Clinical trials: Out-of Hospital Cardiac Arrest
Sudden Cardiac Death, Arrhythmia
Selection of Shock Energy in Out-Of-Hospital Cardiac Arrest
Sudden cardiac death is the most frequent cause of death in industrialized countries. The most efficient interventiont in ventricular fibrillation is defibrillation in an appropriate timely manner.
- Conditions
- Sudden Cardiac Death, Arrhythmia, Survival
- Trial name
- NCT00472147
- Testing
- shock efficacy
- Where
- Germany
- Sponsor
- Charite University, Berlin, Germany
Cardiac Arrest, Out-Of-Hospital
New Information and Communication Technologies (ICT´s) in Basic Life Support Training for Non-medical Students: Educational Trial
With the increase in life expectancy of the general population and advances in medicine, there is now a population with a higher amount of cardiovascular diseases that lead to an increased risk of sudden cardiac arrest.
- Trial name
- NCT04286204
- Testing
- Basic Life Support training based on ICTs, Classic Basic Life Support training
- Where
- Colombia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Cardio Respiratory Arrest, Cardiac Death
Ventilation in Cardiac Arrest
Over the last decades, research in cardiopulmonary resuscitation was primarily focused on uninterrupted chest compressions to restore sufficient circulation.
- Conditions
- Cardio Respiratory Arrest, Cardiac Death, Ventilation Therapy; Complications, Apnea
- Trial name
- VICA (NCT04657393)
- Testing
- mechanical ventilation
- Where
- Austria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Post Cardiac Arrest Patient Who Was Treated by Hypothermia Protocol
Plasma Neutrophil Gelatinase-associated Lipocalin (NGAL) as Early Biomarker for Renal Dysfunction and Good Neurologic Outcome in Out of Hospital Cardiac Arrest Patients
Postresuscitation disease is a constellation of disorders related to whole-body ischemia and reperfusion syndrome. It includes hypoxic damage in brain, liver, kidney, heart and other organ.
- Trial name
- NCT01987466
- Testing
- Serum NGAL level
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Yonsei University
Out-of-Hospital Cardiac Arrest
Early Gastric Decompression During Advanced Cardiopulmonary Resuscitation (EGD_ACLS)
This study aimed to identify the effect of early gastric decompression on the improvement of circulation in arrest patients during cardiopulmonary resuscitation at the clinical setting of emergency department.
- Trial name
- EGD_ACLS (NCT02391857)
- Testing
- Gastric decompression
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Konkuk University Medical Center
Heart Arrest, Out-Of-Hospital, Wounds and Injuries
Pediatric Prehospital Airway Resuscitation Trial
This study is a Phase 3, multi-center, Bayesian Adaptive Sequential Platform Trial testing the effectiveness of different prehospital airway management strategies in the care of critically ill children.
- Conditions
- Heart Arrest, Out-Of-Hospital, Wounds and Injuries, Respiratory Insufficiency in Children, Child, Only
- Trial name
- Pedi-PART (NCT06364280)
- Testing
- BVM, SGA, ETI
- Where
- 10 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Ohio State University
Out-Of-Hospital Cardiac Arrest, Postcardiac Arrest Syndrome
Steroid, Thiamine and Ascorbic Acid for Comatose Out-of-hospital Cardiac Arrest Survivors
The mortality and neurological outcomes among out-of-hospital cardiac arrest survivors have not improved despite the medical advances. The whole body ischemia/reperfusion injuries after cardiac arrest mainly damaged the brain.
- Trial name
- NCT04921189
- Testing
- The combined supplement of Ascorbic acid, Thiamine, and Cortisol
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Asan Medical Center
Cardiac Arrest
Multifaceted Intervention for Increasing Performance of CPR by Laypersons in Out-of-hospital Cardiac Arrest
Cardiac arrest (CA) early recognition is essential in order to rapidly activate emergency services and for bystanders to begin cardiopulmonary resuscitation (CPR).
- Trial name
- DISPATCH (NCT03633370)
- Testing
- Multifaceted intervention including 3 components
- Where
- 15 sites in France
- Volunteers
- 2,481 people
- Sponsor
- University Hospital, Grenoble
Out-Of-Hospital Cardiac Arrest
Tissue Oxygenation During Cardiopulmonary Resuscitation as a Predictor of Return of Spontaneous Circulation
The main objective of the trial is to find out if there is correlation between cerebral and skeletal muscle oxygenation values during cardiopulmonary resuscitation and if these values can predict return of spontaneous…
- Trial name
- NCT04058925
- Testing
- NIRS device
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- Miha Košir
Pain, Out-of-hospital Cardiac Arrest (OHCA)
Pain After Cardiac Arrest and Resuscitation (PAINCARE)
The PAINCARE substudy is an observational cohort substudy nested within the international STEPCARE trial, which evaluates sedation, temperature, and mean arterial pressure strategies after out-of-hospital cardiac arrest.
- Trial name
- PAINCARE (NCT07564778)
- Where
- 3 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Region Skane
Out-of-Hospital Cardiac Arrest
Smartphone Video-assisted Advanced Life Support of Patients With Out-of-hospital Cardiac Arrest by EMS Under Physician Direction
Direct medical control using video conferencing capabilities of smartphones has never been conducted in out-of-hospital cardiac arrest patients.
- Trial name
- SWALS (NCT03041350)
- Testing
- Smartphone video-assisted ALS(advanced life support)
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Seoul National University Hospital
Out-Of-Hospital Cardiac Arrest
Epidemiological Study of Out-of-hospital Cardiac Arrest in Shenzhen
The epidemiology of out-of-hospital cardiac arrest (OHCA) is a significant public health issue, and large-sample studies on such events within China are relatively limited.
- Trial name
- NCT06896006
- Volunteers
- 19,672 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Out-Of-Hospital Cardiac Arrest, Myocardial Infarction, Acute
Benefit of Hypothermia in OHCA Complicating AMI
To determine the clinical effectiveness of hypothermia treatment in patients with out-of-hospital cardiac arrest complicating acute myocardial infarction.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Myocardial Infarction, Acute, Hypothermia Neonatal
- Trial name
- Hypothermia (NCT06141252)
- Testing
- Hypothermia
- Where
- South Korea
- Volunteers
- 2,925 people
- Sponsor
- Yonsei University
Cardiac Arrest
Cardiopulmonary Resuscitation Witnessing by a Relative
The bereavement generated by the loss of a family member can induce pathological situations: depressive state, anxiety, post-traumatic stress disorder and complicated grief.
- Trial name
- PRESENCE (NCT01009606)
- Testing
- Usual strategy, Modified strategy
- Where
- France
- Volunteers
- 570 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Out-of-Hospital Cardiac Arrest
REBOA in Out-of-hospital Cardiac Arrest
Unexpected cardiac arrest is a frequent and devastating event with a high mortality and morbidity. Half of the patients who survive to ICU admission ultimately die because of hypoxic-ischemic encephalopathy.
- Trial name
- NCT04373122
- Testing
- REBOA
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Heart Arrest, Out-Of-Hospital, Defibrillators
Increasing Law Enforcement Application of Automated External Defibrillators (AED)s for Cardiac Arrest
The goal of this study is to learn if an automated external defibrillator (AED) training adjunct video can improve law enforcement self-efficacy, the likelihood of AED application overall, and decrease disparities in women.
- Trial name
- NCT07649616
- Testing
- AED training adjunct
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wayne State University
Cardiac Arrest With Successful Resuscitation
Hemodynamic Optimization Through Pleth Variability Index for OHCA
Less than half of the patients suffering from sudden cardiac arrest arrive at the hospital alive. Within these survivors less than half will be discharged alive from the hospital without being severely disabled.
- Trial name
- HemOpt-PVI (NCT03841708)
- Testing
- Pleth variability index, Standard non invasive monitoring
- Where
- Belgium
- Volunteers
- 82 people
- Sponsor
- Stefano Malinverni, MD
Heart Arrest, Out-Of-Hospital
Calcium for Out-of-Hospital Cardiac Arrest
This is an investigator-initiated, multicenter, randomized, placebo-controlled, parallel group, double-blind, superiority trial of calcium during adult out-of-hospital cardiac arrest.
- Trial name
- COCA (NCT04153435)
- Testing
- Calcium Chloride, Sodium chloride 0.9%
- Where
- Denmark
- Volunteers
- 397 people
- Sponsor
- Lars Wiuff Andersen
Out of Hospital Cardiac Arrest
Drone Delivery of Automated External Defibrillators to Lay Users (DAEDALUS): A Proof of Concept Study
Summary in non-technical language Aim(s) of the research We are working on a way to use drones to deliver Automated External Defibrillators (AEDs) - devices that help restart a person's heart by giving it an electric shock.
- Trial name
- DAEDALUS (NCT07430813)
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Heart Arrest, Death, Sudden, Cardiac
ResQ Trial: Impact of an ITD and Active Compression Decompression CPR on Survival From Out-of-Hospital Cardiac Arrest
The purpose of this study is to determine whether performing active compression decompression cardiopulmonary resuscitation (ACD-CPR) with an impedance threshold device (ITD) compared to conventional standard cardiopulmonary…
- Conditions
- Heart Arrest, Death, Sudden, Cardiac, Cardiopulmonary Resuscitation, Cardiac Arrest
- Trial name
- ResQ (NCT00189423)
- Testing
- Use of an impedance threshold device (ITD) during the performance of active compression decompression CPR (ACD-CPR), Standard cardiopulmonary resuscitation (S-CPR)
- Where
- 7 sites in United States
- Volunteers
- 1,653 people
- Sponsor
- Advanced Circulatory Systems