Clinical trials: PCO
Polycystic Ovary Syndrome, Diminished Ovarian Reserve
Clinical Trial of Anovulatory Infertility
This project aims to study the expression of clock genes and related proteins in follicular fluid and granulosa cells, depicting the periodic, amplitude, and phase changes of biological clock genes and related proteins in women…
- Conditions
- Polycystic Ovary Syndrome, Diminished Ovarian Reserve, Ovulation Disorder
- Trial name
- NCT06601452
- Testing
- a compound prescription of Chinese medicine
- Where
- China
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Nanjing University of Chinese Medicine
Polycystic Ovary Syndrome
A Multi-omic Approach to Evaluate and Characterize the Polycystic Ovary Syndrome (PCOS) Phenotype
The purpose of this research study is to explore the relationship between the gut microbiome and hormone levels in women diagnosed with PCOS and determine whether there are differences in the gut microbiome between women with…
- Trial name
- NCT04981275
- Testing
- No intervention study
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Onegevity Health
Polycystic Ovary Syndrome
Polycystic Ovary Syndrome (PCOS) - Effect Of Physical Exercise And Electroacupuncture
Hypothesis: The overall hypothesis is that women with PCOS, both obese and non-obese, have larger adipocytes, altered metabolism and signs of inflammation in adipose tissue and that these changes are associated with high…
- Trial name
- PCOSNTS (NCT00484705)
- Testing
- Electroacupuncture, Physical exercise, Untreated control
- Where
- Sweden
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Hyperandrogenemia, Polycystic Ovary Syndrome
Assessment of Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone Inhibition
Gonadotropin-releasing hormone (GnRH) is a hormone that regulates the ability of the pituitary to secrete two hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
- Trial name
- JCM026 (NCT01428245)
- Testing
- Progesterone, Estrace (estrogen)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Female Infertility Due to Nonimplantation of Ovum
Letrozole and Sequential Clomiphene to Improve the Outcome of Embryo Transfer
The purpose of this study is to study the effects of letrozole and sequential clomiphene in ovulation and pregnancy in PCOS patients.
- Trial name
- NCT02775877
- Testing
- Letrozole, clomiphene, HMG
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Navy General Hospital, Beijing
Polycystic Ovary Syndrome, Ovulation Disorder
Clusterin Level and Polycystic Ovary Syndrome
Clusterin, a protein involved in metabolic syndrome, insulin resistance, and metabolic disorders associated with inflammation and oxidative stress such as atherosclerosis, Alzheimer's and some malignancies, has elevated levels in…
- Trial name
- NCT06601725
- Testing
- Clusterin level
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
PCOS
Theca Cell Function in Adolescents With Polycystic Ovary Syndrome (PCOS)
In women with polycystic ovary syndrome (PCOS), the cardinal physiological abnormality is excessive ovarian androgen production marked by increased serum testosterone (T) and androstenedione (A) levels.
- Trial name
- NCT01154192
- Testing
- Dexamethasone, recombinant human chorionic gonadotropin (r-hCG)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obesity, Polycystic Ovary Syndrome
Effect of Diet Plus Sibutramine on Hormonal and Metabolic Features in Overweight and Obese Women With PCOS
Studies on the effect of sibutramine, an anti-obesity drug, on hormonal and metabolic features of women with polycystic ovary syndrome (PCOS) are lacking.
- Trial name
- NCT00463112
- Testing
- Sibutramine
- Where
- Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hippocration General Hospital
Poly Cystic Ovary Syndrome
Inspiratory Muscle Training for the Management of Polyendocrine Metabolic Ovarian Syndrome
Inspiratory muscle training (IMT) is a relatively simple and accessible form of exercise that specifically targets the respiratory muscles and has been reported to improve inspiratory muscle strength, respiratory efficiency…
- Trial name
- NCT07871175
- Testing
- Exercise
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Polycystic Ovary Syndrome
AMH for the Identification of PCOM in PCOS Diagnosis
The purpose of this study is to validate the anti-müllerian hormone (AMH) cut-off established and validated in the APHRODITE study, for the determination of PCOM as part of the diagnosis of PCOS, using the Elecsys AMH Plus…
- Trial name
- HARMONIA (NCT05527353)
- Where
- Finland
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Voice Change
Voice Analysis in Women With Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to one in five reproductive-aged women. It is associated with clinical and/or biochemical hyperandrogenism, oligomenorrhea, and polycystic appearance of…
- Trial name
- NCT06085170
- Testing
- Acoustic Analysis by MDVP
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Minia University
Polycystic Ovary Syndrome
L-Carnitine and Clomiphene Citrate for Induction of Ovulation in Women With Polycystic Ovary Syndrome
The purpose of the study to assess the efficacy of adding L-carnitine to clomiphene citrate for increasing the ovulation and the pregnancy rate in women with PCOS.
- Trial name
- NCT03476356
- Testing
- oral clomiphene citrate, oral carnitine supplementation
- Where
- Egypt
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
PCOS- Polycystic Ovary Syndrome
The Synbiotics Effects in Polycystic Ovary Syndrome: A Randomized Controlled Trial
The goal of this clinical trial is to compare the effect of synbiotics and placebo in Thai women with polycystic ovary syndrome.
- Trial name
- PCOS (NCT06169566)
- Testing
- synbiotics
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maharaj Nakorn Chiang Mai Hospital
Polycystic Ovary Syndrome
Role of Insulin Action and Free Fatty Acids in Hyperandrogenism of Women With Polycystic Ovary Syndrome
The investigators hypothesis is that free fatty acids (FFA) accumulation in non fatty tissues would lead to insulin resistance and hyperandrogenism in PCOS women.
- Trial name
- NCT01019356
- Testing
- Rosiglitazone, Acarbose
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Jean-Patrice Baillargeon
Polycystic Ovary Syndrome
Metabolic Disturbances in Polycystic Ovary Syndrome (PCOS)
The scope of the study was to investigate different metabolic aspects that may lead to or are a consequence of insulin resistance in premenopausal women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT00606671
- Where
- Denmark
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Insulin Sensitivity
Insulin Sensitivity and Testosterone Response to Aerobic Exercise Versus Added Sugar Elimination in Polycystic Ovary Syndrome Women
the aim of this study is to investigate the effect of aerobic exercise versus the effect of added sugar elimination on the insulin sensitivity and testosterone levels in females with polycystic ovarian syndrome via measuring the…
- Trial name
- NCT07139275
- Testing
- aerobic exercise, added sugar elimination, aerobic exercise and added sugar elimination
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Polycystic Ovary Syndrome
The Secretion of Incretin Hormones in Patients With Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is an endocrine disease in reproductive women. It is characterized by anovulation and hyperandrogenism.
- Trial name
- NCT02126592
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Polycystic Ovary Syndrome (PCOS)
Body Fat Distribution and Its Associated Factors in Chinese Women With Polycystic Ovary Syndrome
To investigate the body fat distribution in chinese women with polycystic ovary syndrome (PCOS) and the association of those distribution with metabolic parameters, microeconomics, hormone profiles and psychological state.
- Trial name
- NCT04264832
- Testing
- Clinical data collection
- Where
- China
- Volunteers
- 733 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Polycystic Ovary Syndrome
Adipose Tissue Gene Expression Profiles in Women With Polycystic Ovary Syndrome (PCOS) Versus Controls
Adipose tissue is a central organ in mediating metabolic health. There is some evidence that women with polycystic ovary syndrome (PCOS) have a degree of adipose tissue dysfunction which may negatively affect their metabolic…
- Trial name
- NCT01195142
- Where
- 2 sites in Ireland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Adelaide and Meath Hospital
Type 1 Diabetes Mellitus, Polycystic Ovary Syndrome (PCOS)
Polycystic Ovary Syndrome in Type 1 Diabetes
BACKGROUND Functional ovarian hyperandrogenism, including the polycystic ovary syndrome (PCOS), is very prevalent in women with type 1 diabetes (T1D). The pathogenic mechanisms of this association remain unclear.
- Trial name
- NCT07490964
- Testing
- Type 1 diabetes mellitus, Elevated circulating androgen levels, Sex dimorphism
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal