Clinical trials: Ovulation
Contraception
A proof-of Concept, Randomized 3-month Study to Evaluate the Effects of Three Contraceptive Intrauterine Systems Delivering Copper and a Daily Dose of 5, 20 or 40 μg of Ulipristal Acetate (UPA)
The UPA doses to be tested in this new IUS, 5, 20 or 40 μg per day, are not expected to suppress ovulation, however they should prevent endometrial growth resulting in endometrial atrophy, minimal bleeding, or even amenorrhea.
- Trial name
- NCT03230539
- Testing
- Ulipristal Acetate IUS delivering Cu and 5μg, Ulipristal Acetate IUS delivering Cu and 20μg, Ulipristal Acetate IUS delivering Cu and 40μg
- Where
- Dominican Republic
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Population Council
Reproduction
Evaluation of EarlySense for Monitoring Ovulation Cycles and Detection of Early Stages of Pregnancy in Home Environment
The study objective is to collect data to assess the accuracy and reliability of Earlysense fertility cycle monitoring performance vs.
- Trial name
- NCT02634359
- Testing
- EarlySense home device, Vaginal ultrasound, Blood Test
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- EarlySense Ltd.
Polycystic Ovarian Syndrome
Comparison of Clomid and Lezra With Lezra for Ovulation Induction in Clomid Resistant PCOS Case
Clomiphene citrate resistant i.e failure to ovulate after 6 cycles of ovulation induction effects 15-40% of patients with PCOS.Two treatment groups will be formed one recieving letrozole alone and another recieving CC and…
- Trial name
- NCT06813118
- Testing
- Clomiphene Citrate and letrozole
- Where
- Pakistan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- HITEC-Institute of Medical Sciences
Ovulation, Female Fertility
FemiClock: Non-invasive Tools Development (Salivary and Hair Progesterone) for Ovulation Detection in Heathy Women With Regular Menstrual Cycles Without Contraception.
Currently, the gold standard to confirm ovulation is measuring LH and/or progesterone in blood. However, because confirmation requires a blood sample, this approach is not suitable for epidemiological studies evaluating the…
- Conditions
- Ovulation, Female Fertility, Menstrual Cycle
- Trial name
- FemiClock (NCT07687823)
- Testing
- Diagnostic Test: Non-invasive ovulation biomarker assessment - Smartwatch, Diagnostic Test: Non-invasive ovulation biomarker assessment - Questionnaires, Hormonal blood assessment
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Pregnancy, Fertility
Creighton Model Effectiveness, Intentions and Behaviors Assessment (CEIBA)
The Creighton Model (CrM) FertilityCare System is a natural family planning method that teaches couples to recognize and chart the signs of fertility and infertility in the woman's cycle and to use that knowledge to either…
- Trial name
- CEIBA (NCT01012596)
- Testing
- Creighton Model System of Natural Family Planning
- Where
- 18 sites in United States, Canada
- Volunteers
- 624 people, healthy volunteers welcome
- Sponsor
- University of Utah
Polycystic Ovary Syndrome, Anovulation
The Effect of Metformin Added to Clomiphene Citrate on Pregnancy Rates in Hyperandrogenic, Chronic Oligoovulatory or Anovulatory Women
The purpose of our study was to conduct a placebo controlled, double-blind randomized trial in chronic oligoovulatory or anovulatory , hyperandrogenic, infertility patients comparing the effects of adjuvant metformin plus…
- Conditions
- Polycystic Ovary Syndrome, Anovulation, Oligoovulation, Infertility
- Trial name
- NCT00413179
- Testing
- Metformin, Clomiphene citrate
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Infertility
Luteal Support and Intrauterine Insemination (IUI) With Clomiphene Citrate
The purpose of this study is to assess the effect of luteal phase supplement (LPS) on pregnancy rate in IUI cycles stimulated with clomiphene citrate.
- Trial name
- NCT01046708
- Testing
- micronized progesterone
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
in Vitro Fertilization, Ovulation Induction
Trial Comparing Start Stimulation of Recombinant Follicle Stimulating Hormone (rFSH) on Cycle Day 2 Versus Cycle Day 5 in In Vitro Fertilization (IVF)
Background of the study: Milder stimulation protocols have the advantage of being less expensive and more patient-friendly. Moreover, recent evidence suggests that mild stimulation protocols lead to lower embryo aneuploidy rates…
- Trial name
- LITE (NCT00823472)
- Testing
- Mild stimulation
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Induction of Ovulation, PCO - Polycystic Ovaries
Sodium-Glucose Co-Transporter-2 Inhibitors as Adjuvant Therapy With Letrozole in Induction of Ovulation in Women With Polycystic Ovarian Syndrome
The aim of the study is to assess the efficacy of adjuvant therapy dapagliflozin, metformin as monotherapy and combination of both in comparison to control group in induction of ovulation with letrozole in women PCOS, focusing…
- Trial name
- SGLT-2/PCOS (NCT07589075)
- Testing
- Metformin 1000 mg Oral Tablet, Dapagliflozin 10 MG Oral Tablet [Farxiga], Combined Dapagliflozin-Metformin 5/1000mg
- Where
- Egypt
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Fertility
Kegg Fertility Study
Fertility Awareness Based Methods (FABMs), such as calendar tracking, basal body temperature (BBT), and monitoring cervical mucus, are widely used but may have limitations in accurately detecting the complete fertility window.
- Trial name
- CMTrak-US (NCT06862440)
- Testing
- Kegg
- Where
- United States
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Lady Technologies Inc
Infertility, Decreased Ovarian Reserve
A Trial of Dehydroepiandrosterone (DHEA) Treatment for in Vitro Fertilization (IVF)
Our long term goal is to elucidate the role of DHEA on follicular dynamics in the human ovary and to better understand the interaction of DHEA supplementation with other treatments for ovulation induction, especially among older…
- Trial name
- NCT00419913
- Testing
- Dehydroepiandrosterone
- Where
- 2 sites in United States, Austria
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Infertility
Does Letrozole Improve the Outcomes and/or Reduce the Cost of IVF-ET Cycles?
This research is being done to determine whether the success rate of in vitro fertilization treatment can be improved, while lowering the cost incurred from infertility medications using a pill called letrozole.
- Trial name
- Cost-Less (NCT00804960)
- Testing
- Letrozole, Std IVF Protocol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Polycystic Ovary Syndrome, Ovulation Disorder
Clusterin Level and Polycystic Ovary Syndrome
Clusterin, a protein involved in metabolic syndrome, insulin resistance, and metabolic disorders associated with inflammation and oxidative stress such as atherosclerosis, Alzheimer's and some malignancies, has elevated levels in…
- Trial name
- NCT06601725
- Testing
- Clusterin level
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Polycystic Ovary Syndrome
Efficacy of Letrozole Versus Clomiphene Citrate on Ovulation Induction in Patients With Polycystic Ovarian Syndrome
We aimed this study to determine and compare frequency of induction of ovulation in women with polycystic ovarian syndrome treated with Letrozole versus clomiphene citrate as published literature shows variations.
- Trial name
- NCT05075863
- Testing
- Letrozole
- Where
- Pakistan
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Nishtar Medical University
Pregnancy
Connected Ovulation Test Efficacy Study
Clearblue Connected Ovulation Test System (COTS) has been designed for home use by women who are either planning or trying for a pregnancy.
- Trial name
- NCT03424590
- Testing
- Clearblue Connected Ovulation Test System
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- SPD Development Company Limited
Treatment Resistant Disorders
Adding L-carnitine in Clomiphene Resistant Polycystic Ovary Improves the Quality of Ovulation and the Pregnancy Outcome
Adding L-carnitine is more successful than clomiphene as a first line therapy for ovulation induction in women with clomiphene resistant PCOS
- Trial name
- NCT01665547
- Testing
- l-carnitine
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Menstruation, Ovulation
Menstrual Cycle Study
A data collection study to develop algorithms to estimate menstrual cycle phases.
- Trial name
- NCT05999123
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Fitbit LLC
Infertility
Ulipristal Acetate on Progesterone Levels and Glycodelin-A Endometrial Pattern
Controlled ovarian stimulation (COS) for FIV increases progesterone (P) and estradiol (E2) serum levels in supraphysiologic concentrations at the end of follicular phase.
- Trial name
- NCT01391845
- Testing
- ulipristal acetate
- Where
- Argentina
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Programa de Asistencia Reproductiva de Rosario
Ovulation
Accuracy of SPD Persona LH Assay When Compared to Ultrasound Observed Ovulation and Other Indices of Ovulation
This study will examine the performance of the Persona assays in identifying the time when risk of pregnancy is highest by comparing results to ultrasound observed ovulation and other indices of ovulation.
- Trial name
- NCT01802060
- Where
- Germany
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- SPD Development Company Limited
Pregnancy
Effect of Luteal Progesterone Support on Pregnancy Rates With Combined Clomid/ Gonadotropin & IUI
To determine the difference in clinical pregnancy rates with and without luteal progesterone support in a young reproductive aged population having undergone ovulation induction with combined clomiphene citrate and gonadotropin…
- Trial name
- NCT02510534
- Testing
- Menopur 150 international units, Endometrin 100 mg
- Where
- United States
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Northwest Center for Infertility and Reproductive Endocrinology