Clinical trials: Pain, Experimental
Acute Pain
Human Experimental Models of Pain (HEMP)
This pilot study will test an innovative way to establish how pain medicines provide analgesia in healthy adults. The study uses a group of short, controlled pain tests to look at different types of pain responses in the body.
- Trial name
- NCT07549490
- Testing
- Naproxen, Pregabalin
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Headache, Cervical Pain
Effectiveness of Yoga@Work to Reduce Head and Muscle Pain in Office Workers
The primary objective of this study is to evaluate the effectiveness of a workplace yoga intervention in reducing the frequency of pain involving the head and neck area.
- Conditions
- Headache, Cervical Pain, Musculoskeletal Pain
- Trial name
- NCT04313491
- Testing
- Yoga
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Aarogyam UK
Headache, Migraine
Carbon Monoxide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow
In this study the investigators will research the hypothesis that the gas carbon monoxide induces headache and increases the blood flow velocity in the middle cerebral artery.
- Trial name
- NCT02066558
- Testing
- Carbon monoxide
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Pharmacological Action (PA)
The Effect Methylphenidate Hydrochloride on Pain and Auditory Sensitivity in Healthy Subjects
1. To examine whether Ritalin has analgesic properties in healthy subjects. 2. To examine if Ritalin analgesic effect is a pain specific phenomenon or a part of a broader, non-specific effect on high mental functions.
- Trial name
- NCT01914822
- Testing
- methylphenidate hydrochloride
- Where
- Israel
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Healthy Subjects
Evaluate Onset of Action of a Fast Release Aspirin
To compare the safety and efficacy (onset, duration of relief and overall efficacy) of a single dose of a fast release formulation of aspirin 1000 mg compared to acetaminophen 1000 mg and placebo for relief of pain following…
- Trial name
- TAROT compare (NCT01420094)
- Testing
- Acetylsalicyclic acid (Fast release Aspirin, BAY1019036), Acetaminophen (Tylenol extra strength)
- Where
- United States
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Bayer
Apical Periodontitis
"Effect of Apical Patency on Post-endodontic Pain"
This study is designed to find out the effect of maintaining apical patency versus non maintaining apical patency on post-operative pain after single visit endodontic treatment in necrotic teeth with asymptomatic apical…
- Trial name
- NCT04551209
- Testing
- Maintaining apical patency
- Where
- Pakistan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National University of Medical Sciences, Pakistan
Dyspnea, Pain
Non Opioid Treatment for Experimental Dyspnea
The purpose of this protocol is to test the effects of the non opioid nefopam on experimental dyspnea and on the counterirritation (ie inhibition of one pain by another pain) induced by dyspnea in healthy subjects.
- Trial name
- Nefopel (NCT01577407)
- Testing
- Nefopam
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fibromyalgia
The Innate Central Nervous System Immune Response to an Experimental Immune Challenge in People With Fibromyalgia
The major goal of this study is to determine if the innate immune response is dysregulated in people with fibromyalgia, compared to healthy controls.
- Trial name
- NCT04263454
- Testing
- Endotoxin, Escherichia Coli, Magnetic Resonance Spectroscopy
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pain Perception
The Impact of an Immersive Digital Therapeutic Tool on Pain Perception
The goal of this experimental study is to examine the impact of a virtual reality paradigm on heat pain perception in healthy volunteers.
- Trial name
- NCT06130267
- Testing
- Endocare
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Stéphane Potvin
Surgical Procedure, Unspecified, Pain, Postoperative
Experimental Pain Reporting Accuracy and Clinical Post-operative Pain
Pain is a subjective experience that differs in intensity from one person to another. Appropriate medical care relies on an accurate assessment of the patients' condition.
- Conditions
- Surgical Procedure, Unspecified, Pain, Postoperative, Ear, Nose, and Throat (ENT) Disease
- Trial name
- NCT03854669
- Testing
- pain reporting accuracy
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Low Back Pain, Compare Pain Modulation Assessments in Pain-free Cohorts
Pain Modulation - Experimental Assessments Using Different Modalities
The goal of this study is to investigate how different painful stimuli are processed and modulated in the nervous system. In various pain conditions, including low back pain, often no specific source can be identified as the…
- Trial name
- NCT04323293
- Testing
- Cold Water Bath, Neutral Water Bath
- Where
- Switzerland
- Volunteers
- 705 people, healthy volunteers welcome
- Sponsor
- Schweinhardt Petra
Experimental Pain, Hyperalgesia
Dextromethorphan Effect on Central Sensitization to Pain in Healthy Volunteers
The aim of this study is to assess the anti-hyperalgesic effect of dextromethorphan in healthy volunteers compared to placebo.
- Trial name
- Hydex (NCT02596360)
- Testing
- Pulmodexane® 30mg, lactose
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Healthy
OXY-2: The Pharmacogenetics of Oxycodone Analgesia in Human Experimental Pain Models
Thirty-two healthy volunteers will be submitted to experimental pain and on the 2 study days receive Oxycodone 20 mg po vs. placebo.
- Trial name
- NCT00271973
- Testing
- Oxycodone
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Drugs, Investigational
Evaluate Analgesic Efficacy of Fast Release Aspirin
The objective of the study is to evaluate the analgesic efficacy of a single, oral dose of fast release aspirin tablets, 650 mg (2 x 325 mg) compared to regular aspirin tablets, 650 mg (2 x 325 mg) and placebo in subjects with…
- Trial name
- TAROT (NCT01122602)
- Testing
- Acetylsalicyclic acid (Fast acting Aspirin, BAY1019036), Acetylsalicyclic acid (Aspirin, BAYE4465)
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Bayer
Pain, Experimental
Could Self-distancing Alter the Perception of Experimental Pain?
Physical pain leads to a narrow, egocentric focus on the self, in the here and now, particularly when experienced at high intensity levels.
- Trial name
- NCT05511857
- Testing
- Self-distancing, third-person self-talk., Self-immersed, first-person self-talk., Distraction
- Where
- Sweden
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- Linnaeus University
Psoriatic Arthritis, Foot Arthritis
Effect of Custom Foot Orthoses in Patients With Psoriatic Arthritis
Foot involvement is a major concern in psoriatic arthritis (PsA). The patients could experience severe levels of foot pain and disability and reduced mobility and quality of life.
- Trial name
- NCT05075343
- Testing
- Custom foot orthoses
- Where
- 2 sites in Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Patrick Boissy
Pain, Muscle, Healthy
Modulation of an Experimental Prolonged Pain Model Using High Definition Transcranial Direct Current Stimulation
The purpose of this double-blinded, parallel group randomized controlled trial is to investigate the effects of high definition transcranial direct current stimulation (HD-tDCS) on an experimental prolonged pain model in healthy…
- Trial name
- NCT04650048
- Testing
- Active HD-tDCS
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Pain
An Exploratory Study to Assess the Effects of JNJ-39439335 on the Relief of Pain Using a Thermal-Grill Experimental Model
This exploratory study will use a thermal-grill experimental model to assess the effects of JNJ-39439335 (50 mg, single oral dose) on the relief of pain.
- Trial name
- NCT01006304
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Pain
Analgesic and Antihyperalgesic Effects of Morphine and Buprenorphine
Tissue injury is associated with pain from the injured site (primary hyperalgesia) and pain from non-injured tissue in the vicinity of the trauma (secondary hyperalgesia).
- Trial name
- PASORII (NCT01296334)
- Testing
- morphine LO, Morphine Hi, Buprenorphine LO
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- mads u werner
Pain
Effect of Opioids on Experimental Hyperalgesia in Oesophagus, Skin and Muscles
The study is a multi-modal multi-tissue human experimental pain study in 24 healthy volunteers. The study is a randomized cross-over study. The effect of 2 opioids will be compared on pain stimuli in skin, muscle an oesophagus.
- Trial name
- AEO-2007-01 (NCT00489684)
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus