Clinical trials: Pain, Experimental
Ipsi- and Contralateral Hypoesthesia
A Human Experimental Model for Neuropathic Pain Using Combined Application of Capsaicin and Local Anesthetics
Main of the present study was to develop a model of concomitant C-fibre block and sensitization eliciting spontaneous pain as well applying topical capsaicin and local anesthetics (LA) to examine the sensory alterations after…
- Trial name
- NCT01540877
- Testing
- Application of capsaicin 0.6%, Application of local anesthetics (EMLA plaster), Application of 1 capsaicin 0.6% and 2. EMLA
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Pain, Esophageal Sensitivity
Esophageal Hypersensitivity Study in Healthy Volunteers
The purpose of the study is to compare sensitivity and sensitization of visceral pain in the esophagus using different pain stimuli
- Trial name
- NCT00711048
- Testing
- AZD1386
- Where
- 2 sites in Denmark, Sweden
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Procedural Pain
Paternal vs Maternal Holding-Cuddling for Procedural Pain in Healthy Term Neonates
This study investigated the effect of maternal holding-cuddling (MHC) and paternal holding-cuddling (PHC) on heel prick pain and crying duration in healthy term neonates
- Trial name
- NCT06111534
- Testing
- Holding
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Procedural Pain
Virtual Reality for Procedural Pain During IV Cannulation in Children
This study evaluates whether virtual reality (VR)-based distraction can reduce pain during intravenous cannulation and venous blood sampling in children treated in a pediatric emergency department.
- Trial name
- VR-PED (NCT07740850)
- Testing
- Virtual Reality-Based Distraction
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ege University
Endometrial Biopsy
The Effect of Virtual Reality on Anxiety and Pain During Endometrial Biopsy
The aim of this study was to reduce the anxiety and pain felt during endometrial biopsy procedure.
- Trial name
- NCT06180317
- Testing
- Virtual reality
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kırklareli University
Itch, Pain
The Effects of Performing a Motor Imagery Task on Cortical Excitability During Acute Experimental Muscle Pain and Acute Itch
The aim of this project is to determine the effects of performing a motor imagery task on cortical excitability during acute experimental muscle pain (induced by hypertonic saline), acute histaminergic itch (induced by…
- Trial name
- NCT06503523
- Testing
- Hypertonic Saline, Histamine, Cowhage
- Where
- 2 sites in Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Cognitive Ability, General
Relationship Between Cognitive Function and Pain
Patients with chronic pain can experience considerable changes in their cognitive function such as forgetfulness, increased absentmindedness, confusion etc. Opioids (e.g.
- Trial name
- NCT01375348
- Where
- Denmark
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Pain, Individual Difference
Identifying Neuroimaging Biomarkers, Demographic, Personality and Sensory Factors for Predicting Extreme Pain Responses to Various Experimental Pain Stimulations in Healthy Subjects
The proneness to react to noxious stimuli varies widely between individuals and pain ratings of seemingly identical noxious stimuli may range from "no pain" to "excruciating pain" .
- Trial name
- NCT03436264
- Testing
- MRI
- Where
- Israel
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Fibromyalgia, Irritable Bowel Syndrome
Clinical Study on Implicit Learning, Comorbidity and Stress Vulnerability in Chronic Functional Pain
The project investigates on the role of pain avoidance, comorbidity and stress response for the development of chronic somatic and visceral pain.
- Trial name
- NCT00222209
- Testing
- Experimental heat pain model
- Where
- Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
No Disease State or Condition
Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 on Gingival Mucosal Tissue in Normal Volunteers
The purpose of this study is to determine if the topical application to gingival tissue of the combination of benzocaine and tetracaine has a longer duration of local anesthetic activity than benzocaine alone.
- Trial name
- NCT03233737
- Testing
- One spray CTY-5339-A, One spray CTY-5339-CB, One spray CTY-5339-P
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cetylite Industries
Pain
Experimental Study of Detection an Intentional Performance Degradation in Grip Strength
In this study, the detection of the feigning weakness in grip strength is measured using different grip strength testing instruments.
- Trial name
- NCT02260999
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Christoph Maier, Prof. Dr.
Pain, Acute, Pain, Chronic
Noninvasive Brain Stimulation for Pain Relief
Non-invasive brain stimulation techniques, transcranial magnetic stimulation (TMS) and transcranial focused ultrasound (FUS), is be applied to healthy human subjects, acute pain patients, and chronic pain patients to investigate…
- Conditions
- Pain, Acute, Pain, Chronic, Pain, Experimental
- Trial name
- NCT04283643
- Testing
- Transcranial Focused Ultrasound, Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Tooth Bleaching Pain
The Effect of an Experimental Gel Based on Copaiba Oil Resin in Reducing Post-bleaching Tooth Sensitivity
This randomized, double-blind clinical trial aimed to evaluate the effect of an experimental gel containing copaiba oil resin in reducing postoperative tooth sensitivity caused by bleaching with 35% hydrogen peroxide.
- Trial name
- NCT06066671
- Testing
- GCO (Experimental copaiba oil resin gel)
- Where
- Brazil
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Para
Healthy, Neck Pain
The Effect of Experimental Neck Pain in Healthy Participants
This study investigates if/how an experimentally applied muscle pain/soreness, lasting for some days may affect brain activity, balance, movement patterns, muscle function and pain sensitivity in a healthy population
- Trial name
- NCT03848247
- Testing
- Injection of Isotonic saline, Injection of NGF
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Procedural Pain, Pain-related Fear
Cartoon Watching Versus Ball Squeezing During Venous Blood Sampling in Children
This single-center, parallel-group, randomized experimental study will compare the effects of two non-pharmacological distraction/coping interventions - cartoon watching and ball squeezing - on procedural pain and pain-related…
- Trial name
- NCT07669948
- Testing
- Cartoon-Watching Group, Ball-Squeezing Group
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Mersin University
Pain
Non-pharmacological Pain Management in Term Neonates
A randomised clinical trial in a single centre. This study was performed to compare the effect of white noise, facilitated tucking, and their concerted application during heel-stick sampling on pain in term babies.
- Trial name
- NCT04144543
- Testing
- White Noise, Facilitated Tucking, White Noise+Facilitated Tucking
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Low Back Pain
Central Mechanisms of Intervention for Low Back Pain
Body-based interventions have consistently shown clinical effectiveness in patients with back pain. The primary objective for this study is to compare the effect of body-based interventions commonly used in the management of low…
- Trial name
- NCT01406847
- Testing
- Spinal Manipulation, Spinal Mobilization, Static Touch
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- University of Florida
Pain, Inflammation
Study of Experimental Models of Pain and Inflammation.
The experimental pain model studied in this proposal show characteristics of an inflamed wound with a pro-inflammatory response.
- Trial name
- NCT01097902
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Martin Angst
Cannabis, Pain
Repeated Cannabis Administration on Experimental Pain and Abuse Liability
Chronic pain is a significant public health concern in the U.S., for which prescription opioids have historically been the standard treatment. This has resulted in striking rates of opioid use disorders and fatal overdoses.
- Conditions
- Cannabis, Pain, Tolerance, Hyperalgesia
- Trial name
- NCT04576507
- Testing
- Active Cannabis
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Spinal Manipulation
Effect of Spinal Manipulation on Experimental Pain in Asymptomatic Subjects.
Spinal manipulation is often used for its effect on pain, but more information is needed concerning its mechanisms of action.
- Trial name
- NCT03776708
- Testing
- Spinal manipulation
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institut Franco Europeen de Chiropratique