Clinical trials: PYY
Taste Disorder, Primary, Sweet
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY
The purpose of this study is to determine the functional significance of sweet taste receptors in the secretion of GI satiation peptides by using a specific sweet taste receptor antagonist to block sweet taste perception in the…
- Trial name
- NCT01304823
- Testing
- lactisole, mixed liquid meal
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity
The Role of Peptide YY (PYY)Infusions in Inhibiting Food Intake.
The aim of the study is to compare fasting and postprandial PYY levels between overweight/obese and lean subjects during and after an infusion of saline, PYY1-36 or PYY3-36 and to evaluate the efects on appetite, energy intake…
- Trial name
- NCT00259246
- Testing
- Peptide YY infusion
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy Male Adults
Testing the Potential Metabolic Effect of the Human Gut Bacterial Peptide, RUCILP, in Healthy Men
The goal of this randomized, double-blinded and placebo-controlled clinical cross-over trial is in healthy men to explore the potential metabolic effects of the naturally occurring gut bacterial polypeptide, RUCILP.
- Trial name
- NCT06923839
- Testing
- Test bacterial peptide: RUCILP
- Where
- Denmark
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Oluf Pedersen
Diabetes Mellitus
Insulin Detemir Compared to Insulin Glargine: Appetite and Calories Consumed in Type 1 Diabetes
Patients with diabetes treated with insulin often gain weight, which may deter patients from adhering to insulin treatment. Detemir is one type of long acting insulin approved by the Food and Drug Administration for use in people…
- Trial name
- NCT00659165
- Testing
- Insulin Detemir, Insulin Glargine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of New Mexico
Healthy
Effects of Artificial Sweetener on Gastrointestinal (GI) Peptide Secretion
The purpose of this study is to examine the influence of artificial sweeteners (aspartame, acesulfame K, sucralose) and carbohydrate sugars (glucose, fructose) on the release of gastrointestinal satiety hormones in humans.
- Trial name
- NCT00978900
- Testing
- Artificial sweeteners; Carbohydrate Sugars, Water
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Pre-diabetes, Obesity
Sub-Study of the PREVIEW Study Australia
The aim of this study is to investigate possible enduring effects of a standard 2-month weight loss program on appetite regulation, bone homeostasis and muscle strength in younger and older adults, as well as the impact of…
- Trial name
- NCT02030249
- Testing
- Low calorie diet administered from 0 to 2 months, High Protein / Low Glycaemic Index, Moderate Protein / High Glycaemic Index
- Where
- 3 sites in Australia
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Overweight, Obesity
The Beneficial Effects of a Protein-rich Breakfast on Appetite Control & Cognition in Overweight and Obese Adolescents
The purpose of this study is to assess whether the daily addition of a protein-rich breakfast leads to beneficial changes in appetite control, food intake regulation,and cognitive function in overweight \& obese 'breakfast…
- Trial name
- NCT01192100
- Testing
- Breakfast Skipping, Normal Protein Breakfast Meals, Protein-rich Breakfast Meals
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Obesity & Overweight, Appetite Regulation
Effect of Lower Doses of Colonic Nutrient Supplementation on Appetite Hormones and Food Intake in Obese Adults
Here are both updated sections: Brief Summary: The goal of this clinical trial is to learn if two different doses of dietary supplements delivered to the lower gut can reduce appetite and food intake in obese adults (men and…
- Trial name
- NCT07491835
- Testing
- Arm 1 (Medium Dose): 250mg DIM and 1050mg Perilla oil in GuardCap™ colon-targeted capsules, activating GPR84 and FFA4 to stimulate PYY and GLP-1 release., Arm 2 (Low Dose): 125mg DIM and 525mg Perilla oil in GuardCap™ colon-targeted capsules, activating GPR84 and FFA4 to stimulate PYY and GLP-1 release.
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- Queen Mary University of London
Short Bowel Syndrome, Intestinal Resection
Gastrointestinal Hormone Secretion, Intestinal Permeability and Short Bowel Syndrome
The gastrointestinal tract is a complex endocrine organ that regulates a wide range of physiological processes, including those involved in the digestion of nutrients.
- Trial name
- NCT07235670
- Testing
- Standardized meal
- Where
- Denmark
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Obesity
High Quality Protein for Assisting With Weight Loss
The purpose of this study is to determine if, in presence of a reduced calorie diet, a breakfast containing high quality protein source (eggs) would be more effective in reducing hunger and increasing feeling of fullness compared…
- Trial name
- Egg_breakfast (NCT03085511)
- Testing
- Egg breakfast (EB), Weight Loss Counseling, Weight Loss Diet
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Type 2 Diabetes
The Impact of Food Order on Glycemic Excursions in Type 2 Diabetes Assessed by Continuous Glucose Monitoring
The purpose of this study is to explain the effect of food order/nutrient sequencing on glycemic excursions over a 2 week period, utilizing a device known as a continuous glucose monitor (CGM), for people who have been diagnosed…
- Trial name
- NCT04738799
- Testing
- Carbohydrate-Last Meal Sequence, Carbohydrate-First Meal Sequence
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Healthy
Brain Natriuretic Peptide Effects on Appetite Regulating Hormones and Endothelial Derived Peptides
Chronic heart failure is accompanied by anorexia and increased release of B-type natriuretic peptide (BNP) from the ventricular myocytes.
- Trial name
- BNP/Appetite (NCT01375153)
- Testing
- BNP, 0.9% NaCl
- Where
- 2 sites in Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Type 2 Diabetes Mellitus
Diet Oil Induced Stimulation of GLP-1
Activation of G protein-coupled receptor GPR119 stimulates glucagon-like peptide-1 (GLP-1)release from the intestinal L-cells. Previously, administration of 2-oleyl-glycerol (2-OG) to humans significantly increased plasma GLP-1.
- Trial name
- NCT01453842
- Testing
- Diet oil, Olive oil, Carrot
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Copenhagen
Morbid Obesity
Gut Hormones After Roux-en-Y Gastric Bypass (RYGBP) Plus Gastric Fundus Resection
Laparoscopic Roux-en-Y gastric bypass (LRYGBP) is considered a combination of restriction-malabsorption procedure and one of the most common operative procedures implemented.
- Trial name
- NCT01341028
- Testing
- Roux-en-Y gastric bypass (LRYGBP), LRYGBP+gastric fundus resection
- Where
- Greece
- Volunteers
- 24 people
- Sponsor
- University of Patras
Metabolic Health, Gut Hormones
Breaking Sitting and Metabolic Health in Sedentary Lean Adults
The purpose of this project is to investigate the effects of breaking up prolonged sitting on postprandial metabolic responses, gut hormones secretion and energy balance in sedentary lean adults.
- Conditions
- Metabolic Health, Gut Hormones, Energy Balance
- Trial name
- NCT05306613
- Testing
- Prolonged sitting, Breaking sitting
- Where
- Taiwan
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Obesity
APPETITE: linguAl PYY3-36 on aPpEtite and acuTe Energy InTakE
A double-blind, cross-over, placebo-controlled, proof-of-concept study using oral peptide YY3-36 solution to investigate the mechanistic role of lingual PYY in regulating appetite, energy intake and food preference in people with…
- Trial name
- APPETITE (NCT05110664)
- Testing
- PYY (3-36) Peptide, Placibo
- Volunteers
- 40 people
- Sponsor
- University College, London
Neuroendocrine Reproductive Status
Impacts of Metabolic Variation on Neuroendocrine Control of Reproduction
This study will evaluate the potential effects of a changing metabolic environment on GnRH hypothalamic neurons, by performing studies of LH pulsatility (basal and during clamp studies) in different groups of male subjects fed…
- Trial name
- NCT01058681
- Testing
- effect of metabolic variations on LH pulsatility
- Where
- Switzerland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Obesity
Breakfast Intake and Satiety Hormones
The experiments in this study will assess if while following a reduced energy diet, eating a breakfast with higher protein quality will enhance weight loss compared to another breakfast with lower protein quality, but matched for…
- Trial name
- NCT02497859
- Testing
- Egg Breakfast (EB), Cereal Breakfast (CB), Weight Loss Counseling
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Texas Tech University
Satiety in Healthy Volunteers
Effect of Prebiotic Sodas on Postprandial Levels of GLP-1, PYY, Transit Time and Satiety Levels: A Pilot Study
The main objective of this study is to evaluate the acute effects of prebiotic sodas on postprandial levels of glucagon-like peptide-1 (GLP-1), peptide YY (PYY), gastric emptying, and satiety levels in healthy adults.
- Trial name
- NCT07362563
- Testing
- Control Soda, Prebiotic Soda - Shelf Stable, Prebiotic Soda - Refrigerated
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Olipop, PBC
Eating Disorder, Bulimia Nervosa
Co-Feedback Action of Growth Hormone, PP and PYY on Ghrelin in Bulimia
This study evaluates the addition of Acipimox or placebo to exercise on growth hormone release and ghrelin secretion in bulimic patients and in healthy women.
- Trial name
- NCT03338387
- Testing
- Acipimox
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic