Clinical trials: Pain, Nerve
Stroke, Spinal Cord Diseases
Use of tDCS Stimulation in Neurological and Gynaecological Conditions
The aim of the study is to test the effect of tDCS stimulation on upper and lower limb function in neurological patients and to reduce pain in gynaecological patients.
- Conditions
- Stroke, Spinal Cord Diseases, Nerve Root Disorder, Endometriosis
- Trial name
- tDCS (NCT06891690)
- Testing
- tDSC stimulation
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Pain Management, Capsaicin-Induced Pain
TaVNS for Capsaicin-Induced Pain
Effective pain management remains a major clinical challenge. Transcutaneous auricular vagus nerve stimulation (taVNS) has emerged as a promising, non-invasive neuromodulation technique due to its safety, ease of administration…
- Conditions
- Pain Management, Capsaicin-Induced Pain, Transcranial Magnetic Stimulation Repetitive, Electroencephalography
- Trial name
- NCT07719868
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Sciatic Leg Pain, Hamstring Muscle Tightness
Acute Effects of Neurodynamics on Strength and Endurance in Athletes
This study explores the acute effects of neurodynamics, an intervention commonly used by physical therapist to improve nerve mobility and decrease pain, on the strength and muscular endurance in the athletic population.
- Conditions
- Sciatic Leg Pain, Hamstring Muscle Tightness, Hamstring Muscle Strain, Hamstring Muscle Strength
- Trial name
- NCT07721220
- Testing
- Sciatic Slider, Sciatic Tensioner, Mechanically loaded neurodynamic sciatic floss
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- High Point University
Sciatic Nerve, Lower Extremity Pain
Effect of Sciatic Nerve Mobilization on Lower Extremity Pain Perception
This randomized controlled study aims to investigate the effect of sciatic nerve mobilization on pain perception in lower extremity peripheral nerves, specifically the tibial and common peroneal nerves.
- Trial name
- NCT07525895
- Testing
- Sciatic Nerve Mobilization
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Fenerbahce University
Dental Anxiety, Inferior Alveolar Nerve
Reducing Pain During Dental Nerve Block Injections in Children
Title of Study: Effect of External Cooling and Vibration, Counterstimulation, and Needle Type on Pain, Physiological, and Behavioral Outcomes During Inferior Alveolar Nerve Block in Pediatric Patients Why was this study done? The…
- Conditions
- Dental Anxiety, Inferior Alveolar Nerve, Pain Management
- Trial name
- IANB (NCT07667725)
- Testing
- Buzzy Device, Counterstimulation, 30-Gauge Needle
- Where
- Iraq
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Al-Mustansiriyah University
Neuropathic Pain
Safety, Tolerability, and Pharmacokinetics of ASCT-83 in Healthy Adults
The goal of this clinical trial is to learn if ASCT-83 is safe and well-tolerated and measure how ASCT-83 is absorbed, distributed, and eliminated from the body over time. The study will be conducted in healthy adults.
- Trial name
- NCT07363395
- Testing
- ASCT-83
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Alcamena Stem Cell Therapeutics
Opioid Consumption, Postoperative, Pain, Postoperative
Comparison of Pain Relief Methods for Hip Surgery: A Study on Two Different Nerve Block Techniques
This prospective randomized comparative study aims to compare the analgesic efficacy of pericapsular nerve group block (PENG) and lumbar erector spinae plane block (L-ESP) groups to relieve postoperative pain in participants over…
- Conditions
- Opioid Consumption, Postoperative, Pain, Postoperative, Nerve Block, PENG Block
- Trial name
- NCT06821516
- Testing
- Evaluation of the postoperative analgesic effectiveness of PENG block in participants undergoing total hip arthroplasty under spinal anesthesia, Evaluation of the postoperative analgesic effectiveness of lumbar erector spinae block in participants undergoing total hip arthroplasty under spinal anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Vagus Nerve Autonomic Disorder, Heart Rate
Balance, Autonomic Response, and Sensory Modulation to Dosage of Mechanical Vagal Stimulation in Healthy Adults
The vagus nerve (VN) plays a crucial role in regulating vital functions (heart rate, blood pressure, digestion, and immune response) and maintaining communication between internal organs and the brain.
- Conditions
- Vagus Nerve Autonomic Disorder, Heart Rate, Pain, Equilibrium; Disorder, Labyrinth
- Trial name
- BARVANS (NCT06541808)
- Testing
- mechanical Vagus Nerve Stimulation (Low Intensity), mechanical Vagus Nerve Stimulation (Intermediate Intensity), mechanical Vagus Nerve Stimulation (High Intensity)
- Where
- Austria
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Pain Modulation, Sensorimotor Function
Transcutaneous vs Percutaneous Electrical Stimulation of the Radial Nerve
This study aims to compare the effects of two types of electrical nerve stimulation techniques-Transcutaneous Electrical Nerve Stimulation (TENS) and Percutaneous Electrical Nerve Stimulation (PENS)-on the sensory and motor…
- Conditions
- Pain Modulation, Sensorimotor Function, Nerve Stimulation
- Trial name
- TENS vs PENS (NCT07247721)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS), Percutaneous Electrical Nerve Stimulation (PENS)
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Orthodontic Appliance, Pain
The Effect of Intraoral Transcutaneous Electrical Nerve Stimulation in Orthodontics Pain
The goal of this clinical trial is to determine whether an intraoral Transcutaneous Electrical Nerve Stimulation (TENS) device can reduce pain during orthodontic alignment and leveling in adolescents and adults.
- Conditions
- Orthodontic Appliance, Pain, Transcutaneous Electric Nerve Stimulation, Orthodontic Appliance Complication
- Trial name
- NCT06573996
- Testing
- Active TENS Device
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of the Pacific
Pain Management, Anesthesia , Analgesia
Comparison Between External Oblique Intercostal Plane Block and Rectus Sheath Block Combined With Transversus Abdominis Plane Block
Effective perioperative pain management remains a cornerstone in enhancing recovery and improving patient outcomes in laparoscopic cholecystectomy.
- Conditions
- Pain Management, Anesthesia , Analgesia, Nerve Block
- Trial name
- NCT07384000
- Testing
- External intercostal plane puncture, control group (nalbuphine), the single-puncture technique of (rectus sheath block) combined with (Transversus abdominis plane block)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Nerve Block, Postoperative Pain
A Block Method for Pain After Back Surgery
The purpose of this clinical trial is to evaluate whether bilateral lumbar erector spinae plane (ESP) block can reduce postoperative pain in adult patients undergoing lumbar spine surgery.
- Conditions
- Nerve Block, Postoperative Pain, Randomised Clinical Trial
- Trial name
- NCT07346599
- Testing
- ESP block group
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Kutahya City Hospital
Pain Measurement, Knee Replacement Arthroplasty
Anterior Cutaneus Nerve and Distal Adductor Canal Block With USG for Total Knee Replacement Analgesia
This prospective clinical study was approved by the institutional ethics committee on September 27, 2023, and patient enrollment started in October 2023.
- Conditions
- Pain Measurement, Knee Replacement Arthroplasty, Nerve Block
- Trial name
- NCT06201195
- Testing
- Adductor canal blockade, Distal adductor canala blockade and anterior cutaneus nerve blockade
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Diskapi Teaching and Research Hospital
Post Operative Pain, Anesthesia
Comparison of Interscalene Catheter to Single Injection Interscalene Blocks for Total Shoulder Arthroplasties
Comparison of post-operative pain after total shoulder surgery. The Principle Investigator will be comparing Exparel single shot block to Interscalene catheter
- Conditions
- Post Operative Pain, Anesthesia, Nerve Block, Shoulder Osteoarthritis
- Trial name
- NCT05868330
- Testing
- Interscalene Catheter, Exparel Single Shot Interscalene Block
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Melinda Seering
Postoperative Pain Management, Postoperative Pain
Comparative Efficacy of Sciatic and Femoral Blocks in Ankle Surgery
Comparison of Anesthetic and Postoperative Analgesic Efficacy of Femoral and Popliteal Sciatic Block vs Femoral and Anterior Sciatic Block in Ankle Surgery
- Conditions
- Postoperative Pain Management, Postoperative Pain, Analgesia, Nerve Blocks
- Trial name
- NCT06758245
- Testing
- femoral and anterior sciatic nerve block, femoral and popliteal sciatic nerve block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Symptomatic Irreversible Pulpitis (SIP), Dental Pain
Intraligamentary vs Inferior Alveolar Nerve Block for Pulpitis: A Randomized Clinical Trial
This multicenter randomized trial compares the clinical effectiveness of intraligamentary injection versus inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis in mandibular molars.
- Conditions
- Symptomatic Irreversible Pulpitis (SIP), Dental Pain, Inferior Alveolar Nerve Block Failure, Local Anesthesia
- Trial name
- NCT07130760
- Testing
- Intraligamentary Injection, Inferior Alveolar Nerve Block
- Where
- 2 sites in Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Aula Dental Avanzada
Postoperative Pain Management, Postoperative Pain
Postoperative Analgesic Efficacy of Modified TAPA and QL Blocks in Laparoscopic Cholecystectomies
Comparison of Postoperative Analgesic Effects of M-TAPA and Anterior Quadratus Lumborum Blocks in Laparoscopic Cholecystectomies.
- Conditions
- Postoperative Pain Management, Postoperative Pain, Analgesia, Nerve Blocks
- Trial name
- NCT06540586
- Testing
- anterior Quadratus lumborum block, M-TAPA BLOCK
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Chronic Pain, Peripheral Neuropathy
StimRouter Registry Clinical Protocol
This Registry study will prospectively evaluate the long-term effectiveness, safety, and tolerability of the StimRouter Neuromodulation System, along with evaluating the technical performance of StimRouter, surgical outcomes…
- Conditions
- Chronic Pain, Peripheral Neuropathy, Nervous System Diseases, Peripheral Nervous System Diseases
- Trial name
- NCT03913689
- Testing
- StimRouter Neuromodulation System
- Where
- 9 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Bioness Inc
Healthy Females, Vagus Nerve Stimulation
Effects of tVNS on Visceral Pain
Transcutaneous auricular vagal nerve stimulation (taVNS) has shown promise in reducing chronic abdominal pain, such as in irritable bowel syndrome (IBS).
- Conditions
- Healthy Females, Vagus Nerve Stimulation, Abdominal Pain
- Trial name
- NCT06659172
- Testing
- taVNS
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Chronic Neck Pain, Telerehabilitation
Telerehabilitation With Transcutaneous Electrical Nerve Stimulation Chronic Neck Pain:
Nonspecific chronic neck pain (NCNP) is defined as non-specific neck pain lasting more than three months. It is a very common disease that causes a great obstacle in the daily life activities of individuals in the society.
- Conditions
- Chronic Neck Pain, Telerehabilitation, Transcutaneous Electrical Nerve Stimulation, Pain
- Trial name
- NCT06206343
- Testing
- TENS application, Tele-rehabilitation treatment program
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University