Clinical trials: Overweight
Overweight, Obese
A Study of CT-868 in Type 1 Diabetes Mellitus
This study will evaluate the changes in glycemic control in overweight and obese adults with Type 1 Diabetes Mellitus after receiving CT-868 for 16 weeks. The effectiveness and safety of CT-868 will be compared to placebo.
- Conditions
- Overweight, Obese, Type 1 Diabetes Mellitus
- Trial name
- NCT06062069
- Testing
- CT-868, CT-868 Pen Injector
- Where
- 22 sites in United States
- Volunteers
- 111 people
- Sponsor
- Carmot Therapeutics, Inc.
Overweight or Obese, Type 2 Diabetes Mellitus (T2DM)
A Study of Enicepatide (CT-388) in Participants Who Are Overweight or Obese With Type 2 Diabetes Mellitus
This is a multi-center, randomized, double-blind, placebo-controlled, parallel group dose-finding study to evaluate the efficacy and safety of enicepatide at low, middle, and high doses in participants who are overweight or obese…
- Trial name
- NCT06628362
- Testing
- Enicepatide
- Where
- 70 sites in United States, Argentina and 4 more
- Volunteers
- 447 people
- Sponsor
- Carmot Therapeutics, Inc.
Weight Loss, Bone Density
Metabolic Health, Bones and Nuts During Weight Loss in Adults
The aging population is rapidly increasing, and it is important to identify dietary factors that can prevent disease and promote health in this group.
- Conditions
- Weight Loss, Bone Density, Obesity and Overweight
- Trial name
- BERN (NCT06949280)
- Testing
- Peanut Snack Experimental, Nut-free Snack
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Physical Activity, Overweight or Obesity
eMOTION: Examining Implicit Attitudes in Physical Activity Engagement
This early-phase trial will test intervention strategies to influence implicit attitudes towards physical activity and determine whether changes in those mechanisms result in change in physical activity behavior among inactive…
- Conditions
- Physical Activity, Overweight or Obesity, Cancer
- Trial name
- NCT07044570
- Testing
- Physical Activity Goals mHealth Intervention, TYPE/CONTEXT enhancement, SAVOR enhancement
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Overweight or Obesity
Healthy Living BEYOND Weight Study
The Healthy Living BEYOND Weight Study is an observational research study of participants living with overweight and obesity. The principal objectives for this project will be to answer fundamental unanswered questions regarding…
- Trial name
- NCT07075341
- Testing
- None - Observational study
- Where
- United States
- Volunteers
- 1,000,000 people
- Sponsor
- American Heart Association
Overweight , Obesity, Obesity (Disorder)
Real-world Effectiveness and Dosing Patterns of Tirzepatide in People With Obesity
Tirzepatide is one of the new medications for the treatment of obesity. In clinical research people treated with Tirzepatide have weight loss up to 21%.
- Trial name
- TIRZ-DOSE-NL (NCT07504172)
- Testing
- Tirzepatide
- Where
- 10 sites in Netherlands
- Volunteers
- 915 people
- Sponsor
- Radboud University Medical Center
Obesity or Overweight, Diabetes Mellitus, Type 2
A Study to Evaluate Effect of AZD6234 in Adult Participants With Type 2 Diabetes Mellitus and Obesity or Overweight
The study will evaluate how well AZD6234 works and how safe it is in adults with excess weight or obesity. Efficacy of AZD6234 will be compared to placebo in percent body weight change from baseline at 68 weeks of treatment
- Trial name
- SELENE 2 (NCT07784270)
- Testing
- Lenbelintide
- Where
- 230 sites in United States, Argentina and 14 more
- Volunteers
- 1,500 people
- Sponsor
- AstraZeneca
Overweight , Obesity
Phase Ib Clinical Study of MWN109 Injection in Participants With Overweight or Obesity
This study is a randomized, double-blind, placebo-controlled, multiple-dose phase Ib clinical trial, aiming to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and immunogenicity characteristics of MWN109…
- Trial name
- NCT07787728
- Testing
- MWN109 1, MWN109 2, MWN109 3
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
Obesity & Overweight, Weight Loss
Sustaining Health After an Intensive Weight-loss Pro-gramme
Since 2021 Copenhagen University Hospital - Hvidovre, Denmark, has offered a 2-year, highly specialised, intensive clinical weight loss programme to patients living with severe and complex obesity, who due to somatic and/or…
- Conditions
- Obesity & Overweight, Weight Loss, Weight Management in Adult Patients With Obesity or Overweight
- Trial name
- SHAPe (NCT07900178)
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Obesity, Overweight
A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, Type 2 Diabetes, and Increased Cardiovascular Risk
The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with a placebo in participants with obesity or overweight, type 2 diabetes, and increased cardiovascular risk.
- Conditions
- Obesity, Overweight, Cardiovascular Diseases, Diabetes Mellitus, Type 2
- Trial name
- ENLIGHTEN-10 (NCT07900633)
- Testing
- Eloralintide
- Where
- 309 sites in United States, Argentina and 19 more
- Volunteers
- 3,000 people
- Sponsor
- Eli Lilly and Company
Obesity & Overweight
Two-Year Weight Loss With GLP-1 Medications Compared With Sleeve Gastrectomy in Adults With Obesity
This observational study will compare weight loss over two years in adults receiving GLP-1 receptor agonist medications with weight loss in adults who previously underwent laparoscopic sleeve gastrectomy, an operation that…
- Trial name
- GLP-BARI-VAN (NCT07901777)
- Testing
- GLP-1 Receptor Agonist Therapy, Laparoscopic Sleeve Gastrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Yuzuncu Yil University
Overweight
The Influence of Honey-flavored Yogurt on Low-grade Inflammation and Gut Health in Middle to Older Aged Women.
A randomized, double-blind, crossover dietary intervention trial will test the effects of 4 weeks of daily honey-flavored yogurt intake on markers of inflammation (Th17 cytokines) and oxidative stress (NOX2, UA, RSNO) and…
- Trial name
- NCT04248127
- Testing
- Honey sweetened yogurt, Sugar sweetened yogurt
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Obesity, Metabolic Syndrome
The Interaction and Regulation Mechanism of Different Exercise Patterns With Metabolic Syndrome and Related Metabolic Diseases
In order to obtain suitable exercise intervention model for children and adolescents with obese or metabolic syndrome in China, we conduct a RCT to examine the effects of different intensity exercise intervention on weight, and…
- Trial name
- NCT04984005
- Testing
- Low intensity exercise training, Moderate intensity exercise training, Intermittent high intensity exercise training
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Peking University Third Hospital
Adolescent Obesity, Adolescent Overweight
Helping Educate and Advance Learning Through Healthy Bite-Sized Eating Strategies
The goal of this clinical trial is to compare the effectiveness of a mobile health intervention in adolescents (14-17 years) with overweight or obesity.
- Conditions
- Adolescent Obesity, Adolescent Overweight, Diet, Healthy
- Trial name
- HEALTHY BITES (NCT06082830)
- Testing
- Intervention
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Hospital of Philadelphia
Obesity
Study of BMF-650 in Otherwise Healthy Overweight or Obese Adult Participants
A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BMF-650 in Otherwise Healthy Overweight or Obese…
- Trial name
- NCT07223216
- Testing
- BMF-650
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Biomea Fusion Inc.
Diabetes Type 2, Overweight or Obesity
Effect of the Thrive AI Health App on Lifestyle Behaviors and Quality of Life
The goals of this randomized trial is to learn: 1. If the Thrive AI Health app will help adults improve their everyday habits (diet, exercise, and sleep). 2.
- Trial name
- NCT07376655
- Testing
- App
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yale University
Overweight and Obesity, Diabetes Mellitus, Type 2
AI-Driven Metabolic Cohort in Overweight/Obese Chinese Adults
The goal of this observational cohort study is to delineate the five-year dynamic trajectories of metabolic phenotypes in Chinese adults with overweight or obesity, with or without type 2 diabetes, focusing on transition rates…
- Conditions
- Overweight and Obesity, Diabetes Mellitus, Type 2, Prediabetic State, Metabolic Syndrome
- Trial name
- COMET-AI (NCT07584330)
- Where
- China
- Volunteers
- 2,800 people
- Sponsor
- Zhujiang Hospital
Obesity, Overweight
Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities
Obesity is a condition where a person has excessive body fat, defined by a body mass index (BMI) of 30 kg/m2 or higher. The goal of this study is to evaluate the effect of various doses of ABBV-295 compared to placebo on reducing…
- Trial name
- NCT07752979
- Testing
- ABBV-295
- Where
- 64 sites in United States, Puerto Rico
- Volunteers
- 360 people
- Sponsor
- AbbVie
Underweight, Overweight and Obesity
SHIFT-TB: Nutrition Intervention and Evaluation
The goal of this trial is to evaluate a community-based nutrition intervention for adults in Cambodia who are underweight or overweight/obese.
- Trial name
- NCT07836322
- Testing
- Community-Based Nutrition Intervention
- Where
- Cambodia
- Volunteers
- 700 people
- Sponsor
- National University of Singapore
Atrial Fibrillation (AF), Ablation Treatment
Mazdutide for Reducing Atrial Fibrillation Recurrence After Catheter Ablation in Obese Patients
This is a multicenter, open-label, superiority randomized controlled trial enrolling adult patients aged 18 to 75 years. All participants have abdominal obesity (BMI ≥ 28 kg/m² with specific waist circumference standards) and…
- Conditions
- Atrial Fibrillation (AF), Ablation Treatment, Obesity & Overweight, Mazdutide
- Trial name
- MOTIVE-AF (NCT07897305)
- Testing
- Mazdutide, Conventional treatment
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Beijing Anzhen Hospital