Clinical trials: PEEP, Intrinsic
Ventilation Therapy, PEEP, Occult
PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest
Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge.
- Conditions
- Ventilation Therapy, PEEP, Occult, CPR, Cardiac Arrest (CA)
- Trial name
- PerAVent (NCT06836830)
- Testing
- PEEP 5 mbar, ZEEP 0 mbar
- Where
- 3 sites in Germany
- Volunteers
- 600 people
- Sponsor
- Muehlenkreiskliniken, MKK
Ventilated Patient in Intensive Care, Management of the Expiratory End-expiratory Pressure (PEEP) and Body Position
Effect of PEEP and Trendelenburg on Ultrasound Size of Internal Jugular and Subclavian Veins
There is no recommendation for the management of the positive end-expiratory pressure (PEEP) during setting of a central venous catheter (CVC) in a ventilated patient.
- Trial name
- PEEPUS (NCT02569424)
- Testing
- Patient's position
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Obstructive Pulmonary Disease
The Relationship Between the Neural Drive and Intrinsic Positive End-expiratory Pressure
To investigate the relation the nreural drive and intrinsic positive end-expiratory pressure(PEEPi) of the chronic obstructive pulmonary disease(COPD) patients with respiratory failure.In present study the PEEPi of COPD patients…
- Trial name
- NCT04840628
- Testing
- Resistance of the respiratory system
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
COPD (Chronic Obstructive Pulmonary Disease)
End-Inspiratory Pause in COPD Patients During Controlled Ventilation
In patients with airflow obstruction receiving mechanical ventilation, an important objective is to reduce lung hyperinflation often using controlled hypoventilation.
- Trial name
- PYE (NCT07207967)
- Testing
- END INSPIRATORY PAUSE DURING CONTROLLED VENTILATION, NO PAUSE VENTILATION
- Where
- Argentina
- Volunteers
- 14 people
- Sponsor
- Sanatorio Anchorena San Martin
Speckle Tracking, Diaphragm
End-Expiratory Diaphragmatic Residual Contraction Index for Identifying Intrinsic PEEP and Assisting PEEP Titration: A Prospective Physiological Study
This study proposes the End-expiratory Diaphragmatic Residual Contraction (EDRC) index to quantify residual diaphragmatic activity at end-expiration during Pressure Support Ventilation (PSV) mode.
- Trial name
- NCT07697703
- Testing
- Short-term PEEP Step Trial and EDRC Ultrasound Assessment
- Volunteers
- 100 people
- Sponsor
- Sir Run Run Shaw Hospital
Intensive Care Ventilation
Pressure Support Ventilation With the Anesthetic Conserving Device
Sevoflurane inhalational anesthetic has got pulmonary effects such as bronchodilatation. These effects could be of interest in intensive care patients ventilated in pressure support ventilation mode.
- Trial name
- NCT01017744
- Testing
- Anesthetic Conserving Device
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Clermont-Ferrand
PEEP, Occult
Evaluation of AI Models in Determining the Optimal PEEP
his study is designed as a prospective observational clinical trial. Patients over 18 years old who are hemodynamically stable and require mechanical ventilation in the Intensive Care Unit (ICU) will be included.
- Trial name
- NCT06844916
- Testing
- AI-Assisted PEEP Optimization
- Where
- Turkey (Türkiye)
- Volunteers
- 145 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
PEEP, Intrinsic, PEEP, Occult
A New Method for Estimating Dynamic Intrinsic PEEP
Dinamic intrinsic PEEP is
- Conditions
- PEEP, Intrinsic, PEEP, Occult, Respiratory Insufficiency
- Trial name
- echoPEEPi (NCT02388282)
- Testing
- diaphragm ecography
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Obstructive Sleep Apnea, Adverse Effects
Comparison of Nasal Positive End Expiratory Pressure Valve to Dental Device as an Alternative Treatment for Obstructive Sleep Apnea
Determine the clinical efficacy in terms of Apnea Hypopnea Index (AHI), excessive daytime sleepiness (EDS), nocturnal oxygenation of a nasal Positive end-expiratory pressure (PEEP) valve "Provent" in obstructive sleep apnea.
- Trial name
- NCT01553383
- Testing
- nasal peep valve "Provent"
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Acute Respiratory Distress Syndrome
Estimation of Intrinsic Positive End-Expiratory Pressure (PEEP) in Acute Respiratory Distress Syndrome (ARDS)
ARDS (Acute Respiratory Distress Syndrome) is a condition of severe inflammation and excess fluids in the lungs that impairs their function of oxygen uptake to the point of needing a ventilator (breathing machine) to help them…
- Trial name
- NCT00446706
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Severe Bronchiolitis
Prone Position Effects on Work of Breathing and Intrinsic PEEP in Children With Severe Acute Viral Bronchiolitis
Acute viral bronchiolitis is the first cause of respiratory distress in infant. Airway inflammation increases the respiratory system resistances and dynamic hyperinflation. This leads to an increase in the work of breathing.
- Trial name
- BRONCHIO-DV (NCT02602678)
- Testing
- Supine then Prone position, Prone then supine position
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Hospices Civils de Lyon
Obesity, Pulmonary Atelectasis
Effects of PEEP on Heart and Lungs in Obese Subjects
Aim of this study is to better understand pathophysiology of the alteration of respiratory mechanics and cardiovascular function in obese volunteer subjects.
- Conditions
- Obesity, Pulmonary Atelectasis, Obesity Hypoventilation Syndrome, Magnetic Resonance Imaging
- Trial name
- NCT02523352
- Testing
- Non-Invasive Ventilation, Esophageal catheter positioning
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Obstructive Airway Diseases
Physiological Effects of External PEEP in Controlled Mechanical Ventiated Patients With autoPEEP
This experimental physiologic study is conducted to determine the effect of different mechanical ventilation settings (in terms of positive end-expiratory pressure) on patients receiving mechanical ventilation with expiratory…
- Trial name
- NCT07611409
- Testing
- PEEP titration
- Where
- Argentina
- Volunteers
- 20 people
- Sponsor
- Hospital Donación Francisco Santojanni
Chronic Obstructive Pulmonary Disease
Closed Loop Ventilation With High Tidal Volumes and Safe Transpulmonary Pressure in COPD (COPD-SAFE)
This study evaluates the safety and efficacy of high tidal volumes generated by "Adapted Support Ventilation (ASV) mode' in mechanically ventilated severe COPD patients.
- Trial name
- COPD-SAFE (NCT04089111)
- Testing
- Minute volume target of 100%, Minute volume target to reach PaCO2 less than 45% (high tidal volume)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Intracranial Hypertension, Critical Illness
Mechanical Ventilation in Severe Brain Injury: The Effect of Positive End Expiratory Pressure on Intracranial Pressure
The purpose of this study is to collect physiologic data from patients with severe brain injury who require mechanical ventilation in order to describe the impact of ventilation, specifically positive end expiratory pressure…
- Conditions
- Intracranial Hypertension, Critical Illness, Brain Injuries, Lung Injury
- Trial name
- NCT02680704
- Testing
- PEEP titrated mechanical ventilation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Obstructive Pulmonary Disease
Intrinsic PEEP and Laryngeal Aperture in COPD
In this study the investigators aim to investigate the extent to which in patients with chronic obstructive pulmonary disease narrowing of the vocal cords causes a positive pressure within the airways thus improving airflow and…
- Trial name
- NCT02437630
- Testing
- Oesophageal balloon to measure intra-thoracic pressure, Fibre-optic laryngoscopy, standard lung function tests
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Pulmonary Disease (COPD), Chronic Obstructive, Lung Resection Surgery
Effect of Individualized Positive End-expiratory Pressure (PEEP) in Patients Who Have an Intrinsic PEEP During One-lung Ventilation
This study investigates the effects of three extrinsic PEEP settings-5 cmH2O, 0 cmH2O, and an individualized PEEP (70% of the measured intrinsic PEEP)-on intrinsic PEEP and hemodynamic stability in patients with intrinsic PEEP…
- Trial name
- NCT07638176
- Testing
- PEEP0, PEEP5, PEEPi
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Samsung Medical Center
General Anesthesia, Laparoscopic Cholecystectomy
Intrinsic PEEP During Mechanical Ventilation of Patients With Obesity
It is demonstrated that expiratory flow limitation and as a consequence, intrinsic positive end-expiratory pressure (PEEP) is present in grossly obese subjects especially in the supine position.
- Trial name
- NCT01267916
- Testing
- RR 6 + 0, RR 10 + 0, RR 16 + 0
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul Medical Center
One Lung Ventillation (OLV), Two Lung Ventillation (TLV)
The Use of Constant-flow Technique for Determining the Lower Inflexion Point of Pressure-volume Curve and Intrinsic PEEP During One-lung Ventilation
One method for treating intraoperative hypoxia during one-lung ventilation (OLV) is application of PEEP to the dependent lung. However, only a minority of patients benefit from this maneuver.
- Conditions
- One Lung Ventillation (OLV), Two Lung Ventillation (TLV), Positive End Expiratory Pressure (PEEP), Zero End-expiratory Pressure (ZEEP)
- Trial name
- NCT01532245
- Testing
- two lung ventilation (TLV), one lung ventilation (OLV) without PEEP, One lung ventilation (OLV) with positive end-expiratory pressure (PEEP)
- Sponsor
- The Cleveland Clinic
ARDS, Human, PEEP, Occult
Effect of Initial Empirical PEEP Setting on the Esophageal Pressure-guided PEEP Titration in ARDS
Esophageal manometry was used as surrogate of pleural pressure to titrate positive end-expiratory pressure (PEEP) in ARDS patients. However, Absolute values of esophageal pressure (Pes) could be affected by the PEEP setting.
- Conditions
- ARDS, Human, PEEP, Occult, Esophageal and Pleural Pressure
- Trial name
- NCT05442073
- Testing
- PEEP adjustment
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Peking Union Medical College Hospital