Clinical trials: PREG1
GDM, Preterm Preeclampsia
Advancing Stillbirth Prevention Through Innovative Risk Evaluation (ASPIRE) Clinical Study
ASPIRE will be a multi-site, prospective, two-part longitudinal, noninterventional observational cohort study of nulliparous singleton pregnant women to evaluate biomarkers from blood and ocular imaging for prediction of…
- Conditions
- GDM, Preterm Preeclampsia, Preeclampsia, Fetal Growth Restriction (FGR)
- Trial name
- ASPIRE (NCT07669935)
- Testing
- None (this is an observational study with no intervention)
- Where
- 2 sites in United States
- Volunteers
- 5,500 people, healthy volunteers welcome
- Sponsor
- Medicines360
Pre-Eclampsia, Obesity; Endocrine
C1q/TNF-related Protein 9 (CTRP 9) Level in Preeclamptic Obese and Non-obese Pregnancies
The complement C1q tumor necrosis factor-associated protein-9 (CTRP-9), which is responsible for regulating cardiovascular and metabolic functions, increases vascular relaxation by pathway dependent on AMPK / endothelial nitric…
- Trial name
- CTRP (NCT03650790)
- Testing
- Blood test
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Diyarbakir Women's and Children's Diseases Hospital
Pre Eclampsia
Accuracy Assessment of an Automatic Blood Pressure Measurement Device in Adult Volunteers
The research team has developed an automatic blood pressure monitor (Sphygmo) to be used for the monitoring and diagnosis of pre-eclampsia in pregnant women, particularly in low-resource settings where current monitoring is…
- Trial name
- NCT02267577
- Testing
- Sphygmo: Automatic Blood Pressure Monitor, GE Dinamap ProCare Automatic Blood Pressure Monitor
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- William Marsh Rice University
Phthalate Exposure, Preeclampsia
The Relationship of Phthalate Exposure During Pregnancy and Preeclampsia
Phthalates are a group of ubiquitous synthetic endocrine-disrupting chemicals. Fetal and neonatal periods are particularly susceptible to endocrine disorders, which prenatal exposure to phthalates causes.
- Conditions
- Phthalate Exposure, Preeclampsia, Estrogen, Progestin
- Trial name
- NCT04777929
- Testing
- test Phthalates, estrogen and progesterone
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Twin Pregnancy, Preeclampsia
Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies
Twin pregnancies are associated with increased risk of perinatal adverse outcomes , including preeclampsia , fetal growth restriction , preterm premature rupture of membranes and preterm birth.
- Conditions
- Twin Pregnancy, Preeclampsia, Preterm Birth, Fetal Growth Restriction
- Trial name
- NCT04051567
- Testing
- Aspirin 100mg
- Where
- China
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Ministry of Science and Technology of the People´s Republic of China
Preeclampsia/Toxemia
The Prediction of Preeclampsia/Toxemia in Twin Pregnancy
The purpose of this study is to finout whetere uterinae artery flow , PP13 and endogolin levels in the serum and kongo red in the urine can predict preeclamsia toxemia in twin pregnancies.
- Trial name
- NCT01255202
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Pregnancy, Preeclampsia
Influence of Physical Exercise on Endothelial Function in Pregnant Women
The purpose of this study is to determine the effect of regular aerobic exercise on endothelial function in pregnancy.
- Conditions
- Pregnancy, Preeclampsia, Exercise
- Trial name
- NCT00741312
- Testing
- Regular aerobic physical exercise, Activities of daily living
- Where
- Colombia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Universidad del Valle, Colombia
Pre-Eclampsia
Evaluation of Neutrophil/Lymphocyte Ratio ,Platelet/Lymphocyte Ratio and CRP as Markers of Severity of Pre-eclampsia
Evaluation of neutrophil/lymphocyte ratio, Platelet /lymphocyte ratio and CRP as markers of severity of Pre-eclampsia
- Trial name
- NCT03630276
- Testing
- Neutrophil/lymphocyte ratio, Platelet /lymphocyte ratio and CRP
- Where
- Egypt
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pregnancy Toxemia, Hypertension
Treatment Targets for Chronic Hypertension in Pregnancy
This project is a clinical study of women with high blood pressure who become pregnant. Preeclampsia is a syndrome developing at the end of a pregnancy characterized by an abrupt rise in blood pressure (BP), blood clotting and…
- Conditions
- Pregnancy Toxemia, Hypertension, Proteinuria
- Trial name
- NCT00194974
- Testing
- methyldopa, labetalol, nifedipine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Preeclampsia Postpartum, Adverse Pregnancy Outcomes
A Community Health Worker Intervention to Address Adverse Pregnancy Outcomes
United States maternal mortality and preterm birth rates are among the highest among high-income countries due in part to a combination of racial, regional and socioeconomic disparities in access to care and overall health.
- Trial name
- AW2H (NCT06353256)
- Testing
- usual postpartum care, usual postpartum care + community health worker intervention
- Where
- 2 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Severe Pre-eclampsia
Nitroglycerin Versus Labetalol in Acute Severe Pre-eclampsia
Two hundred patients with severe PE were admitted prepartum to the ICU to stabilize blood pressure. They were randomly assigned to one of two groups (100 in each group): Group N received nitroglycerine intravenous infusion in a…
- Trial name
- NCT05310929
- Testing
- Labetalol and Glyceril trinitrate
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Preeclampsia, Eclampsia
The Effect of neutrophil-to Lymphocyte Ratio in Preeclampsia- Eclampsia
Neutrophil/lymphocyte ratio (NLR) is a marker of systemic inflammation and endothelial dysfunction. In recent years, it has been reported that the individual components of the differential white cell count, specifically the…
- Trial name
- NCT01856387
- Testing
- high neutrophil to lymphocyte ratio, normal neutrophil-to Lymphocyte ratio
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Preeclampsia
Exercise Induced Improvement of the Venous Reserve Capacity in Formerly Pre-eclamptic Women
Primary objective: To investigate whether physical exercise prior to pregnancy in formerly preeclamptic women results in a comparable improvement of vascular and endothelial functioning as in women who had an uneventful…
- Trial name
- NCT00900458
- Testing
- Aerobic Exercise training
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Maternal Death, Neonatal Death
Evaluating the Effects of SMS Text Messaging Support System Among Frontline Health Workers in Ghana
Introduction Maternal and neonatal mortality continue to be to be prominent public health issues in sub Saharan Africa including Ghana, with slow progress made towards attainment of Millennium Development Goals (MDG) 4 \& 5.
- Conditions
- Maternal Death, Neonatal Death, Postpartum Haemorrhage, Pre-eclampsia
- Trial name
- Accelerate (NCT02468310)
- Testing
- Maternal and neonatal emergency protocols
- Where
- Ghana
- Volunteers
- 65,831 people, healthy volunteers welcome
- Sponsor
- Hannah Brown Amoakoh
Preeclampsia, Maternal Deaths
The Project of Gestational Hypertension and Preeclampsia Screening and Prevention Center
Preeclampsia is the main cause of illness and death in pregnant women and fetuses. Currently, there is no effective treatment for preeclampsia in clinical practice, and the fundamental treatment is still termination of pregnancy…
- Trial name
- NCT06383858
- Testing
- Screening method
- Where
- China
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated Hospital of Guangzhou Medical University
Pre-Eclampsia
Interest of Circulating Endothelial Biomarkers in Vascular Pregnancy Complications
This is a prospective multicentric study including four clinical units of Gynecology and Obstetrics (3 public health hospitals and one private team), one research team in Hematology and one Center of Clinical investigation (CIC).
- Trial name
- NCT00485784
- Testing
- Blood test
- Where
- 4 sites in France
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Hypertension in Pregnancy, Pre-Eclampsia
The BEET-BP Trial - Investigating the Effect of Dietary Nitrates on Hypertension in Pregnancy
This is a randomised placebo controlled trial investigating the effects of dietary nitrate supplementation on hypertension in pregnancy
- Conditions
- Hypertension in Pregnancy, Pre-Eclampsia, Gestational Hypertension, Pregnancy Induced Hypertension
- Trial name
- NCT04604535
- Testing
- Concentrated beetroot juice
- Where
- United Kingdom
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Preeclampsia, Pregnancy Complications
The Correlation Between Immunological Reaction of the Seminal Fluid in the Mother's Blood and Pregnancy Complications
It is known that if there isn't an efficient exposure to the paternal antigens before conception, there is an increased risk for the pre-eclampsia (PE) cascade and other pregnancy complications to take place.
- Conditions
- Preeclampsia, Pregnancy Complications, Insemination; Complication, Immune Tolerance
- Trial name
- NCT04314518
- Where
- 2 sites in Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Preeclampsia
Increased Salt Sensitivity of Ambulatory Blood Pressure in Women With a History of Severe Preeclampsia
Cardiovascular diseases are the principal cause of death in women in developed and developing countries and are importantly promoted by hypertension.
- Trial name
- NCT01874990
- Testing
- high sodium diet, low-salt diet
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Hypertension, Pregnancy
Exercise in Pregnancy for Reduction of Blood Pressure in Obese Patients
Preeclampsia and other high blood pressure disorders of pregnancy are a significant cause of both maternal and fetal complications of pregnancy.
- Conditions
- Hypertension, Pregnancy, Preeclampsia, Exercise
- Trial name
- NCT01261884
- Testing
- Exercise support, Exercise intervention
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center