Clinical trials: Pain Modulation
Kinesiophobia (Fear of Movement), Experimental Pain
Pain Beliefs and Intracortical Excitability During Experimental Pain
Pain can influence the way the motor system functions. However, responses to pain vary widely between individuals, and this variability may be partly related to pain-related beliefs such as kinesiophobia.
- Trial name
- NCT07688525
- Testing
- Topical Capsaicin Cream (1%)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Pain
Influence of Percutaneous Electrolysis on Endogenous Pain Modulation
Percutaneous electrolysis is a minimally invasive approach that consists in the application of a galvanic current through an acupuncture needle.
- Trial name
- NCT04710992
- Testing
- Isolated needling procedure, Low intensity percutaneous electrolysis, High intensity percutaneous electrolysis
- Where
- Spain
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Healthy Volunteers
Effects of Cerebral and Peripheral Electrical Stimulation on Conditioned Pain Modulation in Healthy Subjects.
The Neuromatrix pain model and new findings on pain chronification process point to a greater efficacy of treatments that address central and peripheral rather than only peripheral structures.
- Trial name
- NCT03752502
- Testing
- Transcranial direct current stimulation (tDCS), Peripheral electrical stimulation (PES)
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Piauí
Fibromyalgia, Whiplash
Diffuse Noxious Inhibitory Controls (DNIC): Nociceptive Modulation and Interaction With Neurocognitive Performance in Chronic Pain
Diffuse noxious inhibitory control In order to quantify central sensitization in chronic pain patients, the Diffuse Noxious Inhibitory Control (DNIC) model has been used frequently.
- Conditions
- Fibromyalgia, Whiplash, Chronic Pain
- Trial name
- NCT01172795
- Testing
- Relaxation session, Neurocognitive test battery
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Opioid Pain Medication
Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation
This study is a prospective randomized trial examining the effect of topically combined antifibrinolytics (Tranexamic acid) with local anesthetics in all electively created surgical wound beds in hand surgery to provide long term…
- Trial name
- NCT04814433
- Testing
- Tranexamic acid, Aminocaproic acid, Recombinant Human Thrombin
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Chronic Pain, Central Sensitisation
Effect of Boswellia Serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers
This planned study is based on a randomized, placebo-controlled cross-over design. Boswellic acids, the triterpenes found in the gum resins of Boswellia serrata (family: Burseraceae), are traditionally used in the Indian…
- Conditions
- Chronic Pain, Central Sensitisation, Peripheral Sensitization, Neuroinflammatory Response
- Trial name
- BSPP (NCT07109843)
- Testing
- Boswellia serrata extract
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Habituation
Conditioned Pain Modulation Using Painful Cutaneous Electrical Stimulation or Simply Habituation?
Painful cutaneous electrical stimulation (PCES) and corresponding evoked potentials led to a significant pain relief and decrease of evoked potentials and has been used to analyze conditioned pain modulation (CPM).
- Trial name
- NCT03237650
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Low Back Pain, Compare Pain Modulation Assessments in Pain-free Cohorts
Pain Modulation - Experimental Assessments Using Different Modalities
The goal of this study is to investigate how different painful stimuli are processed and modulated in the nervous system. In various pain conditions, including low back pain, often no specific source can be identified as the…
- Trial name
- NCT04323293
- Testing
- Cold Water Bath, Neutral Water Bath
- Where
- Switzerland
- Volunteers
- 705 people, healthy volunteers welcome
- Sponsor
- Schweinhardt Petra
Cold Exposure
Comparison of the Analgesic Effects of Acupuncture and Modulated Electroanalgesia in Cold Induced Pain
Physiotherapy offers a range of therapeutic modalities for pain management including Transcutaneous Electrical Nerve Stimulation (TENS), Interferential current (IC) and Acupuncture.
- Trial name
- NCT01483885
- Testing
- Transcutaneous Electric Nerve Stimulation, Interferential Current, Manual Acupuncture
- Where
- Brazil
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Piauí
Acute Pain, Neuroplasticity
HD-tDCS: Effects on the Somatosensory System
The purpose of this study is to investigate the efficacy of high definition tDCS on different cortical targets in modulating the nociceptive system in the healthy subjects.
- Conditions
- Acute Pain, Neuroplasticity, Brain Modulation, Somatosensory Function
- Trial name
- NCT04165876
- Testing
- Primary Motor Cortex Stimulation, Dorsolateral Prefrontal Cortex Stimulation, Multimodal Stimulation (DLPFC+M1)
- Where
- Denmark
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Median Nerve Injury
Effects of Motor Imagery in Pain Modulation and Median Nerve Mechanosensitive in Healthy Patients
The aim of this study are 1) to determinate the effectiveness of motor imagery or strength training in differens aspects of pain modulation. 2) evaluate the functional improvement of the hand by a motor imagery protocol.
- Trial name
- NCT04086563
- Testing
- Action observation, Mirror therapy, Neurodynamic exercises
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Amnesia, Pain
Memory Modulation by Pain During Anesthesia
The purpose of this study is to determine the effects of pain on facilitating long-term auditory memory in the presence and absence of distinct intravenous anesthetics.
- Conditions
- Amnesia, Pain, Anesthesia
- Trial name
- MMA (NCT02515890)
- Testing
- Dexmedetomidine, Midazolam, Peripheral nerve stimulation
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Fibromyalgia
Isometric Exercise and Endogenous Pain Inhibition
The purpose of this study is to identify the acute effects of isometric exercise on the inhibition of pain in individuals with fibromyalgia.
- Trial name
- NCT03778476
- Testing
- Isometric Exercise
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Marquette University
Nerve Growth Factor, Exercise
Cortical Neuroplasticity by Muscle Pain of Pain-induced Plasticity
The purpose of this study is to investigate the sensory-motor cortical excitability response to delayed onset muscle soreness (DOMS) on Extensor Carpi Radialis (ECR) muscle during muscle hyperalgesia provoked by nerve growth…
- Conditions
- Nerve Growth Factor, Exercise, Motor Activity, Abnormality of SSEPs
- Trial name
- NCT03354624
- Testing
- Sterile solutions of recombinant human nerve growth factor (NGF)
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Prolonged Pain, Neuroplasticity
Modulatory Effects of Multichannel tDCS During Prolonged Experimental Pain
Corticomotor excitability, pain sensitivity, descending pain control and somatosensory evoked potentials (SEPs) is often altered in acute and chronic pain.
- Conditions
- Prolonged Pain, Neuroplasticity, Brain Modulation
- Trial name
- NCT04165980
- Testing
- transcranial direct current stimulation
- Where
- Denmark
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Chronic Widespread Pain, Fibromyalgia (FM)
The Added Value of Transcranial Direct Current Stimulation (tDCS) During Exercise for People With Chronic Widespread Pain
Many people with chronic widespread pain (CWP) feel more pain and fatigue after exercise. This makes it hard to stay active. Unfortunately, the investigators do not fully understand why this happens and how to prevent it.
- Trial name
- NCT07212829
- Testing
- Active tDCS, Aerobic exercise
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Pain, Acute, Pain, Chronic
The Impact of Music on Nociceptive Processing
The investigators are studying the ways that different music may change pain perception
- Conditions
- Pain, Acute, Pain, Chronic, Anxiety, Anxiety Disorders
- Trial name
- NCT04087564
- Testing
- music intervention
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pain, Muscle, Healthy
Modulation of an Experimental Prolonged Pain Model Using High Definition Transcranial Direct Current Stimulation
The purpose of this double-blinded, parallel group randomized controlled trial is to investigate the effects of high definition transcranial direct current stimulation (HD-tDCS) on an experimental prolonged pain model in healthy…
- Trial name
- NCT04650048
- Testing
- Active HD-tDCS
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Complex Regional Pain Syndrome Type I
Pain in Complex Regional Pain Syndrome
CRPS is a complex pain condition that usually develops in response to trauma and immobilization which is very painful and debilitating.
- Trial name
- NCT04667364
- Testing
- Transcutaneous electrical nerve stimulation (TENS)
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Pain
The Influence of Expectations, Attention and the Test Paradigm on the Efficacy of the Pain Processing System
Conditioned pain modulation (CPM) is the endogenous pain relief mechanism responsible for the "pain-inhibits-pain" phenomenon. This mechanism can be activated experimentally, and its efficiency evaluated by experimental pain…
- Trial name
- CPM_AWARE (NCT05161286)
- Where
- Belgium
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Ghent