Clinical trials: Overweight , Obesity
Polycystic Ovarian Syndrome, Obesity
Oral Amino Acid Nutrition to Improve Glucose Excursions in PCOS
The Investigators will measure hepatic glucose and fat metabolism in obese girls with Polycystic Ovarian Syndrome (PCOS) and hepatic steatosis (HS) after taking 4 weeks of an essential amino acid (EAA) supplement or placebo and…
- Conditions
- Polycystic Ovarian Syndrome, Obesity, Hepatic Steatosis
- Trial name
- ORANGE (NCT03717935)
- Testing
- Essential Amino Acid (EAA) Supplement
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Colorado, Denver
Healthy, Obesity
Break It Up: A Study Evaluating Breaking Up Daily Sedentary Behavior in Youth
Background: Some studies have found that people can better process sugars when they take walking breaks. Studies have also found that children's attention and memory may improve after exercise.
- Conditions
- Healthy, Obesity, Overweight
- Trial name
- NCT03223649
- Testing
- Walking Bouts, Sedentary
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Morbid Obesity
Usefulness and Safeness Of Intra-Gastric Balloon Before Bariatric Surgery In Morbid Obesity
Introduction: bariatric surgery shows an important morbidity and there are some reports that have used preoperative intragastric-balloons (IGB-BIB®) to decrease surgical morbidity.
- Trial name
- NCT01998243
- Testing
- Intragastric Balloon (IGB), group A, diet, control group B
- Where
- Spain
- Volunteers
- 81 people
- Sponsor
- Hospital Severo Ochoa
Obesity
A Study of the Efficacy of Subcutaneous Phosphatidylcholine and Deoxycholate Injections for Localized Fat Removal
The primary objective of this study is to determine the efficacy of phosphatidylcholine and deoxycholate subcutaneous injections for localized fat removal.
- Trial name
- NCT00851747
- Testing
- Phosphatidylcholine Deoxycholate, Saline
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Obesity
The EMBER Trial for Weight Management Engagement
This study will test whether EMBER, a self-help tool to increase weight loss treatment engagement, helps veterans engage in Veterans Health Administration (VHA) weight management programs.
- Trial name
- NCT05424081
- Testing
- EMBER, Control
- Where
- 2 sites in United States
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Antipsychotic-induced Weight Gain (AIWG)
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Miricorilant in Obese Adult Patients With Schizophrenia While Taking Antipsychotic Medications (GRATITUDE II)
This Phase 2, double-blind, placebo-controlled, randomized study is to assess the safety, efficacy, and pharmacokinetics (PK) of miricorilant (CORT118335) in obese patients with schizophrenia treated with antipsychotic…
- Trial name
- NCT04524403
- Testing
- Miricorlilant
- Where
- 40 sites in United States
- Volunteers
- 150 people
- Sponsor
- Corcept Therapeutics
Overweight, Obese
A Study of CT-868 in Type 1 Diabetes Mellitus
This study will evaluate the changes in glycemic control in overweight and obese adults with Type 1 Diabetes Mellitus after receiving CT-868 for 16 weeks. The effectiveness and safety of CT-868 will be compared to placebo.
- Conditions
- Overweight, Obese, Type 1 Diabetes Mellitus
- Trial name
- NCT06062069
- Testing
- CT-868, CT-868 Pen Injector
- Where
- 22 sites in United States
- Volunteers
- 111 people
- Sponsor
- Carmot Therapeutics, Inc.
Overweight and Obesity, PreDiabetes
Clinical Effectiveness of Body Fat Distribution Imaging in Real-World Practice: The BODY-REAL Study
The overall goal is to determine the real-world feasibility and utility of body fat imaging using rapid MRI to enhance risk perception, induce behavioral change, and improve clinical outcomes in overweight and obese individuals.
- Conditions
- Overweight and Obesity, PreDiabetes, Type 2 Diabetes, Cardiovascular Risk Factor
- Trial name
- BODY-REAL (NCT04763772)
- Testing
- Body Fat Distribution Imaging Report, Basic Weight Information, Patient Provided
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University Hospitals Cleveland Medical Center
Obesity
Water Induced Thermogenesis in Obese Children
Drinking water is largely advocated for obesity prevention and management. Recent studies have suggested that water has a thermogenic effect, this has not been examined in children.
- Trial name
- NCT00794469
- Testing
- Water
- Where
- Israel
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Obesity
Reduced Carbohydrate Versus Fat in Obese Subjects
Popular weight loss strategies often involve reducing an individual's consumption of carbohydrates or fat. However, no controlled study has been carried out to evaluate the effects of reducing carbohydrate versus fat consumption…
- Trial name
- NCT00846040
- Testing
- Reduced fat diet, Reduced carbohydrate diet, Drug: f-18 fallypride
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Non-Alcoholic Fatty Liver Disease
Gemcabene for the Treatment of Pediatric NAFLD
This is a multicenter, prospective, open-label, Phase 2, proof of concept study to test preliminary efficacy and safety of gemcabene in children with established nonalcoholic fatty liver disease (NAFLD) incompletely treated by…
- Trial name
- NCT03436420
- Testing
- Gemcabene
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Emory University
Obesity-induced Hyperfiltration
Effect of Acetazolamide and Furosemide on Obesity-induced Glomerular Hyperfiltration
Background: Obesity is associated with a high prevalence of chronic kidney disease.The glomerular hyperfiltration associated with obesity may play a role in the pathogenesis of obesity associated chronic kidney disease.
- Trial name
- NCT01146288
- Testing
- Furosemide first, then Acetazolamide, Acetazolamide first, then Furosemide
- Where
- Israel
- Volunteers
- 13 people
- Sponsor
- Rabin Medical Center
Obesity, Weight Loss
Project Activate: Mindfulness and Acceptance Based Behavioral Treatment for Weight Loss
Mindfulness and Acceptance based Behavioral Therapies (MABTs) are among the most promising behavioral approaches for obesity, with two recent large trials showing that they achieve better initial weight loss and/or better weight…
- Trial name
- Activate (NCT04337619)
- Testing
- Behavioral Treatment, Willingness, Values
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- Drexel University
Overweight; Hyperlipidemia
Efficacy and Safety of Fermented Barley on Decrement of Body Fat in Obese Subjects
Barley, like oats, is a rich source of the soluble fibre β-glucan, which has been shown to significantly lower LDL-cholesterol (LDL-C). However, barley foods have been less widely studied.
- Trial name
- NCT01402128
- Testing
- Barley beta-glucan(3.0g)
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Obesity, Weight Loss
Saxenda in Obesity Services (STRIVE Study)
A two year, parallel, two group, open-label, real-world randomised controlled trial (RCT) design for subjects with severe and complex obesity who are referred to a Tier 3 or equivalent specialist weight management/obesity…
- Conditions
- Obesity, Weight Loss, Diabetes Mellitus
- Trial name
- STRIVE (NCT03036800)
- Testing
- Saxenda, Specialist Obesity Management Services
- Where
- 5 sites in Ireland, United Kingdom
- Volunteers
- 392 people
- Sponsor
- University of Leicester
Obesity
Sleep Timing and Insulin Resistance in Adolescents With Obesity
This study examines the relationship between sleep timing and insulin resistance in adolescents with obesity. The investigators also aim to develop a physiologically-based mathematical model of adolescent sleep/wake and circadian…
- Trial name
- NCT02585830
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity; Rurality
Feasibility Trial of the iAMHealthy Intervention
This research study is being done to find out which of 2 ways works best to get rural participants interested in joining a research study about children who weigh more than is considered healthy.
- Trial name
- iAmHealthy (NCT04142034)
- Testing
- the iAmHealthy Behavioral Intervention, Newsletter only arm, Consecutive Recruitment
- Where
- 4 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- IDeA States Pediatric Clinical Trials Network
Cardiovascular Diseases, Hypertension
Cardiovascular Risk Screening and Risk Reduction in Women Vets
Cardiovascular (CV) disease is the number one cause of death in American women, and all adult women are potentially at risk for CV disease.
- Conditions
- Cardiovascular Diseases, Hypertension, Hyperlipidemias, Dyslipidemias
- Trial name
- NCT02991534
- Testing
- CV Toolkit Components
- Where
- 4 sites in United States
- Volunteers
- 6,009 people
- Sponsor
- VA Office of Research and Development
Weight Maintenance, Overweight
Litramine in Weight Maintenance
The effect of Litramine on weight loss has previously been studied during a 12-week intervention period with promising results. The present study looks into the effect of weight maintenance using Litramine following initial…
- Conditions
- Weight Maintenance, Overweight, Obese
- Trial name
- NCT01505387
- Testing
- Litramine
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- InQpharm Group
Pro-opiomelanocortin (POMC) Deficiency Obesity
Setmelanotide for the Treatment of Early-Onset Pro-Opiomelanocortin (POMC) Deficiency Obesity
To demonstrate statistically significant and clinically meaningful effects of setmelanotide on percent body weight change in participants with pro-opiomelanocortin (POMC) deficiency or proprotein convertase subtilisin/kexin type…
- Trial name
- NCT02896192
- Testing
- Setmelanotide
- Where
- 7 sites in United States, Belgium and 5 more
- Volunteers
- 15 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
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