Clinical trials: Pacap-38
Migraine, Headache
The Hemodynamic Effects of PACAP38 After Glibenclamide Administration in Healthy Volunteers
To investigate the hemodynamic effects of PACAP38 after glibenclamide administration.
- Conditions
- Migraine, Headache, Pain
- Trial name
- NCT04960657
- Testing
- glibenclamide, PACAP38
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine Headache
Repeat Dosing of Psilocybin in Migraine Headache
In seeking to understand the capacity for psilocybin to reduce migraine headache burden, this study will investigate single and repeated dosing of psilocybin up to two doses.
- Trial name
- NCT04218539
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Yale University
Headache
The Role of Inflammation and Vasodilatation in PACAP38-induced Headache Using MRI on Healthy Subjects
Studying Pituitary adenylate cyclase-activating peptide 38 (PACAP38) induced headache effects on extra- and intracerebral arteries and pre-posttreated by sumatriptan and ketorolac assessed by magnetic resonance imaging (MRI) on…
- Trial name
- NCT03585894
- Testing
- Sumatriptan, Ketorolac
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine Without Aura
PACAP38 Induced Headache, Migraine and Flushing in Patients With Migraine
The aim is to investigate the incidence of headache, migraine attacks and flushing after pituitary adenylate cyclase-activating peptide-38 (PACAP38) with and without treatment with sumatriptan in patients with migraine
- Trial name
- NCT03881644
- Testing
- Imigran, Isotonic Saline, Pituitary adenylate cyclase-activating peptide-38
- Where
- Denmark
- Volunteers
- 37 people
- Sponsor
- Danish Headache Center
Migraine
Safety, Tolerability and Pharmacokinetics of ALD1910 in Healthy Men and Woman
The purpose of this study is to determine the safety, tolerability and pharmacokinetics of ALD1910, a monoclonal antibody, administered by intravenous infusion and subcutaneous injection.
- Trial name
- NCT04197349
- Testing
- ALD1910, Sumatriptan
- Where
- Australia
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Post-Traumatic Headache
Hypersensitivity to PACAP-38 in Post-Traumatic Headache
The aim is to investigate whether signaling molecule PACAP-38 induces headache with migraine-like features in people with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI).
- Trial name
- NCT05378061
- Testing
- Pituitary adenylate cyclase activating polypeptide-38
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Rosacea
PACAP38 Induced Headache and Rosacea-like Symptoms in Patients With Rosacea
The investigators aim is to investigate the incidence of headache and rosacea-like flushing after pituitary adenylate cyclase-activating peptide-38 (PACAP38) with and without treatment with sumatriptan in patients with rosacea
- Trial name
- NCT03878784
- Testing
- Imigran, Isotonic Saline
- Where
- Denmark
- Volunteers
- 38 people
- Sponsor
- Danish Headache Center
Cluster Headache
PACAP-38 Infusion in Patients With Cluster Headache
A randomized, double-blinded, two-way crossover study investigating the headache inducing capabilities of PACAP-38 in patients with cluster headache.
- Trial name
- NCT03814226
- Testing
- Evaluation of headache inducing capabilities of PACAP38
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Danish Headache Center
Major Depression
Assessment of Pituitary Adenylate Cyclase Activating Polypeptide-Brain Derived Neurotrophic Factor (PACAP-BDNF) Signaling System Involvement in Etiology and Treatment of Major Depression
The neuropeptide Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) and its receptors PAC1 and VPAC2 are widely expressed in the nervous system.
- Trial name
- NCT00944996
- Testing
- SSRI; SNRI; TCA
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tirat Carmel Mental Health Center
Migraine
Tear Biomarkers for Migraine
The goal of this observational monocentric study is to investigate tear and serum biomarkers in patients with migraine compared with healthy controls, and to explore their potential diagnostic, clinical, and predictive value.
- Trial name
- TEAR (NCT07690696)
- Testing
- Patients with migraine
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Migraine
To Evaluate the Blockade of CGRP in Preventing PACAP-38 Induced Migraine-like Attacks With AMG 334 in Migraine Patients
Phase I, Randomized, Parallel-group, Double-Blind, Placebo-Controlled, Single Dose Study to Evaluate the Blockade of CGRP Receptor by AMG 334 in Preventing PACAP-38 Induced Migraine-like Attacks in Migraine Patients.
- Trial name
- NCT02542605
- Testing
- Erenumab, PACAP-38 Challenge Agent
- Where
- 3 sites in United States, Belgium and 1 more
- Volunteers
- 35 people
- Sponsor
- Amgen
Migraine Without Aura
The Effect of Histamine H1 Receptor Antagonist, Clemastin, on PACAP38 Induced Headache in Migraine Patients
The purpose of this study is to determine the effects of antihistamine (Clemastin) on migraines triggered by pituitary adenylate cyclase activating peptide-38 (PACAP38) as well as on biochemical markers for mast cell…
- Trial name
- NCT02364453
- Testing
- PACAP38
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Song Guo
Nephrotic Syndrome
Role of PACAP in Nehprotic Syndrome
This study will identify the role of PACAP (pituitary adenylate cyclase-activating polypeptide) deficiency in patients with nephrotic syndrome.
- Trial name
- NCT01411982
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Headache, Migraine
The Effect of PACAP27 on the Extra- and Intracerebral Arteries Assessed by Magnetic Resonance Angiography (MRA) on Healthy Volunteers
Studying Pituitary adenylate cyclase-activating peptide 27 (PACAP27) effects on extra- and intracerebral arteries assessed by MRA on healthy volunteers.
- Trial name
- NCT03560024
- Testing
- PACAP27
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine
Migraine Induction Properties of PACAP-38 After Eptinezumab in Migraine Without Aura Patients.
To investigate whether administration of calcitonin gene-related peptide (CGRP) binding monoclonal antibodies eptinezumab prevents pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) induced migraine attacks in…
- Trial name
- NCT05635604
- Testing
- Eptinezumab, PACAP-38
- Where
- Denmark
- Volunteers
- 38 people
- Sponsor
- Danish Headache Center
Healthy
A Single Dose Study of Lu AG09222 in a Headache Model With Healthy Subjects
The purpose of this study is to evaluate how well Lu AG09222 can prevent blood vessel dilation in a headache model.
- Trial name
- NCT04976309
- Testing
- Lu AG09222
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Migraine Without Aura
PACAP27 Headache Properties in Migraine Without Aura Patients
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a signaling molecule, localized in sensory and parasympathetic perivascular nerves fibres.
- Trial name
- NCT03471039
- Testing
- PACAP27, Saline
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Chronic Migraine Headache, Radiofrequency Ablation
The Effect of Interventional Procedures on Serum CGRP and PACAP-38 Levels in Chronic Migraine
The study included 100 patients diagnosed with chronic migraine (CM) who received a diagnosis from the headache clinics of the Neurology Department of Adnan Menderes University Hospitals between May 2025 and May 2026.
- Conditions
- Chronic Migraine Headache, Radiofrequency Ablation, Greater Occipital Nerve Block, Calcitonin Gene-related Peptide
- Trial name
- NCT07395908
- Testing
- Greater occipital nerve Pulse radiofrequency, Greater occipital nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Migraine Without Aura
Effect of PACAP38/VIP on Migraineurs Measured by Magnetic Resonance
The purpose of this study is to examine and compare the effect of pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) and vasoactive intestinal polypeptide (VIP) on intracranial arteries and neuronal activity in…
- Trial name
- NCT01471990
- Testing
- Pituitary Adenylate Cyclase-Activating Polypeptide-38, Vasoactive Intestinal Peptide
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Migraine Without Aura
PACAP38´s (Pituitary Adenylate Cyclase-Activating Polypeptide) Headache Inducing Characteristics and Effects on the Cerebral Blood Flow
To investigate headache score and accompanying symptoms during and after infusion of PACAP38 i migraine patients
- Trial name
- NCT00380263
- Testing
- PACAP38
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Danish Headache Center