Clinical trials: PERIODONTAL DISEASE
Gingival Recession
Morbidity and Coverage Outcome With Connective Tissue Graft Used With Coronally Advanced Flap and Tunneling Technique
The aim of this randomized-controlled clinical trial is to compare the patient morbidity and root coverage outcomes of a sub-epithelial connective tissue (SeCTG) used in combination with a coronally advanced flap (CAF) and tunnel…
- Trial name
- NCT02269748
- Testing
- Tunnel technique with subepithelial connective tissue, Coronally advanced flap, Analgesic Therapy
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Padova, School of Dental Medicine
Healthy
Clinical Comparision of Three Types of Toothbrushes Pulsar, Crossaction and Butler on Gingivitis and Plaque Removal
Objective: To compare clinical results of three types of manual tooth brushes on gingivitis and plaque removal efficacy. Material and Methods: This study is a single blind randomized trial with crossover design which involved 30…
- Trial name
- NCT02412358
- Testing
- toothbrush
- Where
- Iran
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Bone Atrophy, Alveolar
Comparative Study Between Autogenous Bone Block and Tent Pole Technique for Augmentation of Atrophic Anterior Maxilla
The goal of this clinical trial is to compare in patients with atrophied anterior maxilla, bone augmentation techniques ( gold standard bone block and tent pole technique).
- Trial name
- NCT06125938
- Testing
- tent pole technique, Autogenous bone block technique
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Treatment, Cytokines
Non-surgical Periodontal Treatment and Periostin Levels
Two different studies were planned from the recruited samples. The aim of these studies was to investigate the effect of non-surgical periodontal treatment on the inflammatory markers levels in serum and gingival crevicular fluid…
- Trial name
- NCT05535049
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Gingivitis, Dental Plaque
A Clinical Comparison of an Experimental Power Brush Compared to a Manual Toothbrush
The objective of the study is to evaluate and compare the efficacy of an experimental power brush to a regular manual brush in the reduction of gingivitis and dental plaque over an 8 week period by using the Modified Gingival…
- Trial name
- NCT03624647
- Testing
- Power toothbrush, Manual toothbrush
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Periapical Periodontitis, Root Canal Infection
Antibacterial Efficacy of Bioceramic and Calcium Hydroxide Intracanal Medicaments
This study evaluates the antibacterial effectiveness of two different intracanal medicaments, Bio-C Temp and UltraCal XS , in mandibular molar teeth with chronic apical periodontitis.
- Conditions
- Periapical Periodontitis, Root Canal Infection, Intracanal Medicaments
- Trial name
- NCT07671326
- Testing
- Root canal treatment with Bio-C Temp, a calcium silicate-based bioceramic intracanal medicament, Root canal treatment with UltraCal XS, a calcium hydroxide-based intracanal medicament
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medipol University
Periodontitis, Gingivitis
(NOD)-Like Receptors CARD Domain-Containing 4 Levels in Individuals With Periodontitis
NLRC4, an inflammasome , is a cytosolic multiprotein complex involved in the initiation and modulation of the immune response. Periodontitis is a chronic inflammatory disease that can start with localized inflammatory reactions…
- Conditions
- Periodontitis, Gingivitis, Healthy
- Trial name
- NCT04850768
- Testing
- Saliva, gingival crevicular fluid
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Gingivitis and Periodontal Diseases
Evaluation and Correlation of Serum Fetuin-A Levels in Periodontal Health and Disease: A Clinico-biochemical Study
The present clinico-biochemical study was carried out to estimate the levels of Fetuin A and MMP7 in serum of systemically healthy subjects in periodontal health and disease and to evaluate the impact of periodontal…
- Trial name
- NCT04198610
- Testing
- Non surgical periodontal therapy
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Periodontitis, Periodontal Diseases
Accuracy of an AI-clinical Knowledge-based Hybrid System for Detecting Periodontitis in OPG Images
Periodontitis is highly prevalent and rarely detected and treated in the earlier stages of the disease. Orthopantomography (OPG) is the most frequently taken dental radiograph around the world, and its systematic screening may…
- Trial name
- NCT06306677
- Testing
- AI-clincial-based hybrid system for radiographic image analysis
- Where
- 3 sites in China, Hong Kong and 1 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Chronic Periodontitis
Advantages of Autologous Platelet-Rich Fibrin Membrane on Growth Factor Levels and Periodontal Healing
Platelet rich fibrin is a second generation platelet concentration which contains various growth factors. The aim of this study is to evaluate the clinical and biochemical efficacy of PRF in subjects of chronic periodontitis in…
- Trial name
- NCT02898675
- Testing
- Platelet rich fibrine, Open Flap Debridement
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Nutrition Disorders in Old Age, Caries,Dental
LifE Style, Nutrition and Oral Health in Care Givers (LENTO)
The LENTO study sample includes the caregivers and their clients living in eastern Finland. The aims of this study are 1. to study the nutritional status, oral health, coping, functional capacity and quality of life 2.
- Conditions
- Nutrition Disorders in Old Age, Caries,Dental, Dentures, Oral Mucositis
- Trial name
- NCT04003493
- Testing
- Nutrition and oral health intervention
- Where
- Finland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Periimplantitis, Periodontal Disease
Preventive Maintenance Therapy on Peri-implant Diseases
In the field of periodontics, periodontal support therapy has proven to be essential in preventing the incidence or recurrence of periodontal diseases. The protocol is designed according to the risk profile of a patient.
- Trial name
- PIMT (NCT02789306)
- Testing
- Epidemiological study on the incidence of peri-implantitis
- Where
- Spain
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Center of Implantology, Oral and Maxillofacial Surgery, Badajoz, Spain
Periodontitis, Type 2 Diabetes
Inflammatory Response and Gingival iNOS Levels in Diabetic vs. Non-Diabetic Periodontitis Patients
This study investigates the relationship between Type 2 diabetes mellitus (T2DM), glycemic control, and periodontal disease. Researchers analyzed the levels of inducible nitric oxide synthase (iNOS) and proinflammatory cytokines…
- Conditions
- Periodontitis, Type 2 Diabetes, Glycemic Control
- Trial name
- NCT06803836
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Gingival Recession
Gingival Recession Treatment With Concentrated Growth Factor(CGF)
Platelet concentrates(PC) are used in the field of periodontology and implantology for the content necessary key cells and growth factors to accelerate healing and to provide regeneration.
- Trial name
- NCT03020732
- Testing
- test groups, control groups
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Gazi University
Periodontitis, Hyaluronic Acid
Adjunctive Use Of A Novel Hyaluronic Acid/Chlorhexidine Gel In The Non Surgical Treatment Of Periodontitis
General Objective : To evaluate the outcome of non surgical periodontal therapy with local drug delivery adjunct to scaling and root planning Specific Objective : To determine the effect of intra-pocket application of hyaluronic…
- Conditions
- Periodontitis, Hyaluronic Acid, Chlorhexidine
- Trial name
- NCT05682833
- Testing
- Non surgical periodontal therapy
- Where
- United Arab Emirates
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
Gingival Recession, Lack of Keratinized Gingiva (Disorder)
Progenitor Potential of Mesenchymal Stem Cells in Palatal Tissue Harvested From Molar and Premolar Sites
The primary purpose of this protocol is to isolate, investigate and compare the regenerative and differentiation potential of mesenchymal stem cells (MSC's) in the gingival (gum) tissue harvested from two different locations from…
- Trial name
- NCT03570333
- Testing
- progenitor potential of Gingival Mesenchymal cells
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Chronic Periodontitis
Effect of the Diode Laser on Bacteremia Associated With Periodontal Flap Surgery: A Clinico-Microbiological Study
The objective of the present study is 1. To study the incidence and magnitude of bacteremia after periodontal flap surgery . 2. To compare and evaluate the effect of diode laser on frequency of bacteremia associated with…
- Trial name
- NCT04207034
- Testing
- flap surgery with diode laser, flap surgery
- Where
- India
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Periodontitis
Ozone Application in Periodontal Treatment
This clinical trial aims to evaluate the clinical, biochemical and microbiological efficacy of ozone treatment as an adjunct to nonsurgical periodontal treatment (NSPT) in periodontitis patients.
- Trial name
- NCT05971706
- Testing
- Ozone therapy using a device (Ozone DTA Ozone Generator, Denta Tec Dental AS, Norway), Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Biruni University
Gingivitis
Effectiveness of the Use of Dental Floss
Bacterial plaque-induced gingivitis is considered the most common oral disease in dentate individuals and the most frequent type of periodontal disease.
- Trial name
- NCT04909840
- Testing
- Instructions oral hygiene with toothbrush plus dental floss, Instructions oral hygiene with toothbrush only
- Where
- Brazil
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Maria
Periodontal Diseases, Periodontitis
Interaction Between Immune Cells and Bacteria Associated With Periodontitis
This study evaluates the interaction between host immune cells and bacteria associated with periodontitis. It comprises biological material from donors with and without periodontal disease.
- Conditions
- Periodontal Diseases, Periodontitis, Aggressive Periodontitis, Immunologic Disease
- Trial name
- NCT03225950
- Testing
- In vitro stimulation of blood with periodontitis-associated- and control bacteria, Anti-CCP- and anti-P.g.-antibodies titers, Analysis of selected single nucleotide polymorphisms (SNPs)
- Where
- 2 sites in Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen