Clinical trials: PDD
Neurodevelopmental Disorders, Autism Spectrum Disorder
Early Recognition and Intervention in Siblings at High-risk for Neurodevelopmental Disorder
H1The primary goal of this intervention study is to learn if very early parent-mediated intervention in children at risk for neurodevelopmental disorders in the first year of life can be implemented in routine care, positively…
- Trial name
- ERI-SIBS (NCT06512649)
- Testing
- Early intervention, Active monitoring
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Metastatic Breast Cancer
Vinorelbine/Gemcitabine Versus Vinorelbine/Cisplatin in Metastatic Breast Cancer
Development of an active second-line treatment option for metastatic breast cancer patients previously pre-treated with anthracyclines and taxanes in neoadjuvant, adjuvant or palliative settings.For each randomisation arm, 100…
- Trial name
- NCT02544243
- Testing
- Vinorelbine, Gemcitabine, Cisplatin
- Volunteers
- 200 people
- Sponsor
- Shandong Cancer Hospital and Institute
Autism Spectrum Disorder, Asperger Disorder
Understanding the Effects of Intervention on the Brain in Autism
This study examines how the PEERS (Laugeson \& Frankel, 2010; Laugeson, 2016) social-behavioral intervention affects social relationships and brain development and function in autistic preschoolers, adolescents, and young adults.
- Conditions
- Autism Spectrum Disorder, Asperger Disorder, PDD-NOS, Autism
- Trial name
- NCT02680015
- Testing
- PEERS
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Marquette University
Autism Spectrum Disorder, Autism
Effectiveness of a Developmental Reciprocity Treatment Program in Autism
This is a research study examining the effectiveness of a Developmental Reciprocity Treatment Program (DRT-P) in treating social deficits in children with Autism Spectrum Disorders (ASD).
- Trial name
- DRTP (NCT03131635)
- Testing
- Developmental Reciprocity Treatment Program (DRT-P)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Stanford University
Autism
Learning Enhancement Through Neurostimulation in Autism
This study will examine whether brain stimulation paired with social skills learning can help teenage boys with autism learn how to make and keep friends. Brain stimulation can enhance learning in some people.
- Trial name
- LENS (NCT02998684)
- Testing
- Active Transcranial Direct Current Stimulation, PEERS Social Skills Training
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Autism Spectrum Disorder
Acceptability and Efficacy of a Culturally Adapted, Low-Frequency Parent-Mediated Early Start Denver Model (ESDM) Versus Standard Care in Young Children With Autism
Early intervention is effective in improving developmental outcomes of children on the autism spectrum. However, cultural and contextual factors may influence parental acceptability of treatment models, highlighting a need for…
- Trial name
- NCT07840586
- Testing
- Early Start Denver Model
- Where
- Singapore
- Volunteers
- 58 people
- Sponsor
- National University Hospital, Singapore
Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
Radiation Therapy and Cisplatin With or Without Cetuximab in Treating Patients With HPV Positive, KRAS-Variant Stage III-IV Oropharyngeal Squamous Cell Carcinoma
This phase II trial studies how well radiation therapy and cisplatin with or without cetuximab works in treating patients with human papillomavirus (HPV) positive, KRAS-variant stage III-IV oropharyngeal squamous cell carcinoma.
- Conditions
- Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, KRAS Protein Variant, Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
- Trial name
- NCT04106362
- Testing
- Cetuximab, Cisplatin, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Advanced Cancer
Cisplatin HAI Study in Patients With Advanced Cancer and Dominant Liver Involvement
The goal of this clinical research study is find the highest safe dose of cisplatin that can be given with liposomal doxorubicin in the treatment of advanced cancer involving the liver.
- Trial name
- NCT00507962
- Testing
- Cisplatin, Liposomal Doxorubicin
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- M.D. Anderson Cancer Center
Autism Spectrum Disorder, Intellectual Disability
Transcranial Magnetic Stimulation Studies in Autism Spectrum Disorders
Autism Spectrum Disorder (ASD) is the most prevalent of the developmental disorders and their incidence is rising. However, the variability in the behavioral symptoms is large.
- Trial name
- NCT02591446
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Cervical Cancer
S9717 Tirapazamine Plus Cisplatin in Treating Patients With Metastatic, Recurrent, or Refractory Cervical Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003369
- Testing
- cisplatin, tirapazamine
- Where
- 85 sites in United States
- Volunteers
- 56 people
- Sponsor
- SWOG Cancer Research Network
Autism Spectrum Disorder
Electrical Brain Stimulation and Pharmacological Treatments in Autism Spectrum Disorder
This project aims to comparing the effectiveness of transcranial direct current stimulation with common pharmacological treatments on behavioral problems and cognitive deficits of children with autism spectrum disorder
- Trial name
- NCT05491720
- Testing
- RisperiDONE 1 MG/ML, transcranial direct current stimulation
- Where
- Iran
- Volunteers
- 45 people
- Sponsor
- The National Brain Mapping Laboratory (NBML)
Melanoma
Rh-endostatin in Combination With Dacarbazine and Cisplatin as the First Line Therapy for Metastatic Melanoma
The incidence of Melanoma is rapidly growthing,and in China,dacarbazine combined with cisplatin is conmendly used as the first-line chemotherapy of metastatic melanoma.
- Trial name
- NCT03095079
- Testing
- recombinant human endostatin
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University Cancer Hospital & Institute
Autism, Major Depressive Disorder (MDD)
Investigating the Brain's Physiological Responses in Depression and Autism, Using Transcranial Magnetic Stimulation and Electroencephalography
The goal of this observational study is to investigate the brain physiological responses in depression and autism. The main questions aim to answer are: 1.
- Trial name
- NCT06821646
- Testing
- Positron Emission Tomography (PET), transcranial magnetic stimulation and electroencephalography(TMS-EEG)
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Autism Spectrum Disorder
CPI Training for Parents of Children With ASD
The purpose of this 24-week study is to determine whether the "Parent-based Crisis Prevention Institute (CPI) physical management training program" (i.e., P-CPI) is effective in increasing self-efficacy in parents of children…
- Trial name
- NCT03537261
- Testing
- Parent-based Crisis Prevention Institute (CPI) physical management training program (P-CPI)
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Lung Cancer
Vinorelbine + Cisplatin or No Further Therapy in Non-small Cell Lung Cancer That Has Been Surgically Removed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known if combination chemotherapy is more effective than no further treatment for non-small…
- Trial name
- NCT00002583
- Testing
- cisplatin, vinorelbine ditartrate
- Where
- 155 sites in United States, Canada
- Volunteers
- 482 people
- Sponsor
- NCIC Clinical Trials Group
Emotion Regulation, Autism Spectrum Disorder
Equine-assisted Therapy for Therapy-resistant Adolescents With Autism Spectrum Disorders, a Replicated AB-design
The purpose of this study is to assess the (cost)effectivity of Equine assisted Therapy in adolescents with Autism Spectrum disorders.
- Conditions
- Emotion Regulation, Autism Spectrum Disorder, Adolescent - Emotional Problem
- Trial name
- NCT05200351
- Testing
- Equine assisted Therapy (EAT)
- Where
- 3 sites in Netherlands
- Volunteers
- 35 people
- Sponsor
- Karakter Kinder- en Jeugdpsychiatrie
Autism Spectrum Disorder
Medial Prefrontal Cortex Brain Magnetic Stimulation in Autism
Despite decades of research, no definitive, effective biological treatments exist for core symptoms of Autism Spectrum Disorder (ASD).
- Trial name
- NCT07770451
- Testing
- TMS
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Autism Spectrum Disorders
Intranasal Oxytocin and Learning in Autism
: The objective of this study is to determine the tolerability and therapeutic potential of oxytocin in children and adolescents with Autism Spectrum Disorders (ASD) when paired with a computer game intervention that is designed…
- Trial name
- NCT02090829
- Testing
- Syntocinon (synthetic oxytocin)
- Where
- United States
- Sponsor
- University of Minnesota
Non-small Cell Lung Cancer
Neoadjuvant Furmonertinib and Cisplatin/Pemetrexed as in EGFR Mutated Stage IIA-IIIB Resectable NSCLC (FORESEE)
In this single-arm, phase II clinical trial, patients with resectable, EGFR-mutated, stage II-IIIB NSCLC received neoadjuvant therapy with furmonertinib (oral, 80 mg once daily, stopped 1 week preoperatively) in combination with…
- Trial name
- NCT05430802
- Testing
- Furmonertinib+cisplating/pemetrexed
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Tang-Du Hospital
Colorectal Cancer, Photodynamic Diagnosis
The Correlation of Surgical Colorectal Cancer Specimen Pathology With the Fluorescence of Photodynamic Diagnostics
This will be a pilot study involving 5 patients diagnosed with colorectal carcinoma and treated with pre-operative chemotherapy and external beam radiation therapy at the Jewish General Hospital, whom will very soon undergo…
- Trial name
- PDD (NCT03272659)
- Testing
- Cysview
- Sponsor
- Dr. Te Vuong