Clinical trials: Pain, Chronic Disease
Endometriosis
Impact of Ziwig Endotest® on the Management of Patients With Clinical Symptoms of Endometriosis Inconsistent With Their Imaging Work-up
The goal of this study is to evaluate the impact of Ziiwg Endotest on patient management decisions before and after the test. The main questions it aims to answer are: Does the test reduce the intention and number of…
- Trial name
- ENDOBEST (NCT06794424)
- Testing
- Ziwig Endotest®
- Where
- France
- Volunteers
- 2,503 people
- Sponsor
- ZIWIG
Cancer-related Problem/Condition, Neurotoxicity
Electrical Stimulation Pain Therapy in Treating Chronic Pain and Numbness Caused By Chemotherapy in Patients With Cancer
RATIONALE: Electrical stimulation pain therapy may help relieve chronic pain and numbness caused by chemotherapy. PURPOSE: This pilot trial studies electrical stimulation pain therapy in treating chronic pain and numbness caused…
- Conditions
- Cancer-related Problem/Condition, Neurotoxicity, Pain, Peripheral Neuropathy
- Trial name
- NCT01196442
- Testing
- electrical stimulation pain therapy, questionnaire administration
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Virginia Commonwealth University
Pain, Neck
Chronic Neck Pain: Mobility, Sleep, Function
The goal of this observational study is to compare pain, cervical mobility, sleep quality, and functional status between individuals with chronic neck pain (CNP) and healthy individuals.
- Trial name
- observational (NCT06583850)
- Testing
- The Neck Disability Index, Visual analog scale (VAS), Pittsburgh Sleep Quality Index
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Gamze Demircioğlu
Chronic Pancreatitis
CPB Versus Sham Treatment for Pain Management in Small Duct Chronic Pancreatitis
This study assesses the pain response to Endoscopic Ultrasound (EUS) guided Celiac Plexus Block (CPB) treatment in comparison to EUS without a pain block administered. All participants will receive medications for pain as needed.
- Trial name
- NCT02054910
- Testing
- Celiac Plexus Block
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Alabama at Birmingham
Pain, Virtual Reality
Neural Mechanisms of Immersive Virtual Reality in Chronic Pain (VR TMD EEG)
This project examines, in chronic pain, the mechanisms of immersive virtual reality compared to the mechanisms of placebo hypoalgesia.
- Conditions
- Pain, Virtual Reality, Placebo, Temporomandibular Disorder
- Trial name
- VR TMD EEG (NCT06214923)
- Testing
- RelieVRx, No-VR (natural history control)
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of Maryland, Baltimore
Critical Limb Ischemia, Peripheral Vascular Disease
Study of Remodulin in Patients With Critical Limb Ischemia With No Planned Revascularization Procedures
The purpose of this study is to assess and compare the safety of continuous and daily subcutaneous Remodulin therapy in patients with critical limb ischemia (CLI) with no planned vascular interventional procedures; and to…
- Conditions
- Critical Limb Ischemia, Peripheral Vascular Disease, Foot Ulcers, Rest Leg Pain
- Trial name
- NCT00060996
- Testing
- Remodulin® (treprostinil sodium) Injection
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- United Therapeutics
Neuropathic Pain, Chronic Postsurgical Pain
Efficacy of an Intraoperative Periradicular Application of Platelet Rich Fibrin (PRF) on the Intensity of Residual Post-surgical Neuropathic Pain After a Surgery for Disc Herniation
The prevalence of post-surgical lumbar neuropathic radiculopathy is approximately 30%. Poor response to the treatments recommended for neuropathic pain, namely antidepressants and/or gabapentinoids, requires the development of…
- Trial name
- NeuroPRF (NCT05196503)
- Testing
- Treatment
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Shoulder Impingement Syndrome, Chronic Pain
Sensorimotor Cortex Excitability in Shoulder Impingement Syndrome
Shoulder pain is a common musculoskeletal system complaint, accounting for 7-34% of patients in the clinic. The most common shoulder problem is subacromial impingement syndrome (SIS).
- Conditions
- Shoulder Impingement Syndrome, Chronic Pain, Transcranial Magnetic Stimulation, Electroencephalography
- Trial name
- NCT05627986
- Testing
- No intervention
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Endometriosis
Remote Electrical Stimulation as a Long-term Intervention for Endometriosis Flare Ups
The goal of this clinical trial is to learn if a wearable brain stimulation device called NettleEndo can reduce chronic pelvic pain and improve wellbeing in women with endometriosis.
- Trial name
- RELIEF (NCT06974773)
- Testing
- NettleEndo
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Samphire Group, Inc.
Chronic Pain
CANPAIN Feasibility Study Pragmatic Real World Trial Investigating CBMP in Chronic Pain Patients
The CANPAIN study has been devised to evaluate the efficacy and safety of a defined cannabis based medicinal product (CBMP) delivered by inhalation to patients with non cancer chronic pain attending a private clinic.
- Trial name
- CANPAIN (NCT05288010)
- Testing
- Cannabis
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Harley Street (CPC) Limited
Cancer
Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain
RATIONALE: Ketamine hydrochloride may lessen neuropathic pain in patients with cancer. It is not yet known whether ketamine hydrochloride given together with the best pain management is more effective than a placebo given…
- Trial name
- NCT01316744
- Testing
- ketamine hydrochloride, pharmacogenomic studies, questionnaire administration
- Where
- 3 sites in United Kingdom
- Volunteers
- 214 people
- Sponsor
- University of Glasgow
Chronic Pain
Effect of Guanfacine on Opioid-induced Hyperalgesia (OIH) and Tolerance
Dual medication (guanfacine and morphine) as a standard treatment for chronic pain.
- Trial name
- NCT01681264
- Testing
- Morphine, Guanfacine 1mg, Guanfacine 2mg
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Massachusetts General Hospital
Prostatitis, Cystitis, Interstitial
Linkage Analysis in Interstitial Cystitis
Urologic pelvic pain syndrome (UCPPS), variably termed painful bladder syndrome/interstitial cystitis (PBS/IC) in females and chronic prostatitis/chronic pelvic pain syndrome in men (CP/CPPS), is a chronic, debilitating clinical…
- Conditions
- Prostatitis, Cystitis, Interstitial, Urinary Bladder, Overactive, Chronic Pelvic Pain Syndrome
- Trial name
- IC (NCT00675298)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Pain
Clinical Assessment of Pain Processes in Pediatric Patients With Chronic Musculoskeletal Pain
Musculoskeletal (MSK) pain is one of the most common types of pain among children and adolescents. Recurring episodes of MSK pain during childhood does not only impact physical and psychological aspects of daily life but may…
- Trial name
- MSK (NCT04308044)
- Where
- Canada
- Volunteers
- 518 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
Chronic Pain, Post-traumatic Stress Disorder
Treatment of Post-Traumatic Stress Disorder (PTSD) and Chronic Pain After Traumatic Orthopedic Injury
The purpose of this study is to examine the efficacy of multiple treatment options in addressing the co-morbidity between pain and PTSD symptoms.
- Trial name
- NCT00957164
- Testing
- Brief Prolonged Exposure Protocol, Chronic Pain Management Treatment, Self-Care
- Where
- 4 sites in United States
- Volunteers
- 51 people
- Sponsor
- The University of Texas at Arlington
Fibromyalgia, Sleep Initiation and Maintenance Disorders
Nabilone Versus Amitriptyline in Improving Quality of Sleep in Patients With Fibromyalgia
Most chronic pain patients with insomnia are currently not well-managed using existing medications. If found to safely improve sleep with chronic pain patients, nabilone could be added to the treatment options available in the…
- Trial name
- NCT00381199
- Testing
- Amitriptyline Hydrochloride, Nabilone
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Chronic Low Back Pain, Urinary Incontinence
Radiofrequency and Pelvic Floor-Core Exercise for Chronic Low Back Pain in Women With Pelvic Floor Dysfunction
The goal of this clinical trial is to learn whether capacitive-resistive radiofrequency, a supervised core and pelvic floor exercise programme, or both together reduce low back pain in premenopausal women with chronic…
- Conditions
- Chronic Low Back Pain, Urinary Incontinence, Pelvic Floor Disorders
- Trial name
- NCT07906431
- Testing
- Capacitive-resistive radiofrequency, Lumbopelvic-pelvic floor therapeutic exercise
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- SERGIO MONTERO NAVARRO
Chronic Pain, Chronic Pain Syndrome
STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis
The investigators propose to conduct a dose-escalation trial of an FDA-approved antiepileptic drug, lacosamide, added to opioid therapy in patients with chronic abdominal pain from chronic pancreatitis (CP).
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pancreatitis, Hyperalgesia
- Trial name
- STTEPP (NCT05603702)
- Testing
- Lacosamide
- Where
- 5 sites in United States
- Volunteers
- 21 people
- Sponsor
- Indiana University
Fatigue Syndrome, Chronic, Chronic Pain
Subjective Memory Complaints, Objective Memory Performance and Cognitive Training
The aim of this study is to examine if repetitive computerized cognitive training improves working memory in patients who are on sick leave due to complex symptom disorders (chronic pain, chronic fatigue, anxiety, depression and…
- Conditions
- Fatigue Syndrome, Chronic, Chronic Pain, Anxiety Disorders, Depressive Disorder
- Trial name
- NCT02156128
- Testing
- Cogmed working memory training, Control group
- Where
- Norway
- Volunteers
- 54 people
- Sponsor
- Norwegian University of Science and Technology
Critical Limb Ischemia
Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia
This study will compare the effectiveness of best available surgical treatment with best available endovascular treatment in adults with critical limb ischemia (CLI) who are eligible for both treatment options.
- Trial name
- BEST-CLI (NCT02060630)
- Testing
- Open surgical revascularization, Endovascular revascularization
- Where
- 161 sites in United States, Canada and 3 more
- Volunteers
- 1,843 people
- Sponsor
- Carelon Research
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