Clinical trials: Oxydative Stress
Type 2 Diabetes Mellitus, High-Intensity Interval Training
Development of Structured Exercise Program for T2DM Management
The study started by the process of designing a structured exercise that will manage the T2DM with regards to the effectiveness in glycemic control, the benefit for physical fitness, and safe.
- Conditions
- Type 2 Diabetes Mellitus, High-Intensity Interval Training, Resistance Training, Oxidative Stress
- Trial name
- NCT03563456
- Testing
- structured combined exercise, cardiorespiratory exercise
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Universitas Indonesia
Malnutrition, Sarcopenia
Maintaining Immune and Mitochondrial Functions in Old Adults With SAfe Nutrition.
Aging is associated with an increased inflammation named "inflammageing" and with an altered immune response. Different mechanisms have been proposed to explain the phenomenon of inflammageing and increased oxidative stress…
- Trial name
- MIMOSA (NCT05324475)
- Testing
- BCAA, Micronutriments
- Where
- Switzerland
- Volunteers
- 240 people
- Sponsor
- Patrizia D'Amelio
Acute Radiation Enteritis
Prevention of Acute Radiation Enteritis With Glutamine
Ionizing radiation has cytotoxic effects, and is commonly used as treatment for neoplasm. A common adverse effect of radiation is acute diarrhoea.
- Trial name
- NCT00828399
- Testing
- Glutamine, Whole protein
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Castilla-León Health Service
Inflammation, Oxydative Stress
Physical Activity Oxidative Stress and Inflammation With Ageing
Sarcopenia, an age-related decline in muscle function, are thought to be influenced by oxidative stress and low-grade inflammation, resulting in significant muscle mass reduction and altered physical performance.
- Conditions
- Inflammation, Oxydative Stress, Sarcopenia, Older Patient
- Trial name
- POXI-AGEING (NCT06980896)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Tourniquet Pain, Ischemia-reperfusion
The Effect of Prolonged ischemıa and anesthetıc Agents on Oxidative Stress
The goal of this observational study is to learn about the relationship between postoperative pain and tourniquet-induced oxidative damage in adults undergoing orthopedic knee arthroscopy surgery.The goal of this observational…
- Conditions
- Tourniquet Pain, Ischemia-reperfusion, Postoperative Pain, Anesthesia
- Trial name
- NCT06942650
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duzce University
Overweight
Evaluation of SODB® in Metabolic Adaptations in Overweight Women
The objective of this study is to evaluate the influence of a 3 months SODB® supplementation in adipose tissue modulations of overweight women, in comparison to a placebo.
- Trial name
- SORESCAL (NCT02667691)
- Testing
- SODB Dimpless, caloric restriction
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Robertet SA
Immunocompetent Patient on Septic Shock
Bio-clinical Evolutive Dynamic in Patients Suffering From Communitary Septic Shock (Biosepsis)
Septic shock is a frequent pathology responsible for over 30000 deaths/year in France. Its outcome has not been improved despite the knowledge on inflammatory processes; a reason for these lack of results may lay on the lack of…
- Trial name
- BIOSEPSIS (NCT01668329)
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Grenoble
Chronic Heart Failure (CHF), Iron Deficiency
Evaluation on Performance and Oxydative Stress in Patient With Iron deficIency and Stable Heart Failure Study
ERADAL-HF is a double blinded, multi-centre, prospective, randomized, three arm study, enrolled ambulatory patients with chronic heart failure [New York Heart Association (NYHA) class II/III], with iron deficiency [defined as…
- Trial name
- ERADAL-HF (NCT04225728)
- Testing
- Iron Sucrose IV, Ferric polymaltose hydroxide complex IM, Saline solution
- Where
- Cameroon
- Volunteers
- 45 people
- Sponsor
- CN NGANOU-GNINDJIO, MD, MSc
Sickle Cell Disease
Implication of the Oxydative Stress in the Pathophysiology of Sickle Cell Anemia:
Despite important advances in the current understanding of sickle cell vaso-occlusion, the basis of its control and prevention remain partially unknown.
- Trial name
- STRESS (NCT03368924)
- Testing
- SCA patients (SS genotype)
- Where
- Guadeloupe
- Volunteers
- 38 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Iron, Acute Myeloid Leukemia
Metabolism Des LAM
In this study, the investigators study the prognostic role of oxidative stress metabolism and iron in Acute myeloid leukemia.
- Conditions
- Iron, Acute Myeloid Leukemia, Diagnosis, Oxydative Stress
- Trial name
- LAM-ROS (NCT02176109)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Grenoble
Aortic Aneurysm and Dissection
MITAORTA - Role of Mitochondrial Dynamic in Aneurysm and Dissection of Ascending Thoracic Aorta
The main objective is to compare the mitochondrial dynamic between patients operated for aneurysm of ascending aorta or type A aortic dissection (AAD) or control group
- Trial name
- MITAORTA (NCT05434481)
- Testing
- Mitochondrial dynamic analysis in the aorta samples and metabolomic profiling in the aortic diseases
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Hepatectomy
Effects of Propofol on Oxidative Stress and Liver Regeneration After Partial Hepatectomy
Propofol is an anaesthetic agent that showed in vitro and in vivo anti oxidant properties. No data are available concerning the potential benefit of a total anaesthesia with propofol in partial hepatic surgery.
- Trial name
- NCT00219856
- Testing
- Propofol, Penthotal, Desflurane
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Rennes University Hospital
Coronary Microvascular Disease, Microvascular Disease
Hyperoxia and Microvascular Dysfunction
Coronary artery disease (CAD) pathophysiology involves endothelium-dependent (e.g. nitric oxide, acetylcholine) and -independent (e.g.
- Conditions
- Coronary Microvascular Disease, Microvascular Disease, Ischemic Heart Disease
- Trial name
- NCT04321434
- Testing
- Hyperoxia, Normoxia, laser Doppler
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Université Libre de Bruxelles
Oxidative Stress, Endothelial Function
Uric Acid Effects on Endothelium and Oxydative Stress
Cardiovascular disease is the leading cause of mortality worldwide. Endothelial dysfunction (ED) is the main mechanism which leads to atherosclerosis, where the balance between pro and antioxidant factors results in a decreased…
- Conditions
- Oxidative Stress, Endothelial Function, Cardiovascular System, Hypertension
- Trial name
- NCT03395977
- Testing
- Febuxostat, Rasburicase
- Where
- Belgium
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
COVID 19, Oxydative Stress
Oxidative Stress and Cognitive Dysfunction After COVID-19
This observational cohort study will investigate the association between oxidative stress biomarkers and post-COVID-19 cognitive impairment.
- Conditions
- COVID 19, Oxydative Stress, Cognitive Impairments
- Trial name
- NCT07029048
- Testing
- Standard Post-COVID Rehabilitation Program
- Where
- Kazakhstan
- Volunteers
- 45 people
- Sponsor
- Karaganda Medical University
Alzheimer Disease
Influence of Oxidative Stress and Nutrition Biomarkers on the Cognitive Decline Evolution in Alzheimer Disease
According to several reports, the oxidative stress and the nutrition could have an impact in the Alzheimer disease. The association of these two parameters measurements and the cognitive impairment decline could help in a…
- Trial name
- GERIOX (NCT02800395)
- Testing
- Malnutrition screening and perioperative nutritional support
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Hospices Civils de Lyon
Hypertension
Predisposition and Transition Mechanisms From Arterial Hypertension to Heart Failure
This project aims at investigating the genetic, genomic and proteomic basis of hypertension and susceptibility to hypertension-related end organ damage (renal damage and heart failure).
- Trial name
- Hypercare (NCT02430805)
- Testing
- dna extraction and genotyping
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France