Clinical trials: Oxygen Inhalation Therapy
Lung Disease
Evaluation of Sleep Mode Within the Respironics SimplyGo Portable Oxygen Concentrator
The SimplyGo Study is a single site, cross-over study which aims to enroll a maximum of 30 participants (to allow for 20 completed data sets) with a prescription for nocturnal oxygen, and meeting all eligibility criteria.
- Trial name
- NCT01679301
- Testing
- Pulse Dose (Sleep Mode), Continuous Dose
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Philips Respironics
COVID-19, Critical Illness
Impact and Sequelae of High Ventilatory Drive in Critically Ill COVID-19 Patients
Critically ill COVID-19 patients with acute respiratory failure, in the intensive care unit (ICU), often feature high respiratory drive, determining large inspiratory efforts resulting in high pressures and global and regional…
- Conditions
- COVID-19, Critical Illness, Hypoxemic Respiratory Failure, Neurocognitive Dysfunction
- Trial name
- NCT05363332
- Where
- 3 sites in Spain
- Volunteers
- 126 people
- Sponsor
- Corporacion Parc Tauli
High Grade Glioma
Trans Sodium Crocetinate (TSC) Study of Intra-tumoral Oxygen Concentration, Safety, and Pharmacokinetics in Patients With High Grade Glioma
The purpose of this study is to evaluate the impact of Trans Sodium Crocetinate (TSC) on oxygen levels in brain tumor tissue in patients with high grade glioma.
- Trial name
- NCT00826930
- Testing
- Trans Sodium Crocetinate (TSC)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Diffusion Pharmaceuticals Inc
Primary Peritoneal Cavity Cancer, Stage I Endometrial Carcinoma
EF5 in Finding Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Cervical, Endometrial, or Ovarian Epithelial Cancer
This phase II trial is studying how well EF5 works in finding oxygen in tumor cells of patients who are undergoing surgery or biopsy for cervical, endometrial, or ovarian epithelial cancer.
- Conditions
- Primary Peritoneal Cavity Cancer, Stage I Endometrial Carcinoma, Stage I Ovarian Epithelial Cancer, Stage IA Cervical Cancer
- Trial name
- NCT00107445
- Testing
- EF5
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute (NCI)
Infant, Premature, Congenital Heart Disease
Splanchnic and Renal Tissue Oxygenation During Enteral Feedings in Neonates With Patent Ductus Arteriosus
Patent ductus arteriosus (PDA) is a common problem in the neonatal intensive care unit and can be secondary to prematurity or congenital heart disease (CHD).
- Conditions
- Infant, Premature, Congenital Heart Disease, Patent Ductus Arteriosus, Necrotizing Enterocolitis
- Trial name
- NCT03551600
- Testing
- Near-infrared spectroscopy (NIRS)
- Where
- 3 sites in United States
- Volunteers
- 64 people
- Sponsor
- University of Utah
Oxygen Deficiency
Research of the Effect of Reservoir Oxygen Mask Application on Respiratory Parameters in Sedated Adult Patients for Gastrointestinal System Endoscopy
With the oxygen mask with reservoir, oxygen can be given to patients with FiO2 values that can reach 80-100%. Reservoir oxygen mask is superior to other oxygen treatment methods with the high oxygen rate applied.Our hypothesis is…
- Trial name
- NCT05684900
- Where
- Turkey (Türkiye)
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Derince Training and Research Hospital
Right Ventricular Dysfunction
Right Ventricular Echocardiography in caRdiac SurgEry
Postoperative right ventricular (RV) dysfunction increases mortality and risk of cardiac failure after cardiac surgery substantially.
- Trial name
- ReVERSE (NCT03301571)
- Testing
- Change in preload and afterload, Inspired oxygen, Pacemaker mode
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Hypoxemic Respiratory Distress
HFNO or Conventional Oxygen Therapy for Patients With Acute Hypoxemic Respiratory Distress
A quarter of the patients admitted to the Shock Room or Resuscitation Room of an Emergency Department (ED) are admitted for severe hypoxemia resulting from acute respiratory distress.
- Trial name
- HIFLOWED (NCT04607967)
- Testing
- High Flow Nasal Oxygen
- Where
- 10 sites in France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Lung Cancer, Lymphadenopathy
Assessment of High Flow Nasal Cannula Oxygenation in EBUS Bronchoscopy
This study is a prospective randomised trial where a computer will randomly allocate patients to one of two possible methods of delivering oxygen during the procedure of bronchoscopy.
- Trial name
- AHOE (NCT03226964)
- Testing
- high flow nasal oxygen
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- University College Hospital Galway
Cancer
The Role of Oxygen in the Management of Dyspnoea in Advanced Cancer
The purpose of this study is to determine the effect that oxygen has when administered to patients complaining of shortness of breath, where the underlying cause of this symptom is advanced cancer.
- Trial name
- NCT00206609
- Testing
- Oxygen and air administration
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Bayside Health
Regional Saturation of Oxygen (rSO2)
Performance Comparison of Masimo O3 Regional Oximetry Sensors in Neonates
The aim of the study is to compare the performance of the O3 cerebral oximeter and sensor to a 510(k) cleared NIRS (Near-Infrared Spectroscopy) device on neonatal subjects based on data collected from the cutaneously placed…
- Trial name
- NCT03828487
- Testing
- Masimo O3 Neonatal Sensors, 510(k) cleared sensor
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Masimo Corporation
Coronary Artery Disease
FiO2 and Outcomes After OPCAB (the CARROT Trial)
Conventionally, a relatively high level of fraction of inspired oxygen (FiO2) has been used for secure a margin of safety in patients undergoing cardiac surgery including off-pump coronary artery bypass grafting (OPCAB).
- Trial name
- NCT03945565
- Testing
- Fraction of inspired oxygen level
- Where
- South Korea
- Volunteers
- 414 people
- Sponsor
- Seoul National University Hospital
Tissue Oxygenation
The Correlation Between Tissue Oxygenations Using NIRS and Clinical Outcomes in Very Preterm Infants.
With the development of neonatal critical medicine, the survival rate of premature infants has gradually increased, and the incidence of late complications has significantly decreased, but preterm delivery is still the main cause…
- Trial name
- TCBTOUNACOIVPI (NCT06483867)
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Jilin University
Heart Arrest
Comparison of Cerebral SctO2 Between 36℃ and 33℃ of TTM After Cardiac Arrest
The investigators hypothesize that 1. if decrease in SctO2 level is caused by the degree of hypothermia, SctO2 level in the 33-TH may be lower than that in the 36-TH group. 2.
- Trial name
- NCT02889744
- Testing
- Arctic Sun
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Seoul National University Hospital
Anterior Wall Acute Myocardial Infarction
Evaluation of Intracoronary Hyperoxemic Oxygen Therapy in Anterior Acute Myocardial Infarction Patients (IC-HOT)
The primary objective of the study is to collect confirmatory data supporting the safety and effectiveness of SSO2 Therapy in treatment of anterior acute myocardial infarction (AMI) patients who have undergone successful…
- Trial name
- IC-HOT (NCT02603835)
- Testing
- SSO2 Therapy
- Where
- 15 sites in United States
- Volunteers
- 100 people
- Sponsor
- TherOx
Pulmonary Arterial Hypertension
Oxygen Treatment and Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a disease characterised with significant morbidity and poor prognosis. Dyspnoea and impaired exercise capacity are very common manifestations of the disease, and result in significant…
- Trial name
- NCT03683082
- Testing
- Oxygen supplementation
- Where
- Greece
- Volunteers
- 10 people
- Sponsor
- George Papanicolaou Hospital
Ventilator Weaning
Physiologic Effects of High-flow Nasal Cannula Versus Standard Oxygen Therapy Postextubation in Critically Ill Patients
High-flow nasal cannula (HFNC) is a rather novel system to provide oxygen therapy, which provides flows up to 60 liters/minute (LPM) of heated and humidified gas through nasal prongs.
- Trial name
- NCT04711759
- Testing
- High flow nasal cannula, Standard oxygen therapy
- Where
- Chile
- Volunteers
- 26 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Fatigue
Coca-Cola vs. Oxygen for Fatigue Management in Tibet Surgeons
The study will be conducted among surgeons in Tibet, comparing the effects of Coca-Cola and supplemental oxygen on fatigue alleviation.
- Trial name
- COMETS (NCT06557746)
- Testing
- Coca-Cola, Supplemental oxygen
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
PaO2/FiO2 Ratio
The Effect of FiO2 on PaO2/FiO2 Ratio
The PaO2/FiO2 ratio is frequently used to determine the severity of lung injury in mechanically ventilated patients. However, several mathematical models have shown that PaO2/FiO2 ratio depends on FiO2.
- Trial name
- NCT03156218
- Testing
- Modulation of FiO2
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Contrast-induced Acute Kidney Injury (CI-AKI)
Hemodynamic Effects Of Impella On Renal Circulation And Risk Of CA-AKI Among Patients Undergoing Protected PCI
Patients undergoing Percutaneous Coronary Intervention (PCI) are exposed to the risk of suffering from a damage to the kidneys which goes under the name of Contrast-Associated Acute Kidney Injury (CA-AKI), which is more common if…
- Trial name
- NCT04928118
- Testing
- Evaluate the blood flow and pressure into kidneys
- Sponsor
- Virginia Commonwealth University