Clinical trials: Overweight , Obesity
Cardiovascular Disease (CVD), Hypertension
Veteran Peer Coaches Optimizing and Advancing Cardiac Health
The purpose of this study is to test if having a Veteran peer health coach will improve blood pressure control among Veterans with high blood pressure and at least one other Cardiovascular disease (CVD) risk factor.
- Conditions
- Cardiovascular Disease (CVD), Hypertension, Hyperlipemia, Obesity
- Trial name
- Vet-COACH (NCT02697422)
- Testing
- Community-based peer health coach intervention
- Where
- United States
- Volunteers
- 264 people
- Sponsor
- VA Office of Research and Development
Obesity, Metabolic Syndrome X
Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity
Obesity is common (>30% of US adults), contributes to substantial morbidity and mortality, but is difficult to treat. Partly this is due to the transient, arduous and modest nature of lifestyle interventions.
- Trial name
- REVIVE (NCT01351753)
- Testing
- Metformin, Orlistat, Topiramate
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of Iowa
Triglycerides, Weight Gain Trajectory
Effects of RDX-002 on Postprandial Triglycerides in Patients Discontinuing GLP-1 Agonists
The goal of this clinical trial is to learn if drug RDX-002 works to treat high levels of fat (known as triglycerides, or TGs) in the blood in adults. It will also learn about the safety of drug RDX-002.
- Conditions
- Triglycerides, Weight Gain Trajectory, Cholesterol, Elevated
- Trial name
- NCT06640972
- Testing
- RDX-002
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Response Pharmaceuticals
Obesity, Overweight
Effectiveness Between Nutritional Counseling Monthly Phone Call Versus Self Help Informative Booklet
The purpose of this study is to evaluate the most effectiveness between a personalized nutritional program with a counseling monthly phone call Versus personalized nutritional program with self help Informative Booklet in a group…
- Trial name
- NCT01602965
- Testing
- Counseling Monthly Phone Calls, Self Help Informative Booklet
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Istituto Ortopedico Rizzoli
Obesity, Type 2 Diabetes
Changes in Ectopic Fat Following Surgically Induced Weight Loss
This study evaluates how ectopic fat (in the pancreas, heart, liver and skeletal muscle), visceral fat, and subcutaneous fat changes following surgically induced weight loss using gastric banding.
- Trial name
- NCT00840307
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center
Obesity, Metabolic Syndrome
Effects of Leptin Replacement in Children
To assess the endocrine and immune effects of leptin replacement in leptin-deficient children, from a consanguineous family. The hypothesis is that leptin replacement will have significant effects on endocrine function.
- Conditions
- Obesity, Metabolic Syndrome, Diabetes
- Trial name
- NCT00659828
- Testing
- Recombinant methionyl human leptin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Miami
Obesity
Peer Support for Weight Loss Maintenance
The primary aim of this study is to test the efficacy of patient-provided treatment for weight-loss maintenance.
- Trial name
- NCT03396653
- Testing
- Peer-delivered Weight Maintenance, Professionally-Delivered Weight Maintenance
- Where
- 2 sites in United States
- Volunteers
- 849 people
- Sponsor
- University of Connecticut
Obesity
Exendin-9,39 and Satiety After Bariatric Surgery
The overall aim of the application is to determine the contribution of the elevated incretin hormone concentrations seen after certain types of bariatric surgery to the regulation of food intake and satiety.
- Trial name
- NCT02779075
- Testing
- Saline, Exendin-9,39
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Prader-Willi Syndrome, Hyperphagia
Effects of Livoletide (AZP-531) on Food-related Behaviors in Patients With Prader-Willi Syndrome
This Phase 2b/3 double-blind, placebo-controlled study will evaluate the safety, tolerability, and effects of livoletide on food-related behaviors in patients with Prader-Willi Syndrome (PWS).
- Trial name
- ZEPHYR (NCT03790865)
- Testing
- Livoletide
- Where
- 37 sites in United States, Australia and 6 more
- Volunteers
- 158 people
- Sponsor
- Millendo Therapeutics SAS
Obesity
Reducing Health Disparities in Childhood Obesity
In this study, we will address cost barriers to participating in summer programs and hypothesize this will lead to marked improvements in children's obesogenic behaviors and a reduction in excessive, unhealthy weight gain over…
- Trial name
- NCT04072549
- Testing
- Free Summer Programming
- Where
- 2 sites in United States
- Volunteers
- 651 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Breast Cancer, Obesity
Self-monitoring Activity: a Randomized Trial of Game-oriented Applications
The purpose of this study is to compare an enhanced intervention that includes narrative and game components to a standard intervention that only targets self-monitoring.
- Trial name
- SMARTGOAL (NCT02341235)
- Testing
- Game intervention, Standard intervention
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Obesity, Knee Osteoarthritis
Wearable Bioimpedance Analyzer for Tracking Body Composition Changes
Obesity, namely at body mass index (BMI) levels exceeding 40kg/m2 (class III obesity), is a risk factor for many diseases including osteoarthritis (OA).
- Trial name
- NCT05986617
- Testing
- InBody Band 2
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Iowa
Obesity, Type 2 Diabetes
PREMIER: PREvention of Metabolic Illness Through prEcision nutRition
Dietary intake is a major driving force behind the escalating obesity and type 2 diabetes epidemics. Large, high-quality clinical trials have shown that close adherence to healthy dietary recommendations significantly reduce the…
- Conditions
- Obesity, Type 2 Diabetes, Metabolic Syndrome, Diet Habit
- Trial name
- PREMIER (NCT04148482)
- Testing
- Dietary intervention
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Metabolic Syndrome
Simvastatin With or Without Ezetimibe and Atherothrombotic Biomarker Assessment
To determine whether the combination of ezetimibe and simvastatin improves biomarkers of atherothrombosis compared to simvastatin alone in patients with the metabolic syndrome.
- Trial name
- NCT00819403
- Testing
- simvastatin, ezetimibe/simvastatin
- Where
- 3 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Overweight and Obesity, Insulin Resistance
Relative Sarcopenia and Cardiometabolic Risk in Young Adults With Obesity
The goal of this research study is to learn more about the hormones that muscles make during exercise, and if those hormones are associated with type 2 diabetes risk in adults who are overweight or obese.
- Trial name
- NCT04195061
- Testing
- Cardiopulmonary exercise test (CPET)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Obesity
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals
Background: Roflumilast is a drug used to treat chronic obstructive pulmonary disease (COPD). It is designed to help reduce lung inflammation.
- Trial name
- NCT01862029
- Testing
- Roflumilast
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Overweight, Obese
Internet Treatment for Weight Loss in Primary Care
This study will test the effectiveness of two distinct treatments for weight loss: 1. Motivational Interviewing 2. Nutritional Counseling. These treatments will be compared to Treatment as Usual.
- Trial name
- NCT01558297
- Testing
- Motivational Interviewing, Nutritional Counseling, Treatment as usual with primary care physician
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Yale University
Coronary Heart Disease, Obesity
Alternate Day Fasting for Weight Loss, Weight Maintenance and Cardio-protection
The proposed research will demonstrate that alternate day modified fasting (ADMF) is a suitable alternative to daily calorie restriction (CR) for weight loss, weight maintenance, and heart disease prevention.
- Conditions
- Coronary Heart Disease, Obesity, Weight Loss
- Trial name
- NCT00960505
- Testing
- Alternate day fasting, Calorie restriction, Control diet
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Peer Support and Chronic Disease, Obesity
Peer Support Dyads in Churches
The purpose of this study is to explore how working with a partner can influence participation in a church wellness program. There are many different types of church wellness programs.
- Conditions
- Peer Support and Chronic Disease, Obesity, Type II Diabetes, Cardiovascular Disease
- Trial name
- NCT03463941
- Testing
- Peer Support Dyad Intervention
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duke University
Obesity, Childhood
Storytelling To Prevent Obesity and Encourage Responsive Feeding Practices in Young Children
The goal of this qualitative trial study is to assess the usefulness and acceptability of the intervention in diverse clinical and community settings.
- Trial name
- STORY (NCT05994924)
- Testing
- Educational Handout, Video Series, Group Discussion Sessions
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
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