Clinical trials: Overweight, open to volunteers
Obesity & Overweight
Safety, Tolerability and Pharmacokinetics of a Subcutaneous Semaglutide Implant
The study will evaluate the safety, tolerability and drug levels of a semaglutide implant placed just under the skin for a period of 4 weeks compared to 4 weekly injections of semaglutide (Wegovy) in overweight/obese participants…
- Trial name
- SLIM-1 (NCT07430059)
- Testing
- Semaglutide Implant (NPM-139), Semaglutide (Wegovy) weekly injection
- Volunteers
- 20 people
- Sponsor
- Vivani Medical, Inc
Typ 2 Diabetes, Obesity
Multicentric Approval Study Trans-Duodenal Barrier for Typ 2 Diabetes With Obesity
Approval study Trans-Duodenal Barrier The goal of this clinical trial is to determin the safety and performance of the newly developed Trans-Duodenal Barrier in adult Tryp 2 diabetic and obese patients.
- Conditions
- Typ 2 Diabetes, Obesity, Obesity Type 2 Diabetes Mellitus, MASH
- Trial name
- LuST (NCT07417683)
- Testing
- endoscopic implant
- Where
- 8 sites in Germany
- Volunteers
- 126 people
- Sponsor
- Trans-Duodenal Concepts GmbH
Inflammation, Obesity (Disorder)
The ISAR InflEx Trial (Inflammation and Exercise)
A sedentary lifestyle and obesity are associated with chronic low-grade inflammation and an elevated risk of cardiovascular disease (CVD).
- Trial name
- InflEx (NCT07543666)
- Testing
- moderate-intensity exercise, vigorous-intensity exercise, short bouts of maximal exercise
- Where
- Germany
- Volunteers
- 33 people
- Sponsor
- Department of Cardiology German Heart Center Munich TUM University Hospital
Overweight (BMI > 25), Obesity & Overweight
Global Overweight and oBesE (GLOBE) Patient Registry, Development and Implementation of Disease-specific: Severity, Quality of Life and Cost Instruments.
We are conducting this study to develop a disease-specific instrument, a quality of life instrument and a comprehensive list of costs associated with overweight and obesity.
- Trial name
- GLOBE (NCT07229027)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Medialis Ltd.
Sleep Deprivation, Obesity
Sleep and Metabolism
The goal of this study is to uncover sleep and circadian mechanisms contributing to adverse metabolic health. The protocol is a 21 day (7 outpatient days, 14 inpatient days) mechanistic randomized-crossover study designed to…
- Conditions
- Sleep Deprivation, Obesity, Glucose Intolerance, Weight Gain
- Trial name
- SAM (NCT05775627)
- Testing
- Sleep Restriction
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Obesity
Effectiveness and Safety of Tirzepatide Among Participants With Obesity With or Without Type 2 Diabetes Mellitus (T2DM)
This is a prospective, multicenter, real-world study conducted in Bangladesh to assess the effectiveness and safety of Tirzepatide compared to structured lifestyle interventions, including dietary modifications and exercise, in…
- Trial name
- NCT07099742
- Testing
- Tirzepatide, Life Style Modification
- Where
- 3 sites in Bangladesh
- Volunteers
- 364 people
- Sponsor
- Dr. Md. Alimur Reza
Low Back Pain
A Combined Lifestyle Intervention Delivered by Physio/exercise Therapists for Patients with Persistent Low Back Pain and Overweight or Obesity
Low back pain (LBP) is the leading cause of disability worldwide and is costly. Lifestyle factors, such as physical inactivity, stress, sleep, excess weight, and an unhealthy diet contribute to the burden of LBP and the…
- Trial name
- Back2Health (NCT06594796)
- Testing
- Combined lifestyle intervention and LBP care (physiotherapy, exercise therapy)
- Where
- Netherlands
- Volunteers
- 318 people
- Sponsor
- Willeke Boonstra
Obesity in Adolescents
Impact of a Targeted Nutritional Intervention on Glycaemic Variability and Correlation Between Glycaemic Parameters and Satiety.
Obesity affects 18% of French adults and increasingly impacts adolescents. Dietary management is challenging, particularly with eating disorders like hyperphagia.
- Trial name
- APETIT (NCT07771842)
- Testing
- The primary intervention in this study is dietary counseling and education on adopting a low glycaemic index diet with sample menus provided, continuous glucose monitoring (CGM) sensors
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Obstructive Sleep Apnea, Obesity (BMI>30)
Hypercapnic Burden in Adults With Obesity Undergoing Diagnostic Polysomnography for Suspected Obstructive Sleep Apnea
Obesity-related sleep hypoventilation represents a continuum ranging from isolated nocturnal hypoventilation to obesity hypoventilation syndrome.
- Conditions
- Obstructive Sleep Apnea, Obesity (BMI>30), Obesity Hypoventilation Syndrome (OHS), Sleep Hypoventilation
- Trial name
- HBO-POSA (NCT07809061)
- Testing
- Sleep Inertia Questionnaire (SIQ)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
Cardiovascular Disease, Frailty
Investigating the Combined Effects of Protein, Blueberries, and Exercise on Cardiovascular Health and Frailty in Older Nova Scotians
Cardiovascular diseases (CVD) are a leading cause of morbidity and mortality worldwide. While CVDs are predominantly diseases of aging, age itself does not predict CVD risk; people age at different rates.
- Trial name
- STRONG (NCT06693271)
- Testing
- intervention of protein, blueberries, Exercise training
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- Nova Scotia Health Authority
CIDP, Immunoglobulin Deficiency
IVIG vs SCIG in CIDP
Current dosing practices for immunoglobulin G (IgG) may be inadequate in extreme body weight. The current study will evaluate the influence of body composition on intravenous and subcutaneous administration of immunoglobulin G in…
- Conditions
- CIDP, Immunoglobulin Deficiency, Chronic Inflammatory Demyelinating Polyneuropathy
- Trial name
- NCT05584631
- Testing
- Intravenous immune globulin G, Subcutaneous immune globulin G
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Rutgers, The State University of New Jersey
Obesity
Incisionless Suture Plications in a POSE2.0 Obesity Study
This is a multi-center, open-label, 2-group randomized pivotal study evaluating a minimally invasive weight loss procedure. The intent is to evaluate the safety and effectiveness of POSE2.0 (sutures placed in the mid + distal…
- Trial name
- INSPIRO (NCT06272201)
- Testing
- POSE2.0 procedure with g-Cath EZ Delivery Catheter with Snowshoe Suture Anchors
- Volunteers
- 186 people
- Sponsor
- USGI Medical
Primary Open Angle Glaucoma, Obstructive Sleep Apnea
Glaucoma Respsosne to Lifestyle Corrections in Sleep Apnea
glaucoma is prevalent among obstructive sleep apnea (OSA). contnous passive airway pressure is main treatment of OSA. lifestyle corrections also recommended
- Conditions
- Primary Open Angle Glaucoma, Obstructive Sleep Apnea, Obesity
- Trial name
- NCT07447011
- Testing
- lifetyle corrections and CPAP, CPAP
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Excessive Gestational Weight Gain, Pregnancy
An Online Intuitive Eating Program for Pregnant Women With Obesity to Support Well-Being
The goal of this feasibility randomized controlled trial is to assess the feasibility, acceptability, and demand, as well as preliminary effects of an evidence-based Intuitive Eating (IE) intervention among pregnant women who…
- Conditions
- Excessive Gestational Weight Gain, Pregnancy, INTUITIVE EATING, Perceived Stress
- Trial name
- NCT07792837
- Testing
- Intuitive Eating Intervention
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- San Diego State University
Brain Vascular Function, Cognitive Function
Effects of Protein Supplementation on Brain Function
Protein-rich foods may improve brain insulin-sensitivity, which is important for cognitive and metabolic health, and may also translate into an improved food intake regulation.
- Conditions
- Brain Vascular Function, Cognitive Function, Satiety, Cerebral Blood Flow
- Trial name
- NCT07057245
- Testing
- Protein supplementation with an animal-based protein isolate, Protein supplementation with a plant-based protein isolate, Control arm - cornstarch
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity & Overweight
Microrandomized Trial to Optimize Use of Burden-reducing Self-monitoring Approaches in Behavioral Obesity Treatment
This clinical trial is focused on testing dietary self-monitoring strategies used in behavioral obesity treatment. The goal is to determine which self-monitoring strategies are most useful for whom, at which points in treatment…
- Trial name
- NCT07228130
- Testing
- Online Behavioral Obesity Treatment, Full Dietary Self-monitoring, Reduced-frequency Dietary Self-monitoring
- Where
- United States
- Volunteers
- 275 people
- Sponsor
- The Miriam Hospital
Metabolic Syndrom
Response Of Metabolic Syndrome Severity Score To High Intenisty Interval Training In Women With Central Obesity.
This study will be conducted to investigate any significant effect of high intensity interval training on metabolic syndrome severity score in women with central obesity.
- Trial name
- NCT06509464
- Testing
- High intensity interval training, Caloric restricted diet
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Soma Adel Gaber Abd El-Ghany
Obesity / Overweight
Effects of Pistachios on Postprandial Metabolic Responses in Adults With Overweight or Obesity
This randomized controlled crossover study will examine the acute effects of pistachio consumption on postprandial metabolic responses in adults with overweight or obesity.
- Trial name
- NCT07853898
- Testing
- Pistachio Co-consumption, Refined-Carbohydrate Control Co-consumption
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- St. Louis University
Child Obesity
Applying Navigation and Care to Help Ongoing Retention
Canada's health care system has established numerous clinics over the past 20 years to treat childhood obesity. However, up to 80% of children at these clinics drop out before they finish treatment.
- Trial name
- ANCHOR (NCT07834632)
- Testing
- Family Navigation, Usual Care
- Where
- Canada
- Volunteers
- 252 people
- Sponsor
- University of Alberta
Overweight/Obesity, Puberty
Improving Health Among Disadvantaged Girls to Slow Pubertal Onset and Reduce Long-term Health Risks
This study is testing whether improving health in girls during the prepubertal period may slow the onset of puberty. This study will focus on prepubertal girls who have a high weight status (at or above the 85th percentile for…
- Conditions
- Overweight/Obesity, Puberty, Health Behavior, Cardiometabolic Health
- Trial name
- NCT07460544
- Testing
- Family-Based Treatment (FBT)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Washington
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