Clinical trials: Pain Perception
Low Back Pain, Low Back Pain, Mechanical
Effects of Mental Participation During Lumbar Stabilization and Neuromuscular Electrical Stimulation in Chronic Non-Specific Low Back Pain
This study was conducted to investigate the effects of incorporating synchronized voluntary muscle activation and active motor engagement during neuromuscular electrical stimulation (NMES) into a lumbar stabilization exercise…
- Conditions
- Low Back Pain, Low Back Pain, Mechanical, NMES, Mental Perception
- Trial name
- NCT07857642
- Testing
- Exercise + NMES, Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Pain Perception in Endodontic Treatment, Menstrual Cycle
Menstrual Cycle, Menopause, and Pain Perception During Endodontic Treatment
The goal of this observational study is to investigate whether menstrual cycle phases and menopausal status are associated with pain perception in patients undergoing endodontic treatment.
- Conditions
- Pain Perception in Endodontic Treatment, Menstrual Cycle, Menopause
- Trial name
- NCT07850167
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Acute Pain, Pain Perception
Effects of Transcutaneous Vagus Nerve Stimulation on Pain and Brain Activity in Healthy Adults
The goal of this clinical trial is to learn whether stimulating a nerve in the neck changes how much pain people feel. It also looks at whether this stimulation changes brain activity.
- Conditions
- Acute Pain, Pain Perception, Healthy Adult Participants
- Trial name
- NCT07827690
- Testing
- Active transcutaneous vagus nerve stimulation, Cold pressor test
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- David A. Purger
Pain Perception, Root Resorption
The Potential Effect of the Local Administration of Vitamins C and E on Orthodontic Treatment: A Randomized Clinical Trial
Brief Summary of the Study This study investigates the effects of locally administered vitamins C and E on orthodontic tooth movement during the initial stage of treatment.
- Conditions
- Pain Perception, Root Resorption, Rate of Orthodontic Tooth Movement, Biomarkers
- Trial name
- NCT06847880
- Testing
- 1: Vitamin C Supplementation, Vitamin E Supplementation, Saline Solution (Control)
- Where
- 3 sites in Iraq
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Pain, Postoperative, Numbness
Lidocaine Versus Bupivacaine in Orthognathic Surgery
In this research study, we want to learn more about the impact of two different local anesthetics (bupivacaine and lidocaine) on patient experience following orthognathic (jaw) surgery.
- Conditions
- Pain, Postoperative, Numbness, Temperature Sensation, Perception of Touch
- Trial name
- NCT06450028
- Testing
- 10 cc of 0.25% bupivacaine hydrochloride with 1:200,000 epinephrine, 6.8 cc of 2% lidocaine hydrochloride with 1:100,000 epinephrine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Hyperalgesia, Pain Perception
Session-Order Sensitivity of TS and OA in a Capsaicin Crossover Model
Temporal summation (TS) and offset analgesia (OA) are widely used psychophysical endpoints in pain research that index different components of central nociceptive processing.
- Conditions
- Hyperalgesia, Pain Perception, Central Nervous System Sensitization, Pain Threshold
- Trial name
- TS-OA-Cap (NCT07625475)
- Testing
- Topical 0.075% capsaicin cream (Zostrix), Topical vehicle lotion (Lubriderm)
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Carbon Monoxide, Pain Perception, Sensory Thresholds, Anxiety, Depression, Tobacco Smoking
Effects of CO Level on Pain, Sensory Function, and Subjective Health
Carbon monoxide (CO) is a colorless and odorless gas that can enter the human body through environmental exposure and especially tobacco use.
- Trial name
- NCT07571941
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Pain Perception of the New Device
Assessment of Maxillary Local Anesthesia Infiltration Using Needle-free Jet vs Conventional Syringe in Tooth Extraction
Managing pain and anxiety during dental anesthesia remains a key concern, particularly in procedures involving needle-sensitive adult patients.
- Trial name
- NCT07498621
- Testing
- needle-free anesthesia jet (Comfort-in™), Conventional dental syringe injection
- Where
- Saudi Arabia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Anterior Teeth Alignment Efficiency, Pain Perception
Comparison of Conventional and Cu-NiTi Archwires Regarding Clinical Efficiency and Pain Intensity Using Prostaglandin E2 Biomarker During Alignment and Leveling
Orthodontic treatment can inflame the periodontium and dental pulp, it can be uncomfortable and even painful at times. This may induce discomfort and the release of different biochemical mediators, which is one of the main causes…
- Conditions
- Anterior Teeth Alignment Efficiency, Pain Perception, PGE2 Biomarker and Their Correlation
- Trial name
- NCT06653881
- Testing
- ARCHWIRE
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Local Anesthetic Infiltration, Topical Anesthesia
Topical Cryoanesthesia Versus Benzocaine in Pediatric Dentistry
This clinical study tested and compared two ways (cold-base technique or "cryoanesthesia" and conventional benzocaine gel) to reduce pain from dental injections in children.
- Conditions
- Local Anesthetic Infiltration, Topical Anesthesia, Pain Perception
- Trial name
- No acronym (NCT07351383)
- Testing
- Local Anesthesia (lidocaine hydrochloride)
- Where
- Mexico
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Exercise Induced Hypoalgesia, Circadian Rhythm
Pain Perception and Exercise-Induced Hypoalgesia Across Circadian Rhythms
The goal of this randomized crossover clinical trial is to investigate whether exercise-induced hypoalgesia (EIH) is influenced by circadian rhythm in healthy adults aged 18-40 years.
- Conditions
- Exercise Induced Hypoalgesia, Circadian Rhythm, Pain Perception, Healthy Participants
- Trial name
- NCT07290465
- Testing
- High-Intensity Functional Training (HIFT), Supervised Deep Breathing
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Medipol University
Pain Perception
Electronic Anesthetic Efficacy Prof. Ali Rokia Ph.D. Al-Andalus University Prof . Mouetaz Kheirallah Ph.D ArabUST
A Spilt Mouth Clinical Comparative Evaluation Of The Electronic Anesthetic Efficacy Comparison of traditional local anesthesia with electronic local anesthesia in terms of the ability to reduce pain during injection and the…
- Trial name
- ArabUST (NCT07257432)
- Testing
- Experimental group: Electronic syringe therapeutic intervention arm, control group: therapeutic intervention using a traditional syringe
- Where
- 2 sites in Syria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mouetaz Kheirallah
Low Back Pain, Life Style
Prognostic Factors of Importance on Who Develops Chronic Low Back Pain
The incidence of low back pain (LBP) is increasing and prognostic factors for developing LBP are unclear. Based on questionnaires, different prognostic factors are being explored over time.
- Conditions
- Low Back Pain, Life Style, Illness Perception
- Trial name
- NCT03940456
- Testing
- Questionnaire
- Where
- Denmark
- Volunteers
- 607 people, healthy volunteers welcome
- Sponsor
- Frederiksberg University Hospital
Birth Outcomes, Labor Pain and to Reduce Pain
The Effect of the Intrapartum Care Model Given in Line With WHO Recommendations on the Birth Process and Care
This study aimed to evaluate the effects of the intrapartum care model provided in line with the World Health Organization (WHO) recommendations on labor pain, fear, comfort, duration, oxytocin use and perception of midwifery…
- Conditions
- Birth Outcomes, Labor Pain and to Reduce Pain, Fear of Birth, Birth Comfort
- Trial name
- NCT06681675
- Testing
- The group that applied the Intrapartum Care Model
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Computer-controlled Intraligamentary Anaesthesia, Inferior Alveolar Nerve Block
Comparison of the Computer Controlled and Conventional Local Anesthesia Techniques in Primary Molar Extraction in Children Aged 5 to 9 Years Old
The goal of this clinical trial is to assess pain perception, child stress level and compare the effectiveness between periodontal ligament anesthesia using Computer-controlled Local Anesthetic delivery system and the…
- Conditions
- Computer-controlled Intraligamentary Anaesthesia, Inferior Alveolar Nerve Block, Pain Perception, Anesthesia Effectiveness
- Trial name
- RCT (NCT06669039)
- Testing
- Computer-controlled Local Anesthetic delivery system, Inferior Alveolar Nerve Block
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Autonomic Nervous System Modulation, Pain Perception
Pain Perception and the Autonomic Nervous System
In this study, we want to investigate how pain processing and sensation are related to a certain part of the nervous system, the so-called autonomic nervous system.
- Conditions
- Autonomic Nervous System Modulation, Pain Perception, Pain Sensitivity, Central Sensitization
- Trial name
- NCT06667895
- Testing
- respiratory gated taVNS, random burst stimulation, continuous stimulation
- Where
- Switzerland
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Schweinhardt Petra
Autism Spectrum Disorder (ASD), Pain Perception
Quantitative Sensory Testing to Study Pain Perception in Autism
This study aims at assess sensory perception, and pain perception, in neurodivergent children and adolescent in the autism spectrum.
- Trial name
- PPiA (NCT06659731)
- Testing
- Quantitative Sensory testing (QST), EEG
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Pain Perception
Pain Perception Following Computer-Controlled vs. Conventional Dental Anesthesia
This single-blind two-arm randomized control trial (RCT) aims to evaluate the pain perception during and following administration of dental local anaesthesia using two different systems; i.e.
- Trial name
- NCT05192902
- Testing
- Computer-controlled Local Anaesthesia (CCLA), Conventional Local Anaesthesia
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Infant, Newborn, Infant, Premature
Effect of a Vibratory Stimulus on Mitigating Nociception-specific Responses to Skin Puncture in Neonates
The assessment and treatment of pain in neonates remains a challenge. In an effort to improve the quality of care while limiting opioid-related adverse effects, this study aims to determine the efficacy of a non-pharmacological…
- Conditions
- Infant, Newborn, Infant, Premature, Pain Perception, Pain Measurement
- Trial name
- NCT04050384
- Testing
- Baby GentleStick
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Lance M Relland, MD, PhD
Pain Perception, Secondary Hyperalgesia
Electrical Intra-cutaneous Half-sine Stimulation for Optimized Preferential C-fiber Activation
This exploratory study is to improve an established pain model by a new stimulation profile that allows preferential activation of C fibers that are of main clinical interest in chronic pain and also to generate a stable…
- Trial name
- NCT05440266
- Testing
- Study Intervention: 25 ms half-sine wave stimulation, Control Intervention: 500 µs rectangular shaped stimulation
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland