Clinical trials: Pacing Therapy
Neck Pain, Chronic Pain Syndrome
Neck Exercises, Training and Pain Management as a Treatment for Whiplash Patients With Chronic Neck Pain
The purpose of this study is to test whether a physiotherapy intervention containing pain management, general training and specific neck exercises can improve function for patients with chronic neck pain.
- Trial name
- WADNECXT (NCT01431261)
- Testing
- Education and training, Pain management
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- University of Southern Denmark
Bradycardia, Pacing
"Physiological vs Right Ventricular Pacing Outcome Trial Evaluated for bradyCardia Treatment" (PROTECT-HF)
The PROTECT-HF multi-centre randomised controlled trial will compare two different pacing approaches for treating patients with slow heart rates.
- Conditions
- Bradycardia, Pacing, Right Ventricular Pacing, His Bundle Pacing
- Trial name
- PROTECT-HF (NCT05815745)
- Testing
- Pacemaker - Physiological pacing, Pacemaker - Right Ventricular pacing
- Where
- 45 sites in Ireland, Slovenia and 1 more
- Volunteers
- 2,600 people
- Sponsor
- Imperial College London
Physiological Pacing, Resynchronization Therapy
LEft VEntricuLar Activation Time Shortening With Physiological Pacing vs Biventricular Resynchronization Therapy
The LEVEL-AT Trial (LEft VEntricuLar Activation Time Shortening with Physiological Pacing vs Biventricular Resynchronization therapy: a randomized study) is a non-inferiority study that aims to determine if physiological pacing…
- Trial name
- LEVEL-AT (NCT04054895)
- Testing
- Lead placed in the His-Purkinje system in order to achieve QRS shortening., Lead is placed in a tributary of the coronary sinus.
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Josep Lluis Mont Girbau
Heart Failure, Cardiomyopathy
InSync Model 8040 (InSync) and InSync III Model 8042 (InSync III) Registry
Heart failure is a progressive disease that decreases the pumping action of the heart. This may cause a backup of fluid in the heart and may result in heart beat changes.
- Trial name
- NCT00273182
- Testing
- InSync Model 8040, InSync III Model 8042
- Where
- 82 sites in United States
- Volunteers
- 1,999 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure, CRT and/or ICD
Evaluation of Electrical and Hemodynamic Effects of Different Pacing Strategies in CRT Candidates
Heart failure patients with delayed electrical activation of the heart often benefit from cardiac resynchronization therapy (CRT). However, traditional CRT using biventricular pacing is not effective in all patients.
- Trial name
- NCT07032064
- Testing
- Sequential ventricular pacing at five sites
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Shanghai Zhongshan Hospital
Non-ischemic Cardiomyopathy, Dilated Cardiomyopathy (DCM)
Multimodal and Multidisciplinary Approach to Optimize Diagnostic, Prognostic, and Therapeutic Management of Patients with Non-ischemic Cardiomyopathies and Arrhythmogenic-inflammatory Phenotypes: a Multicenter, Observational, Retrospective and Prospective Registry Study.
Non-ischemic cardiomyopathies (NICM) represent a heterogeneous group of pathologies characterized by absence of obstructive disease of the epicardial coronary vessels and distinct structural and functional changes of the…
- Conditions
- Non-ischemic Cardiomyopathy, Dilated Cardiomyopathy (DCM), Hypertrophic Cardiomyopathy (HCM), Restrictive Cardiomyopathy
- Trial name
- AINICM (NCT06607471)
- Testing
- Support treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation, Support treatment, cardiac medical treatment, aetiology-specific treatment
- Where
- Italy
- Volunteers
- 15,000 people
- Sponsor
- Scientific Institute San Raffaele
Pacemaker, Artificial, Cohort Studies
Morbidity, Mortality and Gender Differences in Patients With Pacemakers
Previous publications suggest gender difference in outcome parameters after pacemaker implantation. Aim of this study is to investigate gender differences in patients with pacemaker.
- Conditions
- Pacemaker, Artificial, Cohort Studies, Arrhythmias Requiring Therapy, Cardiac Pacing, Artificial
- Trial name
- NCT03388281
- Testing
- No intervention, retrospective analysis only.
- Volunteers
- 11,444 people
- Sponsor
- Medical University of Vienna
Heart Failure, Wide QRS Complex
Effect of Rate-responsive Compared to VDD Pacing in Cardiac Resynchronization Therapy Recipients
This study aims to understand the best programming pacing mode for cardiac resynchronization therapy devices used to treat chronic heart failure.
- Trial name
- NCT06592690
- Testing
- Atrial pacing support, Atrial tracking pacing mode
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Ospedale Centrale Bolzano
Heart Failure
CRT In Narrow QRS Heart Failure: Mechanistic Insights From Cardiac MRI And Electroanatomical Mapping
Cardiac Resynchronisation Therapy (CRT) is a specialist pacemaker procedure that aims to improve the efficiency of the heartbeat.
- Trial name
- NCT03258060
- Testing
- Temporary pacing study, Body Surface Mapping
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Heart Failure, Left Bundle Branch Block
High Septal Pacing for Cardiac Resynchronization Therapy
The purpose of this acute study is to perform a preliminary investigation of high septal right ventricular pacing in the vicinity of the His bundle region as an alternate or adjunctive means for cardiac resynchronization in…
- Conditions
- Heart Failure, Left Bundle Branch Block, Heart Disease
- Trial name
- HISTORY (NCT01325480)
- Testing
- Cardiac Pacing
- Where
- Hong Kong
- Volunteers
- 15 people
- Sponsor
- Boston Scientific Corporation
Heart Failure, Ventricular Dysfunction
Wireless Stimulation Endocardially for Cardiac Resynchronization Therapy
The WiCS-LV system is an alternative means to providing left ventricular stimulation for Cardiac Resynchronization Therapy (CRT).
- Conditions
- Heart Failure, Ventricular Dysfunction, Cardiomyopathy
- Trial name
- WiSE-CRT (NCT01294527)
- Testing
- Wireless cardiac stimulator implant to pace the left ventricle for CRT
- Where
- 10 sites in France, Germany and 2 more
- Volunteers
- 17 people
- Sponsor
- EBR Systems, Inc.
Heart Failure
Attain Stability™ Quad Clinical Study
The purpose of this clinical study is to evaluate the safety and efficacy of the Attain Stability Quadripolar MRI SureScan Left Ventricular (LV) lead (Model 4798).
- Trial name
- NCT03099655
- Testing
- Attain Stability Quad Left Ventricular Pacing Lead
- Where
- 50 sites in United States, Canada and 8 more
- Volunteers
- 471 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure, Cardiac Resynchronization Therapy
LVSP Based CRT vs. RVAP Based CRT
To find out whether left ventricular septal pacing (LVSP)-based cardiac resynchronization therapy (CRT) is superior to right ventricular apical pacing (RVAP)-based CRT in patients with failed left bundle branch pacing at the…
- Conditions
- Heart Failure, Cardiac Resynchronization Therapy, Left Ventricular Septal Pacing, Right Ventricular Septal Pacing
- Trial name
- NCT05985408
- Testing
- left ventricular septal pacing, right ventricular apical pacing
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Arrhythmias, Cardiac, Atrioventricular Block
ConTempoRary Cardiac Stimulation in Clinical practicE: lEft, BivEntriculAr, Right, and conDuction System Pacing
The goal of this observational study is to evaluate the clinical characteristics of patients undergoing permanent cardiac pacing and to compare procedural efficacy and safety of different implantation approaches in the clinical…
- Conditions
- Arrhythmias, Cardiac, Atrioventricular Block, Reduced Systolic Function, Atrial Fibrillation
- Trial name
- TREEBEARD (NCT06324682)
- Testing
- Cardiac pacing - Conventional RV pacing, Cardiac pacing - Conduction System Pacing, Cardiac pacing - Cardiac resynchronization therapy (pacing - CRTP - or defibrillation - CRTD)
- Where
- 31 sites in Italy
- Volunteers
- 8,400 people
- Sponsor
- University Hospital of Ferrara
Heart Failure
Biventricular Versus Right Ventricular Pacing
The study is a randomized, single-blind crossover prospective study in which investigators will determine the clinical outcomes of cardiac resynchronization therapy (CRT) pacing modalities in patients with left ventricular assist…
- Trial name
- NCT06298669
- Testing
- Biventricular Pacing, Right Ventricular Pacing
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Indiana University
Heart Failure, Cardiac Resynchronization Therapy
Left Ventricular Septal Pacing: Potential Application for Cardiac Resynchronization Therapy
In cardiac resynchronization therapy (CRT), biventricular pacing is performed by pacing the right ventricle (RV) and epicardium of the left ventricular (LV) postero-lateral wall.
- Conditions
- Heart Failure, Cardiac Resynchronization Therapy, Left Bundle-Branch Block
- Trial name
- NCT03415945
- Testing
- Cardiac resynchronization therapy (CRT)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Maastricht University Medical Center
Systolic Heart Failure, Ventricular Premature Complexes
Impact of Catheter Ablation of Ventricular Arrhythmias on Suboptimal Biventricular Pacing in Cardiac Resynchronization Therapy
Cardiac resynchronization therapy reduces mortality in patients with systolic heart failure and left bundle branch block. Reduced biventricular pacing can lead to therapy failure.
- Conditions
- Systolic Heart Failure, Ventricular Premature Complexes, Ventricular Tachycardia, Cardiac Resynchronization Therapy
- Trial name
- NCT04065893
- Testing
- Catheter ablation of ventricular arrhythmia, Intensified medical therapy
- Where
- Germany
- Volunteers
- 65 people
- Sponsor
- Universitätsklinikum Köln
Post Market Surveillance Study Following Clinical Routine
Optimizing Pacing Therapy by Using Multi-Programmable Pulse Generators for Cardiac Resynchronization Pacing (CRT-P)
The objective of this Post Market Clinical Follow-up (PMCF) is to collect data on the performance of the Ingenio 2 CRT-P devices and to document that device-related events, device malfunctions or device deficiencies (DDs) do not…
- Trial name
- Rally CRT-P (NCT02488239)
- Testing
- CRT-P indicated patients
- Where
- 8 sites in Finland, Germany
- Volunteers
- 64 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation
Recurrence of Atrial Fibrillation in Patients With Dual-chamber Pacemakers and Drug Therapy
Comparison of AF-Burden in patients with paroxysmal atrial fibrillation and the necessity of a Dual-Chamber-Pacemaker-Therapy either with a DDD[R]60-Stimulation or AF prevention pacing.
- Trial name
- NCT00215761
- Where
- Germany
- Volunteers
- 263 people
- Sponsor
- Atrial Fibrillation Network
Heart Failure, Left Bundle Branch Pacing
Clinical Efficacy of Early Left Bundle Branch Pacing for Cardiac Resynchronization Therapy
This is a two-center, prospective randomized controlled trial. The aim of this study is to compare the clinical efficacy of early left bundle branch pacing for cardiac resynchronization therapy and guideline-directed medical…
- Trial name
- Early-RESYNC (NCT06126081)
- Testing
- LBBP+GDMT, GDMT
- Where
- 2 sites in China
- Volunteers
- 36 people
- Sponsor
- Fu Wai Hospital, Beijing, China