Clinical trials: Paclitaxel-induced Peripheral Neuropathy
Neuropathy Associated With Dysproteinaemias
Relationship Between Serum Interleukin-20 Level and Paclitaxel-associated Neuropathy
This study aims to investigate the correlation between paclitaxel-induced neuropathy and the measurement values of serum IL-20 levels at baseline and during chemotherapy in patients who will receive neoadjuvant or adjuvant…
- Trial name
- NEUROTOX (NCT05622617)
- Testing
- no intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Namik Kemal University
Paclitaxel Adverse Reaction, Neuropathy;Peripheral
ABCB1 SNPs as Predictors of PIPN
The study aim is to determine the allele frequencies of 1236 G>A and 3435 G>A in ABCB1 and study their association with the incidence and severity of paclitaxel-induced peripheral neuropathy while adjusting for other baseline…
- Conditions
- Paclitaxel Adverse Reaction, Neuropathy;Peripheral, Breast Cancer
- Trial name
- NCT05093023
- Testing
- Real-Time PCR
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- Ain Shams University
Chemotherapy-induced Peripheral Neuropathy
A Study of Topical Pirenzepine or Placebo in Oncology Patients With Chemotherapy Induced Peripheral Neuropathy
This is a randomized, double-blind, placebo-controlled adaptive study of the safety, tolerability, and exploratory efficacy of once-daily topical WST-057 administered for up to 19 weeks (or up to 24 weeks for subjects who…
- Trial name
- NCT05488873
- Testing
- WST-057 Active
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- WinSanTor, Inc
Breast Cancer, Chemotherapy-Induced Peripheral Neuropathy
TENS, Compression, and Cryotherapy for Paclitaxel-Induced Peripheral Neuropathy in Women With Breast Cancer
This single-center, four-arm, parallel-group randomized controlled trial evaluates transcutaneous electrical nerve stimulation (TENS), compression, and cryotherapy for the management of chemotherapy-induced peripheral neuropathy…
- Trial name
- NCT07817979
- Testing
- Transcutaneous Electrical Nerve Stimulation, Cryotherapy, Compression Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Cumhuriyet University
Chemotherapy-induced Peripheral Neuropathy
Chemotherapy Induced Peripheral Neuropathy (CIPN)
Chemotherapy induced peripheral neuropathy (CIPN) is a common side effect of many forms of chemotherapy having a negative impact on the quality of life for cancer survivors due to numbness, decreased sensation, pain (of various…
- Trial name
- NCT03272919
- Testing
- Arm 1: Investigational INF, Arm 2: standardized muscle stretching and strength
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Loma Linda University
Acute Pain, Breast Carcinoma
Minocycline Hydrochloride in Reducing Chemotherapy-Induced Peripheral Neuropathy and Acute Pain in Patients With Breast Cancer Undergoing Treatment With Paclitaxel
This randomized pilot trial studies how well minocycline hydrochloride works in reducing chemotherapy-induced peripheral neuropathy and acute pain in patients with breast cancer undergoing treatment with paclitaxel.
- Conditions
- Acute Pain, Breast Carcinoma, Peripheral Neuropathy
- Trial name
- NCT02297412
- Testing
- Minocycline Hydrochloride, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 12 sites in United States
- Volunteers
- 47 people
- Sponsor
- Academic and Community Cancer Research United
Breast Cancer
Effectiveness of Cryotherapy Combined With Compression Therapy for Preventing Chemotherapy-induced Peripheral Neuropathy
This is a prospective, multi-center, randomized study designed to evaluate the clinical efficacy of cryotherapy combined with compression therapy in preventing albumin-paclitaxel induced peripheral neuropathy.
- Trial name
- NCT05341141
- Testing
- Frozen glove and sock, ddEC-ddT
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Peking University
Breast Cancer
The Effect of Oral Administration of Hesperidin and Diosmin in Reducing Paclitaxel-induced Peripheral Neuropathy in Breast Cancer Patients
The aim of this study is evaluation of the potential neuroprotective effect of oral hesperidin and diosmin in reducing paclitaxel- induced peripheral neuropathy in the treatment of breast cancer patients.
- Trial name
- NCT06811220
- Testing
- Hespiridin and Diosmin
- Volunteers
- 140 people
- Sponsor
- Alexandria University
Chemotherapy-induced Peripheral Neuropathy (CIPN)
PREventing CHemotherapy Induced Neuropathy (PreChIN)
The project is designed to study the use of localized hypothermia alone, or with compression to the limbs during chemotherapy infusion for the prevention of chemotherapy induced peripheral neuropathy (CIPN).
- Trial name
- NCT03299582
- Testing
- Hypothermia, Cryocompression
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Nasopharyngeal Carcinoma, CIPN - Chemotherapy-Induced Peripheral Neuropathy
Compression Therapy as a Prophylactic Method Against CIPN: a Prospective Self-controlled Trial
This is a single-center, self-controlled, evaluator-blinded prospective study, which applies pressurized gloves and foot caps to prevent paclitaxel-induced peripheral neuropathy in patients with nasopharyngeal carcinoma.
- Trial name
- CIPN (NCT05531916)
- Testing
- Pressurized gloves and foot caps
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Sun Yat-sen University
Paclitaxel-Induced Peripheral Neuropathy, Breast Cancer
Surgical Glove Compression to Prevent Paclitaxel Neuropathy
This study aims to evaluate the effect of surgical glove compression as a prophylactic method to prevent paclitaxel-induced peripheral neuropathy.
- Conditions
- Paclitaxel-Induced Peripheral Neuropathy, Breast Cancer, Surgical Glove
- Trial name
- Surgical Glove (NCT07504770)
- Testing
- Surgical glove compression during paclitaxel infusion
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Necmettin Erbakan University
Gastric Cancer, Chemotherapy-induced Peripheral Neuropathy
Predicting Peripheral Neuropathy of Paclitaxel for Gastric Cancer
Although advances in chemotherapy have improved the prognosis of gastric cancer patients, many patients still suffer from adverse events.
- Conditions
- Gastric Cancer, Chemotherapy-induced Peripheral Neuropathy, Paclitaxel, Ramucirumab
- Trial name
- NCT06490159
- Testing
- Paclitaxel
- Where
- Japan
- Volunteers
- 150 people
- Sponsor
- City of Hope Medical Center
Breast Neoplasms, Breast Cancer
Paclitaxel-induced Polyneuropathy in Breast Cancer: Early Detection, Risk Factors, Quality of Life and Lifestyle Outcomes
This is a single center prospective observational cohort study that aims to: examine and identify possible risk and susceptibility factors for the incidence and progression of chemotherapy-induced polyneuropathy (CIPN) in female…
- Conditions
- Breast Neoplasms, Breast Cancer, Early-stage Breast Cancer, Non-Metastatic Breast Carcinoma
- Trial name
- CIPN-REBECCA (NCT06052345)
- Testing
- Garmin smartwatch, REBECCA Mobile application, REBECCA PC plug-in
- Where
- Sweden
- Sponsor
- Theodoros Foukakis
Chemotherapy-induced Peripheral Neuropathy, Breast Cancer Female
Acupuncture Treatment of Chemotherapy-Induced Peripheral Neuropathy in Women
This pilot study aims to evaluate the feasibility to conduct a study of acupuncture treatment (AT) for Chemotherapy-Induced Peripheral Neuropathy (CIPN) at Huntsman Cancer Institute and to investigate changes in physiological…
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Breast Cancer Female, Gynecologic Cancer
- Trial name
- NCT04067544
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Utah
Breast Cancer Stages I Through III
The Efficacy of Acupuncture in Treating Chemotherapy Side Effects in Breast Cancer Patients
The goal of this study is to determine if acupuncture improves multiple symptoms associated with chemotherapy on the MD Anderson Symptom Inventory (MDASI): nausea, vomiting, fatigue, anxiety, anorexia, pain, disturbed sleep…
- Trial name
- NCT01996410
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- OhioHealth
Breast Cancer, Lung Cancer
Amifostine in Treating Peripheral Neuropathy Caused by Paclitaxel in Patients With Solid Tumors
RATIONALE: Amifostine may be effective in reducing pain, numbness, tingling, and other symptoms of peripheral neuropathy. PURPOSE: This phase II trial is studying how well amifostine works in reducing pain, numbness, tingling…
- Conditions
- Breast Cancer, Lung Cancer, Neurotoxicity, Ovarian Cancer
- Trial name
- NCT00078845
- Testing
- Amifostine
- Where
- 15 sites in United States
- Volunteers
- 24 people
- Sponsor
- M.D. Anderson Cancer Center
Chemotherapy-induced Peripheral Neuropathy
A New Diagnostic Method to Assess Paclitaxel-Induced Peripheral Neuropathy
To assess the impact of Paclitaxel treatment on the nerve excitability of the small and large nerve fibers
- Trial name
- PacTox (NCT04237194)
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Carsten Dahl Mørch
Breast Cancer, Gynecologic Cancer
Evaluation of Hydroxychloroquine to Prevent CIPN
The study is being done to research if hydroxychloroquine can prevent chemotherapy induced peripheral neuropathy. Certain chemotherapy drugs, like paclitaxel, are known to cause neuropathy which can impact quality of life.
- Conditions
- Breast Cancer, Gynecologic Cancer, Early-stage Breast Cancer, Peripheral Neuropathy
- Trial name
- NCT05689359
- Testing
- Hydroxychloroquine
- Sponsor
- University of Arizona
Peripheral Neuropathy, Breast Cancer
Efficacy of Metformin as Preventive Treatment in Paclitaxel Induced Peripheral Neuropathy in Breast Cancer Patients
At present, there are no FDA-approved treatments for chemotherapy-induced neuropathy. Discrete neuro anti-inflammatory effects of metformin support its repurposing as a neuroprotective agent in patients with neurodegenerative…
- Trial name
- NCT05351021
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Peripheral Neuropathy
Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer
Purpose: The purpose of the study is to test a new way of measuring nerve damage in women with breast cancer receiving chemotherapy drug paclitaxel (Taxol).
- Trial name
- NCT02549534
- Testing
- Axon Reflexes, Axon Flares, Self-Reported Signs & Symptoms of CIPN
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Indiana University