Clinical trials: Ovarian Reserve, open to volunteers
Breast Cancer, Perimenopause
AMH Dynamic Changes to Predict Ovarian Reserve in Perimenopausal Breast Cancer
This study is a prospective observational cohort study aimed at developing a clinical model based on dynamic changes in anti-Müllerian hormone (AMH) to predict ovarian reserve in perimenopausal women with hormone…
- Conditions
- Breast Cancer, Perimenopause, Ovarian Reserve
- Trial name
- NCT07497191
- Volunteers
- 300 people
- Sponsor
- Shengjing Hospital
Fertility Awareness, Ovarian Reserve
Improving Women's Fertility Awareness and Reducing Anxiety Through Ovarian Reserve Screening and AI Counseling
This study evaluates the impact of preventive ovarian reserve screening and artificial intelligence (AI)-enabled counseling on fertility awareness and reproductive anxiety among women in Hong Kong.
- Conditions
- Fertility Awareness, Ovarian Reserve, Family Planning
- Trial name
- NCT07894302
- Testing
- AI-Enabled Fertility Counseling, Standard Educational Materials or PDF laboratory reports
- Where
- Hong Kong
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- City University of Hong Kong
Endometriosis, Ovarian Reserve
Impact of Surgery for Deep Posterior Endometriosis on Ovarian Reserve (ENDORO)
Endometriosis is a chronic condition typically affecting women of reproductive age and often responsible for chronic pelvic pain and/or infertility. Its prevalence is estimated at 10% of the female population.
- Trial name
- ENDORO (NCT07469007)
- Testing
- pelvic ultrasound, Anti-Müllerian hormone assay, Questionnaire
- Where
- France
- Volunteers
- 100 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Diminished Ovarian Reserve, Female Infertility
Hippo-Related Competing Endogenous RNA (ceRNA) Network Dysregulation and In Vitro Fertilization (IVF) Outcomes in Women With Diminished Ovarian Reserve
Diminished Ovarian Reserve (DOR) is an important cause of female infertility and is associated with poor ovarian response and lower pregnancy rates during In Vitro Fertilization (IVF).
- Conditions
- Diminished Ovarian Reserve, Female Infertility, In Vitro Fertilization
- Trial name
- DOR-HIPPO-IVF (NCT07658846)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Diminished Ovarian Reserve
DPOS Versus GnRH Antagonist Protocol for Oocyte Accumulation in Low Ovarian Reserve Patients: An RCT
One of the barriers in patients with diminished ovarian reserve (DOR) is the significantly reduced number of oocytes resulting in fewer oocytes collected and embryos formed.
- Trial name
- DPOS (NCT05847283)
- Testing
- Dydrogesterone priming ovarian stiumulation protocol, GnRH antagonist protocol
- Where
- 2 sites in Vietnam
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- Tam Anh TP. Ho Chi Minh General Hospital
Diminished Ovarian Reserve
Characterization of Gut and Tongue Coating Microbiota in Patients With Diminished Ovarian Reserve
The goal of this observational study is to investigate the distinct tongue manifestation characteristics in patients with diminished ovarian reserve (DOR) compared to healthy individuals, and to clarify the features of tongue…
- Trial name
- CGTCMPDOR (NCT07124260)
- Testing
- gut microbiota, tongue coating microbiota, tongue picture
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University
Primary Ovarian Insufficiency
Oral GDC-0077 in Premature Ovarian Insufficiency
This is a single-center, single-arm, exploratory clinical trial evaluating the safety and potential effect of oral GDC-0077 on ovarian function in women with premature ovarian insufficiency (POI).
- Trial name
- NCT07904208
- Testing
- GDC-0077
- Volunteers
- 12 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Diminished Ovarian Reserve (DOR)
Application of Autologous Adipose Stromal Vascular Fraction in the Treatment of Diminished Ovarian Reserve
A multi-center, prospective, randomised controlled clinical trial (1:1 treatment ratio), designed to investigate the efficacy and safety of autologous SVF in improving the pregnancy outcome of infertile patients with DOR.
- Trial name
- aSVF-DOR (NCT07901218)
- Testing
- Lower abdominal liposuction and preparation of SVF, Ovarian injection, Conventional ART treatment
- Where
- 4 sites in China
- Volunteers
- 260 people
- Sponsor
- Peking University Third Hospital
Lymphoma, Follicular
Long-term Ovarian Fertility in Patients Treated for Lymphoma.
This is an observational, single-center, longitudinal cohort study. In order to evaluate the gonadotoxicity of chemotherapy, an AMH monitoring was initiated in 2006 in our fertility observatory in young patients with lymphoma…
- Trial name
- FERTILymph (NCT05616325)
- Where
- France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Lille
Diminished Ovarian Reserve (DOR)
Clinical and Metabolomics Studies on the Improvement of Ovarian Reserve by Acupoint Photodynamic Therapy and Traditional Chinese Medicine Treatment
Diminished Ovarian Reserve (DOR) refers to a reduction in the number of recruitable follicles in the ovaries and/or a decline in oocyte quality. Current research on its etiology and treatment remains unsatisfactory.
- Trial name
- NCT07376824
- Testing
- Traditional Chinese Medicine, Photodynamic therapy (PDT)
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Perimenopause, Perimenopause-Related Depression
Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY)
This observational study examines the safety and effects of injecting Muse cells (a type of naturally occurring stem like cells found in adult tissues such as fat or bone marrow) directly into the ovaries of women aged 28 to 70…
- Conditions
- Perimenopause, Perimenopause-Related Depression, Premature Ovarian Insufficiency, Premature Ovarian Failure (POF)
- Trial name
- MUSE-OVARY (NCT07511660)
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- Healing Hope International
Infertility, In Vitro Maturation of Oocytes
Aspire In Vitro Maturation Study
A study to assess the Capacitation - in-vitro maturation (CAPA-IVM) system as an option for patients with a good ovarian reserve to achieve pregnancy.
- Conditions
- Infertility, In Vitro Maturation of Oocytes, Assisted Reproduction Technologies
- Trial name
- AIM (NCT07789730)
- Testing
- CAPA-IVM
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Inception Fertility Research Institute, LLC
Infertility Female
Chlordecone Exposure and Female Fertility
Chlordecone is an organochlorine pesticide used in the French West Indies (FWI) from 1972 to 1993 to control the banana root borer.
- Trial name
- KARU-FERTIL (NCT07231510)
- Where
- Guadeloupe
- Volunteers
- 634 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Multiple Sclerosis
Study of Ovarian Reserve Concerning Patients With Multiple Sclerosis (MS), Compared to a Control Group
The investigators want to evaluate ovarian reserve concerning patients with multiple sclerosis, compared to a control group of healthy women. This study will include women from 25 to 35 years old.
- Trial name
- FEMINISEP (NCT05754593)
- Testing
- Anti-Mullerian hormone (AMH) level, Antral follicle count (AFC), Clinical assessment
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Infertility, Female
Efficacy and Safety of Gushen Antai Pill on Ongoing Pregnancy Rate in Women With Normal Ovarian Reserve Undergoing IVF-ET
The purpose of this study is to investigate whether oral Gushen Antai pills supplementation for luteal phase support will improve ongoing pregnancy rate in women with normal ovarian reserve in fresh embryo transfer cycles.
- Trial name
- GSATP-FreET (NCT04872660)
- Testing
- Gushen Antai Pill
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Shandong University of Traditional Chinese Medicine
Anti-Mullerian Hormone Deficiency
Ovarian Reserve in Intensive Care Patients
Gastrointestinal, pulmonary, nephrological, cardiac, neurologic and psychological effects in critically ill patients followed in the intensive care unit have been shown in the literature.
- Trial name
- NCT06999291
- Testing
- Glaskow coma scala, The Acute Physiology and Chronic Health Evaluation System- APACHE, Injury Severity Score- ISS)
- Volunteers
- 75 people
- Sponsor
- Haseki Training and Research Hospital
Infertility, Female, Ovarian Reserve
hCG Priming in Women With Diminished Ovarian Reserve
The aim of this randomized controlled trial is to further examine the possible effects of low dose human chorionic gonadotropin (hCG) priming for eight weeks in women with diminished ovarian reserve (DOR) undergoing in vitro…
- Conditions
- Infertility, Female, Ovarian Reserve, In Vitro Fertilization (IVF)
- Trial name
- NCT07108621
- Testing
- Choriongonadotropin alfa (hCG)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Kristine Loessl
Infertility, Female
Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation
The goal of this clinical trial is to evaluate a long Clomid protocol as compared to a 5-day Clomid protocol for ovarian stimulation in patients with diminished ovarian reserve undergoing ovarian stimulation for in-vitro…
- Trial name
- NCT06701071
- Testing
- Clomiphene Citrate
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Southern California
Diminished Ovarian Reserve
A Randomized Controlled Trial of Combined Bu Shen Yi Qi Decoction and Dehydroepiandrosterone (DHEA) for the Treatment of Ovarian Function Decline
The purpose of this clinical trial is to evaluate the efficacy and safety of Bushen Yiqi formula combined with dehydroepiandrosterone (DHEA) in the treatment of women with diminished ovarian reserve (DOR).
- Trial name
- NCT07535983
- Testing
- Bushen formula combined with dehydroepiandrosterone
- Where
- China
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Jiangxi University of Traditional Chinese Medicine
Childhood Cancer Survivors, Fertility
Fertility and Ovarian Reserve in Female Childhood Cancer Survivors
Ovarian function impairment affects the quality of life of the survivors of paediatric cancer by impacting fertility, bone quality and mental and cognitive health.
- Conditions
- Childhood Cancer Survivors, Fertility, Ovarian Reserve, CED
- Trial name
- PRINCESS (NCT06626282)
- Where
- 3 sites in Belgium
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege