Clinical trials: Oxidative Injury
Heart Arrest, Sport Injury
Tour de Borobudur Troponin Study on Predictors and Synergistic Role of MDA and Hs-CRP Levels
Prospective observational study to determine predictors that related to cardiac troponin I (cTnI) release, malondialdehyde (MDA) and high sensitivity C Reactive Protein (hs-CRP) after Tour de Borobudur (TdB) 2017
- Conditions
- Heart Arrest, Sport Injury, Inflammatory Response, Oxidative Stress
- Trial name
- TdBTS (NCT03310450)
- Testing
- 140kms cycling
- Where
- Indonesia
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Universitas Negeri Semarang
Vascular System Injuries
Natural Antioxidant Ice-cream, Oxidative Stress and Vascular Function
Formation of reactive oxygen species (ROS) contributes to pathogenesis and progression of several diseases. Polyphenols, have been shown to be beneficial against ROS.
- Trial name
- NCT02685163
- Testing
- Antioxidant ice-cream, Control Ice-cream
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Muscular Injury
Turmeric and Exercise-Induced Muscle Damage and Oxinflammation
The purpose of this study is to measure the effect of using a turmeric-based supplement for 2-weeks on muscle damage and soreness that occur in the body after 90-minutes of exercise.
- Trial name
- NCT04765527
- Testing
- Turmeric Strength for Joint
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Oxidative Stress
The Effect of Protandim Supplementation on Oxidative Damage and Athletic Performance
Nutrition supplementation with antioxidants have been discussed as a way to further enhance overall well-being of athletes, promote faster recovery, and improve overall performance.
- Trial name
- NCT02172625
- Testing
- Protandim Dietary Supplement
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Psychoses
Brain Cell Injury in Patients With A First Episode of Psychosis
Patients experiencing a first episode of psychosis may have brain cell damage due to a chemical process called oxidation. This study will compare patients with psychosis to healthy volunteers to determine if there are differences…
- Trial name
- NCT00070889
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Reactive Hyperemia, Micro RNA
Effect on Markers of Cardiovascular, Reproductive and Cancer Risk From Firefighting Training
Epidemiological studies based on Danish registries have observed that Danish male firefighters have more cardiovascular disease, infertility diagnose and a trend to increased risk of cancer than other Danish employed males.
- Conditions
- Reactive Hyperemia, Micro RNA, Heart Rate Variability, DNA Strand Breaks
- Trial name
- BIOBRAND3 (NCT05753254)
- Testing
- Firefighting training exercises with no fire, Firefighting training exercises under wood fire, Firefighting training exercises under gas fire
- Where
- 2 sites in Denmark
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Research Centre for the Working Environment, Denmark
Inflammation, Mental Health Wellness 1
Health Effects of Traditional Indigenous Chokeberry
American Indian populations continue to suffer disproportionately from health problems including such nutrition-related chronic diseases as diabetes and heart disease.
- Conditions
- Inflammation, Mental Health Wellness 1, Oxidative Stress
- Trial name
- NCT05410327
- Testing
- Chokeberry (Aronia melanocarpa) juice
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of North Dakota
Atrial Fibrillation
Paroxysmal Atrial Fibrillation: Role of Inflammation, Oxidative Stress Injury and Effect of Statins
The purpose of this study is to determine the effect of statin therapy for prevention of atrial fibrillation (AF) in pacemaker and non-pacemaker patients with paroxysmal atrial fibrillation in the absence of significant coronary…
- Trial name
- PAFRIOSIES (NCT00321802)
- Testing
- Simvastatin
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Heat Stroke, Healthy
The Development Of A Novel Biomarker For Early Identification Of The Individual's State Of Tolerance To Heat
Today, the level of tolerance to heat is based on physiological strain indices, with no correlates to any relevant biomarker. We hypothesize that oxidative stress (OS) and the formation of reactive oxygen and nitrogen species…
- Trial name
- NCT01290159
- Testing
- heat tolerance test (HTT)
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Posttraumatic Stress Disorder, Cardiovascular Diseases
NightWare and Cardiovascular Health in Adults With PTSD
The purpose of this study is to determine whether NightWare therapeutic intervention improves biomarkers of vascular aging and autonomic function in adults with nightmares related to PTSD.
- Conditions
- Posttraumatic Stress Disorder, Cardiovascular Diseases, Autonomic Dysfunction, Vascular Stiffness
- Trial name
- NCT05365607
- Testing
- NightWare
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Oophorectomy, Oxidative Stress
Role of Oxidative Stress in Ovarian Tissue After CO2-pneumoperitoneum Application-induced I/R
Because of cellular changes in response to ischemia and a following period of reperfusion, damages to organs and different tissues occur.
- Conditions
- Oophorectomy, Oxidative Stress, Ischemia Reperfusion Injury
- Trial name
- NCT04493983
- Testing
- laparoscopic salpingo-oophorectomy, Laparoscopic bilateral salpingo-oophorectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ismet Hortu
Athletic Injuries
Effect of Vitis Vinifera Extract on Oxidative Stress, Inflamatory Biomarkers and Hormones in High Trained Subjects
There is evidence that intense physical activity has a potential effect on thrombotic events due to catecholamine release. The hormones leptin and adiponectin have been used as markers of cardiovascular risk, but they are few and…
- Trial name
- NCT01875497
- Testing
- grape fruit (vitis vinifera) extract in capsule with 205 mg
- Where
- Brazil
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Oxidative Stress
Antioxidants Vitamins and Muscle Damage
Determine if acute supplementation with antioxidant vitamins (vitamin C and vitamin E) influences the muscle damage and fatigue caused after an acute session of eccentric training.
- Trial name
- Antioxidant (NCT05127928)
- Testing
- Dietary Supplement: Vitamin C and vitamin E
- Where
- Spain
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Post-traumatic Stress Disorder (PTSD), Cardiovascular Diseases
NightWare and Cardiovascular Health in Veterans With PTSD
The purpose of this study is to learn more about the effectiveness of a prescription wrist-wearable device called NightWare (NW) on improving sleep in Veterans with nightmares related to posttraumatic stress disorder (PTSD).
- Conditions
- Post-traumatic Stress Disorder (PTSD), Cardiovascular Diseases, Autonomic Dysfunction, Vascular Stiffness
- Trial name
- NCT06419959
- Testing
- NightWare
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Adverse Childhood Experience, Endothelial Function (FMD)
Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity
Adverse childhood experiences (ACEs) represent highly stressful events in the first 18 years of life that include abuse, neglect, and household and community-level dysfunction.
- Conditions
- Adverse Childhood Experience, Endothelial Function (FMD), Endothelial Injury, Mitochondrial Function
- Trial name
- PROMISE (NCT07244809)
- Testing
- Mitoquinone mesylate (MitoQ)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Healthy
Effects of Tea Catechin Extracts on Oxidative Damage
The purpose of this study is to clarify the effects of tea catechin extracts on the frequency changes of micronuclei in peripheral lymphocytes compared with other oxidative stress markers in late middle aged healthy volunteers
- Trial name
- NCT00448513
- Testing
- catechin extracts
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Shizuoka
Silicosis
Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone)
Silicosis is well-known occupational disease caused by free crystalline silica (silicon dioxide) and is marked by inflammation and pulmonary fibrosis.
- Trial name
- NCT01338064
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Metabolic Syndrome
Beneficial Effects of Exercise and Healthy Diets on Muscle and Adipose Tissue
Both dietary caloric restriction (CR) and physical exercise (PE) exert beneficial effects, which retard or prevent age-related diseases and prolong life span.
- Trial name
- NCT01793896
- Testing
- Control period, Diet Group, Exercise group
- Where
- Chile
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Chile
Muscle Injury, Muscle Soreness
Lemon Verbena Extract Oxidative Stress and Muscle Damage
In the present study, investigators investigated whether supplementation with lemon verbena extract (LVE) could improve muscle damage and biochemical indicators after exhaustive exercise challenge.
- Trial name
- NCT04742244
- Testing
- Lvemon verbena extract, maltodextrin
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan Sport University
Oxidative Stress, Inflammation
Influence of a Short Term Supplementation With Ubiquinol on Diverse Aspects Related to the Physical Activity
The General Aim of this study is to verify if a short term supplementation can modulate diverse aspects related to the physical regular high intensity activity.
- Conditions
- Oxidative Stress, Inflammation, Muscle Injury
- Trial name
- NCT01940627
- Testing
- Ubiquinol, Control
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada