Clinical trials: Pain, Medication
Pediatric Obstructive Sleep Apnea Syndrome
Investigating the Safety of Post-surgical Analgesics in Children With Obstructive Sleep Apnea
Every year thousands of young children with obstructive sleep apnea undergo surgery which requires them to be prescribed pain medication.
- Trial name
- NCT01680939
- Testing
- Morphine, Ibuprofen
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Post-Traumatic Stress Disorders, Major Depressive Disorder
Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans
Co-occurring post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) is the most common response to trauma; it is associated with poor clinical outcomes and substantial human disability.
- Trial name
- NCT04032301
- Testing
- Ketamine, Normal Saline
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Pain
A Study of Whether 3 New Oral Formulations of a Strong Pain Killer Release the Same Amount of Drug Into the Body as the Marketed Medication
To determine whether three new oral formulations of a strong pain killer release the drug into the body in a similar pattern as the already marketed reference capsule formulation with or without food
- Trial name
- NCT02446561
- Testing
- MRXXX, MR1XXX, MR2XXX
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mundipharma Research Limited
Dexmedetomidine VS Fentanyl as Adjuvants to Epidural Bupivacaine in Patients Undergoing Lumbar Spine Surgeries
Evaluation of the Analgesic Effect of Dexmedetomidine Versus Fentanyl as Adjuvants to Epidural Bupivacaine in Patients Undergoing Lumbar Spine Surgeries
To determine if the epidural route provide an acceptable analgesia in spine surgeries and avoided the need for excessive IV analgesics.
- Trial name
- NCT03463083
- Testing
- Dexmedetomidine, Bupivacaine, Fentanyl
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain, Post-operative
Multimodal Analgesic Protocol to Moderate Acute Pain
With a prospective, observational study assess post-surgery pain levels and patient's use of opioids and other analgesic drugs to moderate pain following third molar surgery.
- Trial name
- NCT03456141
- Testing
- third molar surgery
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Oral Soft Tissue Conditions, Drug Effect
Flurbiprofen Tablet vs Spray In Oral Soft Tissue Wounds
The amount of active ingredient in tablet form of flurbiprofen is higher than that in the oral spray form. Therefore, based on the hypothesis that the side effects that may occur depending on the dose can be reduced, this…
- Conditions
- Oral Soft Tissue Conditions, Drug Effect, Drug Use
- Trial name
- NCT06238154
- Testing
- Flurbiprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Pain
Analgesic Use and Effectiveness for Dental Procedures
Opioid analgesics prescribed by dentists may contribute to the larger national issue of the use and abuse of the drug. On occasion dental pain may be sufficiently severe to support the use of opioids.
- Trial name
- NCT02929602
- Where
- United States
- Volunteers
- 2,773 people, healthy volunteers welcome
- Sponsor
- Pearl Network
Knee Arthritis
The Efficacy of Collaborative Patient Education on Total Knee Arthroplasty
This project is about the integrated rehabilitation program for the patients receiving total knee arthroplasty. The investigators are monitoring the WOMAC(Western Ontario and Mcmaster University Arthritis Index)/ Pain…
- Trial name
- NCT05346822
- Testing
- integrated rehabilitation (the collaborative patient education)
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Low Back Pain, Pregnancy Related
Treatment of Low Back Pain in Pregnant Women : Uses of Drugs and Other Therapies
Low back pain is a frequent clinical condition in pregnancy. Drugs treatments are limited. Other therapies are often used, associated or not with drugs (acupuncture, manipulative medicine, physical therapies, homeopathy).
- Trial name
- LomboMat2021 (NCT05072002)
- Testing
- no intervention / observational study
- Where
- France
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Opiate Addiction
Buprenorphine and Methadone for Opioid Dependent Chronic Pain Patients
The purpose of this study is to determine if buprenorphine or methadone is better for the treatment of chronic pain among patients who have become addicted to prescription narcotics.
- Trial name
- NCT00879996
- Testing
- Methadone, Buprenorphine/naloxone
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Oxytocin, Labor Pain
The Stimulation To Induce Mothers Study
The investigators propose a parallel group randomized clinical trial of intrapartum nipple stimulation versus exogenous oxytocin infusion for nulliparous women undergoing induction of labor near term.
- Conditions
- Oxytocin, Labor Pain, Induction of Labor Affected Fetus / Newborn, Physiologic Effects of Drugs
- Trial name
- STIM (NCT05079841)
- Testing
- Electric breast pump, Exogenous oxytocin intravenous infusion without nipple stimulation.
- Where
- 3 sites in United States
- Volunteers
- 933 people, healthy volunteers welcome
- Sponsor
- Yale University
Endometriosis Related Pain, Overactive Bladder
Study on the Safety of BAY1817080 How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given to Participants With Moderate Renal Impairment and End Stage Renal Disease Requiring Dialysis Compared With Matched Participants With Normal Renal Function
BAY1817080 is currently under clinical development to treat pain related to unexplained chronic cough or chronic cough not affected by a treatment (refractory and/or unexplained chronic cough, RUCC), or a condition where the…
- Conditions
- Endometriosis Related Pain, Overactive Bladder, Diabetic Neuropathic Pain, Refractory or Unexplained Chronic Cough
- Trial name
- NCT04471337
- Testing
- BAY1817080
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
Osteoarthritis
A Study of Orthotic Shoe Inserts for Controlling Osteoarthritic Knee Pain
Osteoarthritis is a degenerative joint disease and is the most common form of arthritis. This study will evaluate the effectiveness of customized shoe inserts in controlling and relieving the pain of knee osteoarthritis.
- Trial name
- NCT00076453
- Testing
- Lateral wedge orthotic shoe inserts, Standard orthotic shoe inserts
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Pain, Abuse, Drug
Age-dependent Effects of Smoked and Oral Delta-9-THC
This study will assess the age-dependent effects of smoked and oral THC on abuse liability, intoxication, analgesia and impairment as a function of age.
- Conditions
- Pain, Abuse, Drug, Intoxication; Cannabinoids
- Trial name
- SAGE (NCT05865470)
- Testing
- Cannabis, Dronabinol
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Mobile-based Mindfulness Intervention to Reduce Preoperative Anxiety, Pre-operative Anxiety
Effects of Mobile-based Mindfulness Intervention to Reduce Preoperative Anxiety for Patients Undergoing Elective Surgery
This study is a pilot randomized controlled trial (RCT) conducted at Tin Shui Wai Hospital to evaluate the effectiveness of a mobile-based mindfulness intervention in reducing preoperative anxiety among patients scheduled for…
- Conditions
- Mobile-based Mindfulness Intervention to Reduce Preoperative Anxiety, Pre-operative Anxiety, Postoperative Pain, Postoperative Use of Analgesics
- Trial name
- NCT07005973
- Testing
- mobile-based mindfulness intervention
- Where
- Hong Kong
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Hospital Authority, Hong Kong
Endometriosis, Endometriosis-related Pain
Metabolomic Profile in Women With and Without Endometriosis
The pathogenesis of endometriosis is very complex as several factors, including genetic, environmental and lifestyle-related factors, are involved in the development, progression and maintenance of the disease.
- Conditions
- Endometriosis, Endometriosis-related Pain, Infertility
- Trial name
- METABOLENDO (NCT05496218)
- Testing
- Blood samples
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Pain, Postoperative
Analgesic Efficacy of Two Adjuvants During Spinal Anaesthesia.
: Pain modulation is very important after operation, particularly for women who undergo caesarean section. A pain-free postoperative period is essential following a caesarean section so new mothers may care for and bond with…
- Trial name
- NCT03458078
- Testing
- Saline Solution, Magnesium Sulfate, Midazolam 5 MG/ML Injection
- Where
- 2 sites in Tunisia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre de Maternité de Monastir
Intracanal Medication, N-acetylcystine
Effect of N-acetylcysteine Versus Calcium Hydroxide Used as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Levels of MMP -9 in Periapical Fluids in Patients With Necrotic Pulp
To compare the effect of N-acetylcysteine versus calcium hydroxide as intra canal medication on: Intensity of postoperative pain. Bacterial load reduction. levels of MMP -9 in Periapical Fluids.
- Conditions
- Intracanal Medication, N-acetylcystine, Calcium Hydroxide, Mediators
- Trial name
- NCT05666089
- Testing
- N-acetyl cysteine, Calcium hydroxide
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Medication Adherence, Medication Compliance
Connected Healthcare for Individuals Living at Home With Chronic Conditions
Managing and taking medications as prescribed can be a difficult task. This is especially true for older adults living at home with chronic conditions while managing multiple prescribed medications.
- Conditions
- Medication Adherence, Medication Compliance, Medication Nonadherence, Hypertension
- Trial name
- NCT04339296
- Testing
- Spencer
- Where
- Canada
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Alberta Health Services, Calgary
Decrease Post Laproscopy Shoulder and Abdominal Pain
Multimodal Analgesic Technique for Control of Post-laproscopy Abdominal Pain
The advancement of laparoscopy and minimal access surgery has greatly influenced the evolution of anaesthetic techniques. However, postoperative pain intensity may be significant, with up to 40% of patients unsatisfied by routine…
- Trial name
- NCT03241602
- Testing
- Intraperitoneal lidocaine, Pulmonary Recruitment, Combined intraperitoneal lidocaine and pulmonary recruitment maneuver
- Where
- Egypt
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Cairo University