Clinical trials: Pain, Intractable
Cancer Pains
Change the Dose Frequency of Controlled-Release Oxycodone to Refractory Pain
Many patients with cancer experience moderate to severe pain that requires treatment with strong opioids, of which oxycodone and morphine are examples, they are widely applied in clinical treatment because of sustained-released…
- Trial name
- NCT03639415
- Testing
- Increasing the Controlled-Release Oxycodone dose frequency
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fujian Cancer Hospital
Complex Regional Pain Syndrome
Randomized Controlled Trial of Ketamine Infusion With Continuous Epidural Infusion for Treatment of Complex Regional Pain Syndrome
The purpose of this study is to determine whether epidural and ketamine infusions are effective in the treatment of Complex Regional Pain Syndrome (CRPS).
- Trial name
- NCT02094352
- Testing
- Ketamine Infusion + Epidural Infusion, Control Group + Epidural infusion, Ketamine Booster Infusion
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Refractory Angina
Cardiac Rehabilitation in Patients With Refractory Angina
The purpose of this study is to evaluate the safety and feasibility of cardiovascular rehabilitation in Patients with refractory angina, evaluate the effect of cardiovascular rehabilitation in patients with angina Refractory, by…
- Trial name
- NCT03218891
- Testing
- Cardiac Rehabilitation
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hospital Israelita Albert Einstein
Chronic Pain, Pain, Chronic
Investigating Biological Targets, Markers, and Intervention for Chronic Pain
This multi-modal methods study will investigate neurophysiological, endocrinological, cognitive, psycho-social-emotional markers of chronic pain, and therapeutic targets using integrative health treatments.
- Conditions
- Chronic Pain, Pain, Chronic, Pain Syndrome, Pain, Neuropathic
- Trial name
- NCT04625504
- Testing
- Mindfulness Based Intervention
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Chronic Low-Back Pain, Refractory Pain
Spinal Cord Stimulation vs. Medical Management for Low Back Pain (DISTINCT)
The objective of this study is to evaluate the efficacy of BurstDR dorsal column stimulation, compared with conventional medical management, in improving pain and back-related physical function in subjects suffering with chronic…
- Conditions
- Chronic Low-Back Pain, Refractory Pain, Neuropathic Pain
- Trial name
- NCT04479787
- Testing
- Spinal Cord Stimulation, Conventional Medical Management
- Where
- 30 sites in United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Devices
Endometriosis Related Pain, Overactive Bladder
A Trial to Learn How a New Liquid Form of BAY1817080 is Tolerated and Taken up by the Body of Healthy Male Participants (Part A). By Labeling BAY1817080 With a Radioactive Substance (Carbon 14) Researchers Want to Learn How the Study Drug is Processed and Excreted by the Body After Dosing (Part B)
Researchers are looking for a new way to treat people suffering either from a condition where the bladder is unable to hold urine normally (overactive bladder), or a condition in which tissue similar to the tissue that normally…
- Conditions
- Endometriosis Related Pain, Overactive Bladder, Diabetic Neuropathic Pain, Refractory or Unexplained Chronic Cough
- Trial name
- NCT04487431
- Testing
- BAY1817080, [14C]BAY1817080
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Bayer
Neuralgia, Neuralgia; Postherpetic
Evaluation of an Effectiveness and Safety of the Electroacupuncture in the Management of Intractable Neuropathic Pain
The investigators will evaluate the effectiveness and safety of acupuncture treatment in refractory neuropathic pain patients.
- Conditions
- Neuralgia, Neuralgia; Postherpetic, Diabetic Neuropathy, Painful, Failed Back Surgery Syndrome
- Trial name
- NCT03315598
- Testing
- Electroacupuncture
- Where
- South Korea
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Seoul National University
Pain Syndrome, Pain, Intractable
Determination of Longus Colli Muscle Thickness by Ultrasonography
This study aims to assess the longus colli muscle thickness by ultrasonography in order to guide stellate ganglion blocks
- Conditions
- Pain Syndrome, Pain, Intractable, Complex Regional Pain Syndromes, Hyperhidrosis
- Trial name
- NCT05108103
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Orofacial Pain
Effects of Transcranial Direct Current Stimulation (tDCS) on Patients With Chronic Orofacial Pain
Patients affected by chronic orofacial pain represent an emergent medical problem due to the lack of knowledge on the cause, pathophysiology and psychology of many of these conditions, that belongs to a multifactorial origin.
- Trial name
- NCT01883245
- Testing
- real tDCS
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Endometriosis Related Pain, Overactive Bladder
Study on the Safety of BAY1817080 How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given to Participants With Moderate Renal Impairment and End Stage Renal Disease Requiring Dialysis Compared With Matched Participants With Normal Renal Function
BAY1817080 is currently under clinical development to treat pain related to unexplained chronic cough or chronic cough not affected by a treatment (refractory and/or unexplained chronic cough, RUCC), or a condition where the…
- Conditions
- Endometriosis Related Pain, Overactive Bladder, Diabetic Neuropathic Pain, Refractory or Unexplained Chronic Cough
- Trial name
- NCT04471337
- Testing
- BAY1817080
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
Chronic Pain, Intractable Pain
Multi-center Prospective Study Determining the Sustainability of Pain Relief and Psychosocial and Functional Responses When Utilizing a Multiple Waveform Enabled Neurostimulator
The TRIUMPH study is a post-market, international, multicenter, interventional, prospective, single-arm study intended to evaluate the sustainability of pain control and psychosocial and functional responses utilizing a…
- Trial name
- TRIUMPH (NCT03082261)
- Testing
- Prodigy, Prodigy MRI or Proclaim Elite IPG
- Where
- 22 sites in United States, Canada and 5 more
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Devices
Changes in Brain Network Connectivity
Anesthesia and Functional Connectivity: An Analysis of fMRI Changes
Functional connectivity is defined as a correlation in neural activity between distinct regions of the brain. Several recent studies have demonstrated areas of low-frequency functional connectivity inherent to brain tissue at…
- Trial name
- NCT02196259
- Testing
- Anesthetics, Dissociative
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Pain, Intractable
Pain Blocking During Drug Administration or Blood Collection With Needles
There is a gating mechanism in the dorsal horn of the spinal cord that acts to facilitate or inhibit transmission of pain signals to the brain. The gate can be closed by mechanical stimuli such as touch and vibration.
- Trial name
- NCT01166906
- Testing
- pain blocking
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Endometriosis Related Pain, Overactive Bladder
Study on the Safety of Drug BAY1817080 at Different Doses and the Way the Body Absorbs and Eliminates the Drug in Japanese Healthy Adult Male Participants
Researchers in this study want to learn about the safety of drug BAY1817080 at different doses and the resulting blood levels of the study drug in Japanese healthy adult male participants.
- Conditions
- Endometriosis Related Pain, Overactive Bladder, Diabetic Neuropathic Pain, Refractory or Unexplained Chronic Cough
- Trial name
- NCT04265781
- Testing
- BAY1817080
- Where
- Japan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Bayer
Chronic Pain
The Benefits of Massage for Back Pain
This study evaluates the effectiveness of a oriented massage by comparing it with that of a classic symmetrical massage.
- Trial name
- NCT07664969
- Testing
- Massage
- Where
- New Caledonia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cabinet d'ostéopathie Michel Boeuf
Endometriosis
Spinal Cord Stimulation for Intractable Chronic Lower Abdominal Neuropathic Pain Caused by Endometriosis
Endometriosis is a chronic, inflammatory disease where endometrium-like tissue is present outside the uterus. Nerve cells in the proximity of this tissue express cytokine receptors causing a signaling cascade.
- Trial name
- NCT05558540
- Testing
- spinal cord stimulator
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Prof. Velja Mijatovic
Pain, Postoperative, Ketamine Adverse Reaction
Efficacy of Ketamine in Post Anesthesia Recovery Room
Observational study to assess efficacy of IV ketamine bolus when used in the post anesthesia recovery unit for uncontrolled pain despite use of opioids.
- Conditions
- Pain, Postoperative, Ketamine Adverse Reaction, Pain, Refractory, Pain, Intractable
- Trial name
- NCT04701008
- Testing
- Ketamine
- Where
- Canada
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Pain, Pain, Chronic
Transitioning to a Valve -Gated Intrathecal Drug Delivery System
This study is designed to explore if the valve-gated pump requires less drug to manage subject pain than the prior standard peristaltic pump in the same subject.
- Conditions
- Pain, Pain, Chronic, Pain, Intractable, Pain, Back
- Trial name
- TRANSIT (NCT04312685)
- Testing
- Prometra II Programmable Pump system - Flowonix Medical
- Where
- 8 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bux, Anjum, MD
Refractory Cervicothoracic Myofascial Pain Syndrome (CMPS), Cervical Dystonia
Botulinum Toxin Type A (Botox) for the Treatment of Cervical Dystonia and Upper Thoracic Muscular Pain
The purpose of this study is to investigate the use of injections of Botox (botulinum toxin type A) for the treatment of chronic neck pain. Botox is an approved treatment for patients with cervical dystonia.
- Trial name
- NCT00178945
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University