?
To give chest compressions during cardiopulmonary resuscitation (CPR), mechanical chest compression devices can be used. During synchronous 30:2 CPR, the standard setting on these devices leave an automated 3-second chest…
- Trial name
- LUCASVP (NCT06824961)
- Testing
- 5-second ventilation pause duration during mechanical CPR, 3-second ventilation pause duration during mechanical CPR
- Where
- 2 sites in Netherlands
- Volunteers
- 692 people
- Sponsor
- Amsterdam UMC, location VUmc
Cardiac Arrest (CA)
Strategies for Defibrillation During Out-of-Hospital Cardiac Arrest
The "Strategies for Defibrillation during Out-of-Hospital Cardiac Arrest" (STRAT-DEFI) trial is an investigator-initiated, individually randomized, 3-group clinical trial comparing standard anterior-lateral pad positioning with…
- Trial name
- STRAT-DEFI (NCT06781892)
- Testing
- Anterior-lateral pad positioning, Anterior-posterior pad positioning, Double-sequential defibrillation
- Where
- 6 sites in Denmark
- Volunteers
- 909 people
- Sponsor
- Lars Wiuff Andersen
Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication
Advanced Reperfusion Strategies for Refractory Cardiac Arrest
This is a Phase II, single center (Under the Center for Resuscitation Medicine at the University of Minnesota Medical School), partially blinded, prospective, intention to treat, safety and efficacy clinical trial, randomizing…
- Conditions
- Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication, Ventricular Fibrillation, Pulseless Ventricular Tachycardia
- Trial name
- ARREST (NCT03880565)
- Testing
- Early Extracorporeal Membrane Oxygenation (ECMO) Facilitated Resuscitation, Standard Advanced Cardiac Life Support (ACLS) Resuscitation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Hypothermia, Heart Arrest
Clinical and Economical Interest of Endovascular Cooling in the Management of Cardiac Arrest (ICEREA Study)
According to international guidelines, mild therapeutic hypothermia is recommended for resuscitated patients after cardiac arrest due to ventricular fibrillation.
- Trial name
- NCT00392639
- Testing
- Comparison of 2 cooling procedures
- Where
- France
- Volunteers
- 389 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Out-Of-Hospital Cardiac Arrest, BIS
Frontal EEG in OHCA Feasibility Study
This study aims to optimize the treatment of out-of-hospital cardiac arrest (OHCA) by focusing on neurological outcomes through Bispectral Index (BIS) monitoring.
- Trial name
- FEICA (NCT06072092)
- Testing
- BIS Monitor
- Where
- Austria
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Out-of-Hospital Cardiac Arrest
Resuscitative Balloon Occlusion of the Aorta in Non-traumatic Out of Hospital Cardiac Arrest
The primary aim of this study is to investigate the feasibility and complications of inserting a REBOA-catheter to patients suffering from non-traumatic out-of-hospital cardiac arrest, by anesthesiologist working in the…
- Trial name
- REBOA (NCT03534011)
- Testing
- Resuscitative Balloon Occlusion of the Aorta, REBOA catheter
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Norwegian University of Science and Technology