Clinical trials: Pain Modulation
Mechanisms and Modulators of Placebo Analgesia in Healthy Volunteers
The Effect of Oxytocin on Placebo Analgesia: an Experimental Study in Healthy Volunteers
Placebo responses contribute to medical treatment outcome. The purpose of this study is to determine whether a single intranasal application of oxytocin can increase the placebo response in an experimental model of placebo…
- Trial name
- NCT01886014
- Testing
- Oxytocin
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Work-related Illness
Central and Peripheral Sensitization, Pain Mediators in Thumb Pain Among Physiotherapists
The work-related thumb pain is a common problem among physiotherapists which deal with this experience at least once in their life.
- Trial name
- NCT05345496
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Healthy
Pain Inhibitory Effects of a Single Painful Mechanical Stimulus Compared to Multiple and Multiple at Different Locations
The objective is to estimate the effects on pain thresholds of a single painful mechanical stimulus compared to multiple and multiple stimuli at different locations.
- Trial name
- NCT05730179
- Testing
- Mechanical Conditioning stimulus
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Josue Fernandez Carnero
Neuropathic Pain
Exploring the Role of the GABAergic Modulation in Pain Transmission in Human
Neuropathic pain affects about 7% of the general population in European countries. Meta-analyses indicate that only a minority of neuropathic pain patients has adequate response to drug therapy and management of neuropathic pain…
- Trial name
- NDMC-101 (NCT03375034)
- Testing
- NDMC 20mg, NDMC60mg, Clonazepam 1.5mg
- Where
- Switzerland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Jules Desmeules
Motor Activity
Investigating Motor Cortex Processing for Pain Modulation
The purpose of this study is to investigate the effects of different types of interventions (motor learning, somatosensory learning, observation task, mental imagery and tDCS) on the perception of pain and motor cortex…
- Trial name
- NCT01404039
- Testing
- Motor Learning, Somatosensory Learning, Observational Task
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Pain Perception, Autonomic Nervous System Functioning
Music-based Intervention for the Reduction of Pain
This study aims to compare the impact of listening to frequency-modulated music vs. non-modulated music (both researcher-selected), and to test whether there are differential effects on pain and stress perception.
- Trial name
- MINTREP (NCT02991014)
- Testing
- researcher-selected frequency-modulated music, researcher-selected non-modulated music, participant-selected non-modulated music
- Where
- 2 sites in Austria, Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Healthy Volunteers
Reliability of Measuring Conditioned Pain Modulation With the Nociceptive Withdrawal Reflex
Conditioned pain modulation is the ability of the spine to describe changes in pain perception, if two different painful stimulations take place.
- Trial name
- NCT01636440
- Testing
- Conditioned Pain Modulation
- Where
- Switzerland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Healthy Subjects
Effect of Prayer on Conditioned Pain Modulation and on Pain Intensity in Healthy Religious University Students
With this study the investigators wish to examine the effect of prayer on pain intensity and on the conditioned pain modulation in healthy religious university students.
- Trial name
- NCT04614272
- Testing
- Prayer, Reading a poem
- Where
- Lebanon
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Antonine University
Pain
In Vitro Studies on Pharmacological Regulation and Genetic Risk Factors of Peripheral Human Nociceptors
This protocol is for a number of in vitro studies using human surgical biopsies and evaluating the pharmacology and genetics of human nociceptors ("pain detecting") neurons
- Trial name
- NCT00223366
- Where
- United States
- Volunteers
- 2,007 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pain
Peripheral KV7 Activation for Pain Relief
The goal of this clinical trial is to learn if the drug Flupirtine can safely lower pain when used in tiny amounts directly in the skin.
- Trial name
- NCT06971250
- Testing
- Capsaicin only (7.6 ng), Capsaicin + Flupirtine 0.5 µg, Capsaicin + Flupirtine 1.2 µg
- Where
- Austria
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Stefan Heber
Shoulder Pain
Central and Peripheral Sensitization, and Pain Contributing Factors in Shoulder Pain Patients and Healthy People
Compared to healthy subjects, central and peripheral sensitization will be investigated in patients with non-specific shoulder pain, since no data is available at the moment.
- Trial name
- NCT05360589
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Tennis Elbow, Health Adult Subjects
Assessment of Pressure Pain Threshold (PPT) and Conditioned Pain Modulation (CPM) After Effect in Patients With and Without Tennis Elbow (TE)
This study at Hashemite University looks at how people with and without tennis elbow (AKA lateral elbow tendinopathy) feel pressure pain and how their bodies briefly "turn down" pain after a cold stimulus.
- Conditions
- Tennis Elbow, Health Adult Subjects, Lateral Elbow Tendinopathy (Tennis Elbow), Pressure Pain Threshold (PPT)
- Trial name
- NCT07178288
- Testing
- Physiological/measurement-validation study
- Where
- Jordan
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- The Hashemite University
Pain, Transcranial Direct Current Stimulation
Transcranial Versus Suboccipital Direct Current Stimulation
Randomized controlled trial, in parallel with cross-control design. Two groups of healthy subjects will be randomly selected to transcranial stimulation group or suboccipital stimulation group.
- Trial name
- NCT04117256
- Testing
- Direct Current Stimulation
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Low Back Pain, Disc, Herniated
Motor Control Mechanisms by CNS of Tuina in Patients With Lumbar Disk Herniation
Lumbar disk herniation (LDH)is a prevalent health problem around the world. It can cause symptoms of low back pain, numbness or weakness.The understanding of low back pain in traditional Chinese medicine(TCM) theory"unbalanced…
- Trial name
- NCT03475095
- Testing
- Tuina
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Post-op Pain
Study to Assess Dopamine Receptor Modulation With Rotigotine to Enhance Morphine Analgesia in the Dental Model
Narcotics are widely used as the mainstay of pain treatment, although increasing doses are required over time as the individual becomes tolerant to their effects.
- Trial name
- NCT02123979
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Healthy Participants
The Power of Belief: Expectation-driven and Placebo Modulation of Empathic Pain
This study investigates how belief and expectation influence empathic pain-the pain we feel when observing others in distress. Healthy adult participants will be randomly assigned to one of three groups: no-treatment control…
- Trial name
- PoB-EP (NCT07367672)
- Testing
- Intranasal Oxytocin (OT) 24 IU
- Where
- 2 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Arthritis, Knee Osteoarthritis
Immediate Effects Of Alliance Therapy In Modulation Of Pain And Disability In Subjects With Knee Osteoarthritis
INTRODUCTION: The Osteoarthritis (OA) is the most common type of joint disease, its features include joint space narrowing, osteophytes formation of the joint margins, motor deficit, reduced strength, and persistent pain.
- Trial name
- NCT03928054
- Testing
- Kinesio Taping and therapeutic alliance
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
Neck Pain
Conditioned Pain Modulation in Chronic Neck Pain Patients
The aim of this study was to evaluate changes in local and segmental hypersensitivity and endogenous pain inhibition in people with chronic nonspecific neck pain.
- Trial name
- NCT03362203
- Testing
- Patients with chronic neck pain, Subjects without chronic neck pain
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Pectus Excavatum, Pectus Deformity
Assessing Virtual Reality for Perioperative Anxiolysis in Adolescents Undergoing MIRPE Surgery
In this randomized control trial, investigators would like to assess as primary objective the effectiveness of VR in anxiolysis via using State Trait Anxiety- Inventory test various time during the perioperative period with…
- Trial name
- NCT06446518
- Testing
- Virtual reality exposure
- Where
- Hungary
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Tinnitus, Pain
Modulating Mechanisms in Patients With Chronic Subjective Tinnitus and/or Chronic Pain
This is a cross-sectional investigation into modulating mechanisms in patients with chronic subjective tinnitus, which will compare 4 patient groups namely chronic tinnitus with chronic pain, chronic tinnitus without chronic…
- Trial name
- NCT05186259
- Testing
- Self-reported signs of central sensitization, Objective signs of central sensitization, Audiological outcome measures (audiometry, tinnitus analysis, uncomfortable loudness) in tinnitus patients with and without pain
- Where
- Belgium
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University Ghent