Clinical trials: Pain, Inflammatory, open to volunteers
Asymptomatic Apical Periodontitis
Effects of Intracanal Cryotherapy on Biomarkers and Postoperative Pain in Apical Periodontitis
This randomized controlled clinical study will evaluate the effects of intracanal cryotherapy during root canal treatment in patients with asymptomatic apical periodontitis.
- Trial name
- NCT07850219
- Testing
- Temperature-Controlled Intracanal Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Medipol University
Postoperative Pain, Facial Swelling
Aescin-Based Herbal Extract (Reparil) for Postoperative Sequelae After Mandibular Third Molar Surgery
This randomized, single-blind, controlled clinical trial aims to evaluate the efficacy and safety of Aescin-based herbal extract (Reparil®) compared with Ibuprofen in managing postoperative sequelae following surgical removal of…
- Conditions
- Postoperative Pain, Facial Swelling, Trismus
- Trial name
- Reparil (NCT07244029)
- Testing
- Escin, Ibuprofen 400 mg
- Where
- Oman
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oman Medical Speciality Board
Quality of Recovery After Mastectomy, Serratus Anterior Plane Block
Timing of Serratus Anterior Plane Block in Mastectomy Surgery
Postoperative pain following mastectomy may adversely affect early mobilization, patient comfort, and overall quality of recovery.
- Conditions
- Quality of Recovery After Mastectomy, Serratus Anterior Plane Block, Postoperative Pain, Mastectomy
- Trial name
- NCT07661212
- Testing
- Ultrasound-Guided Serratus Anterior Plane Block, Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Reproductive Health
Anti-Inflammatory Diet and Physical Activity for Reproductive Health in Adolescent Girls
This study will evaluate whether a 16-week anti-inflammatory dietary intervention, delivered alone or together with a physical activity programme, can improve diet quality and support reproductive health in girls aged 14-19…
- Trial name
- 4fertil (NCT07834489)
- Testing
- Anti-Inflammatory Dietary Intervention, Physical Activity and Training Programme
- Where
- 2 sites in Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Intensive Care Unit ICU, Intubation
The Effects of Endotracheal Suctioning on Pain and Serum Markers
The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients.
- Conditions
- Intensive Care Unit ICU, Intubation, Critical Illness, Mechanical Ventilation
- Trial name
- NCT06692400
- Testing
- endotracheal tube suctioning
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Loma Linda University
Intracanal Dressing, Apical Periodontitis
Effect of Bio-C Temp Versus Calcium Ydroxide as Intracanal Dressings on Postoperative Pain Intensity and Periapical MMP-9 Level in Patients With Necrotic Pulp
To compare the effect of Bio-C Temp Bioceramic intracanal dressing versus calcium hydroxide as intracanal medicaments on: Intensity of postoperative pain levels of MMP -9 in Periapical Fluids.
- Conditions
- Intracanal Dressing, Apical Periodontitis, Calcium Hydroxide, Biomarkers
- Trial name
- NCT07101029
- Testing
- Bio-C Temp Intracanal Medication, Calcium Hydroxide Intracanal medication
- Volunteers
- 30 people
- Sponsor
- Cairo University
Post Operative Pain, Acute, Periodontitis
The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration
Possible participants will be scheduled to have 2 gum flap surgeries done on 2 similar surgical sites in the mouth. The study looks at two different ways of giving dexamethasone, a medication used to reduce inflammation.
- Trial name
- NCT07832110
- Testing
- Dexamethasone IV injection, Dexamethasone Capsule
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Non-steroidal Anti-inflammatory Drugs, Pleurodesis
Non-steroidal Anti-inflammatory Drugs in Pleurodesis
Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended in a multimodal pain management to reduce pain intensity and to spare opioid use.
- Conditions
- Non-steroidal Anti-inflammatory Drugs, Pleurodesis, Pneumothorax, Pain Management
- Trial name
- KETOTHORAX (NCT06731647)
- Testing
- pleurodesis procedures, KETOPROFEN(RP19583)
- Where
- France
- Volunteers
- 358 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Disorders of Gut-brain Interaction, Inflammatory Bowel Disease (IBD)
A Pilot Study Using Gut-Directed Hypnotherapy for Hospitalized Patients
The purpose of the study is to compare the effectiveness of recorded gut-directed hypnosis to an educational recording in people with chronic problems in their gastrointestinal (GI) system.
- Conditions
- Disorders of Gut-brain Interaction, Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome, Abdominal Pain
- Trial name
- NCT07676136
- Testing
- Gut directed hypnotherapy via telephone intervention, Educational recording
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Stanford University
Chronic Pain, Chronic Pain Syndrome
Shiatsu for Chronic Non-Inflammatory Pain in Children and Adolescents
The goal of this clinical trial is to learn if adding Shiatsu therapy to standard treatment can improve quality of life in children and adolescents with chronic pain that is not caused by inflammation.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain and Comorbid Emotional Problems, Chronic Pain, Psychogenic
- Trial name
- ShiQoL (NCT06929598)
- Testing
- Shiatsu Therapy
- Where
- 2 sites in Israel
- Volunteers
- 40 people
- Sponsor
- Tel Aviv University
Low Back Pain, Lumbopelvic Pain
Proprioceptive, Fear-related and Inflammatory Factors in the Persistence of Pregnancy-related Lumbopelvic Pain.
Pregnancy-related lumbopelvic pain (PLPP) affects 50-90% of pregnant women and is often dismissed as a normal part of pregnancy. However, the long-term consequences can be dramatic.
- Conditions
- Low Back Pain, Lumbopelvic Pain, Pelvic Girdle Pain
- Trial name
- PROFit (NCT06785909)
- Testing
- Assessment of postural control, body perception, psychosocial factors and inflammation
- Where
- 2 sites in Belgium
- Volunteers
- 211 people
- Sponsor
- Hasselt University
Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine, Chronic Low Back Pain
SPINE-RISK VE: Multimodal Predictive Model for Failed Back Surgery Syndrome in Venezuelan Surgical Patients
SPINE-RISK VE is a prospective multicenter cohort study designed to develop and internally validate a multimodal preoperative predictive model for Failed Back Surgery Syndrome (FBSS), now classified as Persistent Spinal Pain…
- Conditions
- Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine, Chronic Low Back Pain, Postoperative Pain, Lumbar Spine Surgery
- Trial name
- SPINE-RISK VE (NCT07693517)
- Testing
- SPINE-RISK VE multimodal preoperative assessment
- Where
- Venezuela
- Volunteers
- 150 people
- Sponsor
- juan jose valero quintero,MD
Hemorrhoidectomy, Hemorrhoid Pain
Acupuncture for Post-hemorrhoidectomy Pain Control
The goal of this clinical trial is to learn if acupuncture improves pain control after hemorrhoidectomy in patients with symptomatic hemorrhoids. It will also learn about the safety of using acupuncture in surgical patients.
- Conditions
- Hemorrhoidectomy, Hemorrhoid Pain, Acupuncture
- Trial name
- NCT07238504
- Testing
- Acupuncture
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Endometrial Carcinoma
Low Dose Aspirin to Lower Inflammation and Prevent Endometrial Cancer in Postmenopausal Women With Non-atrophic Endometrial Changes and Pain
This phase IV trial studies whether low dose aspirin can be used to lower inflammation and prevent endometrial cancer in postmenopausal women with changes in the endometrial tissue that are not related to thinning (non-atrophic…
- Trial name
- NCT07281547
- Testing
- Biospecimen Collection, Low-Dose Aspirin, Patient Observation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Acute Coronary Syndromes, Unstable Angina (UA)
Oregano and Basil Leaves and Coronary Artery Disease
The present study will examine the effects of increasing dietary polyphenol intake by consumption of oregano and basil leaves, on plasma inflammatory and lipid factors and total urinary polyphenol levels in patients who have…
- Trial name
- NCT07123181
- Testing
- Control (Standard treatment), Higher polyphenol intake by consumption of oregano and basil
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Necrotic Teeth With Chronic Apical Periodontitis
Regenerative Endodontics in Mature Necrotic Teeth
The goal of this clinical trial is to learn if nanochitosan can achieve regeneration in mature necrotic teeth. It will also provide data about the healing potential \& postoperative pain after using different irrigation…
- Trial name
- NCT07584928
- Testing
- Intervention 1: 1% nanochitosan, Intervention 2: 1% nanochitosan & 17% EDTA
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Suez Canal University
Rib Fractures
Low Dose Dexmedetomidine Versus Normal Saline in Multiple Fracture Ribs
In our study, we assess the diaphragmatic function, pain quality and anti-inflammatory properties between low dose infusion of dexmedetomidine normal saline in patients with multiple fracture ribs on conservative treatment.
- Trial name
- NCT04928300
- Testing
- Dexmedetomidine, 0.9% saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Inflammatory Bowel Diseases
GenesiDol for the Management of Musculoskeletal Pain
Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic, relapsing conditions characterized by persistent inflammation of the gastrointestinal tract and a significant impact on patients'…
- Trial name
- Genesis-Joint (NCT07447154)
- Testing
- Genesidol
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rotator Cuff Syndrome
Exercise vs. Supplements in Rotator Cuff-Related Shoulder Pain
Rotator cuff-related shoulder pain is a pathology characterized by pain and functional impairment originating from one or more rotator cuff tendons.
- Trial name
- NCT05976035
- Testing
- Exercise, Supplement
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Istanbul University - Cerrahpasa
Root End Resection, Periapical Lesion
Effect of Local Use of Non-steroidal Anti-inflammatory Agent (Diclofenac Sodium) With and Without Hyaluronidase on Post-surgical Pain and Swelling
The goal of this clinical trial is to evaluate whether locally applied diclofenac sodium, with or without hyaluronidase, can reduce post-surgical pain and swelling in adult male and female patients (18 years or older) with…
- Conditions
- Root End Resection, Periapical Lesion, Single Rooted Teeth
- Trial name
- NCT07101016
- Testing
- Diclofenac Sodium Gel
- Volunteers
- 44 people
- Sponsor
- Mariam Hesham Mahmoud Abdelfattah Eissa