Clinical trials: PCO
Polycystic Ovary Syndrome, Anovulation
The Effect of Metformin Added to Clomiphene Citrate on Pregnancy Rates in Hyperandrogenic, Chronic Oligoovulatory or Anovulatory Women
The purpose of our study was to conduct a placebo controlled, double-blind randomized trial in chronic oligoovulatory or anovulatory , hyperandrogenic, infertility patients comparing the effects of adjuvant metformin plus…
- Conditions
- Polycystic Ovary Syndrome, Anovulation, Oligoovulation, Infertility
- Trial name
- NCT00413179
- Testing
- Metformin, Clomiphene citrate
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Polycystic Ovary Syndrome, Obesity
Two Different Dietary Interventions for Girls With Polycystic Ovary Syndrome
This study was conducted to evaluate the efficacy of the MEtabolic Syndrome REduction in NAvarra (RESMENA) diet versus a control diet based on American Heart Association (AHA) recommendations for the treatment of PCOS in…
- Conditions
- Polycystic Ovary Syndrome, Obesity, Androgen; Hypersecretion, Diet, Healthy
- Trial name
- NCT05768724
- Testing
- intervention diet, control diet
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gazi University
Posterior Capsule Opacification
Novel Technique of Pneumatic Posterior Capsulorhexis for Treatment and Prevention of Posterior Capsular Opacification
ABSTRACT PURPOSE: To evaluate a new technique of posterior capsulorhexis using air support to treat primary posterior capsular opacification (PCO) during cataract extraction surgery or to prevent post-operative PCO.
- Trial name
- PCO (NCT04007965)
- Testing
- Pneumatic Posterior Capsulorhexis
- Where
- Saudi Arabia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Minia University
Polycystic Ovary Syndrome
Gut Microbiome in Patients With Polycystic Ovary Syndrome
The polycystic ovary syndrome is intimately associated with body weight and nutrition.The genomic era did not bring a breakthrough to the understanding of the syndrome.
- Trial name
- NCT02078505
- Testing
- diet
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Anovulation, Polycystic Ovary Syndrome
Letrozole Versus Clomiphene Citrate for Ovulation Induction in Women With Poly Cystic Ovary Syndrome ( PCOS )
110 infertile women diagnosed as polycystic ovary syndrome (PCOS) at the age group of 20-35 distributed randomly : 55 women will receive letrozole 2.5mg twice daily orally from the 2nd day to the 6thday of the cycle for three…
- Trial name
- LVCCFOROI (NCT02551367)
- Testing
- Letrozole, Clomiphene citrate, hcg hormone
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- mostafa gomaa hamid halawa
Polycystic Ovary Syndrome
Use of Osteopathic Principles for Nonpharmacologic, Therapeutic Interventions in Women With Polycystic Ovary Syndrome
The overall goals of this project are to assess the efficacy of non-pharmacological, complementary therapies to improve outcomes in the treatment of women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT03383484
- Testing
- OMT, Yoga
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Diana Speelman, Ph.D.
Polycystic Ovary Syndrome, Obesity
Time Restricted Eating for the Treatment of PCOS
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility among young women. This syndrome is a reproductive and endocrinological disorder that affects up to 18% of reproductive-aged women.
- Conditions
- Polycystic Ovary Syndrome, Obesity, Overweight
- Trial name
- NCT05629858
- Testing
- 6-h Time restricted eating (TRE), Calorie restriction (CR), Control
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Polycystic Ovary Syndrome
PCOSMIC Trial - PolyCystic Ovary Syndrome, Metformin for Infertility With Clomiphene
1. Metformin increases the pregnancy rate when added to the standard treatment of anovulatory polycystic ovary syndrome (PCOS). 2.
- Trial name
- PCOSMIC (NCT00795808)
- Testing
- Metformin, Metformin + Clomiphene, Clomiphene
- Where
- New Zealand
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Polycystic Ovary Syndrome, Hirsutism
Combination Therapy With Myo-inositol and Folic Acid Versus Myo-inositol Alone
Previous studies have demonstrated that Myo-inositol is capable of restoring spontaneous ovarian activity, and consequently fertility, in most patients with PCOS.
- Conditions
- Polycystic Ovary Syndrome, Hirsutism, Menstrual Irregularity
- Trial name
- NCT01555190
- Testing
- myo-inositol 1500 gr, myo-inositol 2000 gr + folic acid 200 mcg
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Polycystic Ovary Syndrome
Role of Insulin Action and Free Fatty Acids in Hyperandrogenism of Women With Polycystic Ovary Syndrome
The investigators hypothesis is that free fatty acids (FFA) accumulation in non fatty tissues would lead to insulin resistance and hyperandrogenism in PCOS women.
- Trial name
- NCT01019356
- Testing
- Rosiglitazone, Acarbose
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Jean-Patrice Baillargeon
Polycystic Ovarian Syndrome, Ovarian Hyperstimulation Syndrome
Ovarian Hyperstimulation Syndrome and Cabergoline
Cabergoline prevents ovarian hyperstimulation syndrome in high risk patients by disrupting follicular fluid hormone microenvironmentally altering the follicular fluid levels of insulin like growth hormone -I (IGF-I)…
- Trial name
- NCT01569256
- Testing
- Cabergoline
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanim Womens' Health and Teaching Hospital
Induction of Ovulation, PCO - Polycystic Ovaries
Sodium-Glucose Co-Transporter-2 Inhibitors as Adjuvant Therapy With Letrozole in Induction of Ovulation in Women With Polycystic Ovarian Syndrome
The aim of the study is to assess the efficacy of adjuvant therapy dapagliflozin, metformin as monotherapy and combination of both in comparison to control group in induction of ovulation with letrozole in women PCOS, focusing…
- Trial name
- SGLT-2/PCOS (NCT07589075)
- Testing
- Metformin 1000 mg Oral Tablet, Dapagliflozin 10 MG Oral Tablet [Farxiga], Combined Dapagliflozin-Metformin 5/1000mg
- Where
- Egypt
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Polycystic Ovary Syndrome
Markers and Calculation of Cardiovascular Risk in the Distinct Phenotypes of Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder and cause of anovulatory infertility among reproductive aged women.
- Trial name
- NCT01392781
- Where
- Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Infertility
Dosage Optimization for Letrozole Treatment
In a prospective interventional study, 44 Clomiphene resistant infertile patients were selected from Abolfazl Infertility Clinic of Bushehr University of Medical Sciences.
- Trial name
- NCT01315912
- Testing
- Letrozole
- Where
- Iran
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Bushehr University of Medical Science
PCOS
A Clinical and Biological Research of Combined Chinese and Western Medicine in the Treatment of PCOS
This study evaluates the effects and biological mechanisms of Dingkundan，Diane-35 and the combination of Dingkundan and Diane-35 in the treatment of polycystic syndrome(PCOS) in adults women.
- Trial name
- NCT03264638
- Testing
- Dingkundan, Dingkundan & Diane-35, Diane-35
- Where
- China
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Aijun Sun
Polycystic Ovary Syndrome
Serum Preptin and Amylin Levels in Polycystic Ovary Syndrome Patients
Preptin and amylin are pancreatic hormones which participate in glucose homeostasis. This study aims to evaluate how serum preptin and amylin levels are altered in polycystic ovary syndrome (PCOS) patients and healthy women based…
- Trial name
- NCT03587415
- Testing
- preptin and amylin level
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Ovarian Hyperstimulation Syndrome
Co-administration of Low Dose hCG at the Time of GnRH Agonist Trigger or 35 Hours Later for the Prevention of OHSS
This a prospective randomized double blind study involving patients at high risk of OHSS development with peak serum E2 levels < 4,000 pg/ml comparing the ongoing pregnancy rates in patients who receive adjuvant hCG 1,000 IU at…
- Trial name
- NCT01815138
- Testing
- hCG
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- UConn Health
PCOS, Hyperandrogenism
Ultrasound Three-dimensional Characterization of Ovarian Morphology in Women With Polycystic Ovary Syndrome (PCOS)
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders occurring in women of reproductive age. PCOS is considered a syndrome of ovarian dysfunction that is characterized by the heterogeneous clinical…
- Trial name
- NCT02402413
- Testing
- Ultrasound, Determination of concentrations of androgens, Three dimensional ultrasound probe
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Infertility
Influence of a Prematuration Culture With a Phosphodiesterase-3 Inhibitor (PDE3-I) on Embryonic Aneuploidy Rate and Developmental Potential
A single centre randomised controlled trial investigating the influence of a novel prematuration system (PMS) using a phosphodiesterase-3 inhibitor for in-vitro maturation of oocytes - pilot study.
- Trial name
- NCT00822874
- Testing
- prematuration culture
- Where
- Belgium
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Polycystic Ovary Syndrome
Women With Polycystic Ovary Syndrome Have Increased Plasma Chitotriosidase Activity
In the present study, serum chitotriosidase activity and its relationship with insulin resistance were determined in patients with Polycystic Ovary Syndrome (PCOS).
- Trial name
- NCT01382576
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine