Clinical trials: Pain Modulation
Pain
Mechanism-based Choice of Therapy for Neuropathic Pain
Mechanism-based choice of therapy for neuropathic pain: Can treatments success in neuropathic post-operative pain be coupled to psychophysical pain modulation profile?
- Trial name
- NCT01359514
- Testing
- Pregabalin, Duloxetine
- Where
- Israel
- Volunteers
- 32 people
- Sponsor
- Rambam Health Care Campus
Stroke
The Role of Peripheral Afferents in Modulating Post-stroke Central Pain
Central post-stroke pain (CPP) is extremely difficult to relieve and responds very poorly to analgesics targeting neuropathic pain, probably because the mechanisms underlying this pain remain poorly understood.
- Trial name
- APEDOC (NCT06446960)
- Testing
- Lidocaine 20mg/ml, Levobupivacaine Hydrochloride 1.25 MG/ML, Sodium Chloride 0.9% Inj
- Where
- 2 sites in France
- Volunteers
- 33 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Neck Pain, Diffuse Noxious Inhibitory Control
Neural Tensioner Exercise on Conditioned Pain Modulation
Background: There is evidence linking conditioned pain modulation (CPM) deficiency with musculoskeletal pain syndromes such as fibromyalgia, migraine, tension-type headaches and irritable bowel syndrome, as well as with…
- Trial name
- NCT02816060
- Testing
- manual therapy
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Universidad Rey Juan Carlos
Healthy
Modulation of Painful Perception
The objective of the study is to evaluate in healthy volunteers, the influence of empathy on pain perception. It is widely accepted in the clinical management that the feeling of listening to the patients' pain would have a…
- Trial name
- MODOU (NCT02528578)
- Testing
- thermal stimulation delivered by a thermode., functional MRI
- Where
- 2 sites in France
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Pain, Osteoarthritis, Hip
Modulation of the Surgical Inflammatory Response by Etoricoxib
The purpose of this study is to test the hypothesis that orally administered etoricoxib (COX-2) modulates prostaglandin and cytokine synthesis in the central nervous system (CNS) and in the periphery in surgical patients and thus…
- Conditions
- Pain, Osteoarthritis, Hip, Postoperative Pain
- Trial name
- NCT00746720
- Testing
- Etoricoxib 60 mg
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Postoperative Pain, Acute, Opioid Use
Randomized Trial of Narcotic vs Non-Narcotic Pain Modulation After Labrum Repair
The purpose of this study is to determine if patients age 15 to 30 years old being treated for shoulder labrum repair and SLAP lesions have significant differences in pain levels postoperatively when treated with a combination…
- Conditions
- Postoperative Pain, Acute, Opioid Use, Labral Tear, Glenoid
- Trial name
- NCT05974423
- Testing
- Tylenol, Ibuprofen, and Oxycodone, Tylenol and Ibuprofen only
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cooper Health System
Pain, Neuropathic, Complex Regional Pain Syndromes
Modulating Neuropathic Pain With Transcranial Direct Current Stimulation
This study will examine whether a form of non-invasive brain stimulation can help reduce pain in people with persistent neuropathic pain.
- Conditions
- Pain, Neuropathic, Complex Regional Pain Syndromes, Phantom Limb Pain, Spinal Cord Injuries
- Trial name
- NCT04581525
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Susan McDowell
Pain
Non-invasive Modulation of Spinal Cord Nociceptive Reflexes
The aims of this study are threefold. First, to investigate whether spinal nociceptive processing - represented here by the nociceptive flexion reflex (NFR) - is influenced by thoracic transcutaneous spinal direct current…
- Trial name
- NCT05711498
- Testing
- Transcutaneous spinal direct current stimulation (tsDCS)
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Max Planck Research Group Pain Perception
Low Back Pain
Analysis of Orthopedic Patients Response to New Pain Modulating Substances and Drugs
Data of patient reported outcomes (PRO) are collected during treatment with various pain alleviation methods (drugs or substances)
- Trial name
- NCT03138460
- Testing
- standard medications crossed over to cannabis
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rabin Medical Center
Subacromial Pain Syndrome
Effects of Blood Flow Restriction Training in Rotator Cuff Related Shoulder Pain
Blood flow restriction training is widespread in sport performance areas, where it has proven to be beneficial in strength and hypertrophy development.
- Trial name
- NCT04834271
- Testing
- Side-lying external rotation exercise with a dumbbell, Side-lying external rotation exercise with a dumbbell with 40% arterial occlusion pressure blood flow restriction, Side-lying external rotation exercise with a dumbbell with 80% arterial occlusion pressure blood flow restriction
- Where
- Spain
- Sponsor
- University of Alcala
Atrial Fibrillation
Atrial Fibrillation Symptoms and Pain Sensitization
Atrial fibrillation (AF) is the most common sustained arrhythmia and the number of patients with AF is expected to increase substantially in the coming decades.
- Trial name
- NCT04649437
- Testing
- Quantitative sensory testing
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Region Örebro County
Healthy
The Interaction Between Conditioned Pain Modulation and Expectation in Understanding the Placebo Effect of Pain Reduction
The interaction between conditioned pain modulation and expectation in understanding the placebo effect of pain reduction
- Trial name
- NCT03484728
- Where
- Israel
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Gulf War Syndrome
Transcranial Direct Current Stimulation for Pain Treatment in Gulf War Illness.
The goal of this study is to investigate long-term modulation of pain pathways leading to a suppression of pain symptoms in Gulf War Illness patients by applying transcranial direct current stimulation.
- Trial name
- NCT03547869
- Testing
- Active tDCS
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- The University of Texas at Dallas
Post-operative Chronic Pain
Shifting Pain Modulation From Pro-to Anti-nociceptive
To create a data base that will facilitate the enrichment of the insights regarding post-operative pain development, and to identify those individuals with the potential to develop this kind of pain.
- Trial name
- NCT02672202
- Testing
- Duloxetine, Pregabalin
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Irritable Bowel Syndrome
Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome
The purpose of this study is to provide new information and to determine which kinds of brief, tolerable, experimental pain are affected by the drugs being studied in patients with irritable bowel syndrome, a disease that causes…
- Trial name
- NCT00100425
- Testing
- Viceral Perception Testing
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Knee Osteoarthritis
Percutaneous Electrical Stimulation, Education and Exercise Program in Patients With Knee Osteoarthritis
The purpose of this study is to compare the effectiveness of percutaneous electrotherapy treatment with transcutaneous and placebo.
- Trial name
- NCT05955430
- Testing
- Therapeutic exercise, Pain education, Percutaneous electrical stimulation
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Josue Fernandez Carnero
Fibrous Dysplasia of Bone, McCune Albright Syndrome
PAINDYS_Characterizing Pain in Fibrous Dysplasia of Bone/McCune-Albright Syndrome: an Exploratory Pilot Study
Fibrous dysplasia of bone (FD) / McCune-Albright syndrome (MAS) is a rare congenital bone disorder affecting one or multiple bones, caused by a mosaic somatic mutation of the GNAS gene.
- Trial name
- PAINDYS (NCT07476768)
- Testing
- Visit 1 at the center
- Where
- France
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Knee Osteoarthritis, Chronic Pain
Motor Cortex Plasticity and the Effect of Deep Intramuscular Needling Stimulation Therapy (DIMST) in Osteoarthritis Pain
The aim of this study is to evaluate the cortical excitability in pain of knee osteoarthritis (OA), as well as the effect of one session of a kind of electroacupuncture (deep needling intramuscular stimulation therapy - DIMST) in…
- Trial name
- NCT01855958
- Testing
- DIMST
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Healthy, Pain
Selective Nerve Stimulation (SNS) Pilot Study
The purpose of this study is to examine if a new device, the SNS (Selective Nerve Stimulator), is effective in changing the way nerves work as pain killing drugs sometimes do.
- Trial name
- SNS (NCT01259271)
- Testing
- Selective Nerve Stimulation (SNS) stimulator device
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Codman & Shurtleff
Shoulder Pain, Healthy Volunteers
Sensory Processing and Musculoskeletal Shoulder Pain
The development of chronic pain is a common complication in shoulder pain conditions. Half of these type of patients exhibit persistent pain even after a period of six to twelve months from the start of their pain treatment.
- Trial name
- NCT05368649
- Testing
- Short-wave diathermy
- Where
- Argentina
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Gran Rosario