Clinical trials: PTA
Arterial Disease of Legs, Below-the-knee Obstruction
Sirolimus Coated BALloon Versus Standard Balloon Angioplasty in The Treatment of Below The Knee Arterial Disease
This is a Pivotal, Prospective, randomized, two arm, placebo controlled, single-blind, multicenter trial that will be conducted at approximately 80 sites; approx.
- Conditions
- Arterial Disease of Legs, Below-the-knee Obstruction, PAD - Peripheral Arterial Disease
- Trial name
- MAGICAL BTK (NCT06182397)
- Testing
- MagicTouch PTA Sirolimus drug coated balloon
- Where
- 29 sites in United States
- Volunteers
- 368 people
- Sponsor
- Concept Medical Inc.
Atherosclerosis, Arteriosclerosis
BIOLUX P-II First-in-Man Study to Compare the Passeo-18 Lux DRB Against POBA in Infrapopliteal Arteries
A prospective, multicentric, randomized controlled trial to assess the safety and performance of the Passeo-18 Lux Paclitaxel releasing PTA balloon catheter versus the uncoated Passeo 18 PTA balloon catheter for the treatment of…
- Conditions
- Atherosclerosis, Arteriosclerosis, Vascular Disease, Peripheral Artery Disease
- Trial name
- BIOLUX P-II (NCT01867736)
- Testing
- Passeo-18 Lux DRB, Standard PTA (POBA)
- Where
- 6 sites in Austria, Belgium and 1 more
- Volunteers
- 72 people
- Sponsor
- Biotronik AG
Congenital Heart Disease, Truncus Arteriosus
High Intensity Interval Training in Patients With a Right Ventricle to Pulmonary Artery Conduit
The goal of this clinical trial is to learn if a specific type of exercise training (high intensity interval training) can improve exercise capacity in people with a congenital heart defect that required the creation of a new…
- Conditions
- Congenital Heart Disease, Truncus Arteriosus, Pulmonary Atresia, Tetralogy of Fallot
- Trial name
- Right HIIT (NCT06771687)
- Testing
- High intensity interval training
- Where
- 2 sites in Netherlands
- Volunteers
- 38 people
- Sponsor
- Erasmus Medical Center
Peripheral Arterial Disease
Treatment of Complex Femoropopliteal Artery Lesions Using Drug-coated PTA Balloon
Although DCBs had been widely applicable after registration, there are still lack of clinical data and evidence in the real world condition of Chinese population.
- Trial name
- NCT05616520
- Testing
- drug-coated balloon
- Where
- China
- Volunteers
- 838 people
- Sponsor
- Xuanwu Hospital, Beijing
Peripheral Artery Disease
Compare I Pilot Study for the Treatment of Subjects With Symptomatic Femoropopliteal Artery Disease
To compare two different Paclitaxel coated balloons in the treatment of high grade stenotic or occluded lesions in Superficial femoropopliteal artery (SFA )and/or Proximal Popliteal Artery in Peripheral Artery Disease (PAD)…
- Trial name
- NCT02701543
- Testing
- Ranger Drug Eluting Balloon, In Pact Drug Eluting Balloon
- Where
- Germany
- Volunteers
- 414 people
- Sponsor
- University of Leipzig
Peripheral Artery Disease
SUCCESS (SelUtion, Safety, effiCaCy, hEalth economicS and promS) PTA Study
Open label, real-world, prospective, multi-center, single arm, post-market surveillance study of the SELUTION SLR™ (Sustained Limus Release) drug eluting balloon (DEB).
- Trial name
- SUCCESS PTA (NCT04776434)
- Testing
- SELUTION SLR™ (Sustained Limus Release) drug eluting balloon (DEB)
- Where
- 27 sites in Argentina, Germany and 6 more
- Volunteers
- 723 people
- Sponsor
- M.A. Med Alliance S.A.
Complication of Hemodialysis, Vascular Access Complication
RCT of Paclitaxel DEB Compared to Standard PTA in Dialysis Fistula
A multicenter randomized clinical trial of paclitaxel drug-eluting balloon (DEB) versus standard percutaneous transluminal angioplasty (PTA) to reduce restenosis in 150 patients with haemodialysis access stenoses.
- Trial name
- APERTO (NCT02558153)
- Testing
- DEB, drug eluting balloon, standard PTA
- Where
- 10 sites in Belgium, Netherlands
- Volunteers
- 105 people
- Sponsor
- Groene Hart Ziekenhuis
Atherosclerosis, Restenosis
Drug Coated Balloons for Prevention of Restenosis
The study will be performed as a randomized, double blind trial (in respect of the primary end point) with treatment of the stenotic lesion using uncoated PTA-catheters as control group.
- Conditions
- Atherosclerosis, Restenosis, Limb Ishemia
- Trial name
- Piccolo (NCT00696956)
- Testing
- Balloon angioplasty (uncoated conventional balloon), Balloon angioplasty (conventional but coated with 3 µg/mm2 paclitaxel)
- Where
- 5 sites in Germany
- Volunteers
- 114 people
- Sponsor
- University Hospital Tuebingen
Anemia
Impact of Full Correction of PTA in Renal Transplant Recipients
Background: Post-transplant anemia (PTA) might be associated cardiovascular morbidity and even increased mortality. Objectives: We aimed to assess the impact of full correction of chronic PTA on cardiovascular system and quality…
- Trial name
- NCT03861637
- Testing
- ESA for correction of PTA to 12-13g/dl
- Volunteers
- 280 people
- Sponsor
- Hamid Al-Essa Organ Transplant Center
Critical Limb Ischemia
Drug Eluting Balloons PTA in Infra-popliteal Arteries in Patients With Critical Limb Ischemia
Percutaneous transluminal angioplasty (PTA) of infra-popliteal arteries in patients suffering peripheral arterial occlusive disease (PAOD) provides good results in terms of limb salvage.
- Trial name
- NCT02498080
- Testing
- DEB PTA, Standard PTA
- Volunteers
- 60 people
- Sponsor
- Neuromed IRCCS
Bladder Cancer
Comparison Study of Narrow Band Imaging Versus White Light Resection in Patients With Bladder Tumors/Cancer
The purpose of this study is to compare the recurrence rate at 1 year following Narrow Band Imaging and trans-urethral resection of bladder tumor with White Light and TURB in patients with non-muscle invasive bladder cancer.
- Trial name
- NCT01180478
- Testing
- White Light, Narrow Band Imaging
- Volunteers
- 965 people
- Sponsor
- Clinical Research Office of the Endourological Society
Femoral Artery Stenosis, Popliteal Artery Stenosis
DKutting Balloon Versus Chocolate Balloon to Treat Femoral and Popliteal Artery Stenosis
A Multicenter, Prospective, Randomized Controlled Trial to Evaluate the Efficacy and Safety of DKutting Balloon Versus Chocolate Balloon in the Treatment of Femoral and Popliteal Artery Stenosis
- Trial name
- DELTA (NCT05608655)
- Testing
- DKutting LL balloon, Chocolate balloon
- Where
- 14 sites in China
- Volunteers
- 188 people
- Sponsor
- DK Medical Technology (Suzhou) Co., Ltd.
Atrial Fibrillation
Efficacy and Safety of MAA868 in Patients With Atrial Fibrillation
The purpose of this study is to evaluate the pharmacokinetics, pharmacodynamics, safety and tolerability of MAA868 compared to apixaban in patients with atrial fibrillation.
- Trial name
- NCT03398434
- Testing
- MAA868, Apixaban
- Sponsor
- Novartis Pharmaceuticals
Periodontitis and Pregnancy
L. Reuteri ATCC PTA 5289 + L. Reuteri DSM 17938 in Pregnant Women
Randomized controlled tril to evaluate the safety and efficacy for the combination of L. reuteri ATCC PTA 5289 \& L. reuteri DSM 17938 in pregnant women with periodontitis and/or gingivits to improve oral health and at the same…
- Trial name
- NCT03375125
- Testing
- Probiotic
- Where
- 2 sites in Italy, Mexico
- Volunteers
- 300 people
- Sponsor
- Innovacion y Desarrollo de Estrategias en Salud
Peripheral Arterial Disease, Femoropopliteal Stenosis
PMCF Study for Peripheral Arteries Above the Knee (ATK)
The rationale of this study is to confirm and support the clinical safety and performance of the products in a real-word population of 350 patients who underwent an endovascular intervention within standard-of-care (SOC) of the…
- Conditions
- Peripheral Arterial Disease, Femoropopliteal Stenosis, Angiopathy, Peripheral
- Trial name
- NCT05312580
- Where
- 9 sites in Austria, France and 1 more
- Volunteers
- 387 people
- Sponsor
- Cordis US Corp.
Renal Insufficiency
DEB-after-Cutting Balloon-PTA in Dialysis Fistula Stenosis
The incidence of hemodynamically relevant dialysis fistula stenoses/obstructions after 1 year is between 60-90% (from 62.5 to 91% radiocephalic, brachiocephalic 70-84%, PTFE shunts 62-87%), necessitating a therapeutic measure to…
- Trial name
- DEB-after-CB (NCT02578784)
- Testing
- Angioplasty with drug-coated balloon, Angioplasty with plain old balloon
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Cantonal Hospital of St. Gallen
Stroke
Factor XI Levels in Acute Ischemic Stroke
The purpose of this study is to evaluate the utility of measuring coagulation factor activities in the setting of acute ischemic stroke, as potential markers of inherited thrombotic risk.
- Trial name
- NCT00890812
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- University of Utah
Femoropopliteal Artery Lesions
Ranger™ and Ranger™ SL (OTW) DCB) in China
This clinical study is a prospective, non-randomized, multicenter study to demonstrate the acceptable safety and performance of angioplasty with the Ranger DCB in native femoropopliteal artery lesions.
- Trial name
- NCT02944071
- Testing
- Boston Scientific Ranger™ and Ranger™ SL Paclitaxel-Coated PTA Balloon Catheter
- Where
- 9 sites in China
- Volunteers
- 123 people
- Sponsor
- Boston Scientific Corporation
Peripheral Artery Disease
Sirolimus- vs. Paclitaxel-Drug Coated Ballons in Patients With Peripheral Artery Disease
This study is a prospective, interventional, multi-center 1:1 randomized non-inferiority trial. The trial evaluates the safety and efficacy of the Magic Touch PTA sirolimus drug-coated balloon in comparison to the treatment with…
- Trial name
- SIRONA (NCT04475783)
- Testing
- Percutaneous Transluminal Angioplasty (PTA)
- Where
- 22 sites in Austria, Germany
- Volunteers
- 478 people
- Sponsor
- Jena University Hospital
Venous Thromboembolism (VTE)
REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults
This study is researching an experimental drug called REGN7508 (called "study drug"). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement surgery.
- Trial name
- ROXI-APEX (NCT07015905)
- Testing
- REGN7508, Apixaban, Enoxaparin
- Where
- 47 sites in United States, Bulgaria and 6 more
- Volunteers
- 2,000 people
- Sponsor
- Regeneron Pharmaceuticals