Clinical trials: Ovarian Hyperstimulation
STERILITY
Assessment of the Effectiveness and Tolerability of Ovarian Hyperstimulation
The aim of the study is to assess the effectiveness of 5 mixed protocols of ovarian hyperstimulation with urinary gonadotrophins to achieve clinical pregnancy in females undergoing assisted reproductive techniques (IVF/ICSI)…
- Trial name
- DESCARTES (NCT01331720)
- Testing
- hMG-HP
- Where
- 14 sites in Spain
- Volunteers
- 279 people
- Sponsor
- Ferring Pharmaceuticals
Ovarian Hyperstimulation
Cabergoline Versus Calcium Infusion in Ovarian Hyperstimulation Syndrome Prevention
Giving oral Cabergoline or calcium infusion in women at high risk for developing ovarian hyperstimulation syndrome in context of assisted reproductive technologies aiming in its prevention
- Trial name
- NCT03473613
- Testing
- Oral Cabergoline, Calcium Gluconate
- Where
- Egypt
- Volunteers
- 230 people
- Sponsor
- Benha University
Infertility
Comparative Study Between Minidose Long Protocol and Microdose Flare Protocol in Controlled Ovarian Hyperstimulation
Objective: To compare two stimulation protocols, the minidose long protocol and the microdose flare protocol designed for low responders undergoing ICSI. Design: Randomized prospective study.
- Trial name
- NCT02342197
- Testing
- Decapeptyl
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital
Assisted Reproductive Technology, Controlled Ovarian Hyperstimulation
Efficacy and Safety of BG2109 During Controlled Ovarian Hyperstimulation in Female Subjects Undergoing ART Procedures
To explore the optimal effective daily dose of BG2109 to suppress premature luteinizing hormone (LH) surge during COH in female subjects undergoing ART procedures.
- Trial name
- NCT05738382
- Testing
- BG2109, Cetrorelix
- Where
- 10 sites in China
- Volunteers
- 240 people
- Sponsor
- Bio Genuine (Shanghai) Biotech Co., Ltd.
Ovarian Hyperstimulation Syndrome, Effects of Gonadotropin
GnRH Antagonist for Treatment of Early Ovarian Hyperstimulation Syndrome
The aim of this study is to analyze the effectiveness of GnRh antagonist in the treatment of early ovarian hyperstimulation syndrome.
- Conditions
- Ovarian Hyperstimulation Syndrome, Effects of Gonadotropin, Oocyte Maturation
- Trial name
- NCT01268761
- Testing
- GnRH antagonist (Cetrorelix)
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertile Female Subjects Undergoing Controlled Ovarian Hyperstimulation to Suppress Premature LH Surge and Prevent Early Ovulation
To Compare the Efficacy and Safety of Oral SHR 7280 Tablets With Ganirelix Acetate Injection in Infertile Female Subjects
This study is a multi-center, randomized, double-blind, positive drug-controlled, non-inferiority Phase III clinical trial. The study will enroll approximately 316 infertile female subjects undergoing controlled ovarian…
- Trial name
- NCT05994378
- Testing
- SHR7280；Ganirelix Acetate Injection simulant, SHR7280 simulant； Ganirelix Acetate Injection
- Where
- China
- Volunteers
- 317 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Assisted Reproduction
Gonadotropin Releasing Hormone Antagonist in Treatment of Early-onset Severe Ovarian Hyperstimulation Syndrome
Efficacy of the use of GnRH antagonist in treatment of those who develop early-onset severe ovarian hyperstimulation syndrome and had cancelled embryo transfer
- Trial name
- NCT02784457
- Testing
- Cetrorelix
- Volunteers
- 84 people
- Sponsor
- Ain Shams University
Ovarian Hyperstimulation Syndrome
Luteal Phase Supplementation With Recombinant LH After GnRh Agonist Oocytes Triggering in Women at Risk of OHSS
The purpose of this study is to prove that luteal phase supplementation with recombinant LH can solve the luteal phase deficiency after Gnrh agonist oocytes triggering in women at risk of OHSS
- Trial name
- NCT02200952
- Testing
- recombinant LH
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- San Carlo Public Hospital, Potenza, Italy
Infertility, In Vitro Fertilization
Investigate Dose of Org 36286 to Initiate Multiple Follicular Growth in a Controlled Ovarian Hyperstimulation Protocol for IVF or IVF/ICSI (P07015)
The primary objective of this trial was to investigate the appropriate dose of a single injection of Org 36286 to initiate multifollicular growth for the first seven days in a controlled ovarian hyperstimulation (COH) protocol…
- Trial name
- NCT00702806
- Testing
- Org 36286, Puregon®, Orgalutran®
- Volunteers
- 99 people
- Sponsor
- Organon and Co
Ovarian Hyperstimulation Syndrome
Compare the Efficacy of Human Albumin With Cabergoline to Prevent Ovarian Hyper Stimulation in Assisted Reproductive Technology (ART) Program
The purpose of this study is to investigate the efficacy and safety of cabergoline in prevention of ovarian hyperstimulation syndrome versus albumin in ART program.
- Trial name
- NCT01009567
- Testing
- Cabergoline, Control
- Where
- Iran
- Volunteers
- 10 people
- Sponsor
- Royan Institute
Ovarian Stimulation
Human Menopausal Gonadotropin (HMG) vs Recombinant Follicle Stimulating Hormone (rFSH) in Gonadotropin Releasing Hormone (GnRH) Antagonist Cycles
A randomized controlled trial comparing the ongoing pregnancy rate (primary end-point) in 280 patients undergoing IVF/ICSI after stimulation with hp-hMG or rFSH controlled with a GnRH antagonist.
- Trial name
- NCT00669786
- Testing
- Human Menopausal Gonadotropin (HMG) & - Recombinant Follicle Stimulating Hormone (r-FSH)
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility, Ovarian Hyperstimulation Syndrome
Short Versus Long Protocol for IVF and IVF+ICSI
Purpose: Comparing a GnRH agonist and an antagonist protocol for IVF/ICSI with regard to 1. frequency of ovarian hyperstimulation syndrome (OHSS) (1. outcome measure) 2. quality of life (2. outcome measure) 3. live birth rate (2.
- Conditions
- Infertility, Ovarian Hyperstimulation Syndrome, Quality of Life, Live Birth
- Trial name
- KvL (NCT00756028)
- Testing
- Patients receiving short protocol IVF/ICSI-treatment., Long protocol
- Where
- 2 sites in Denmark
- Volunteers
- 1,099 people
- Sponsor
- Peter Hornnes, MD, DMSc
Infertility, Monofollicular Development
Low-dose Gonal-f® in Ovulation Induction
This is a prospective, multicenter, open-label, comparative and parallel-group study of ovulation induction evaluating tailoring of Recombinant follicle stimulating hormone (FSH) treatment using the Gonal-f® prefilled pen in…
- Trial name
- LoGo (NCT01871532)
- Testing
- Gonal-f®
- Where
- 10 sites in Ireland, United Kingdom
- Volunteers
- 24 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Ovarian Hyperstimulation Syndrome
Study Assessing the Effect of 3-week Treatment With One of Three Oral Doses of Quinagolide
Women included in this study are undergoing controlled ovarian hyperstimulation for assisted reproductive technologies (ART) and present with signs of moderate risk of developing OHSS.
- Trial name
- NCT00329693
- Testing
- Norprolac
- Where
- 7 sites in Spain
- Volunteers
- 182 people
- Sponsor
- Ferring Pharmaceuticals
Ovarian Hyperstimulation Syndrome, Hypercoagulability
Ovarian Hyperstimulation Syndrome in Patients Triggered by GnRH Agonist for Excessive Follicular Response
In the literature, the risk of moderate to severe OHSS is 3 to 6% and reaches 31% in high risk populations 9 days after oocyte triggering with hCG.
- Trial name
- COAGO (NCT02701452)
- Testing
- COAGO
- Volunteers
- 1 people
- Sponsor
- University Hospital, Lille
Ovarian Hyperstimulation Syndrome
Cabergoline Reduces OHSS
The present study was designed to provide clinical confirmation of Cb2's value as a new approach in the prevention of increased vascular permeability and hemoconcentration, both signs of OHSS in humans, and in order to explore…
- Trial name
- NCT00440258
- Testing
- Cabergoline, MR, Ultrasound
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Polycystic Ovary Syndrome
Use of Myo-inositol as Adjuvant Therapy in Patients With Polycystic Ovary Syndrome (PCOS) in Vitro Fertilization (IVF)
The original mechanism of action of myo-inositol and preliminary results available in the literature on its use in IVF suggest its value as adjuvant gonadotropin therapy to reduce the risk of OHSS in PCOS patients.
- Trial name
- FIV-INOPK (NCT02221154)
- Testing
- Inofolic®, Gonadotropins; Folic Acid
- Where
- 4 sites in France
- Volunteers
- 49 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Pregnancy, Ovarian Hyperstimulation Syndrome
The Effect of a Dual Trigger on Intracytoplasmic Sperm Injection (ICSI) Reproductive Outcomes
The use of antagonist controlled ovarian stimulation protocols has allowed the use of GnRH agonist to be used for final oocyte maturation.
- Trial name
- NCT01979341
- Testing
- final oocyte maturation trigger
- Where
- Turkey (Türkiye)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Antalya IVF
Polycystic Ovary Syndrome
Response of VEGF and AT-II to HCG in PCOS
This research is to investigate the response of vascular active factors, vascular endothelial growth factor (VEGF) and angiotensin-Ⅱ (AT-Ⅱ) to ovary stimulation during 24h in patients with polycystic ovary syndrome…
- Trial name
- NCT02265861
- Testing
- HCG
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nanjing University School of Medicine
Ovarian Hyperstimulation Syndrome, Infertility Drugs
Transfer of Fresh Versus Frozen/Thawed Embryos in IVF Cycles Where GnRH Agonist is Utilized for Oocyte Maturation.
It has been suggested that in IVF cycles where GNRH agonist is utilized for final oocyte maturation in patients at risk of ovarian hyperstimulation, pregnancy rates are reduced.
- Conditions
- Ovarian Hyperstimulation Syndrome, Infertility Drugs, Female
- Trial name
- NCT00365027
- Testing
- Delayed embryo transfer
- Sponsor
- HaEmek Medical Center, Israel