Clinical trials: Oxytocin
Chronic Pain Due to Injury
Effects of Intramuscular (IM) Oxytocin on Pupil Diameter and Heart Rate Variability (HRV)
The goal of this study is to test the effects of oxytocin on heart rate variability and pupil diameter, both of which have subtle effects on the activity rate of the autonomic nervous system.
- Trial name
- NCT04105998
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Hypermobile Ehlers-Danlos Syndrome, Pain Assessment
Oxytocin for Hypermobile Ehlers-Danlos Syndrome
The purpose of this pilot study is to evaluate effect of IV oxytocin on chronic pain in patients with Hypermobile Ehlers Danlos syndrome.
- Trial name
- EDS-OXY (NCT05405257)
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Baylor College of Medicine
Alcohol Dependence
Oxytocin Treatment of Alcohol Dependence
Purpose: Test whether oxytocin treatment decreases drinking in people who have been consuming alcohol heavily for long periods and are physically and psychologically dependent on alcohol.
- Trial name
- OTETOH-3 (NCT02251912)
- Testing
- Intranasal Oxytocin
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Phelan-McDermid Syndrome
Piloting Treatment With Intranasal Oxytocin in Phelan-McDermid Syndrome
This is a pilot study examining the efficacy, safety and tolerability of intranasal oxytocin as a novel treatment in Phelan-McDermid syndrome (PMS).
- Trial name
- NCT02710084
- Testing
- Oxytocin, Saline
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Alexander Kolevzon
Autism Spectrum Disorders
Intranasal Oxytocin and Learning in Autism
The main objective of this study is to determine the safety and therapeutic potential of intranasal oxytocin in children and adolescents with autism spectrum disorder (ASD) when paired with a computer game intervention that is…
- Trial name
- NCT01417026
- Testing
- Intranasal Oxytocin (Trade name: Syntocinon)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Robert Schultz
Healthy Adults
Peripheral Oxytocin and Touch
Research shows that slow gentle skin stroking can activate special sensory nerves in the skin that elicit relaxing effects on the body and mind, similar to the effects of the hormone oxytocin.
- Trial name
- POPP (NCT05326776)
- Testing
- Pitocin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Prolonged Grief Disorder, Bereavement
Oxytocin and Approach-avoid in Grief
This is a completed project which was initiated prior to January 18,2017 Background: Theoretical models of complicated grief (CG) suggest that maladaptive approach (e.g., perseverative proximity-seeking of the deceased) or…
- Trial name
- NCT04505904
- Testing
- Syntocinon
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Arizona
Post-Partum Haemorrhage
A Clinical Trial to Study the Effectiveness of a Care Bundle to Prevent Bleeding After a Woman Has Given Birth
Every six minutes a mother dies from postpartum haemorrhage (PPH) in low-resource countries, in the prime of her life and often leaving behind a young family.
- Trial name
- E-MOTIVE (NCT04341662)
- Testing
- E-MOTIVE intervention, Usual care
- Where
- 6 sites in Kenya, Nigeria and 3 more
- Volunteers
- 99,659 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Chronic Daily Headache
Effect of Intranasal Oxytocin on Headache in Chronic Daily Headache
The objective of this prospective, randomized, double-blind, parallel-group, placebo-controlled study is to determine the effectiveness of intranasal oxytocin in subjects suffering from chronic daily headache.
- Trial name
- NCT00963040
- Testing
- Syntocinon, Sterile water
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- MedVadis Research Corporation
Healthy Volunteer Study
Dose Ranging Study of Intravenous Oxytocin for Analgesia to Heat Pain
This is a study of participants that will receive intravenous (IV) infusions of oxytocin (naturally occurring hormone that is made by the brain). In this study healthy participants will be recruited for the study.
- Trial name
- NCT05179421
- Testing
- Low dose oxytocin, High dose oxytocin
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Social Phobia
Social Safety Learning in the Brain Oxytocin System
The investigators are conducting this research study to examine whether oxytocin enhances social safety learning (learning safety through the experience of another individual) in people with social anxiety disorder (SAD) compared…
- Trial name
- NCT05968651
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Washington
Postoperative Pain
Efficacy of Intrathecal Oxytocin to Speed Recovery After Hip Surgery
The purpose of this study is to determine the effect of intrathecal oxytocin on speed of reduction in pain for the first 60 days after hip surgery.
- Trial name
- NCT03011307
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Wake Forest University Health Sciences
Osteoarthritis, Knee, Healthy
Generate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects
This is a study of participants that will receive an intravenous (IV) infusion of oxytocin (naturally occurring hormone that is made in the brain).
- Trial name
- NCT04431206
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Stimulant Use & Co-occuring Opioid Use Disorders
Stimulant Oxytocin Study
This study will investigate the effects of intranasal administration of oxytocin, a social neuropeptide, on reducing stimulant use, enhancing therapeutic engagement, and susceptibility to stress-induced relapse in Veterans with…
- Trial name
- SOS (NCT03016598)
- Testing
- Intranasal oxytocin
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Mood Disorder, Disruptive Behavior Disorders
Oxytocin on Irritability/Emotional Dysregulation of Disruptive Behavior and Mood Disorders
Irritability and emotional dysregulation are recognized as serious aspects of psychopathology seen in in pediatric psychiatric patients.
- Trial name
- NCT02824627
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Nebraska
Autism Spectrum Disorders
Study of Oxytocin in Autism to Improve Reciprocal Social Behaviors
The purpose of this research study is to learn about the effects of supplemental intranasal oxytocin as a treatment for improving social difficulties in children and adolescents with autism.
- Trial name
- SOARS-B (NCT01944046)
- Testing
- double Blind Oxytocin Nasal Spray, Open Label intranasal oxytocin
- Where
- 7 sites in United States
- Volunteers
- 290 people
- Sponsor
- Linmarie Sikich
Anxiety Disorders
Oxytocin Add-on Study for Stable Anxiety Patients
The objective of the study is to compare the efficacy of intranasal oxytocin versus intranasal placebo to improve anxiety symptoms in patients with a variety of anxiety disorders.
- Trial name
- NCT00989937
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of California, San Diego
Maternal Behavior
Intranasal Oxytocin and Maternal Neglect
The investigators plan to conduct functional MRI scanning with a group of mothers who are blindly and randomly assigned either intranasal oxytocin or a placebo.
- Trial name
- OT-MOM (NCT02737436)
- Testing
- Intranasal Oxytocin, Functional MRI scanning
- Where
- 2 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Schizophrenia
Oxytocin Add on Study for Stable Schizophrenic Patients
The objective of the study is to compare the efficacy of intranasal oxytocin versus intranasal placebo to improve symptoms in schizophrenia patients who have residual symptoms despite being on adequate treatment with…
- Trial name
- Oxytocin (NCT00506909)
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- David Feifel
Premature Rupture of Membranes
FOLCROM Trial: Foley Catheter in Rupture of Membranes
Multicenter randomized clinical trial comparing oxytocin versus oxytocin and foley catheter for induction in women who present with premature rupture of membranes who are not in labor.
- Trial name
- FOLCROM (NCT01973036)
- Testing
- Foley Catheter, Oxytocin
- Where
- 5 sites in United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic