Clinical trials: Pain, Chronic Post-Surgical
Pain, Hyperalgesia
Preventing Pain After Heart Surgery
The use of pre-emptive analgesia to prevent pain following sternotomy for cardiac surgery
- Conditions
- Pain, Hyperalgesia, Chronic Illness, Neuropathic Pain
- Trial name
- NCT01480765
- Testing
- Pregabalin, Ketamine infusion
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Barts & The London NHS Trust
Scar, Cesarean Section; Dehiscence
A Comparison of Scar Infiltration, Scar Deactivation, and Standard of Care for the Treatment of Chronic, Post-Surgical Pain After Cesarean Section
To compare scar infiltration with 0.5-1% Lidocaine at a dose of 3 mg/kg (max dose 300 mg) or scar deactivation with acupuncture surface release technique to determine which is more effective in reducing pain in adult patients…
- Trial name
- NCT03936309
- Testing
- Scar Deactivation Surface Release Technique protocol, Scar Infiltration with 0.25-1% Lidocaine, Physical therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Jennifer Loomis
Hypertension
Postoperative Pain and Angiotensin II Receptor Antagonists
An angiotensin II type 2 receptor (AT2R) antagonist has been assessed for its efficacy in neuropathic pain with promising results.
- Trial name
- PP&ARA (NCT02513979)
- Testing
- Angiotensin type II receptor antagonists
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- University of Athens
Surgery
Collecting Outcomes and Managing Pain After Surgery
The primary aim of this study is to measure pain and psychosocial patient reported outcomes, objective functionality, and actual daily at home opioid usage in orthopedic patients.
- Trial name
- COMPAS (NCT03834818)
- Testing
- COMPAS Participants
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Duke University
Chronic Postoperative Pain, Cardiac Surgery
Cardiac Surgery, the Incidence and Impact of Chronic postOperative Pain: a Survey
This survey study aims to investigate the incidence of Chronic post surgical pain (CPSP) in cardiac surgery patients treated at UZ Leuven.
- Trial name
- Cardiac COPS (NCT07640646)
- Where
- Belgium
- Volunteers
- 1,000 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Postoperative Pain, Video-Assisted Thoracoscopic Surgery
US-Guided SAPB Versus ESPB on Acute and Chronic Pain After VATS
Postoperative acute and chronic pain is frequently observed in patients undergoing video assisted thoracoscopic surgery (VATS). This prolongs the discharge time of patients and increases the frequency of postoperative pulmonary…
- Conditions
- Postoperative Pain, Video-Assisted Thoracoscopic Surgery, Serratus Anterior Plane Block, Erector Spinae Plane Block
- Trial name
- NCT05160961
- Testing
- Serratus anterior plane block, Erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Pain, Chronic, Critically Ill
Prevalence of Chronic Pain and Its Risk Factors After a Surgical Intensive Care Unit Stay. Prospective Observational Cohort
The objective of this observational, prospective study is to evaluate the incidence of chronic pain at 3 months after ICU discharge in patients with a prolonged ICU stay (i.e. ≥3 days).
- Conditions
- Pain, Chronic, Critically Ill, Opioid-Related Disorders
- Trial name
- DOUCREA (NCT04164342)
- Testing
- surveys
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Angers
Cardiac Surgery, Chronic Postsurgical Pain
SPIP vs ESP Block in Cardiac Surgery
This multicentre, randomized, assessor-blinded, non-inferiority trial will compare the analgesic efficacy of bilateral superficial parasternal intercostal plane (SPIP) block with bilateral erector spinae plane (ESP) block in…
- Conditions
- Cardiac Surgery, Chronic Postsurgical Pain, Postoperative Pain
- Trial name
- SPARE (NCT07780773)
- Testing
- Bilateral Superficial Parasternal Intercostal Plane Block, Bilateral Erector Spinae Plane Block, morphine PCA
- Where
- Turkey (Türkiye)
- Volunteers
- 308 people
- Sponsor
- Ondokuz Mayıs University
Breast Cancer, Chronic Pain
Can Chronic Post-surgical Pain be Reduced by Preserving Intercostobrachial Nerve During Axillary Lymph Node Dissection? : A Randomized Controlled Trial
Intercostobrachial nerve (ICBN) is a cutaneous nerve that provides sensation to the lateral chest, upper medial arm and axilla. It arises from the second intercostal nerve and leave intercostal space at the level of midaxillary…
- Conditions
- Breast Cancer, Chronic Pain, Intercostobrachial Nerve Injury
- Trial name
- PAINE (NCT05198622)
- Testing
- Intercostobrachial Nerve Preserving Axillary Lymph Node Dissection, Intercostobrachial Nerve Sacrificing Axillary Lymph Node Dissection
- Where
- Pakistan
- Volunteers
- 182 people
- Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
Chronic Anal Fissure, Hemorrhoidal Disease
Female Sexual Function After Surgery for Benign Perianal Diseases
Benign perianal diseases such as chronic anal fissure, hemorrhoidal disease, and cryptoglandular anal fistula may negatively affect female sexual function through pain, bleeding, discharge, discomfort, and impairment in quality…
- Conditions
- Chronic Anal Fissure, Hemorrhoidal Disease, Cryptoglandular Anal Fistula
- Trial name
- PERISEX (NCT07666035)
- Testing
- Surgical Treatment for Benign Perianal Diseases
- Volunteers
- 120 people
- Sponsor
- Gazi University
Persistent Postsurgical Pain
Risk Factors and Mechanisms for Persistent Postsurgical Pain After Total Knee Replacement
Osteoarthritis (OA) is the single most common cause of disability in mid and late life. About 27 million people in the United States suffer from this incurable process and 10 million have OA of the knee.
- Trial name
- PPP-TKA (NCT01320150)
- Where
- United States
- Volunteers
- 311 people
- Sponsor
- Rush University Medical Center
Revision Spine Surgery, Fusion of Spine
Pre-Operative Ketamine Infusion for Post Operative Pain Control After Revision Spinal Surgery
To determine if a pre-operative ketamine infusion would provide a similar decrease in post-operative analgesic and opioid consumption as intra-operative ketamine, but expand the monitoring period through the post-operative phase…
- Conditions
- Revision Spine Surgery, Fusion of Spine, Cervical Fusion, Lumbar Fusion
- Trial name
- KIPSs (NCT06066879)
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- AXIS Spine Center- a division of Northwest Specialty Hospital
Acute Pain, Chronic Post Operative Pain
Understanding the Acute Pain Phenotype in Patients Undergoing Surgery
The goal of this observational study is to learn about how regional anesthesia (numbing medication) affects pain in patients with different psychosocial phenotypes such as different levels of concern about pain, sleep issues, and…
- Conditions
- Acute Pain, Chronic Post Operative Pain, Opioid Use
- Trial name
- NCT06466941
- Testing
- regional anesthesia, no regional anesthesia, acute pain consultation
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Brigham and Women's Hospital
Pain
From Acute to Chronic Postoperative Pain in Patients for Elective Cholecystectomy. Immunological Tests
Chronic Pain after Cholecystectomy is a well known problem. One theory is that it is due to persisting inflammation. The purpose of the study is to measure inflammatory factors in cerebrospinal fluid and blod at patients 12…
- Trial name
- NCT01546480
- Where
- 2 sites in Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Chronic Low Back Pain, After Lumbar Spine Surgery
Efficacy of Cognitive Functional Therapy in Individuals With Chronic Low Back Pain After Spinal Surgery
Chronic low back pain after spinal surgery is a complex and disabling condition influenced by biopsychosocial factors. Cognitive Functional Therapy (CFT) is a promising intervention targeting these multidimensional aspects.
- Conditions
- Chronic Low Back Pain, After Lumbar Spine Surgery, Failed Back Surgery Syndrome (FBSS)
- Trial name
- NCT07576062
- Testing
- CFT
- Volunteers
- 90 people
- Sponsor
- Centro Universitário Augusto Motta
Breast Surgery
Comparison of Erector Spinae Plane Block vs Intravenous Lidocaine for Chronic Pain Post Mastectomy.
Patients undergoing breast surgery were divided into two groups: Intravenous Lidocaine (Lido-IV) vs Erector Spinae Block (ESP). For Lido-IV group, patients received a loading dose of Lidocaine than a continuous infusion till the…
- Trial name
- NCT06383845
- Testing
- Lido-IV, ESP Block
- Where
- Tunisia
- Volunteers
- 80 people
- Sponsor
- University Tunis El Manar
Pain
Photo-biomodulation Therapy for Pain Relief After Caesarean Section
C-sections may result in a lot of pain that is distressing to the mother, and can impact bonding with the baby. Although there are medications used to treat strong pain, they are not good to use after C-sections because they can…
- Trial name
- PBMT (NCT05738239)
- Testing
- Laser therapy
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- McMaster University
Chronic Knee Pain, Chronic Knee Osteoarthritis
Treating Chronic Pain of Peripheral Nerve Origin With the Novel Noninvasive Hypersound Neuromodulation System
First, the subject will undergo screening and provide informed consent. Baseline measurements are then taken. The subject remains seated with back support throughout the session.
- Conditions
- Chronic Knee Pain, Chronic Knee Osteoarthritis, Post Surgical Neuropathic Pain
- Trial name
- NCT06626854
- Testing
- RF-PNS
- Volunteers
- 5 people
- Sponsor
- Hypersound Medical Inc
Acute Postoperative Pain, Chronic Postoperative Pain
Menstrual Phase and Postoperative Pain
Fluctuations of female sex hormones during the menstrual cycle influence pain perception. Endogenous pain is pronounced in the follicular phase of the menstrual cycle.
- Trial name
- NCT02137135
- Testing
- HAD scale, The SF 12 test, Visual analogue score
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Failed Back Surgery Syndrome
Clinical Evaluation of Direct Dorsal Column Stimulation
The study will examine the feasibility of Direct Dorsal Column Stimulation using existing Stimulation Leads (Ad-Tech). Secondary endpoints will include pain relief, somatosensory evoked potentials (SSEPs), stimulator settings…
- Trial name
- DDCS (NCT02020460)
- Testing
- Subdural trial lead, Epidural trial lead
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Duke University