Clinical trials: Oxygenation,
Pneumonia, Bacterial, Extracorporeal Membrane Oxygenation
" Study of the Benefit of Nebulized Amikacin in the Treatment of Gram-negative Bacillus Pneumonia Acquired During Mechanical Ventilation in Patients Receiving Extracorporeal Membrane Veno-arterial Oxygenation "
Pneumonia are the most frequent infectious complication in patients on Extracorporeal Membrane Oxygenation Veno-arterial (ECMO-VA), with a treatment failure rate of around 40%, even though antibiotic therapy is tailored to the…
- Trial name
- NAVAP-ECMO (NCT06602557)
- Testing
- Amikacin, Standard of care
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hemoglobin, Cerebral Oxygenation
Observational Data Collection for Blood Hemoglobin Algorithm Validation in Pediatrics
This study will enroll children and young adults who are scheduled to undergo planned heart surgery or a heart catheterization procedure while under general anesthesia.
- Conditions
- Hemoglobin, Cerebral Oxygenation, Congenital Heart Disease
- Trial name
- NCT07706140
- Testing
- Noninvasive hemoglobin monitoring
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Procedural Sedation, Hypoxemia
HFNO Versus Face Mask for Cerebral Oxygenation During Procedural Sedation
This prospective randomized controlled trial aims to compare the effects of high-flow nasal oxygen (HFNO) and conventional face mask oxygen therapy on cerebral oxygenation during procedural sedation performed outside the…
- Conditions
- Procedural Sedation, Hypoxemia, Cerebral Oxygenation, SEDLine
- Trial name
- NCT07718295
- Testing
- High-Flow Nasal Oxygen (HFNO), Conventional Face Mask Oxygen
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Firat University
Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication
DIC Markers and Thrombin Generation Parameters in Patients on ECMO Support: a Pilot Study
To study the correlation between novel DIC markers and thrombin generation parameters with thrombotic and hemorrhagic complications of patients on ECMO support.
- Trial name
- DIC-ECMO (NCT06095518)
- Testing
- DIC markers and Thrombin Generation Parameters
- Where
- Hong Kong
- Volunteers
- 49 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Blood Flow Restriction Training, Muscle Oxygenation
"How Blood Flow Restriction Exercise Affects Muscle Oxygenation and Lactate in Elite Athletes"
This study investigates the effects of blood flow restriction (BFR) training combined with low-intensity aerobic exercise on muscle oxygenation, total hemoglobin (THb), and blood lactate levels in elite athletes, comparing them…
- Conditions
- Blood Flow Restriction Training, Muscle Oxygenation, Physiological Adaptations
- Trial name
- NCT06918314
- Testing
- Blood Flow Restriction Kaatsu Training Device
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
ExtraCorporeal Membrane Oxygenation (ECMO), Wound Complications
Closed Incision NPWT to Prevent Wound Complications Post-ECMO
Patients undergoing extracorporeal membrane oxygenation (ECMO) are at increased risk of wound complications at the vascular access site after decannulation. These complications may delay recovery and increase healthcare burden.
- Conditions
- ExtraCorporeal Membrane Oxygenation (ECMO), Wound Complications, Surgical Site Infection (SSI)
- Trial name
- PREVENT-ECMO (NCT07709546)
- Testing
- Prophylactic Closed-Incision Negative Pressure Wound Therapy, Standard Wound Dressing
- Volunteers
- 144 people
- Sponsor
- St. Antonius Hospital
Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation
ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)
ASCEND researchers are partnering with families of children who receive extracorporeal membrane oxygenation (ECMO) after a sudden failure of breathing named pediatric acute respiratory distress syndrome (PARDS).
- Trial name
- ASCEND (NCT05388708)
- Testing
- ECMO support, PROSpect protocolized therapies
- Where
- 95 sites in United States, Australia and 9 more
- Volunteers
- 550 people
- Sponsor
- University of Michigan
Extracorporeal Membrane Oxygenation, Red Blood Cell Transfusion
Trial of Indication-Based Transfusion of Red Blood Cells in ECMO
TITRE - Trial of Indication-based Transfusion of Red Blood Cells in ECMO, is a multicenter, prospective, randomized clinical trial.
- Conditions
- Extracorporeal Membrane Oxygenation, Red Blood Cell Transfusion, Organ Failure, Multiple
- Trial name
- TITRE (NCT05405426)
- Testing
- Red blood cell transfusion
- Where
- 22 sites in United States, Australia and 1 more
- Volunteers
- 228 people
- Sponsor
- Boston Children's Hospital
Isometric Exercise, Pain
The Role of Isometric in Individuals With Rheumatoid Arthritis
The aim of this study is to investigate the acute effects of isometric exercise on pain modulation and muscle oxygenation in individuals with rheumatoid arthritis.
- Conditions
- Isometric Exercise, Pain, Oxygenation
- Trial name
- NCT07665086
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Zülal TATAR
Extracorporeal Membrane Oxygenation Complication, Hemorrhage
Platelets and Extracorporeal Membrane Oxygenation Veno-venous
In severe lung or heart disease, ExtraCorporeal Membrane Oxygenation (ECMO) may be used temporarily and can be responsible for major haemorrhagic complications. Thrombocytopenia and possibly thrombopathy promote bleeding.
- Conditions
- Extracorporeal Membrane Oxygenation Complication, Hemorrhage, Blood Platelet Disorder, Thrombosis
- Trial name
- PLAT-VV-ECMO (NCT07580469)
- Testing
- blood draws
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Toulouse
Acute Respiratory Distress Syndrome, Nosocomial Infection
Nosocomial Infections in ECMO Patients
Nosocomial Infections (NI) are a common and dreadful complication for patients suffering from Acute Respiratory Distress Syndrome (ARDS) treated with Extracorporeal Membrane Oxygenation (ECMO).
- Conditions
- Acute Respiratory Distress Syndrome, Nosocomial Infection, Extracorporeal Membrane Oxygenation Complication
- Trial name
- INF-ECMO (NCT05566665)
- Testing
- Collection of blood and bronchoalveolar samples to study Pharmacokinetics of ceftazidime/avibactam, meropenem/varbobactam, ceftolozane/tazobactam, or cefiderocol
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Policlinico Hospital
Apneic Oxygenation
Effect of Continuous Supraglottic Oxygen Insufflation Via Video Laryngoscope Blade on Apneic Oxygenation During Tracheal Intubation Under General Anesthesia
This study is a prospective, randomized controlled clinical trial aimed at investigating the efficacy and safety of a novel oxygenating video laryngoscope blade during apneic oxygenation for intubation under general anesthesia.
- Trial name
- NCT07662304
- Testing
- control group (Group C), The continuous laryngeal oxygen supply group (Group B)
- Volunteers
- 150 people
- Sponsor
- Affiliated Hospital of Jiaxing University
Athletic Performance, Hyperbaric Oxygenation
Acute Effects of Post-Exercise Hyperoxia on Recovery in Cycling
This study examines whether exposition to hyperbaric oxygen after a road-race simulation can help competitive cyclists recover and perform better the following day.
- Conditions
- Athletic Performance, Hyperbaric Oxygenation, Physical Endurance, Muscle Fatigue
- Trial name
- NCT07659301
- Testing
- Post-exercise Recovery
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Athletic Performance, Muscle Oxygenation
Effects of Core and Inspiratory Muscle Training on Muscle Oxygenation and Athletic Performance İn Young Soccer Players
The purpose of this randomized controlled trial is to investigate the effects of core training and inspiratory muscle training (IMT) on muscle oxygenation and athletic performance in youth male soccer players aged 15-18.
- Conditions
- Athletic Performance, Muscle Oxygenation, Respiratory Function
- Trial name
- NCT07657065
- Testing
- Core Training Program, Inspiratory Muscle Training (IMT)
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Istinye University
Obesity (BMI > 35), Sleeve Gastrectomy
Perioperative Respiratory Function in Sleeve Gastrectomy
This retrospective single-center cohort study aims to evaluate the effects of two intraoperative ventilation strategies on perioperative oxygenation and respiratory outcomes in obese patients undergoing laparoscopic sleeve…
- Conditions
- Obesity (BMI > 35), Sleeve Gastrectomy, Oxygenation, Peep Titration in Lung Protective Ventilation
- Trial name
- NCT07629102
- Testing
- PEEP 8 cmH2O + Recruitment Maneuvers, PEEP 5 cmH2O
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Istanbul Saglik Bilimleri University
Deep Sedation, High Flow Nasal Canula
HFNO Flow Rates and Cerebral Oxygenation During Deep Sedation for Cystoscopy
For Patients and Families This study aims to investigate how high-flow oxygen therapy affects oxygen levels, especially brain oxygenation, during cystoscopy procedures performed under sedation.
- Conditions
- Deep Sedation, High Flow Nasal Canula, Cerebral Oxygenation, PSI
- Trial name
- NCT07630038
- Testing
- High-Flow Nasal Oxygen 40 L/min (HF40), High-Flow Nasal Oxygen 55 L/min (HF55), High-Flow Nasal Oxygen 70 L/min (HF70)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Firat University
Extracorporeal Membrane Oxygenation Complication
The ECMO-Free Trial
Decannulation from venovenous extracorporeal membrane oxygenation (VV-ECMO) at the earliest and safest time would be expected to improve outcomes and reduce cost.
- Trial name
- NCT05486559
- Testing
- ECMO-free protocol, Usual Care
- Where
- 8 sites in United States, Canada
- Volunteers
- 225 people
- Sponsor
- Vanderbilt University Medical Center
Lung Protective Ventilation, Cardiopulmonary Bypass
Unilateral Ventilation on Cardiopulmonary Bypass During Cardiac Surgery
This study investigates if single lung ventilation on cardiopulmonary bypass can mitigate postoperative lung water accumulation determined by lung ultrasound in the ventilated lung as compared to the non-ventilated lung in…
- Conditions
- Lung Protective Ventilation, Cardiopulmonary Bypass, High-risk Cardiac Patients, Lung Ultrasound
- Trial name
- NCT07612709
- Testing
- Ventilated lung, Non-ventilated lung.
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- Medical University of Vienna
Hyperbaric Oxygenation, Cardiorespiratory Fitness
Retrospective Analysis of CPET and Cognitive Tests of Healthy Individuals, Treated With 60 Treatment of HBOT
This retrospective observational study evaluates physiological and cognitive changes following a series of 60 hyperbaric oxygen therapy (HBOT) sessions in healthy individuals.
- Conditions
- Hyperbaric Oxygenation, Cardiorespiratory Fitness, Cognition
- Trial name
- HBOT (NCT07596641)
- Testing
- Hyperbaric Oxygen Therapy - HBOT
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Cerebral Oxygenation, Peripheral Oxygenation
Manual Versus Autoflow Ventilation During Anesthesia Inductıon in Geriatric Patients
The objective of this study is to compare the effects of manual ventilation and AutoFlow ventilation, administered during the induction of general anesthesia, on cerebral (s-rSO₂) and peripheral (somatic) oxygenation (p-rSO₂) in…
- Conditions
- Cerebral Oxygenation, Peripheral Oxygenation, Geriatrics, Ventilation
- Trial name
- NCT07582913
- Testing
- Manual Mask Ventilation, AutoFlow Mechanical Mask Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Ankara City Hospital Bilkent